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Forensische Psychiatrie, Psychologie, Kriminologie

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24.07.2018 | Antiepileptika | Übersicht

Zur Pharmakotherapie impulsiver Aggression bei antisozialen und psychopathischen Störungen

verfasst von: Alan R. Felthous, M.D., Matthew S. Stanford, Univ.-Prof. Dr. med. Henning Saß, M.D.

Erschienen in: Forensische Psychiatrie, Psychologie, Kriminologie | Ausgabe 3/2018

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Zusammenfassung

Impulsive Aggression stellt ein häufiges Merkmal bei psychopathischen Störungen dar und kann mit Psychopharmaka behandelt werden. Aus kontrollierten Studien ergeben sich für die folgenden gegen impulsive Aggression eingesetzten Wirkstoffe („anti-impulsive aggressive agent“, AIAA) die stärksten Wirksamkeitsnachweise: Fluoxetin, Phenytoin, Divalproex/Valproat, Carbamazepin/Oxcarbazepin und Lithiumsalz. Diese Übersichtsarbeit beschreibt, ausgehend von einer Risiko-Nutzen-Analyse und der Studienlage in den USA, die Auswahl und den Einsatz eines möglichst gut geeigneten AIAA bei Patienten mit psychopathischer Störung. Dabei werden positive und negative Gesichtspunkte für die Auswahl, die Anwendung sowie mögliche Wirkmechanismen des jeweiligen AIAA umrissen. Des Weiteren werden Möglichkeiten zur Behandlung von impulsiver Aggression bei Patienten erörtert, bei denen ein AIAA keine Besserung gebracht hat.

Ahrens B, Müller-Oerlingshausen B (2001) Does lithium exert an independent antisuicidal effect? Pharmacopsychiatry 34(4):132–136. https://doi.org/10.1055/s-2001-15878 PubMedCrossRef

American Psychiatric Association (2002) Practice guideline for the treatment of patients with bipolar disorder. Am J Psychiatry 159(Suppl. 4):1–50

American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders, 5. Aufl. American Psychiatric Association, Washington DCCrossRef

Barratt ES (1991) Measuring and predicting aggression within the context of a personality theory. J Neuropsychol 3(2):535–539

Barratt ES, Slaughter L (1998) Defining, measuring, and predicting impulsive aggression: A heuristic model. Behav Sci Law 16(3):285–302PubMedCrossRef

Barratt ES, Faulk DM, Brandt ME, Bryant SG (1986) Effects of phenytoin on N100 augmenting/reducing and the late positive complex of the event related potential: A topographical analysis. Pharmacoelectroencephalography 15:201–207. https://doi.org/10.1159/000118264 CrossRef

Barratt ES, Kent TA, Bryant SG, Felthous AR (1991) A controlled trial of phenytoin im impulsive aggression. J Clin Psychopharmacol 11(6):388–389PubMedCrossRef

Barratt ES, Stanford MS, Felthous AR, Kent TA (1997a) The effects of phenytoin on impulsive and premeditated aggression: A controlled study. J Clin Psychopharmacol 17(5):341–349. https://doi.org/10.1097/00004714-199710000-00002 PubMedCrossRef

Barratt ES, Stanford MS, Kent TA, Felthous AR (1997b) Neurological and cognitive psychophysiological substrates of impulsive aggression. Biol Psychiatry 41:1045–1061. https://doi.org/10.1016/5006.3223(96)00175-8 PubMedCrossRef

Baumann P, Nil R, Souche A, Montaldi S, Baettig D, Lambert S, Uehlinger C, Kasas A, Amey M, Jonzier-Perey M (1996) A double-blind, placebo-controlled study of citalopram with and without lithium in the treatment of therapy-resistant depressive patients: A clinical, pharmacokinetic, and pharmacogenetic investigation. J Clin Psychopharmacol 16:307–314. https://doi.org/10.1097/00004714-199608000-00006 PubMedCrossRef

Bernasconi R, Martin P (1979) Effects of antiepileptic drugs on the GABA turnover rate (Abstract 251). Naunyn Schmiedebergs Arch Pharmacol 307:R63

Bocchetta A, Mossa P, Velluzzi F, Mariotti S, Zompo MD, Louiselli A (2001) Ten year follow up of thyroid function in lithium patients. J Clin Psychopharmacol 21:594–598. https://doi.org/10.1097/00004714-200112000-00009 PubMedCrossRef

Bocci V, Beretta G (1976) Esperienzesuglialcoolisti e tossicomania con dipropilacetate di sodio. Lav Neuropsichiatr 58:51–61

Bowden CL (2004) Valproate. In: Schatzberg AF, Nemeroff CB (Hrsg) Textbook of Psychopharmacology, 3. Aufl. American Psychiatric Association, Washington DC, S 567–579

Bowden CL, Brugger AM, Swann AC, Calabrese JR, Janicak PG, Petty F, Dilsaver SC, Davis JM, Rush AJ, Small JG, Garza-Treviño ES, Risch SC, Goodnick PJ, Morris DD, Shu V, Johnson P, Blake M, Javors M, Ereshefsky L, McLeod T, Shoaib A, Johnson M, Kimmel S, Wesley A, Qualtiere R, Trivedi C, Javaid J, Peterson J, Lambert M, Zielinski M, Orsulak P, Sharp L, Akers L, Miller M, Kellams J, Woodham G, Frazer A (1994) Efficacy of divalproex vs. lithium and placebo in the treatment of mania. The Depakote mania study group. JAMA 271:918–924. https://doi.org/10.1001/jama.1994.03510360044034 PubMedCrossRef

Bowden CL, Calabrese JR, McElroy SL, Gyulai L, Wassef A, Petty F, Pope HG, Chou JC-Y, Keck PE, Rhodes LJ, Swann AC, Hirschfeld RMA, Wozniak PJ (2000) A randomized, placebo-controlled 12 month trial of divalproex and lithium in the treatment of outpatients with bipolar I disorder. Arch Gen Psychiatry 57:481–489. https://doi.org/10.1001/archpsyc.57.5.481 PubMedCrossRef

Brown D, Larkin F, Sengupta S, Romero-Ureclay JL, Ross CC, Gupta N, Vinestock M, Das M (2016) Clozapine: An effective treatment for seriously violent and psychopathic men with antisocial personality disorder in UK high-security hospital. In KD Warburton, SM Stahl (Hrsg) Violence in Psychiatry (S 187–201). Cambridge: Cambridge University Press

Butler T, Schofield PW, Greenberg D, Allnut SH, Indig D, Carr V, D’Este C, Mitchell PB, Knight L, Ellis A (2010) Reducing impulsivity in repeat violent offenders: An open label trial of a selective serotonin reuptake inhibitor. Aust N Z J Psychiatry 44(12):1137–1143. https://doi.org/10.3109/0004867.2010.525216 PubMedCrossRef

Buzan RD, Firestone D, Thomas M, Dubovsky SL (1995) Valproate-associated pancreatitis and cholecystitis in six mentally retarted adults. J Clin Psychiatry 56:529–532PubMed

Cade JF (1949) Lithium salts in the treatment of psychotic excitement. Med J Aust 36:349–352

Coccaaro EF, Sripada GS, Yanowitch RN, Phan KL (2011) Corticolimbic function in impulsive aggressive behavior. Biol Psychiatry 69(12):1153–1159. https://doi.org/10.1016/j.biopsych.2011.02.032 CrossRef

Coccaro EF, Lee RJ, Kavoussi RJ (2009) A double-blind, randomized, placebo-controlled trial of fluoxetine in patients with intermittent displosive disorder. J Clin Psychiatry 70:653–662. https://doi.org/10.4088/JPC.08m04150 PubMedCrossRef

Coccaro EF, Fanning JR, Phan KL, Lee R (2015) Serotonin and impulsive aggression. CNS Spectr 20:295–302. https://doi.org/10.1017/s1092852915000310 PubMedCrossRef

Cohen LS, Rosenbaum JF (1998) Psychotropic use during pregnancy. Weighing the risks. J Clin Psychiatry 59:18–28PubMed

Cohen LS, Friedman JM, Jefferson JW, Johnson EM, Weiner ML (1994) A reevaluation of risk of in utero exposure to lithium. JAMA 271:146–150. https://doi.org/10.1001/jama.1994.03510260078033 PubMedCrossRef

Comai S, Tau M, Gobbi G (2012a) The psychopharmacology of aggressive behavior: A translational approach: Part 1: Neurobiology. J Clin Psychopharmacol 32(1):83–94. https://doi.org/10.1097/JCP.0b013e31823f8770 PubMedCrossRef

Comai S, Tau M, Pavlovic Z, Gobbi G (2012b) The psychopharmacology of aggressive behavior: A translational approach. Part 2: Clinical studies using atypical antipsychotics, anticonvulsants, and lithium. J Clin Psychopharmacol 32(2):237–260. https://doi.org/10.1097/JCP0b013e31824929db PubMedCrossRef

Connell JM, Rapeport WG, Gordon S, Brodie MJ (1984) Changes in circulating thyroid hormones during short-term hepatic enzyme induction with carbamazepine. Eur J Clin Pharmacol 26:453–456. https://doi.org/10.1007/BF00542140 PubMedCrossRef

Coxhead N, Silverstone T, Cookson J (1992) Carbamazepine versus lithium in the prophylaxis of bipolar affective disorder. Acta Psychiatr Scand 85(2):114–118. https://doi.org/10.1111/j.1600-0447.1992.tb01453.x PubMedCrossRef

De Montigny C, Chaput Y, Bliér P (1989) Long term tricyclic and electroconvulsive treatment increases responsiveness of dorsal hippocampus 5‑HT_1a receptors: An electrophysiological study. Soc Neurosci Abstr 15:854

Dodge KA, Coie JD (1998) Social information-processing factors in reactive and proactive aggression in children’s peer groups. J Pers Soc Psychol 53:1146–1158CrossRef

Dreifuss FE, Langer DH, Moline KA, Maxwell JE (1989) Valproic acid hepatic fatalities. II. U.S. experience since 1984. Neurology 39:201–207. https://doi.org/10.1212/WNL.39.2.201 PubMedCrossRef

Drevets WC, Price JL, Simpson JR Jr, Todd RD, Reich T, Vannier M, Raischle ME (1997) Subgenual prefrontal cortex abnormalities in mood disorders. Nature 386:824–827. https://doi.org/10.1038/386824aC PubMedCrossRef

Fava M (2003) Anger attacks. In: Coccaro EF (Hrsg) Aggression: Psychiatric assessment and treatment. Marcel Dekker, New York, S 113–122 https://doi.org/10.1201/b14206-8 CrossRef

Feder R (1999) Treatment of intermittent explosive disorders with sertraline in 3 patients. J Clin Psychiatry 60(3):195–196. https://doi.org/10.4088/JCP.v60n0309b PubMedCrossRef

Felthous AR (2013) The treatment of clinical aggression in prison. In: Thienhaus OJ, Piasecki M (Hrsg) Correctional psychiatry. Practice guidelines and strategies, Bd. II. Civic Research Institute, Kingston, S 4–1–4–34

Felthous AR (2015) The appropriateness of treating psychopathic disorders. CNS Spectr 20:182–189. https://doi.org/10.1017/S1092852915000243 PubMedCrossRef

Felthous AR, Barratt ES (2003) Impulsive aggression. In: Coccaro EF (Hrsg) Aggression: psychiatric assessment and treatment. Marcel Dekker, New York, S 123–148 https://doi.org/10.1201/b14206-9 CrossRef

Felthous AR, Stanford MS (2015) A proposed algorithm for the pharmacotherapy of impulsive aggression. J Am Acad Psychiatry Law 43(4):456–467PubMed

Felthous AR, Lake SL, Rundle BK, Stanford MS (2013) Pharmacotherapy of impulsive aggression: A quality comparison of controlled studies. Int J Law Psychiatry 36:258–263. https://doi.org/10.1016/j.ijlp.2013.04.017 PubMedCrossRef

Fenves AZ, Emmett M, White MG (1984) Lithium intoxication associated with acute renal failure. South Med J 77:1472–1474. https://doi.org/10.1097/00007611-198411000-00030 PubMedCrossRef

Finley P, Warren M, Peabody C (1995) Clinical relevance of drug interactions with lithium. Clin Pharmacokinet 29:172–191. https://doi.org/10.2165/00003088-199529030-00004 PubMedCrossRef

Finley PR, O’Brien JG, Coleman RWA (1996) Lithium and angiotensin converting enzyme inhibitors: Evaluation of a potential interaction. J Clin Psychopharmacol 16:68–71. https://doi.org/10.1097/00004714-199602000-00011 PubMedCrossRef

Fleminger S, Greenwood GR, Oliver DL (2003) Pharmacological management for agitation and aggression in people with acquired brain injury. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.cd003299 PubMedCrossRef

Freeman MP, Wiegand C, Gelenberg AJ (2004) Lithium. In: Schatzberg AF, Nemeroff CB (Hrsg) Textbook of Psychopharmacology, 3. Aufl. American Psychiatric Publishing, Washington DC, S 547–565

Frey B, Braegger CP, Ghelfi D (2002) Neonatal cholestatic hepatitis from carbamazepine exposure during pregnancy and breastfeeding. Ann Pharmacother 36:644–647. https://doi.org/10.1345/aph.1A326 PubMedCrossRef

Froescher W, Eichelbaum M, Niesen M, Dietrich K, Rausch P (1984) Carbamazepine levels in breast milk. Ther Drug Monit 6:266–271. https://doi.org/10.1097/00007691-198409000-00002 PubMedCrossRef

Frogley C, Taylor D, Dickens G, Picchioni M (2012) A systematic review of the evidence of clozapine’s anti-aggressive effects. Int J Neuropsychopharmacol 15:1351–1371. https://doi.org/10.1017/s146114571100201x PubMedCrossRef

Gelenberg AJ (2001) Can lithium help to prevent suicide? (editorial). Acta Psychiatr Scand 104(3):161–162. https://doi.org/10.1034/j.1600-0447.2001.104003161.x PubMedCrossRef

Gitlin M (1999) Lithium and the kidney: An updated review. Drug Saf 20:231–243. https://doi.org/10.2165/00002018-199920030-00004 PubMedCrossRef

Glenn AL, Raine A (2011) Antisocial personality disorders. In: Decety J, Cacioppo J (Hrsg) The oxford handbook of social neuroscience. Oxford University Press, New York, S 885–894 https://doi.org/10.1093/oxfordhb/9780195342161.013.0058 CrossRef

Goldstein DJ, Corbin LA, Sundell KL (1997) Effects of first-trimester fluoxetine exposure on the newborn. Obstet Gynecol 89(5 pt.1):713–718. https://doi.org/10.1016/S0029-7844(97)00070-7 PubMedCrossRef

Hare RD (1991) The hare psychopathy checklist – revised. Multi-Health Systems, Toronto

Hare RD (1998) Without conscience: the disturbing world of the psychopaths among us. Guilford, New York

Hare RD (2007) Psychological instruments in the assessment of psychopathy. In: Felthous AR, Saß H (Hrsg) Diagnosis and treatment. The international handbook on psychopathic disorders and the law, Bd. I. John Wiley & Sons, Hoboken, S 41–67

Hollander E, Tracy KA, Swann AC, Coccaro EF, McElroy SL, Wozniak P, Sommerville KW, Nemeroff CB (2003) Divalproex in the treatment of impulsive aggression: efficacy in cluster B personality disorder. Neuropsychopharmacology 28(6):1186–1197. https://doi.org/10.1038/sj.npp.1300153 PubMedCrossRef

Hollander E, Swann AC, Coccaro EF, Jiang P, Smith TB (2005) Impact of trait impulsivity and state aggression in divalproex versus placebo response in borderline personality disorder. Am J Psychiatry 162(3):621–624. https://doi.org/10.1176/appi.ajp.162.3.621 PubMedCrossRef

Isojärvi JIT, Laatikainen TJ, Pakarinen AJ, Juntunen KT, Myllylä VA (1993) Polycystic ovaries and hyperandrogenism in women taking valproate for epilepsy. N Engl J Med 329:1383–1388. https://doi.org/10.1056/NEJM199311043291904 PubMedCrossRef

Johnson AG, Seideman P, Day RO (1993) Adverse drug interactions with nonsteroidal anti-inflammatory drugs (NSAIDS): Recognition, management and avoidance. Drug Saf 8:99–127. https://doi.org/10.2165/00002018-199308020-00002 PubMedCrossRef

Jones RM, Arlidge J, Gilham S, Reagu S, van den Bree M, Taylor PJ (2011) Efficacy of mood stabilizers in the treatment of impulsive or repetitive aggression: Systematic review and meta-analysis. Br J Psychiatry 198:93–98. https://doi.org/10.1192/bjp.bp.110.083030 PubMedCrossRef

Katona CLE, Abov-Saleh MT, Harrison DA, Nairac BA, Edwards DR, Lock T, Burns RA, Robertson MM (1995) Placebo-controlled study of lithium augmentation of fluoxetine and lofepramine. Br J Psychiatry 166:80–86. https://doi.org/10.1192/bjp.166.1.80 PubMedCrossRef

Ketter TA, Wang PW, Post RM (2004) Carbamazepine and oxcarbazepine. In: Schatzberg AF, Nemeroff CB (Hrsg) Textbook of psychopharmacology, 3. Aufl. American Psychiatric Association, Washington DC, S 581–606

Khalifa N, Duggan C, Stoffer J, Huband N, Völlm BA, Ferriter M, Lieb K (2010) Pharmacological interventions for antisocial personality disorder. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD00 PubMedPubMedCentralCrossRef

Krakowski MI, Czobor P, Bark N, Cooper TB (2006) Atypical antipsychotic agents in the treatment of violent patients with schizophrenia and schizoaffective disorder. Arch Gen Psychiatry 63(6):622–629PubMedCrossRef

Kuhnz W, Jäger-Roman E, Rating D, Deichl A, Kunze J, Helge H, Nau H (1982) Carbamazepine and carbamazepine-10, 11-epoxide during pregnancy and post-natal period in epileptic mother and their nursed infants: Pharmacokinetics and clinical effects. Pediatr Pharmacol (New York) 3(3–4):199–208

Kusalic M, Engelsmann F (1999) Effect of lithium maintenance therapy on thyroid and parathyroid function. J Psychiatry Neurosci 24:227–233PubMedPubMedCentral

Lajee HCK, Parsonage MJ (1980) Unwanted effects of sodium valproate in the treatment of adult patients with epilepsy. In: Parsonage NJ, Caldwell ADS (Hrsg) The place of sodium valproate in the treatment of epilepsy. Royal Society of Medicine, London, S 141–158

LaWall JS, Wesselius CL (1982) The use of lithium carbonate in borderline patients. J Psychiatr Treat Eval 4:265–267

Llewellyn A, Stowe ZN, Strader JR (1998) The use of lithium and management of women with bipolar disorder during pregnancy and lactation. J Clin Psychiatry 59:57–64PubMed

Mancke F, Herpertz SC, Bertsch K (2015) Aggression in borderline personality disorder: A multidimensional model. Personal Disord 6(3):278–291PubMedCrossRef

Manji HK, Etcheberrigaray R, Chen G, Olds J (1993) Lithium decreases membrane-associated protein kinase C in hippocampus selectivity for the ɑ isozyme. J Neurochem 61:2303–2310. https://doi.org/10.1111/j.1471-4159.1993.b07474x PubMedCrossRef

Manji HK, Bebchuk JM, Moore GJ, Glitz D, Hasanat KA, Chen G (1999) Modulation of CNS signal transduction pathways and gene expression by mood stabilizing agents: therapeutic implications. J Clin Psychiatry 60(Suppl 2):27–39PubMed

Martin CA, Piascik MT (1985) First-degree A‑V block in patients on lithium carbonate. Can J Psychiatry 30:114–116PubMedCrossRef

Mattes JA (2005) Oxcarbamazepine in patients with impulsive aggression: A double-blind, placebo controlled trial. J Clin Psychopharmacol 25:575–579. https://doi.org/10.1097/01.jcp.0000186739.22395.6b PubMedCrossRef

Mattson RH, Cramer JA, Collins JF (1992) A comparison of valproate and carbamazepine for the treatment of complex partial seizures and secondary generalized tonic-clonic seizures in adults. The department of veterans affairs epilepsy cooperative study no. 264 group. N Engl J Med 327:765–771. https://doi.org/10.1056/NEJM19 PubMedCrossRef

McLean MJ, Macdonald RL (1986) Carbamazepine and 10,11-epoxycarbamazepine produce use- and voltage-dependent limitation of rapidly firing action potentials of mouse central neurons in cell culture. J Pharmacol Exp Ther 238:727–738PubMed

McNamara JO (2011) Pharmacotherapy of the epilepsies. In: Brunton LL, Chabner BA, Knollmann BC (Hrsg) Goodman and Gilman’s the pharmacological basis of therapeutics, 12. Aufl. McGraw-Hill, New York, S 583–607

Mela M, Depiang G (2016) Cloozapine’s effect on recidivism among offenders with mental disorders. J Am Acad Psychiatry Law 44(1):82–90PubMed

Mitchell JE, MacKenzie TB (1982) Cardiac effects of lithium therapy in man: A review. J Clin Psychiatry 43:47–51. https://doi.org/10.1097/00004714-198208000-00029 PubMedCrossRef

Moeller FG, Swann AC (2007) Pharmacotherapy of clinical aggression in individuals with psychopathic disorders. In: Felthous AR, Sass H (Hrsg) The international handbook on psychopathic disorders and the law, Bd. I. John Wiley, Chichester, S 397–416CrossRef

Motohashi N, Ikawa K, Kariya T (1989) GABA_B receptors are up-regulated by chronic treatment with lithium or carbamazepine: GABA hypothesis of affective disorders? Eur J Pharmacol 166:95–99. https://doi.org/10.1016/0014-2999(89)90687-0 PubMedCrossRef

New AS, Buchsbaum MA, Hazlett EA, Goodman M, Koenigsberg HW, Low J, IsKander L, Newmark R, Brand J, O’Flynn K, Siever LJ (2004) Fluoxetine increases relative metabolic rate in prefrontal cortex in impulsive aggression. Psychopharmacology (Berl) 176:451–458. https://doi.org/10.1007/s00213-004-1913-8 CrossRef

O’Donnell JM, Shelton RC (2011) Drug therapy of depression and anxiety disorders. In: Brunton LL, Chabner BA, Knollmann BC (Hrsg) Goodman and Gilman’s the pharmacological basis of therapeutics, 12. Aufl. McGraw-Hill, New York, S 397–415

Post RM, Weiss SRB, Chuang DM (1992) Mechanisms of action of anticonvulsants in affective disorders: Comparisons with lithium. J Clin Psychopharmacol 12(Suppl):23S–35S. https://doi.org/10.1097/00004714-199202001-00005 PubMedCrossRef

Raine A, Meloy JR, Bihrle S, Stoddard J, LaCasse L, Buchsbaum MS (1998) Reduced prefrontal and increased subcortical functioning assessed using positron emission tomography in predatory and affective murderers. Behav Sci Law 16:319–332. https://doi.org/10.1002/(S1C1)1099-0798(199822) PubMedCrossRef

Rifkin A, Quitkin F, Carrillo C, Blumberg AG, Klein DF (1972) Lithium carbonate in emotionally unstable character disorder. Arch Gen Psychiatry 27:519–523. https://doi.org/10.1001/archpsyc.1972.01750280083014 PubMedCrossRef

Rogawski MA, Loscher W (2004) The neurobiology of antiepileptic drugs. Nat Rev Neurosci 5:553–564. https://doi.org/10.1038/nrn1430 PubMedCrossRef

Rosa FM (1991) Spina bifida in infants of women treated with carbamazepine during pregnancy. N Engl J Med 324:674–677. https://doi.org/10.1056/nejm199103073241006 PubMedCrossRef

Rosenbaum JF, Tollefson GD (2004) Fluoxetine. In: Schatzberg A, Nemeroff CB (Hrsg) Textbook of psychopharmacology, 3. Aufl. American Psychiatric Press, Washington DC, S 231–246

Rudorfer MV, Potter WZ (1989) Combined fluoxetine and tricyclic antidepressants. Am J Psychiatry 146(4):562–563. https://doi.org/10.1176/ajp.146.4.562a PubMedCrossRef

Salekin RT, Worley C, Grimes RD (2010) Treatment of psychopathy? A review and brief introduction to the mental model approach for psychotherapy. Behav Sci Law 28(2):235–266. https://doi.org/10.1002/bsl.928 PubMedCrossRef

Saß H (2015) Persönlichkeit und Verantwortung. Forens Psychiatr Psychol Kriminol 9:75–81CrossRef

Sheard MH, Marini JL, Bridges MA, Wagner E (1976) The effect of lithium on impulsive aggressive behavior in man. Am J Psychiatry 133:1409–1413. https://doi.org/10.1176/ajp.133.12.1409 PubMedCrossRef

Siever LJ (2008) Neurobiology of aggression and violence. Am J Psychiatry 165(4):429–442. https://doi.org/10.1176/appi.ajp.2008.07111774 PubMedPubMedCentralCrossRef

Siever LJ, Buchsbaum MS, New AS, Spiegel-Cohen J, Wei T, Hazlett EA, Sevin BS, Nunn M, Mitropoulou MA (1999) d,l-fenfluramine response in impulsive personality disorder assessed with [¹⁸F]fluorode-oxyglucose positron emission tomography. Neuropsychopharmacology 20:413–423. https://doi.org/10.1016/S0893-133X(98)00111-0 PubMedCrossRef

Silva H, Iturra P, Solari A, Villarroel J, Jerez J, Jiménez M, Galleguillos F, Bustamante ML (2010) Fluoxetine response in impulsive-behavior and serotonin transporter polymorphism in personality disorder. Psychiatr Genet 20(1):25–30. https://doi.org/10.1097/ypg.0b013e328335125d PubMedCrossRef

Stahl SM (2011) The prescriber’s guide: Stahl’s essential Psychopharmacology. Cambridge University Press, New York

Stahl SM, Morrisette DA (2014) Stahl’s illustrated violence: neural circuits, genetics and treatment. Cambridge University Press, Cambridge

Stanford MS, Helfritz LE, Conklin SM, Villemarette-Pittman NR, Greve KW, Adams D, Houston RJ (2005) A comparison of anti-convulsants in the treatment of impulsive aggression. Exp Clin Psychopharmacol 13:72–77. https://doi.org/10.1037/1064-1297.13.1.72 PubMedCrossRef

Stecker TL (1994) Lithium- and carbamazepine-associated sinus node dysfunction: nine-year experience in a psychiatric hospital. J Clin Psychopharmacol 14:336–339

Swann AC, Bowden CL, Calabrese JR, Dilsaver SC, Morris DD (2002) Pattern of response to divalproex, lithium or placebo in four naturalistic subtypes of mania. Neuropsychopharmacology 26:530–536. https://doi.org/10.1038/50893-133x(01)00390-6 PubMedCrossRef

Tondo L, Baldessarini RJ, Floris G (2001) Long-term clinical effectiveness of lithium maintainance treatment in types I and II bipolar disorders. Br J Psychiatry 178(1):184–190CrossRef

Trescher WH, Lesser RP (2008) The epilepsies. In: Bradley WG, Daroff RB, Fenichel GM, Jankovic J (Hrsg) The neurological disorders, 5. Aufl. Neurology in clinical practice, Bd. II. Butterworth Heinmann, Oxford, Waltham, Massachusetts, S 1909–1946

Wilder BJ, Karas BJ, Penry JK, Asconape J (1983) Gastrointestinal tolerance of divalproex sodium. Neurology 33:808–811. https://doi.org/10.1212/WNL.33.6.808 PubMedCrossRef

Winner J (2013) Pharmacogenomics in clinical practice. Mo Psychiatry (3):4–5

Titel: Zur Pharmakotherapie impulsiver Aggression bei antisozialen und psychopathischen Störungen
verfasst von: Alan R. Felthous, M.D.
Matthew S. Stanford
Univ.-Prof. Dr. med. Henning Saß, M.D.
Publikationsdatum: 24.07.2018
Verlag: Springer Berlin Heidelberg
Schlagwörter: Antiepileptika
Fluoxetin
Antiepileptika
Carbamazepin
Oxcarbazepin
Phenytoin
Valproat
Erschienen in: Forensische Psychiatrie, Psychologie, Kriminologie / Ausgabe 3/2018
Print ISSN: 1862-7072
Elektronische ISSN: 1862-7080
DOI: https://doi.org/10.1007/s11757-018-0491-2

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Schematherapie bei antisozialem Verhalten und Psychopathie