Antiplatelet Medications and Biomarkers of Hemostasis May Explain the Association of Hematoma Appearance and Subsequent Hematoma Expansion After Intracerebral Hemorrhage
- 27.10.2021
- Original work
Erschienen in:
- Verfasst von
- Mengxuan Tang
- Hye Jung Shin
- William Metcalf-Doetsch
- Yuan Luo
- Paul F. Lindholm
- Hau Kwaan
- Andrew M. Naidech
- Erschienen in
- Neurocritical Care | Ausgabe 3/2022
Abstract
Background
To test the hypothesis that appearances of intracranial hematomas on diagnostic computed tomography (CT) are not idiosyncratic and reflect a biologically plausible mechanism, we evaluated the association between hematoma appearance on CT, biomarkers of platelet activity, and antiplatelet or anticoagulant medication use prior to admission.
Methods
We studied 330 consecutively identified patients from 2006 to 2019. Biomarkers of platelet activity (platelet aspirin assay) and medication history (aspirin, clopidogrel) were prospectively recorded on admission. A blinded interpreter recorded the presence of hematoma appearances from the diagnostic scan. Associations were tested with parametric or nonparametric statistics, as appropriate.
Results
The black hole sign (101, 30%) was most prevalent, followed by the island sign (57, 17%) and blend sign (32, 10%). There was reduced platelet activity in patients with a black hole sign (511 [430–610] vs. 562 [472–628] aspirin reaction units, P = 0.01) or island sign (505 [434–574] vs. 559 [462–629] aspirin reaction units, P = 0.004). Clopidogrel use prior to admission was associated with the black hole sign (odds ratio 2.25, 95% confidence interval 1.02–4.98, P = 0.04).
Conclusions
In patients with acute intracerebral hemorrhage, hematoma appearances on CT are associated with biomarkers of platelet activity and clopidogrel use prior to admission. Appearances of intracranial hematomas on CT may reflect reduced hemostasis from antiplatelet medication use.
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- Titel
- Antiplatelet Medications and Biomarkers of Hemostasis May Explain the Association of Hematoma Appearance and Subsequent Hematoma Expansion After Intracerebral Hemorrhage
- Verfasst von
-
Mengxuan Tang
Hye Jung Shin
William Metcalf-Doetsch
Yuan Luo
Paul F. Lindholm
Hau Kwaan
Andrew M. Naidech
- Publikationsdatum
- 27.10.2021
- Verlag
- Springer US
- Erschienen in
-
Neurocritical Care / Ausgabe 3/2022
Print ISSN: 1541-6933
Elektronische ISSN: 1556-0961 - DOI
- https://doi.org/10.1007/s12028-021-01369-z
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