Erschienen in:
13.07.2021 | ASO Author Reflections
ASO Author Reflections: Breast Cancer: What is in a Positive Node?
verfasst von:
Roi Weiser, MD, V. Suzanne Klimberg, MD, PhD, MHSCT, FACS
Erschienen in:
Annals of Surgical Oncology
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Ausgabe 13/2021
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Excerpt
The prognosis for breast cancer has always relied on nodal staging.
1 Initially, all tumors received chemotherapy regardless of nodal status. Then TAILORx showed that not all node-negative patients benefited from chemotherapy.
2 More recently, data presented from the RxPONDER trial has demonstrated that not all node-positive patients benefited from chemotherapy.
3 So, nodal status alone is not predictive of chemotherapy benefit. However, in terms of prognosis, nodal status in addition to recurrence score (RS) remains important.
4 The authors wanted to know whether multiple micromets differ from a single micromet in terms of prognostic information and whether single versus multiple micromets respond to chemotherapy differently. …