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European Journal of Clinical Microbiology & Infectious Diseases

Erschienen in:

07.02.2022 | Original Article

Assessing the diagnostic accuracy of the Xpert MTB/RIF assay in detecting epididymal tuberculosis

verfasst von: Pengju Liu, Yuan Liu, Yeqiang Wang, Sida Hao, Yong Qin

Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases | Ausgabe 4/2022

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Abstract

To assess the diagnostic efficacy of Xpert MTB/RIF assay in detecting epididymal tuberculosis.

Methods

We analyzed 84 samples from patients with suspected epididymal TB or chronic epididymitis who received surgical treatment (epididymal resection or epididymis-testicular resection) at our hospital between July 1, 2016 and July 1, 2020. A composite reference standard (CRS) was used in this study. We determined the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and area under the curve (AUC) of the Xpert MTB/RIF assay for epididymal TB and compared its diagnostic accuracy with that of the Mycobacterium tuberculosis (MTB) culture test in detecting epididymal TB.

Results

Three patients were excluded because of incomplete data. Comparing with the composite reference standard, the sensitivity, specificity, PPV, NPV, and AUC of Xpert MTB/RIF assay for epididymal TB were 80.95% (69.09–89.75%); 94.44% (72.71–99.86%); 98.08% (89.74–99.95%); and 58.62% (38.94–76.48%), respectively, with an AUC of 0.88 (95% confidence interval: 0.79–0.94). The diagnostic sensitivity of the Xpert MTB/RIF assay was significantly higher than that of the MTB culture test for epididymal TB.

Conclusions

We recommend the Xpert MTB/RIF assay as a diagnostic method for the detection of epididymal TB.

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Titel: Assessing the diagnostic accuracy of the Xpert MTB/RIF assay in detecting epididymal tuberculosis
verfasst von: Pengju Liu
Yuan Liu
Yeqiang Wang
Sida Hao
Yong Qin
Publikationsdatum: 07.02.2022
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases / Ausgabe 4/2022
Print ISSN: 0934-9723
Elektronische ISSN: 1435-4373
DOI: https://doi.org/10.1007/s10096-022-04418-3

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Assessing the diagnostic accuracy of the Xpert MTB/RIF assay in detecting epididymal tuberculosis

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Methods

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