Assessment of atherosclerotic plaques in a rabbit model by delayed-phase contrast-enhanced CT angiography: comparison with histopathology | springermedizin.de

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The International Journal of Cardiovascular Imaging

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01.02.2012 | Original Paper

Assessment of atherosclerotic plaques in a rabbit model by delayed-phase contrast-enhanced CT angiography: comparison with histopathology

verfasst von: Jin Hur, Young Jin Kim, Hyo Sup Shim, Hye-Jeong Lee, Ji Eun Nam, Kyu Ok Choe, Byoung Wook Choi

Erschienen in: The International Journal of Cardiovascular Imaging | Ausgabe 2/2012

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Abstract

The aim of this study was to compare delayed-phase computed tomography angiography (CTA) attenuation values with histopathology, in ability to differentiate between fibrous and lipid-rich plaques in an experimental rabbit model. Twelve atherosclerotic rabbits underwent CTA of the abdominal aorta. The scan protocol included early-phase scans (EP), delayed scans at 90 s after contrast injection (DP_90s), delayed scans at 10 min after contrast injection (DP_10min), and delayed scan with saline infusion (DP_Saline). Plaque composition was analyzed by histopathology (% of lipid-rich, fibrous and macrophage areas) and CT attenuation values in Hounsfield units. Using histopathology as the reference standard (n = 119), the overall sensitivity, specificity and accuracy of 64-slice CTA for the detection of plaques was 59, 100 and 79% for the EP scans; 88, 100 and 94% for the DP_90s scans; 81, 100 and 90% for the DP_10min scans; and 53, 100 and 76% for the DP_Saline scans. CT density measurements showed a substantial overlap between fibrous and lipid-rich plaques, and poor correlations with the percentage of macrophage areas in both fibrous and lipid-rich plaques (r = 0.408, and r = 0.333). In delayed-phase 64-slice CTA, DP_90s images have the best diagnostic performance for the detection of aortic plaques.

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Titel: Assessment of atherosclerotic plaques in a rabbit model by delayed-phase contrast-enhanced CT angiography: comparison with histopathology
verfasst von: Jin Hur
Young Jin Kim
Hyo Sup Shim
Hye-Jeong Lee
Ji Eun Nam
Kyu Ok Choe
Byoung Wook Choi
Publikationsdatum: 01.02.2012
Verlag: Springer Netherlands
Erschienen in: The International Journal of Cardiovascular Imaging / Ausgabe 2/2012
Print ISSN: 1569-5794
Elektronische ISSN: 1875-8312
DOI: https://doi.org/10.1007/s10554-011-9801-x

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