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01.03.2013 | Musculoskeletal

Assessment of glycosaminoglycan content in intervertebral discs using chemical exchange saturation transfer at 3.0 Tesla: preliminary results in patients with low-back pain

verfasst von: Stefan Haneder, Sebastian R. Apprich, Benjamin Schmitt, Henrik J. Michaely, Stefan O. Schoenberg, Klaus M. Friedrich, Siegfried Trattnig

Erschienen in: European Radiology | Ausgabe 3/2013

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Abstract

Objectives

To evaluate glycosaminoglycan-dependent chemical exchange saturation transfer (gagCEST) imaging at 3-T magnetic resonance imaging (MRI) for quantification of glycosaminoglycan (GAG) content in intervertebral discs (IVDs) in patients with low-back pain (LBP).

Methods

Sixteen patients with LBP were examined in this Institutional Review Board-approved study using a clinical whole-body system. The MRI protocol included standard morphological imaging, sagittal T2-mapping and gagCEST imaging. IVD grading according to the Pfirrmann score and region-of-interest analysis of the annulus fibrosus (AF) and the nucleus pulposus (NP) in gagCEST and T2 maps were performed before data were statistically tested for correlations between imaging techniques and quantitative differences between different grades of IVD degeneration.

Results

GagCEST values of the NP were significantly (P < 0.001) lower in degenerative IVDs (Pfirrmann 3 + 4) compared with non-degenerative IVDs (Pfirrmann 1 + 2), but only a weak linear correlation (r = 0.299) with the T2 relaxation times was found. GagCEST values of the NP exhibited a moderate negative correlation with Pfirrmann grades (r = −0.449).

Conclusions

The known loss of GAG in the NP with increasing grade of morphological degeneration can be assessed using gagCEST imaging at 3.0 T. The correlation with single Pfirrmann grades and T2 relaxation times only seems to be moderate, indicating a substantial difference in information provided by the techniques.

Key Points

• 3-T MRI offers new functional data about the degenerating lumbar disc

• GagCEST imaging can assess glycosaminoglycan loss

• GagCEST imaging and T2 mapping provide substantially different information about disc degeneration

• Correlation between glycosaminoglycan loss and grade of morphological degeneration is only moderate

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Titel: Assessment of glycosaminoglycan content in intervertebral discs using chemical exchange saturation transfer at 3.0 Tesla: preliminary results in patients with low-back pain
verfasst von: Stefan Haneder
Sebastian R. Apprich
Benjamin Schmitt
Henrik J. Michaely
Stefan O. Schoenberg
Klaus M. Friedrich
Siegfried Trattnig
Publikationsdatum: 01.03.2013
Verlag: Springer-Verlag
Erschienen in: European Radiology / Ausgabe 3/2013
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-012-2660-6

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Assessment of glycosaminoglycan content in intervertebral discs using chemical exchange saturation transfer at 3.0 Tesla: preliminary results in patients with low-back pain