Introduction
Research design and methods
Results
Cancer type | Clinical parameter | Adult patients with ALL, AML, NHL, or MM | ||||
---|---|---|---|---|---|---|
Overall (n = 2219) | Men (n = 1266) | Women (n = 911) | Non-diabetic | Diabetic | ||
AML | Age (95% CI) | 51.71 (50.48 to 52.93) | 52.43 (50.75 to 54.12) | 50.89 (49.11 to 52.66) | 50.39 (48.98 to 51.81) | 57.23 (55.00 to 59.47)*** |
Fasting plasma glucose (mmol/L) (95% CI) | 6.33 (6.15 to 6.51) | 6.26 (6.01 to 6.51) | 6.40 (6.14 to 6.67) | 5.52 (5.45 to 5.58) | 9.63 (9.04 to 10.22)*** | |
Total cholesterol (mmol/L) (95% CI) | 3.71 (3.60 to 3.82) | 3.57 (3.43 to 3.72) | 3.88 (3.71 to 4.05)* | 3.73 (3.60 to 3.85) | 3.63 (3.37 to 3.89) | |
Low-density lipoprotein (mmol/L) (95% CI) | 2.31 (2.23 to 2.40) | 2.23 (2.12 to 2.34) | 2.42 (2.29 to 2.55)* | 2.32 (2.23 to 2.42) | 2.26 (2.06 to 2.46) | |
High-density lipoprotein (mmol/L) (95% CI) | 0.89 (0.86 to 0.92) | 0.86 (0.83 to 0.90) | 0.93 (0.87 to 0.97)* | 0.91 (0.86 to 0.94) | 0.83 (0.78 to 0.88) | |
Triglycerides (mmol/L) (95% CI) | 1.51 (1.41 to 1.61) | 1.40 (1.29 to 1.52) | 1.65 (1.48 to 1.82)* | 1.50 (1.39 to 1.62) | 1.57 (1.38 to 1.76) | |
ALL | Age (95% CI) | 41.98 (38.99 to 44.97) | 43.29 (38.96 to 47.62) | 40.38 (36.22 to 44.54) | 41.00 (37.82 to 44.18) | 47.57 (38.19 to 56.95) |
Fasting plasma glucose (mmol/L) (95% CI) | 5.70 (5.34 to 6.01) | 5.82 (5.29 to 6.35) | 5.56 (5.06 to 6.06) | 5.11 (4.94 to 5.27) | 9.28 (8.04 to 10.52)*** | |
Total cholesterol (mmol/L) (95% CI) | 4.08 (3.77 to 4.39) | 4.14 (3.72 to 4.56) | 4.02 (3.54 to 4.50) | 4.08 (3.73 to 4.44) | 4.13 (3.28 to 4.98) | |
Low-density lipoprotein (mmol/L) (95% CI) | 2.60 (2.36 to 2.84) | 2.67 (2.38 to 2.96) | 2.54 (2.16 to 2.92) | 2.59 (2.32 to 2.86) | 2.74 (2.11 to 3.37) | |
High-density lipoprotein (mmol/L) (95% CI) | 0.88 (0.80 to 0.96) | 0.84 (0.72 to 0.96) | 0.91 (0.81 to 1.02) | 0.90 (0.81 to 0.99) | 0.81 (0.59 to 1.03) | |
Triglycerides (mmol/L) (95% CI) | 1.92 (1.40 to 2.43) | 1.66 (1.5 to 1.8) | 1.74 (1.53 to 1.93) | 1.66 (1.52 to 1.80) | 1.83 (1.52 to 2.14) | |
NHL | Age (95% CI) | 57.63 (56.22 to 59.03) | 57.56 (55.78 to 59.35) | 57.73 (55.43 to 60.04) | 57.43 (55.88 to 58.98) | 58.84 (55.58 to 62.1) |
Fasting plasma glucose (mmol/L) (95% CI) | 5.71 (5.53 to 5.88) | 5.64 (5.43 to 5.84) | 5.83 (5.51 to 6.16) | 5.15 (5.08 to 5.23) | 9.13 (8.46 to 9.80)*** | |
Total cholesterol (mmol/L) (95% CI) | 4.16 (4.00 to 4.34) | 3.99 (3.78 to 4.20) | 4.50 (4.25 to 4.75)* | 4.21 (4.04 to 4.39) | 3.74 (3.25 to 4.23) | |
Low-density lipoprotein (mmol/L) (95% CI) | 2.69 (2.58 to 2.80) | 2.62 (2.48 to 2.76) | 2.82 (2.64 to 3.00) | 2.71 (2.60 to 2.83) | 2.49 (2.17 to 2.81) | |
High-density lipoprotein (mmol/L) (95% CI) | 1.11 (1.04 to 1.18) | 1.11 (1.01 to 1.21) | 1.10 (1.01 to 1.20) | 1.14 (1.06 to 1.22) | 0.83 (0.73 to 0.93)* | |
Triglycerides (mmol/L) (95% CI) | 1.40 (1.28 to 1.52) | 1.44 (1.27 to 1.60) | 1.33 (1.17 to 1.49) | 1.41 (1.28 to 1.54) | 1.30 (1.00 to 1.61) | |
MM | Age (95% CI) | 61.69 (60.73 to 62.65) | 61.24 (59.91 to 62.57) | 62.34 (60.97 to 63.7) | 61.75 (60.7 to 62.8) | 61.28 (58.92 to 63.63) |
Fasting plasma glucose (mmol/L) (95% CI) | 5.77 (5.57 to 5.97) | 5.79 (5.50 to 6.07) | 5.74 (5.47 to 6.01) | 5.25 (5.18 to 5.33) | 9.54 (8.46 to 10.63)*** | |
Total cholesterol (mmol/L) (95% CI) | 3.82 (3.63 to 4.01) | 3.62 (3.41 to 3.84) | 4.12 (3.76 to 4.45)* | 3.84 (3.63 to 4.04) | 3.71 (3.20 to 4.21) | |
Low-density lipoprotein (mmol/L) (95% CI) | 2.34 (2.19 to 2.49) | 2.20 (2.03 to 2.36) | 2.55 (2.28 to 2.81)* | 2.35 (2.19 to 2.51) | 2.24 (1.88 to 2.61) | |
High-density lipoprotein (mmol/L) (95% CI) | 0.96 (0.92 to 1.01) | 0.94 (0.88 to 1.00) | 0.99 (0.93 to 1.06) | 0.97 (0.92 to 1.01) | 0.90 (0.74 to 1.06) | |
Triglycerides (mmol/L) (95% CI) | 1.40 (1.28 to 1.51) | 1.32 (1.16 to 1.47) | 1.51 (1.33 to 1.69) | 1.35 (1.24 to 1.47) | 1.74 (1.20 to 2.27)* |
ALL | AML | NHL | MM | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
n | Self-reported (%) | FPG≧7 (%) | Self-reported or FPG≧7 (%) | n | Self-reported (%) | FPG≧7 (%) | Self-reported or FPG≧7 (%) | n | Self-reported (%) | FPG≧7 (%) | Self-reported or FPG≧7 (%) | n | Self-reported (%) | FPG≧7 (%) | Self-reported or FPG≧7 (%) | ||
Total | 416 | 5.3 (3.15 to 7.45) | 18.7 (14.95 to 22.45) | 19.7 (15.9 to 23.5)*** | 622 | 6.4 (4.5 to 8.3) | 19.7 (16.6 to 22.8) | 21.3 (18.1 to 24.5)*** | 789 | 3.4 (2.1 to 4.7) | 11.4 (9.2 to 13.6) | 12.5 (10.2 to 14.8)** | 392 | 4.3 (2.3 to 6.3) | 12.0 (8.8 to 15.2) | 14.3 (10.8 to 17.8)** | |
Men | 229 | 4.4 (1.74 to 7.06) | 17.5 (12.58 to 22.42) | 18.3 (13.3 to 23.3)** | 330 | 5.2 (2.8 to 7.6) | 17.5 (13.4 to 21.6) | 19.4 (15.1 to 23.7)*** | 476 | 3.8 (2.1 to 5.5) | 10.2 (7.5 to 12.9) | 11.1 (8.3 to 13.9) | 231 | 2.6 (0.5 to 4.7) | 10.0 (6.1 to 13.9) | 11.7 (7.6 to 15.8) | |
Women | 184 | 6.5 (2.94 to 10.06) | 20.6 (14.76 to 26.44) | 21.7 (15.7 to 27.7)*** | 292 | 7.9 (4.8 to 11.0) | 21.9 (17.2 to 26.6) | 23.6 (18.7 to 28.5)*** | 274 | 3.3 (2.1 to 5.4) | 12.9 (8.9 to 12.9) | 13.9 (9.8 to 18.0)** | 161 | 6.8 (2.9 to 10.7) | 14.9 (9.4 to 20.4) | 18.6 (12.6 to 24.6)*** | |
Age | 18–39 | 124 | 1.6 (0.08 to 3.16) | 12.9 (7.00 to 18.8) | 13.7 (7.7 to 19.8)*** | 143 | — | 5.6 (1.8 to 9.4) | 5.6 (1.8 to 9.4) | 100 | 3.0 (0.1 to 6.0) | 7.0 (2.0 to 12.0) | 7.0 (2.0 to 12.0)* | 7 | — | — | — |
40–59 | 110 | 3.6 (0.12 to 7.08) | 18.2 (10.99 to 25.41) | 19.1 (11.8 to 26.5)* | 255 | 7.5 (4.3 to 10.7) | 21.6 (16.5 to 26.7) | 23.1 (17.9 to 28.3)*** | 293 | 2.0 (0.4 to 3.6) | 10.9 (7.3 to 14.5) | 11.6 (7.9 to 15.3) | 153 | 3.3 (0.5 to 6.1) | 11.8 (6.7 to 16.9) | 12.4 (7.2 to 17.6) | |
> 60 | 173 | 9.2 (4.89 to 13.51) | 23.7 (17.4 to 30.0) | 24.9 (18.5 to 31.3) | 224 | 9.4 (5.6 to 13.2) | 26.3 (20.5 to 32.1) | 29.5 (23.5 to 35.5)* | 357 | 5 (2.7 to 7.3) | 14.3 (10.7 to 17.9) | 16.2 (12.4 to 20.0) | 232 | 5.2 (2.3 to 8.1) | 12.5 (8.2 to 16.8) | 15.9 (11.2 to 20.6) |
Local population-based subjects | Published national surveys | ||||||
---|---|---|---|---|---|---|---|
n | Self-reported (%) | FPG ≥ 7 mmol/L (%) | Self-reported or FPG ≥ 7 mmol/L (%) | Survey 1 [24] | Survey 2 [25] | ||
Total | 1052 | 2.7 (1.7 to 3.7) | 8.0 (6.4 to 9.6) | 9.1 (7.4 to 10.8) | 8.7 | 9.7 | |
Men | 601 | 3.5 (2.0 to 5.0) | 9.7 (7.3 to 12.1) | 11 (8.5 to 13.5) | 9.7 | 10.6 | |
Women | 451 | 1.6 (0.4 to 2.8) | 5.8 (3.6 to 8.0) | 6.7 (4.4 to 9.0) | 7.7 | 8.8 | |
Age | 18–39 | 447 | 0.9 (0 to 1.8) | 1.6 (0.4 to 2.8) | 2.5 (1.1 to 3.9) | 2.6 | 3.2 |
40–59 | 415 | 4.3 (2.3 to 6.3) | 9.4 (6.6 to 12.2) | 10.4 (7.5 to 13.3) | 11.1 | 11.5 | |
> 60 | 188 | 6.9 (3.3 to 10.5) | 20.2 (14.5 to 25.9) | 20.2 (14.5 to 25.9) | 20.4 | 20.4 |