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The journal of nutrition, health & aging

Erschienen in:

28.03.2023 | Original Research

Association between Sarcopenia and Cognitive Trajectories among Middle-Aged and Older Adults in China: A Nationally Representative Cohort Study

verfasst von: M. Xue, X. Jia, X. Shi, C. Yang, R. Wang, C. Zhao, X. Xin, Yongli Yang

Erschienen in: The journal of nutrition, health & aging | Ausgabe 4/2023

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Abstract

Objectives

The relationship between sarcopenia and cognitive function has been extensively studied, but is usually explored at a single time point. We used repeatedly measured cognitive data to examine the relationship between sarcopenia and cognitive trajectories over time among middle-aged and older Chinese adults.

Design

A nationally representative cohort study.

Setting and Participants

Data were from three waves (2011, 2013 and 2015) of the China Health and Retirement Longitudinal Study (CHARLS). A total of 8963 participants with complete baseline data (wave 1) and at least two cognitive function tests (waves 1–3) were enrolled in this study.

Measurements

Sarcopenia was diagnosed at baseline (wave 1). The wave 1–3 data were used to analyze cognitive trajectories over time by constructing a latent class trajectory model (LCTM). Logistic regression model was used to analyze the association between sarcopenia and cognitive trajectories.

Results

Among 8693 participants, we identified two trajectories of cognitive function development, including a persistent low trajectory (n= 4856, 55.86%) and a persistent high trajectory (n= 3837, 44.14%). Sarcopenia was associated with persistently low cognitive trajectory of global cognitive (OR: 1.248, 95%CI: 1.046–1.490) after adjustment for other covariates. This association was still observed when stratified by age, gender, educational level, marital status, social activity, smoking status and drinking status. Mediation analysis showed that body mass index (BMI) mediated efficacy accounting for 42.32% of the relationship.

Conclusions

Our study showed two trajectory groups of global cognitive function. Sarcopenia was associated with a persistent low trajectory over time and BMI mediated the relationship between sarcopenia and cognitive trajectories among middle-aged and older Chinese adults.

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Titel: Association between Sarcopenia and Cognitive Trajectories among Middle-Aged and Older Adults in China: A Nationally Representative Cohort Study
verfasst von: M. Xue
X. Jia
X. Shi
C. Yang
R. Wang
C. Zhao
X. Xin
Yongli Yang
Publikationsdatum: 28.03.2023
Verlag: Springer Paris
Erschienen in: The journal of nutrition, health & aging / Ausgabe 4/2023
Print ISSN: 1279-7707
Elektronische ISSN: 1760-4788
DOI: https://doi.org/10.1007/s12603-023-1906-1

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Abstract

Objectives

Design

Setting and Participants

Measurements

Results

Conclusions

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