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Erschienen in: Comparative Clinical Pathology 6/2015

01.11.2015 | Original Article

Association between serum copper concentration and the risk of bovine leptospirosis

verfasst von: Elham Mohammadi, Ehsanollah Sakhaee

Erschienen in: Comparative Clinical Pathology | Ausgabe 6/2015

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Abstract

Leptospirosis is a zoonotic disease found in nearly all parts of the world. This disease is exacerbated by a weakened immune system. Copper is an important component of the immune system. The aim of this study was to investigate the effect of copper deficiency on leptospirosis occurrence. A total of 260 serum samples were randomly collected from eight industrial and semi-industrial dairy farms from center and southeast of Iran. Microscopic agglutination test to check leptospirosis was performed. Serum copper level was analyzed using an atomic absorption spectrometer. Fifty-eight serum samples had detectable antibodies against at least one serovar of Leptospira interrogans at a dilution of ≥1:100, and among the positive cows, 55 samples were copper deficient. In contrast, there were 202 serologically negative subjects, 29 of these samples had copper deficiency. Copper deficiency can weaken immunity and thus exacerbate the incidence of leptospirosis.
Literatur
Zurück zum Zitat Agampodi S, Peacock SJ, Thevanesam V (2010) The potential emergence of leptospirosis in Sri Lanka. Lancet Infect Dis 9:524–526CrossRef Agampodi S, Peacock SJ, Thevanesam V (2010) The potential emergence of leptospirosis in Sri Lanka. Lancet Infect Dis 9:524–526CrossRef
Zurück zum Zitat Bala S, Failla ML, Lunney JK (1991) Alterations in splenic lymphoid cell subsets and activation antigens in copper-deficient rats. J Nutr 121:745–753PubMed Bala S, Failla ML, Lunney JK (1991) Alterations in splenic lymphoid cell subsets and activation antigens in copper-deficient rats. J Nutr 121:745–753PubMed
Zurück zum Zitat Blakley BR, Hamilton DL (1987) The effect of copper deficiency on the immune response in mice. Drug Nutr Interact 5:103–111PubMed Blakley BR, Hamilton DL (1987) The effect of copper deficiency on the immune response in mice. Drug Nutr Interact 5:103–111PubMed
Zurück zum Zitat Doosti A, Hoveizeh Tamimian N (2011) Diagnosis of leptospiral abortion in bovine by polymerase chain reaction. Global Veterinaria 7:79–82 Doosti A, Hoveizeh Tamimian N (2011) Diagnosis of leptospiral abortion in bovine by polymerase chain reaction. Global Veterinaria 7:79–82
Zurück zum Zitat Dufour B, Moutou F, Hattenberger AM, Rodhain F (2008) Global change impact, management, risk approach and health measures the case of Europe. Rev Sci Tech 27:529–550PubMed Dufour B, Moutou F, Hattenberger AM, Rodhain F (2008) Global change impact, management, risk approach and health measures the case of Europe. Rev Sci Tech 27:529–550PubMed
Zurück zum Zitat Failla ML, Babu U, Seidel KE (1988) Use of immunoresponsiveness to determine that the dietary requirements for copper in young rats is greater with dietary fructose than dietary starch. J Nutr 118:487–496PubMed Failla ML, Babu U, Seidel KE (1988) Use of immunoresponsiveness to determine that the dietary requirements for copper in young rats is greater with dietary fructose than dietary starch. J Nutr 118:487–496PubMed
Zurück zum Zitat Genovez ME, del Fava C, Castro V, Gotti TB, Dib CC, Pozzi CR, Arcaro JRP, Miyashiro S, Nassar AFC, Cirillo SL (2006) Leptospirosis outbreak in dairy cattle due to Leptospira spp. serovar canicola: reproductive rates and serological profile after treatment with streptomycin sulfate. Rev Arq Inst Biol 73:389–393 Genovez ME, del Fava C, Castro V, Gotti TB, Dib CC, Pozzi CR, Arcaro JRP, Miyashiro S, Nassar AFC, Cirillo SL (2006) Leptospirosis outbreak in dairy cattle due to Leptospira spp. serovar canicola: reproductive rates and serological profile after treatment with streptomycin sulfate. Rev Arq Inst Biol 73:389–393
Zurück zum Zitat Haji Hajikolaei M, Ghorbanpour M, Gharibi D, Abdollapour G (2007) Serologic study on leptospiral infection in sheep in Ahvaz, southwestern Iran. J Vet Res 8:333–336 Haji Hajikolaei M, Ghorbanpour M, Gharibi D, Abdollapour G (2007) Serologic study on leptospiral infection in sheep in Ahvaz, southwestern Iran. J Vet Res 8:333–336
Zurück zum Zitat Herd DB (1997) Mineral supplementation of beef cows in Texas. Texas Cooperative Extension Publication 10M-5-97 Herd DB (1997) Mineral supplementation of beef cows in Texas. Texas Cooperative Extension Publication 10M-5-97
Zurück zum Zitat Koller LD, Mulhern SA, Frankel NC, Steven MG, Williams JR (1987) Immune dysfunction in rats fed a diet deficient in copper. Am J Clin Nutr 45:997–1006PubMed Koller LD, Mulhern SA, Frankel NC, Steven MG, Williams JR (1987) Immune dysfunction in rats fed a diet deficient in copper. Am J Clin Nutr 45:997–1006PubMed
Zurück zum Zitat Lukasewycz OA, Prohaska JR (1990) The immune response in copper deficiency. Ann N Y Acad Sci 587:147–159PubMed Lukasewycz OA, Prohaska JR (1990) The immune response in copper deficiency. Ann N Y Acad Sci 587:147–159PubMed
Zurück zum Zitat Lukasewycz O, Prohaska JR, Meyer SM, Schmidtke JR, Hatfield SM, Marder P (1985) Alterations in lymphocyte subpopulations in copper-deficient mice. Infect Immun 48:644–647PubMedCentralPubMed Lukasewycz O, Prohaska JR, Meyer SM, Schmidtke JR, Hatfield SM, Marder P (1985) Alterations in lymphocyte subpopulations in copper-deficient mice. Infect Immun 48:644–647PubMedCentralPubMed
Zurück zum Zitat Montgomery DW, Don LK, Zukosi CF, Chvapil M (1974) The effect of zinc and other metals on complement hemolysis of SRBC in vitro. Proc Soc Exp Biol Med 145:263–267CrossRefPubMed Montgomery DW, Don LK, Zukosi CF, Chvapil M (1974) The effect of zinc and other metals on complement hemolysis of SRBC in vitro. Proc Soc Exp Biol Med 145:263–267CrossRefPubMed
Zurück zum Zitat Mortimer RG, Dargatz DA, Corah LR (1999) Forage analysis from cow/calf herds in 23 states. Collins, CO. Centers for Epidemiology, Animal Health Mortimer RG, Dargatz DA, Corah LR (1999) Forage analysis from cow/calf herds in 23 states. Collins, CO. Centers for Epidemiology, Animal Health
Zurück zum Zitat Mulhern SA, Koller LD (1988) Severe or marginal copper deficiency results in a graded reduction in immune status in mice. J Nutr 118:1041–1047PubMed Mulhern SA, Koller LD (1988) Severe or marginal copper deficiency results in a graded reduction in immune status in mice. J Nutr 118:1041–1047PubMed
Zurück zum Zitat Mulhern SA, Vessey AR, Taylor GL, Magruder LE (1985) Suppression of antibody response by excess dietary zinc exposure during certain stages of ontogeny. Proc Soc Exp Biol Med 180:453–461CrossRefPubMed Mulhern SA, Vessey AR, Taylor GL, Magruder LE (1985) Suppression of antibody response by excess dietary zinc exposure during certain stages of ontogeny. Proc Soc Exp Biol Med 180:453–461CrossRefPubMed
Zurück zum Zitat Percival SS (1998) Copper and immunity. Am J Clin Nutr 67:1064S–1068SPubMed Percival SS (1998) Copper and immunity. Am J Clin Nutr 67:1064S–1068SPubMed
Zurück zum Zitat Prohaska JR, Failla ML (1993) Copper and immunity. In: Klurfield DM (ed) Nutrition and immunology, vol 8. Plenum, New York, pp 309–332CrossRef Prohaska JR, Failla ML (1993) Copper and immunity. In: Klurfield DM (ed) Nutrition and immunology, vol 8. Plenum, New York, pp 309–332CrossRef
Zurück zum Zitat Prohaska JR, Downing SW, Lukasewycz OA (1983) Chronic dietary copper deficiency alters biochemical and morphological properties of mouse lymphoid tissues. J Nutr 113:1583–1590PubMed Prohaska JR, Downing SW, Lukasewycz OA (1983) Chronic dietary copper deficiency alters biochemical and morphological properties of mouse lymphoid tissues. J Nutr 113:1583–1590PubMed
Zurück zum Zitat Radostits OM, Gay CC, Hinchcliff KW, Constable PD (2007) Veterinary medicine. Saunders Co., London Radostits OM, Gay CC, Hinchcliff KW, Constable PD (2007) Veterinary medicine. Saunders Co., London
Zurück zum Zitat Scheiber I, Dringen R, Mercer JFB (2013) Copper: effects of deficiency and overload. In: Sigel A, Sigel H, Sigel RKO (eds) Interrelations between essential metal ions and human diseases, vol 13. Springer, Dordrecht, pp 359–387CrossRef Scheiber I, Dringen R, Mercer JFB (2013) Copper: effects of deficiency and overload. In: Sigel A, Sigel H, Sigel RKO (eds) Interrelations between essential metal ions and human diseases, vol 13. Springer, Dordrecht, pp 359–387CrossRef
Zurück zum Zitat Shafighi T, Abdollahpour G, Zahraei Salehi T, Tadjbakhsh H (2010) Serological and bacteriological study of leptospirosis in slaughtered cattle in north of Iran (Rasht). Afr J Microbiol Res 4:2118–2121 Shafighi T, Abdollahpour G, Zahraei Salehi T, Tadjbakhsh H (2010) Serological and bacteriological study of leptospirosis in slaughtered cattle in north of Iran (Rasht). Afr J Microbiol Res 4:2118–2121
Zurück zum Zitat Stern BR (2007) U-shaped dose-response curve for risk assessment of essential trace elements. In: Robson M, Toscano W (eds) Risk assessment for environmental health. Jossey-Bass, San Francisco, pp 555–562 Stern BR (2007) U-shaped dose-response curve for risk assessment of essential trace elements. In: Robson M, Toscano W (eds) Risk assessment for environmental health. Jossey-Bass, San Francisco, pp 555–562
Zurück zum Zitat Suttle NF, Jones DG (1989) Recent developments in trace element metabolism and function: trace elements, disease resistance and immune responsiveness in ruminants. J Nutr 119:1055–1061PubMed Suttle NF, Jones DG (1989) Recent developments in trace element metabolism and function: trace elements, disease resistance and immune responsiveness in ruminants. J Nutr 119:1055–1061PubMed
Zurück zum Zitat Victoriano AF, Smythe LD, Gloriani-Barzaga N, Cavinta LL, Kasai T, Limpakarnjanarat K, Ong BL, Gongal G, Hall J, Coulombe CA, Yanagihara Y, Yoshida S, Adler B (2009) Leptospirosis in the Asia Pacific region. BMC Infect Dis 9:147PubMedCentralCrossRefPubMed Victoriano AF, Smythe LD, Gloriani-Barzaga N, Cavinta LL, Kasai T, Limpakarnjanarat K, Ong BL, Gongal G, Hall J, Coulombe CA, Yanagihara Y, Yoshida S, Adler B (2009) Leptospirosis in the Asia Pacific region. BMC Infect Dis 9:147PubMedCentralCrossRefPubMed
Zurück zum Zitat Vyas E, Chandra RK (1983) Thymic factor activity, lymphocyte stimulation response and antibody producing cells in copper deficiency. Nutr Res 3:343–349CrossRef Vyas E, Chandra RK (1983) Thymic factor activity, lymphocyte stimulation response and antibody producing cells in copper deficiency. Nutr Res 3:343–349CrossRef
Zurück zum Zitat Zakeri S, Sepahian N, Afsharpad M, Esfandiari B, Ziapour P, Djadid ND (2010) Molecular epidemiology of leptospirosis in northern Iran by nested polymerase chain reaction/restriction fragment length polymorphism and sequencing methods. Am J Trop Med Hyg 82:899–903PubMedCentralCrossRefPubMed Zakeri S, Sepahian N, Afsharpad M, Esfandiari B, Ziapour P, Djadid ND (2010) Molecular epidemiology of leptospirosis in northern Iran by nested polymerase chain reaction/restriction fragment length polymorphism and sequencing methods. Am J Trop Med Hyg 82:899–903PubMedCentralCrossRefPubMed
Zurück zum Zitat Zinpro Corp (2000) Effect of 4-plex pasture supplementation on liver mineral status and post weaning calf health. Zinpro Corporation Technical Bulletin TB-B-5007 Zinpro Corp (2000) Effect of 4-plex pasture supplementation on liver mineral status and post weaning calf health. Zinpro Corporation Technical Bulletin TB-B-5007
Metadaten
Titel
Association between serum copper concentration and the risk of bovine leptospirosis
verfasst von
Elham Mohammadi
Ehsanollah Sakhaee
Publikationsdatum
01.11.2015
Verlag
Springer London
Erschienen in
Comparative Clinical Pathology / Ausgabe 6/2015
Print ISSN: 1618-5641
Elektronische ISSN: 1618-565X
DOI
https://doi.org/10.1007/s00580-015-2069-0

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