nach oben

Journal of Assisted Reproduction and Genetics

Erschienen in:

29.03.2016 | Genetics

Association of interleukin-10 gene promoter polymorphisms with recurrent pregnancy loss: a meta-analysis

verfasst von: Chongjuan Gu, Hongxia Gong, Zheng Zhang, Zhao Yang, Yongxin Ma

Erschienen in: Journal of Assisted Reproduction and Genetics | Ausgabe 7/2016

Einloggen, um Zugang zu erhalten

Abstract

Purpose

It has been reported single-nucleotide polymorphisms (SNPs) of the IL-10 promoter might be associated with the susceptibility to recurrent pregnancy loss (RPL). Owing to the inconclusive results, we conducted a meta-analysis to systematically summarize and clarify the association between the IL-10 promoter SNPs and RPL risk.

Methods

A systematic search of studies on the association of the three SNPs with RPL was conducted in PubMed and Embase. Odds ratios (ORs) and 95 % confidence intervals (95 % CIs) were used to pool the effect size.

Result

Eleven case–control studies on rs1800896, seven studies on rs1800871, and eight studies on rs1800872 were included. A significant association was identified between IL-10 rs1800896 with RPL risk (G versus A: OR = 1.21, 95 % CI 1.09–1.35). No evidence of association was found between rs1800871 and RPL when restricted to those studies in Hardy–Weinberg equilibrium in controls (T versus C: OR = 1.25, 95 % CI 0.76–2.06). No statistical association was demonstrated between rs1800872 and RPL (C versus A: OR = 1.08, 95 % CI 0.83–1.42).

Conclusions

IL-10 rs1800896 significantly increases the risk of RPL, while rs1800872 is not correlated with RPL risk. No significant association is demonstrated between rs1800871 and RPL risk but this requires further investigation.

Nur mit Berechtigung zugänglich

Saravelos SH, Regan L. Unexplained recurrent pregnancy loss. Obstet Gynecol Clin N Am. 2014;41(1):157–66. doi:10.1016/j.ogc.2013.10.008.CrossRef

Practice Committee of American Society for Reproductive M. Definitions of infertility and recurrent pregnancy loss: a committee opinion. Fertil Steril. 2013;99(1):63. doi:10.1016/j.fertnstert.2012.09.023.CrossRef

Bardos J, Hercz D, Friedenthal J, Missmer SA, Williams Z. A national survey on public perceptions of miscarriage. Obstet Gynecol. 2015;125(6):1313–20. doi:10.1097/AOG.0000000000000859.CrossRefPubMedPubMedCentral

Rai R, Regan L. Recurrent miscarriage. Lancet. 2006;368(9535):601–11. doi:10.1016/S0140-6736(06)69204-0.CrossRefPubMed

Yang CJ, Stone P, Stewart AW. The epidemiology of recurrent miscarriage: a descriptive study of 1214 prepregnant women with recurrent miscarriage. Aust N Z J Obstet Gynaecol. 2006;46(4):316–22. doi:10.1111/j.1479-828X.2006.00599.x.CrossRefPubMed

Denney JM, Nelson EL, Wadhwa PD, Waters TP, Mathew L, Chung EK, et al. Longitudinal modulation of immune system cytokine profile during pregnancy. Cytokine. 2011;53(2):170–7. doi:10.1016/j.cyto.2010.11.005.CrossRefPubMed

Cheng SB, Sharma S. Interleukin-10: a pleiotropic regulator in pregnancy. Am J Reprod Immunol. 2015;73(6):487–500. doi:10.1111/aji.12329.CrossRefPubMed

Samanna M, Chaouat G, Moron AF, Freitas V, Kulay L, Frydman R, et al. The emerging role of decidual NK cells for regulation of trophoblast IL-10 synthesis in early pregnancy. Fertil Steril. 2004;82:S60. doi:10.1016/j.fertnstert.2004.07.153.CrossRef

Kalkunte SS, Mselle TF, Norris WE, Wira CR, Sentman CL, Sharma S. Vascular endothelial growth factor C facilitates immune tolerance and endovascular activity of human uterine NK cells at the maternal-fetal interface. J Immunol. 2009;182(7):4085–92. doi:10.4049/jimmunol.0803769.CrossRefPubMedPubMedCentral

10.

Hasnain SZ, Tauro S, Das I, Tong H, Chen ACH, Jeffery PL, et al. IL-10 promotes production of intestinal mucus by suppressing protein misfolding and endoplasmic reticulum stress in goblet cells. Gastroenterology. 2013;144(2):357. doi:10.1053/j.gastro.2012.10.043.CrossRefPubMed

11.

Raghupathy R, Makhseed M, Azizieh F, Hassan N, Al-Azemi M, Al-Shamali E. Maternal Th1-and Th2-type reactivity to placental antigens in normal human pregnancy and unexplained recurrent spontaneous abortions. Cell Immunol. 1999;196(2):122–30. doi:10.1006/cimm.1999.1532.CrossRefPubMed

12.

Bates MD, Quenby S, Takakuwa K, Johnson PM, Vince GS. Aberrant cytokine production by peripheral blood mononuclear cells in recurrent pregnancy loss? Hum Reprod. 2002;17(9):2439–44.CrossRefPubMed

13.

Cochery-Nouvellon E, Nguyen P, Attaoua R, Cornillet-Lefebvre P, Mercier E, Vitry F, et al. Interleukin 10 gene promoter polymorphisms in women with pregnancy loss: preferential association with embryonic wastage. Biol Reprod. 2009;80(6):1115–20. doi:10.1095/biolreprod.108.072215.CrossRefPubMed

14.

Qaddourah RH, Magdoud K, Saldanha FL, Mahmood N, Mustafa FE, Mahjoub T, et al. IL-10 gene promoter and intron polymorphisms and changes in IL-10 secretion in women with idiopathic recurrent miscarriage. Hum Reprod. 2014;29(5):1025–34. doi:10.1093/humrep/deu043.CrossRefPubMed

15.

Mormann M, Rieth H, Hua TD, Assohou C, Roupelieva M, Hu SL, et al. Mosaics of gene variations in the interleukin-10 gene promoter affect interleukin-10 production depending on the stimulation used. Genes Immun. 2004;5(4):246–55. doi:10.1038/sj.gene.6364073.CrossRefPubMed

16.

Daher S, Shulzhenko N, Morgun A, Mattar R, Rampim GF, Camano L, et al. Associations between cytokine gene polymorphisms and recurrent pregnancy loss. J Reprod Immunol. 2003;58(1):69–77. doi:10.1016/S0165-0378(02)00059-1.CrossRefPubMed

17.

Prigoshin N, Tambutti M, Larriba J, Gogorza S, Testa R. Cytokine gene polymorphisms in recurrent pregnancy loss of unknown cause. Am J Reprod Immunol. 2004;52(1):36–41. doi:10.1111/j.1600-0897.2004.00179.x.CrossRefPubMed

18.

Kamali-Sarvestani E, Zolghadri J, Gharesi-Fard B, Sarvari J. Cytokine gene polymorphisms and susceptibility to recurrent pregnancy loss in Iranian women. J Reprod Immunol. 2005;65(2):171–8. doi:10.1016/j.jri.2005.01.008.CrossRefPubMed

19.

Zammiti W, Mtiraoui N, Cochery-Nouvellon E, Mahjoub T, Almawi WY, Gris JC. Association of -592C/A, -819C/T and -1082A/G interleukin-10 promoter polymorphisms with idiopathic recurrent spontaneous abortion. Mol Hum Reprod. 2006;12(12):771–6. doi:10.1093/molehr/gal084.CrossRefPubMed

20.

Parveen F, Shukla A, Agarwal S. Cytokine gene polymorphisms in northern Indian women with recurrent miscarriages. Fertil Steril. 2013;99(2):433–40. doi:10.1016/j.fertnstert.2012.09.025.CrossRefPubMed

21.

Zastavna D, Sosnina K, Terpylyak O, Huleyuk N, Bezkorovayna H, Mikula M, et al. Cytogenetic and immunogenetic analysis of recurrent pregnancy loss in women. TSitologiia i genetika. 2014;48(4):44–50.PubMed

22.

Kamali-Sarvestani B, Zolghadri J, Gharesi-Fard B, Sarvari J. Cytokine gene polymorphisms and susceptibility to recurrent pregnancy loss in Iranian women. J Reprod Immunol. 2005;65(2):171–8. doi:10.1016/j.jri.2005.01.008.CrossRefPubMed

23.

Babbage SJ, Arkwright PD, Vince GS, Perrey C, Pravica V, Quenby S, et al. Cytokine promoter gene polymorphisms and idiopathic recurrent pregnancy loss. J Reprod Immunol. 2001;51(1):21–7.CrossRefPubMed

24.

Kaur A, Kaur A. Recurrent pregnancy loss: TNF-α and IL-10 polymorphisms. J Hum Reprod Sci. 2011;4(2):91–4. doi:10.4103/0974-1208.86090.CrossRefPubMedPubMedCentral

25.

Bombell S, McGuire W. Cytokine polymorphisms in women with recurrent pregnancy loss: meta-analysis. Aust N Z J Obstet Gyn. 2008;48(2):147–54. doi:10.1111/j.1479-828X.2008.00843.x.CrossRef

26.

Medica I, Ostojic S, Pereza N, Kastrin A, Peterlin B. Association between genetic polymorphisms in cytokine genes and recurrent miscarriage—a meta-analysis. Reprod Biomed Online. 2009;19(3):406–14.CrossRefPubMed

27.

Moher D, Liberati A, Tetzlaff J, Altman DG, Grp P. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med. 2009;151(4):264–W64.CrossRefPubMed

28.

Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med. 2002;21(11):1539–58. doi:10.1002/sim.1186.CrossRefPubMed

29.

DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7(3):177–88.CrossRefPubMed

30.

Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics. 1994;50(4):1088–101.CrossRefPubMed

31.

Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315(7109):629–34.CrossRefPubMedPubMedCentral

32.

Alkhuriji AE, Alhimaidi AR, Babay ZA, Wary AS. The relationship between cytokine gene polymorphism and unexplained recurrent spontaneous abortion in Saudi females. Saudi Med J. 2013;34(5):484–9.PubMed

33.

Costeas PA, Koumouli A, Giantsiou-Kyriakou A, Papaloizou A, Koumas L. Th2/Th3 cytokine genotypes are associated with pregnancy loss. Hum Immunol. 2004;65(2):135–41. doi:10.1016/j.humimm.2003.11.007.CrossRefPubMed

34.

C LB, V ER. Interleukin-6 and interleukin-10 gene polymorphisms and recurrent pregnancy loss in Romanian population. Iran J Reprod Med. 2014;12(9):617–22.

35.

Karhukorpi J, Laitinen T, Karttunen R, Tiilikainen AS. The functionally important IL-10 promoter polymorphism (-1082G→A) is not a major genetic regulator in recurrent spontaneous abortions. Mol Hum Reprod. 2001;7(2):201–3.CrossRefPubMed

36.

Bahadori M, Zarei S, Zarnani AH, Zarei O, Idali F, Hadavi R, et al. IL-6, IL-10 and IL-17 gene polymorphisms in Iranian women with recurrent miscarriage. Iran J Immunol: IJI. 2014;11(2):97–104.PubMed

37.

Moore KW, O’Garra A, de Waal MR, Vieira P, Mosmann TR. Interleukin-10. Annu Rev Immunol. 1993;11:165–90. doi:10.1146/annurev.iy.11.040193.001121.CrossRefPubMed

38.

Ouyang W, Rutz S, Crellin NK, Valdez PA, Hymowitz SG. Regulation and functions of the IL-10 family of cytokines in inflammation and disease. Annu Rev Immunol. 2011;29:71–109. doi:10.1146/annurev-immunol-031210-101312.CrossRefPubMed

39.

Didion SP, Kinzenbaw DA, Schrader LI, Chu Y, Faraci FM. Endogenous interleukin-10 inhibits angiotensin II-induced vascular dysfunction. Hypertension. 2009;54(3):619–U331. doi:10.1161/Hypertensionaha.109.137158.CrossRefPubMedPubMedCentral

40.

Burton GJ, Yung HW. Endoplasmic reticulum stress in the pathogenesis of early-onset pre-eclampsia. Pregnancy Hypertens. 2011;1(1-2):72–8. doi:10.1016/j.preghy.2010.12.002.PubMedPubMedCentral

41.

Shkoda A, Ruiz PA, Daniel H, Kim SC, Rogler G, Sartor RB, et al. Interleukin-10 blocked endoplasmic reticulum stress in intestinal epithelial cells: impact on chronic inflammation. Gastroenterology. 2007;132(1):190–207. doi:10.1053/j.gastro.2006.10.030.CrossRefPubMed

42.

von Wolff M, Thaler CJ, Strowitzki T, Broome J, Stolz W, Tabibzadeh S. Regulated expression of cytokines in human endometrium throughout the menstrual cycle: dysregulation in habitual abortion. Mol Hum Reprod. 2000;6(7):627–34.CrossRef

43.

Hennessy A, Pilmore HL, Simmons LA, Painter DM. A deficiency of placental IL-10 in preeclampsia. J Immunol. 1999;163(6):3491–5.PubMed

44.

Hanna N, Bonifacio L, Weinberger B, Reddy P, Murphy S, Romero R, et al. Evidence for interleukin-10-mediated inhibition of cyclo- oxygenase-2 expression and prostaglandin production in preterm human placenta. Am J Reprod Immunol. 2006;55(1):19–27. doi:10.1111/j.1600-0897.2005.00342.x.CrossRefPubMed

45.

Terrone DA, Rinehart BK, Granger JP, Barrilleaux PS, Martin Jr JN, Bennett WA. Interleukin-10 administration and bacterial endotoxin-induced preterm birth in a rat model. Obstet Gynecol. 2001;98(3):476–80.PubMed

46.

Tinsley JH, South S, Chiasson VL, Mitchell BM. Interleukin-10 reduces inflammation, endothelial dysfunction, and blood pressure in hypertensive pregnant rats. Am J Physiol Regul Integr Comp Physiol. 2010;298(3):R713–9. doi:10.1152/ajpregu.00712.2009.CrossRefPubMed

47.

Lai Z, Kalkunte S, Sharma S. A critical role of interleukin-10 in modulating hypoxia-induced preeclampsia-like disease in mice. Hypertension. 2011;57(3):505–14. doi:10.1161/HYPERTENSIONAHA.110.163329.CrossRefPubMedPubMedCentral

48.

Lin Y, Liu X, Shan B, Wu J, Sharma S, Sun Y. Prevention of CpG-induced pregnancy disruption by adoptive transfer of in vitro-induced regulatory T cells. PLoS One. 2014;9(4):e94702. doi:10.1371/journal.pone.0094702.CrossRefPubMedPubMedCentral

49.

Lin MT, Storer B, Martin PJ, Tseng LH, Gooley T, Chen PJ, et al. Relation of an interleukin-10 promoter polymorphism to graft-versus-host disease and survival after hematopoietic-cell transplantation. N Engl J Med. 2003;349(23):2201–10. doi:10.1056/NEJMoa022060.CrossRefPubMed

50.

Costa GC, Rocha MOD, Moreira PR, Menezes CAS, Silva MR, Gollob KJ, et al. Functional IL-10 gene polymorphism is associated with Chagas disease cardiomyopathy. J Infect Dis. 2009;199(3):451–4. doi:10.1086/596061.CrossRefPubMed

51.

Gezen-Ak D, Dursun E, Hanagasi H, Bilgic B, Lohman E, Araz OS, et al. BDNF, TNFalpha, HSP90, CFH, and IL-10 serum levels in patients with early or late onset Alzheimer’s disease or mild cognitive impairment. J Alzheimers Dis: JAD. 2013;37(1):185–95. doi:10.3233/JAD-130497.PubMed

52.

Makris A, Xu B, Yu B, Thornton C, Hennessy A. Placental deficiency of interleukin-10 (IL-10) in preeclampsia and its relationship to an IL-10 promoter polymorphism. Placenta. 2006;27(4-5):445–51. doi:10.1016/j.placenta.2005.05.003.CrossRefPubMed

53.

Daher S, Sass N, Oliveira LG, Mattar R. Cytokine genotyping in preeclampsia. Am J Reprod Immunol. 2006;55(2):130–5. doi:10.1111/j.1600-0897.2005.00341.x.CrossRefPubMed

54.

Sowmya S, Ramaiah A, Sunitha T, Nallari P, Jyothy A, Venkateshwari A. Role of IL-10 -819(t/c) promoter polymorphism in preeclampsia. Inflammation. 2014;37(4):1022–7. doi:10.1007/s10753-014-9824-2.CrossRefPubMed

55.

Murphy SP, Sharma S. IL-10 and pregnancy. In Immunology of Pregnancy. 2006; G Mor (ed.):26-36.

56.

Sharma S, Stabila J, Pietras L, Singh AR, McGonnigal B, Ernerudh J, et al. Haplotype-dependent differential activation of the human IL-10 gene promoter in macrophages and trophoblasts: implications for placental IL-10 deficiency and pregnancy complications. Am J Reprod Immunol. 2010;64(3):179–87. doi:10.1111/j.1600-0897.2010.00854.x.CrossRefPubMedPubMedCentral

57.

Thakkinstian A, McElduff P, D’Este C, Duffy D, Attia J. A method for meta-analysis of molecular association studies. Stat Med. 2005;24(9):1291–306. doi:10.1002/sim.2010.CrossRefPubMed

Titel: Association of interleukin-10 gene promoter polymorphisms with recurrent pregnancy loss: a meta-analysis
verfasst von: Chongjuan Gu
Hongxia Gong
Zheng Zhang
Zhao Yang
Yongxin Ma
Publikationsdatum: 29.03.2016
Verlag: Springer US
Erschienen in: Journal of Assisted Reproduction and Genetics / Ausgabe 7/2016
Print ISSN: 1058-0468
Elektronische ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-016-0699-z

Update Gynäkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.

Newsletter bestellen

Springer Medizin

Association of interleukin-10 gene promoter polymorphisms with recurrent pregnancy loss: a meta-analysis

Abstract

Purpose

Methods

Result

Conclusions

Neu im Fachgebiet Gynäkologie und Geburtshilfe

Hirsutismus bei PCOS: Laser- und Lichttherapien helfen

ICI-Therapie in der Schwangerschaft wird gut toleriert

Weniger postpartale Depressionen nach Esketamin-Einmalgabe

Bei RSV-Impfung vor 60. Lebensjahr über Off-Label-Gebrauch aufklären!

Update Gynäkologie

Springer Medizin

Abstract

Purpose

Methods

Result

Conclusions

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 7/2016

The association between multinucleated blastomeres and poor ovarian response under the Bologna criteria

Follicular fluid soluble receptor for advanced glycation endproducts (sRAGE): a potential protective role in polycystic ovary syndrome

Discrepant diagnosis rate of array comparative genomic hybridization in thawed euploid blastocysts

Comparison of 2, 5, and 20 % O2 on the development of post-thaw human embryos

Clinical application of next-generation sequencing in preimplantation genetic diagnosis cycles for Robertsonian and reciprocal translocations

On the dichotomy (im)posed by developmental autonomy during early human embryogenesis

Neu im Fachgebiet Gynäkologie und Geburtshilfe

Hirsutismus bei PCOS: Laser- und Lichttherapien helfen

ICI-Therapie in der Schwangerschaft wird gut toleriert

Weniger postpartale Depressionen nach Esketamin-Einmalgabe

Bei RSV-Impfung vor 60. Lebensjahr über Off-Label-Gebrauch aufklären!

Update Gynäkologie