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Journal of Assisted Reproduction and Genetics
Erschienen in: Journal of Assisted Reproduction and Genetics 7/2016

12.05.2016 | Assisted Reproduction Technologies

The association between multinucleated blastomeres and poor ovarian response under the Bologna criteria

verfasst von: Johnny S. Younis, Vicky Yazdi, Ido Izhaki, Moshe Ben-Ami

Erschienen in: Journal of Assisted Reproduction and Genetics | Ausgabe 7/2016

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Abstract

Purpose

To investigate the occurrence of multinucleated blastomeres (MNB) in poor ovarian response (POR) women defined under the Bologna criteria.

Methods

This observational study was designed in a prospective controlled manner. Among 380 cases evaluated for eligibility, 102 women were found suitable and recruited; 51 with POR in accordance with the Bologna criteria defined as the study group and 51 with normal ovarian response defined as the control group.

Results

Among the 51 women in each group, 8 and 2 did not achieve embryos in the study and control group, respectively (P < 0.05). The percentage of women that had at least one embryo with one MNB was significantly higher in the study as compared to the control group, corresponding to 49 and 29 %, respectively. The total number of embryos evaluated was 416; 167 in the study and 249 in the control groups. Among these embryos, the MNB rate was significantly higher in the study as compared to the control group, corresponding to 19 and 8 %, respectively.

Conclusions

Blastomere multinuclearity is significantly more common in women and embryos of POR cases, defined under the Bologna criteria. Future studies are warranted to substantiate our observation that has the potential to be clinically implemented in this sub-group of women undergoing assisted reproductive technologies (ART) treatment.
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Metadaten
Titel
The association between multinucleated blastomeres and poor ovarian response under the Bologna criteria
verfasst von
Johnny S. Younis
Vicky Yazdi
Ido Izhaki
Moshe Ben-Ami
Publikationsdatum
12.05.2016
Verlag
Springer US
Erschienen in
Journal of Assisted Reproduction and Genetics / Ausgabe 7/2016
Print ISSN: 1058-0468
Elektronische ISSN: 1573-7330
DOI
https://doi.org/10.1007/s10815-016-0731-3

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