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01.01.2010 | Original Article

Association of UGT2B7 and ABCB1 genotypes with morphine-induced adverse drug reactions in Japanese patients with cancer

verfasst von: Ken-ichi Fujita, Yuichi Ando, Wataru Yamamoto, Toshimichi Miya, Hisashi Endo, Yu Sunakawa, Kazuhiro Araki, Keiji Kodama, Fumio Nagashima, Wataru Ichikawa, Masaru Narabayashi, Yuko Akiyama, Kaori Kawara, Mari Shiomi, Hiroyasu Ogata, Hiroyasu Iwasa, Yasushi Okazaki, Takashi Hirose, Yasutsuna Sasaki

Erschienen in: Cancer Chemotherapy and Pharmacology | Ausgabe 2/2010

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Abstract

Purpose

To investigate the effects of genetic polymorphisms on morphine-induced adverse events in cancer patients.

Methods

We examined the relation of morphine-related adverse events to polymorphisms in UDP-glucuronosyltransferase (UGT) 2B7, ATP-binding cassette, sub-family B, number 1 (ABCB1), and μ-opioid receptor 1 genes in 32 Japanese cancer patients receiving oral controlled-release morphine sulfate tablets.

Results

The T/T genotype at 1236 or TT/TT diplotype at 2677 and 3435 in ABCB1 was associated with significantly lower frequency of fatigue (grades 1–3) (P = 0.012 or 0.011, Fisher’s exact test). The UGT2B7*2 genotype was associated with the frequency of nausea (grades 1–3) (P = 0.023). The frequency of nausea was higher in patients without UGT2B7*2 allele than others. The diplotype at 2677 and 3435 in ABCB1 was associated with the frequency of vomiting (grades 1–3) (P = 0.011). No patient whose diplotype was consisted of no GC allele at 2677 and 3435 suffered from vomiting.

Conclusion

Our findings suggest that pharmacogenetics can be used to predict the risk of morphine-induced adverse events.

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Titel: Association of UGT2B7 and ABCB1 genotypes with morphine-induced adverse drug reactions in Japanese patients with cancer
verfasst von: Ken-ichi Fujita
Yuichi Ando
Wataru Yamamoto
Toshimichi Miya
Hisashi Endo
Yu Sunakawa
Kazuhiro Araki
Keiji Kodama
Fumio Nagashima
Wataru Ichikawa
Masaru Narabayashi
Yuko Akiyama
Kaori Kawara
Mari Shiomi
Hiroyasu Ogata
Hiroyasu Iwasa
Yasushi Okazaki
Takashi Hirose
Yasutsuna Sasaki
Publikationsdatum: 01.01.2010
Verlag: Springer-Verlag
Erschienen in: Cancer Chemotherapy and Pharmacology / Ausgabe 2/2010
Print ISSN: 0344-5704
Elektronische ISSN: 1432-0843
DOI: https://doi.org/10.1007/s00280-009-1029-2

Springer Medizin

Association of UGT2B7 and ABCB1 genotypes with morphine-induced adverse drug reactions in Japanese patients with cancer