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Endocrine

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01.02.2013 | Review

Atrogin-1, MuRF-1, and sarcopenia

verfasst von: Jonathan P. Gumucio, Christopher L. Mendias

Erschienen in: Endocrine | Ausgabe 1/2013

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Abstract

Sarcopenia is one of the leading causes of disability in the elderly. Despite the growing prevalence of sarcopenia, the molecular mechanisms that control aging-related changes in muscle mass are not fully understood. The ubiquitin proteasome system is one of the major pathways that regulate muscle protein degradation, and this system plays a central role in controlling muscle size. Atrogin-1 and MuRF-1 are two E3 ubiquitin ligases that are important regulators of ubiquitin-mediated protein degradation in skeletal muscle. In this review, we will discuss: (i) aging-related changes to skeletal muscle structure and function; (ii) the regulation of protein synthesis and protein degradation by IGF-1, TGF-β, and myostatin, with emphasis on the control of atrogin-1 and MuRF-1 expression; and (iii) the potential for modulating atrogin-1 and MuRF-1 expression to treat or prevent sarcopenia.

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Titel: Atrogin-1, MuRF-1, and sarcopenia
verfasst von: Jonathan P. Gumucio
Christopher L. Mendias
Publikationsdatum: 01.02.2013
Verlag: Springer US
Erschienen in: Endocrine / Ausgabe 1/2013
Print ISSN: 1355-008X
Elektronische ISSN: 1559-0100
DOI: https://doi.org/10.1007/s12020-012-9751-7

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