Erschienen in:
01.12.2000 | Paper Report
Autoimmunity in BAFF transgenic mice
verfasst von:
Chaim Putterman
Erschienen in:
Arthritis Research & Therapy
|
Ausgabe 1/2000
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Excerpt
Apoptosis of autoreactive T cells and B cells is an important mechanism by which self-tolerance is normally maintained. A striking example of this is the Fas/Fas ligand pathway, as the presence of defective Fas or Fas ligand molecules leads to lupus-like systemic autoimmunity in the mouse. The authors of this paper have recently identified another TNF-like ligand, which they called BAFF. This molecule has also been independently discovered by other groups and named TALL-1, THANK, and BlyS. BAFF has been shown to be expressed by dendritic cells, and binds to B cells. To further characterize and understand the physiological role of BAFF by generating mice transgenic for BAFF. …