Erschienen in:
01.12.2000 | Paper Report
IL-4 gene therapy for collagen arthritis
verfasst von:
Richard Brasington
Erschienen in:
Arthritis Research & Therapy
|
Ausgabe 1/2000
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Excerpt
IL-4 is a regulatory cytokine which counteracts the effects of the major pro-inflammatory cytokines IL-1 and TNF-a. Levels of IL-4 are reduced in the synovium of patients with rheumatoid arthritis. Therefore, treatment to increase levels of IL-4 in such patients might be beneficial. Collagen-induced arthritis in mice resembles rheumatoid arthritis, with inflammatory synovitis producing cartilage and bone erosion. To introduce IL-4 via an adenovirus vector into mice with collagen arthritis, and assess the effect of this treatment on cartilage and bone erosion. …