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Erschienen in: Herzschrittmachertherapie + Elektrophysiologie 3/2021

29.06.2021 | Schwerpunkt

Autonomic cardiac innervation: impact on the evolution of arrhythmias in inherited cardiac arrhythmia syndromes

verfasst von: Dr. Philippe Maury, MD, Hubert Delasnerie, MD, Maxime Beneyto, MD, Anne Rollin, MD

Erschienen in: Herzschrittmachertherapie + Elektrophysiologie | Ausgabe 3/2021

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Abstract

The autonomic nervous system (ANS) is an essential component of arrhythmogenicity, especially in the absence of structural heart disease and channelopathy. In this article, the authors review the role and characteristics of ANS in various channelopathies. Some of these, such as most long QT syndromes and catecholaminergic polymorphic ventricular tachycardia, are highly dependent on sympathetic activation, while parasympathetic tone is an important factor for arrhythmias in other channelopathies such as Brugada syndrome or early repolarisation syndrome. Recent advances highlighting the subtle role of ANS in channelopathies are presented here, demonstrating that all is far from being so simple and straightforward and revealing some paradoxical behaviours of channelopathies in relation to discrete ANS imbalance.
Literatur
1.
Zurück zum Zitat Coumel P (1993) Cardiac arrhythmias and the autonomic nervous system. J Cardiovasc Electrophysiol 4:338–355PubMedCrossRef Coumel P (1993) Cardiac arrhythmias and the autonomic nervous system. J Cardiovasc Electrophysiol 4:338–355PubMedCrossRef
2.
Zurück zum Zitat Armour JA, Murphy DA, Yuan BX, Macdonald S, Hopkins DA (1997) Gross and microscopic anatomy of the human intrinsic cardiac nervous system. Anat Rec 247:289–298PubMedCrossRef Armour JA, Murphy DA, Yuan BX, Macdonald S, Hopkins DA (1997) Gross and microscopic anatomy of the human intrinsic cardiac nervous system. Anat Rec 247:289–298PubMedCrossRef
3.
Zurück zum Zitat Schwartz PJ, Periti M, Malliani A (1975) The long Q‑T syndrome. Am Heart J 89:378–390PubMedCrossRef Schwartz PJ, Periti M, Malliani A (1975) The long Q‑T syndrome. Am Heart J 89:378–390PubMedCrossRef
4.
Zurück zum Zitat Swan H, Viitasalo M, Piippo K, Laitinen P, Kontula K, Toivonen L (1999) Sinus node function and ventricular repolarization during exercise stress test in long QT syndrome patients with KvLQT1 and HERG potassium channel defects. J Am Coll Cardiol 34:823–829PubMedCrossRef Swan H, Viitasalo M, Piippo K, Laitinen P, Kontula K, Toivonen L (1999) Sinus node function and ventricular repolarization during exercise stress test in long QT syndrome patients with KvLQT1 and HERG potassium channel defects. J Am Coll Cardiol 34:823–829PubMedCrossRef
5.
Zurück zum Zitat Coumel P, Leenhardt A (1991) Mental activity, adrenergic modulation, and cardiac arrhythmias in patients with heart disease. Circulation 83(4 Suppl):II58–II70PubMed Coumel P, Leenhardt A (1991) Mental activity, adrenergic modulation, and cardiac arrhythmias in patients with heart disease. Circulation 83(4 Suppl):II58–II70PubMed
6.
Zurück zum Zitat Kannankeril PJ, Le FK, Kadish AH, Goldberger JJ (2004) Parasympathetic effects on heart rate recovery after exercise. J Investig Med 52:394–401PubMedCrossRef Kannankeril PJ, Le FK, Kadish AH, Goldberger JJ (2004) Parasympathetic effects on heart rate recovery after exercise. J Investig Med 52:394–401PubMedCrossRef
7.
Zurück zum Zitat Wilders R, Verkerk AO (2018) Long QT syndrome and sinus bradycardia—a mini review. Front Cardiovasc 5:106CrossRef Wilders R, Verkerk AO (2018) Long QT syndrome and sinus bradycardia—a mini review. Front Cardiovasc 5:106CrossRef
8.
Zurück zum Zitat Terrenoire C, Clancy CE, Cormier JW, Sampson KJ, Kass RS (2005) Autonomic control of cardiac action potentials: role of potassium channel kinetics in response to sympathetic stimulation. Circ Res 96:e25–e33PubMedCrossRef Terrenoire C, Clancy CE, Cormier JW, Sampson KJ, Kass RS (2005) Autonomic control of cardiac action potentials: role of potassium channel kinetics in response to sympathetic stimulation. Circ Res 96:e25–e33PubMedCrossRef
9.
Zurück zum Zitat Haapalahti P, Viitasalo M, Perhonen M, Mäkijärvi M, Väänänen H, Oikarinen L, Hekkala AM, Salorinne Y, Swan H, Toivonen L (2006) Ventricular repolarization and heart rate responses during cardiovascular autonomic function testing in LQT1 subtype of long QT syndrome. Pacing Clin Electrophysiol 29:1122–1129PubMedCrossRef Haapalahti P, Viitasalo M, Perhonen M, Mäkijärvi M, Väänänen H, Oikarinen L, Hekkala AM, Salorinne Y, Swan H, Toivonen L (2006) Ventricular repolarization and heart rate responses during cardiovascular autonomic function testing in LQT1 subtype of long QT syndrome. Pacing Clin Electrophysiol 29:1122–1129PubMedCrossRef
10.
Zurück zum Zitat Schwartz PJ, Vanoli E, Crotti L, Spazzolini C, Ferrandi C, Goosen A, Hedley P, Heradien M, Bacchini S, Turco A, La Rovere MT, Bartoli A, George AL Jr, Brink PA (2008) Neural control of heart rate is an arrhythmia risk modifier in long QT syndrome. J Am Coll Cardiol 51:920–929PubMedCrossRef Schwartz PJ, Vanoli E, Crotti L, Spazzolini C, Ferrandi C, Goosen A, Hedley P, Heradien M, Bacchini S, Turco A, La Rovere MT, Bartoli A, George AL Jr, Brink PA (2008) Neural control of heart rate is an arrhythmia risk modifier in long QT syndrome. J Am Coll Cardiol 51:920–929PubMedCrossRef
11.
Zurück zum Zitat Porta A, Girardengo G, Bari V, George AL Jr, Brink PA, Goosen A, Crotti L, Schwartz PJ (2015) Autonomic control of heart rate and QT interval variability influences arrhythmic risk in long QT syndrome type 1. J Am Coll Cardiol 65:367–374PubMedPubMedCentralCrossRef Porta A, Girardengo G, Bari V, George AL Jr, Brink PA, Goosen A, Crotti L, Schwartz PJ (2015) Autonomic control of heart rate and QT interval variability influences arrhythmic risk in long QT syndrome type 1. J Am Coll Cardiol 65:367–374PubMedPubMedCentralCrossRef
12.
Zurück zum Zitat Crotti L, Spazzolini C, Porretta AP, Dagradi F, Taravelli E, Petracci B, Vicentini A, Pedrazzini M, La Rovere MT, Vanoli E, Goosen A, Heradien M, George AL Jr, Brink PA, Schwartz PJ (2012) Vagal reflexes following an exercise stress test: a simple clinical tool for gene-specific risk stratification in the long QT syndrome. J Am Coll Cardiol 60:2515–2524PubMedPubMedCentralCrossRef Crotti L, Spazzolini C, Porretta AP, Dagradi F, Taravelli E, Petracci B, Vicentini A, Pedrazzini M, La Rovere MT, Vanoli E, Goosen A, Heradien M, George AL Jr, Brink PA, Schwartz PJ (2012) Vagal reflexes following an exercise stress test: a simple clinical tool for gene-specific risk stratification in the long QT syndrome. J Am Coll Cardiol 60:2515–2524PubMedPubMedCentralCrossRef
13.
Zurück zum Zitat Shimizu W, Antzelevitch C (2000) Differential effects of beta-adrenergic agonists and antagonists in LQT1, LQT2 and LQT3 models of the long QT syndrome. J Am Coll Cardiol 35:778–786PubMedCrossRef Shimizu W, Antzelevitch C (2000) Differential effects of beta-adrenergic agonists and antagonists in LQT1, LQT2 and LQT3 models of the long QT syndrome. J Am Coll Cardiol 35:778–786PubMedCrossRef
14.
15.
Zurück zum Zitat Bari V, Girardengo G, Marchi A, De Maria B, Brink PA, Crotti L, Schwartz PJ, Porta A (2015) Time, frequency and information domain analysis of heart period and QT variability in asymptomatic long QT syndrome type 2 patients. Annu Int Conf IEEE Eng Med Biol Soc 2015:294–297PubMed Bari V, Girardengo G, Marchi A, De Maria B, Brink PA, Crotti L, Schwartz PJ, Porta A (2015) Time, frequency and information domain analysis of heart period and QT variability in asymptomatic long QT syndrome type 2 patients. Annu Int Conf IEEE Eng Med Biol Soc 2015:294–297PubMed
16.
Zurück zum Zitat Wilde AA, Jongbloed RJ, Doevendans PA, Düren DR, Hauer RN, van Langen IM, van Tintelen JP, Smeets HJ, Meyer H, Geelen JL (1999) Auditory stimuli as a trigger for arrhythmic events differentiate HERG-related (LQTS2) patients from KVLQT1-related patients (LQTS1). J Am Coll Cardiol 33:327–332PubMedCrossRef Wilde AA, Jongbloed RJ, Doevendans PA, Düren DR, Hauer RN, van Langen IM, van Tintelen JP, Smeets HJ, Meyer H, Geelen JL (1999) Auditory stimuli as a trigger for arrhythmic events differentiate HERG-related (LQTS2) patients from KVLQT1-related patients (LQTS1). J Am Coll Cardiol 33:327–332PubMedCrossRef
17.
Zurück zum Zitat Toivonen L, Helenius K, Viitasalo M (1997) Electrocardiographic repolarization during stress from awakening on alarm call. J Am Coll Cardiol 30:774–779PubMedCrossRef Toivonen L, Helenius K, Viitasalo M (1997) Electrocardiographic repolarization during stress from awakening on alarm call. J Am Coll Cardiol 30:774–779PubMedCrossRef
18.
Zurück zum Zitat Fabritz L, Damke D, Emmerich M, Kaufmann SG, Theis K, Blana A, Fortmüller L, Laakmann S, Hermann S, Aleynichenko E, Steinfurt J, Volkery D, Riemann B, Kirchhefer U, Franz MR, Breithardt G, Carmeliet E, Schäfers M, Maier SK, Carmeliet P, Kirchhof P (2010) Autonomic modulation and antiarrhythmic therapy in a model of long QT syndrome type 3. Cardiovasc Res 87:60–72PubMedPubMedCentralCrossRef Fabritz L, Damke D, Emmerich M, Kaufmann SG, Theis K, Blana A, Fortmüller L, Laakmann S, Hermann S, Aleynichenko E, Steinfurt J, Volkery D, Riemann B, Kirchhefer U, Franz MR, Breithardt G, Carmeliet E, Schäfers M, Maier SK, Carmeliet P, Kirchhof P (2010) Autonomic modulation and antiarrhythmic therapy in a model of long QT syndrome type 3. Cardiovasc Res 87:60–72PubMedPubMedCentralCrossRef
19.
Zurück zum Zitat Schwartz PJ, Priori SG, Locati EH, Napolitano C, Cantù F, Towbin JA, Keating MT, Hammoude H, Brown AM, Chen LS, Colatsky TJ (1995) Long QT syndrome patients with mutations of the SCN5A and HERG genes have differential responses to Na+ channel blockade and to increases in heart rate. Implications for gene-specific therapy. Circulation 92:3381–3386PubMedCrossRef Schwartz PJ, Priori SG, Locati EH, Napolitano C, Cantù F, Towbin JA, Keating MT, Hammoude H, Brown AM, Chen LS, Colatsky TJ (1995) Long QT syndrome patients with mutations of the SCN5A and HERG genes have differential responses to Na+ channel blockade and to increases in heart rate. Implications for gene-specific therapy. Circulation 92:3381–3386PubMedCrossRef
20.
Zurück zum Zitat Wilde AA, Moss AJ, Kaufman ES, Shimizu W, Peterson DR, Benhorin J, Lopes C, Towbin JA, Spazzolini C, Crotti L, Zareba W, Goldenberg I, Kanters JK, Robinson JL, Qi M, Hofman N, Tester DJ, Bezzina CR, Alders M, Aiba T, Kamakura S, Miyamoto Y, Andrews ML, McNitt S, Polonsky B, Schwartz PJ, Ackerman MJ (2016) Clinical aspects of type 3 long-QT syndrome: an international multicenter study. Circulation 134:872–882PubMedPubMedCentralCrossRef Wilde AA, Moss AJ, Kaufman ES, Shimizu W, Peterson DR, Benhorin J, Lopes C, Towbin JA, Spazzolini C, Crotti L, Zareba W, Goldenberg I, Kanters JK, Robinson JL, Qi M, Hofman N, Tester DJ, Bezzina CR, Alders M, Aiba T, Kamakura S, Miyamoto Y, Andrews ML, McNitt S, Polonsky B, Schwartz PJ, Ackerman MJ (2016) Clinical aspects of type 3 long-QT syndrome: an international multicenter study. Circulation 134:872–882PubMedPubMedCentralCrossRef
21.
Zurück zum Zitat Priori SG, Napolitano C, Schwartz PJ, Grillo M, Bloise R, Ronchetti E, Moncalvo C, Tulipani C, Veia A, Bottelli G, Nastoli J (2004) Association of long QT syndrome loci and cardiac events among patients treated with beta-blockers. JAMA 292:1341–1344PubMedCrossRef Priori SG, Napolitano C, Schwartz PJ, Grillo M, Bloise R, Ronchetti E, Moncalvo C, Tulipani C, Veia A, Bottelli G, Nastoli J (2004) Association of long QT syndrome loci and cardiac events among patients treated with beta-blockers. JAMA 292:1341–1344PubMedCrossRef
22.
Zurück zum Zitat Rhodes T, Weiss R (2015) Device therapy in the setting of long QT syndrome. Card Electrophysiol Clin 7:479–486PubMedCrossRef Rhodes T, Weiss R (2015) Device therapy in the setting of long QT syndrome. Card Electrophysiol Clin 7:479–486PubMedCrossRef
23.
Zurück zum Zitat Schwartz PJ, Priori SG, Spazzolini C, Moss AJ, Vincent GM, Napolitano C, Denjoy I, Guicheney P, Breithardt G, Keating MT, Towbin JA, Beggs AH, Brink P, Wilde AA, Toivonen L, Zareba W, Robinson JL, Timothy KW, Corfield V, Wattanasirichaigoon D, Corbett C, Haverkamp W, Schulze-Bahr E, Lehmann MH, Schwartz K, Coumel P, Bloise R (2001) Genotype-phenotype correlation in the long-QT syndrome: gene-specific triggers for life-threatening arrhythmias. Circulation 103:89–95PubMedCrossRef Schwartz PJ, Priori SG, Spazzolini C, Moss AJ, Vincent GM, Napolitano C, Denjoy I, Guicheney P, Breithardt G, Keating MT, Towbin JA, Beggs AH, Brink P, Wilde AA, Toivonen L, Zareba W, Robinson JL, Timothy KW, Corfield V, Wattanasirichaigoon D, Corbett C, Haverkamp W, Schulze-Bahr E, Lehmann MH, Schwartz K, Coumel P, Bloise R (2001) Genotype-phenotype correlation in the long-QT syndrome: gene-specific triggers for life-threatening arrhythmias. Circulation 103:89–95PubMedCrossRef
24.
Zurück zum Zitat Noda T, Takaki H, Kurita T, Suyama K, Nagaya N, Taguchi A, Aihara N, Kamakura S, Sunagawa K, Nakamura K, Ohe T, Horie M, Napolitano C, Towbin JA, Priori SG, Shimizu W (2002) Gene-specific response of dynamic ventricular repolarization to sympathetic stimulation in LQT1, LQT2 and LQT3 forms of congenital long QT syndrome. Eur Heart J 23:975–983PubMedCrossRef Noda T, Takaki H, Kurita T, Suyama K, Nagaya N, Taguchi A, Aihara N, Kamakura S, Sunagawa K, Nakamura K, Ohe T, Horie M, Napolitano C, Towbin JA, Priori SG, Shimizu W (2002) Gene-specific response of dynamic ventricular repolarization to sympathetic stimulation in LQT1, LQT2 and LQT3 forms of congenital long QT syndrome. Eur Heart J 23:975–983PubMedCrossRef
25.
Zurück zum Zitat Horner JM, Horner MM, Ackerman MJ (2011) The diagnostic utility of recovery phase QTc during treadmill exercise stress testing in the evaluation of long QT syndrome. Heart Rhythm 8:1698–1704PubMedCrossRef Horner JM, Horner MM, Ackerman MJ (2011) The diagnostic utility of recovery phase QTc during treadmill exercise stress testing in the evaluation of long QT syndrome. Heart Rhythm 8:1698–1704PubMedCrossRef
26.
Zurück zum Zitat Schwartz PJ, Priori SG, Cerrone M, Spazzolini C, Odero A, Napolitano C, Bloise R, De Ferrari GM, Klersy C, Moss AJ, Zareba W, Robinson JL, Hall WJ, Brink PA, Toivonen L, Epstein AE, Li C, Hu D (2004) Left cardiac sympathetic denervation in the management of high-risk patients affected by the long-QT syndrome. Circulation 109:1826–1833PubMedCrossRef Schwartz PJ, Priori SG, Cerrone M, Spazzolini C, Odero A, Napolitano C, Bloise R, De Ferrari GM, Klersy C, Moss AJ, Zareba W, Robinson JL, Hall WJ, Brink PA, Toivonen L, Epstein AE, Li C, Hu D (2004) Left cardiac sympathetic denervation in the management of high-risk patients affected by the long-QT syndrome. Circulation 109:1826–1833PubMedCrossRef
27.
Zurück zum Zitat Niaz T, Bos JM, Sorensen KB, Moir C, Ackerman MJ (2020) Left cardiac sympathetic denervation monotherapy in patients with congenital long QT syndrome. Circ Arrhythm Electrophysiol 13:e8830PubMedCrossRef Niaz T, Bos JM, Sorensen KB, Moir C, Ackerman MJ (2020) Left cardiac sympathetic denervation monotherapy in patients with congenital long QT syndrome. Circ Arrhythm Electrophysiol 13:e8830PubMedCrossRef
28.
Zurück zum Zitat Kashimura T, Briston SJ, Trafford AW, Napolitano C, Priori SG, Eisner DA, Venetucci LA (2010) In the RyR2(R4496C) mouse model of CPVT, β‑adrenergic stimulation induces Ca waves by increasing SR Ca content and not by decreasing the threshold for Ca waves. Circ Res 107:1483–1489PubMedCrossRef Kashimura T, Briston SJ, Trafford AW, Napolitano C, Priori SG, Eisner DA, Venetucci LA (2010) In the RyR2(R4496C) mouse model of CPVT, β‑adrenergic stimulation induces Ca waves by increasing SR Ca content and not by decreasing the threshold for Ca waves. Circ Res 107:1483–1489PubMedCrossRef
29.
Zurück zum Zitat Lieve KVV, Dusi V, van der Werf C, Bos JM, Lane CM, Stokke MK, Roston TM, Djupsjöbacka A, Wada Y, Denjoy I, Bundgaard H, Noguer FRI, Semsarian C, Robyns T, Hofman N, Tanck MW, van den Berg MP, Kammeraad JAE, Krahn AD, Clur SB, Sacher F, Till J, Skinner JR, Tfelt-Hansen J, Probst V, Leenhardt A, Horie M, Swan H, Roberts JD, Sanatani S, Haugaa KH, Schwartz PJ, Ackerman MJ, Wilde AAM (2020) Heart rate recovery after exercise is associated with arrhythmic events in patients with catecholaminergic polymorphic ventricular tachycardia. Circ Arrhythm Electrophysiol 13:e7471PubMedCrossRef Lieve KVV, Dusi V, van der Werf C, Bos JM, Lane CM, Stokke MK, Roston TM, Djupsjöbacka A, Wada Y, Denjoy I, Bundgaard H, Noguer FRI, Semsarian C, Robyns T, Hofman N, Tanck MW, van den Berg MP, Kammeraad JAE, Krahn AD, Clur SB, Sacher F, Till J, Skinner JR, Tfelt-Hansen J, Probst V, Leenhardt A, Horie M, Swan H, Roberts JD, Sanatani S, Haugaa KH, Schwartz PJ, Ackerman MJ, Wilde AAM (2020) Heart rate recovery after exercise is associated with arrhythmic events in patients with catecholaminergic polymorphic ventricular tachycardia. Circ Arrhythm Electrophysiol 13:e7471PubMedCrossRef
30.
Zurück zum Zitat Kannankeril PJ, Shoemaker MB, Gayle KA, Fountain D, Roden DM, Knollmann BC (2020) Atropine-induced sinus tachycardia protects against exercise-induced ventricular arrhythmias in patients with catecholaminergic polymorphic ventricular tachycardia. Europace 22:643–648PubMedPubMedCentralCrossRef Kannankeril PJ, Shoemaker MB, Gayle KA, Fountain D, Roden DM, Knollmann BC (2020) Atropine-induced sinus tachycardia protects against exercise-induced ventricular arrhythmias in patients with catecholaminergic polymorphic ventricular tachycardia. Europace 22:643–648PubMedPubMedCentralCrossRef
31.
Zurück zum Zitat Franciosi S, Roston TM, Perry FKG, Knollmann BC, Kannankeril PJ, Sanatani S (2019) Chronotropic incompetence as a risk predictor in children and young adults with catecholaminergic polymorphic ventricular tachycardia. J Cardiovasc Electrophysiol 30:1923–1929PubMedPubMedCentralCrossRef Franciosi S, Roston TM, Perry FKG, Knollmann BC, Kannankeril PJ, Sanatani S (2019) Chronotropic incompetence as a risk predictor in children and young adults with catecholaminergic polymorphic ventricular tachycardia. J Cardiovasc Electrophysiol 30:1923–1929PubMedPubMedCentralCrossRef
32.
Zurück zum Zitat Faggioni M, Hwang HS, van der Werf C, Nederend I, Kannankeril PJ, Wilde AAM, Knollmann BC (2013) Accelerated sinus rhythm prevents catecholaminergic polymorphic ventricular tachycardia in mice and in patients. Circ Res 112:689–697PubMedPubMedCentralCrossRef Faggioni M, Hwang HS, van der Werf C, Nederend I, Kannankeril PJ, Wilde AAM, Knollmann BC (2013) Accelerated sinus rhythm prevents catecholaminergic polymorphic ventricular tachycardia in mice and in patients. Circ Res 112:689–697PubMedPubMedCentralCrossRef
33.
Zurück zum Zitat Makimoto H, Nakagawa E, Takaki H, Yamada Y, Okamura H, Noda T, Satomi K, Suyama K, Aihara N, Kurita T, Kamakura S, Shimizu W (2010) Augmented ST-segment elevation during recovery from exercise predicts cardiac events in patients with Brugada syndrome. J Am Coll Cardiol 56:1576–1584PubMedCrossRef Makimoto H, Nakagawa E, Takaki H, Yamada Y, Okamura H, Noda T, Satomi K, Suyama K, Aihara N, Kurita T, Kamakura S, Shimizu W (2010) Augmented ST-segment elevation during recovery from exercise predicts cardiac events in patients with Brugada syndrome. J Am Coll Cardiol 56:1576–1584PubMedCrossRef
34.
Zurück zum Zitat Maury P, Hocini M, Haïssaguerre M (2005) Electrical storms in Brugada syndrome: review of pharmacologic and ablative therapeutic options. Indian Pacing Electrophysiol J 5:25–34PubMed Maury P, Hocini M, Haïssaguerre M (2005) Electrical storms in Brugada syndrome: review of pharmacologic and ablative therapeutic options. Indian Pacing Electrophysiol J 5:25–34PubMed
35.
Zurück zum Zitat Miyazaki T, Mitamura H, Miyoshi S, Soejima K, Aizawa Y, Ogawa S (1996) Autonomic and antiarrhythmic drug modulation of ST segment elevation in patients with Brugada syndrome. J Am Coll Cardiol 27:1061–1070PubMedCrossRef Miyazaki T, Mitamura H, Miyoshi S, Soejima K, Aizawa Y, Ogawa S (1996) Autonomic and antiarrhythmic drug modulation of ST segment elevation in patients with Brugada syndrome. J Am Coll Cardiol 27:1061–1070PubMedCrossRef
36.
Zurück zum Zitat Yan GX, Antzelevitch C (1999) Cellular basis for the Brugada Syndrome and other mechanisms of arrhythmogenesis associated with ST-segment elevation. Circulation 100:1660–1666PubMedCrossRef Yan GX, Antzelevitch C (1999) Cellular basis for the Brugada Syndrome and other mechanisms of arrhythmogenesis associated with ST-segment elevation. Circulation 100:1660–1666PubMedCrossRef
37.
Zurück zum Zitat Litovsky SH, Antzelevitch C (1990) Differences in the electrophysiological response of canine ventricular subendocardium and subepicardium to acetylcholine and isoproterenol. A direct effect of acetylcholine in ventricular myocardium. Circ Res 67:615–627PubMedCrossRef Litovsky SH, Antzelevitch C (1990) Differences in the electrophysiological response of canine ventricular subendocardium and subepicardium to acetylcholine and isoproterenol. A direct effect of acetylcholine in ventricular myocardium. Circ Res 67:615–627PubMedCrossRef
38.
Zurück zum Zitat Abe A, Ikeda T, Tsukada T, Ishiguro H, Miwa Y, Miyakoshi M, Mera H, Yusu S, Yoshino H (2010) Circadian variation of late potentials in idiopathic ventricular fibrillation associated with J waves: insights into alternative pathophysiology and risk stratification. Heart Rhythm 7:675–682PubMedCrossRef Abe A, Ikeda T, Tsukada T, Ishiguro H, Miwa Y, Miyakoshi M, Mera H, Yusu S, Yoshino H (2010) Circadian variation of late potentials in idiopathic ventricular fibrillation associated with J waves: insights into alternative pathophysiology and risk stratification. Heart Rhythm 7:675–682PubMedCrossRef
39.
Zurück zum Zitat Krittayaphong R, Veerakul G, Nademanee K, Kangkagate C (2003) Heart rate variability in patients with Brugada syndrome in Thailand. Eur Heart J 24:1771–1778PubMedCrossRef Krittayaphong R, Veerakul G, Nademanee K, Kangkagate C (2003) Heart rate variability in patients with Brugada syndrome in Thailand. Eur Heart J 24:1771–1778PubMedCrossRef
40.
Zurück zum Zitat Behar N, Petit B, Probst V, Sacher F, Kervio G, Mansourati J, Bru P, Hernandez A, Mabo P (2017) Heart rate variability and repolarization characteristics in symptomatic and asymptomatic Brugada syndrome. Europace 19:1730–1736PubMed Behar N, Petit B, Probst V, Sacher F, Kervio G, Mansourati J, Bru P, Hernandez A, Mabo P (2017) Heart rate variability and repolarization characteristics in symptomatic and asymptomatic Brugada syndrome. Europace 19:1730–1736PubMed
41.
Zurück zum Zitat Pierre B, Babuty D, Poret P, Giraudeau C, Marie O, Cosnay P, Fauchier L (2007) Abnormal nocturnal heart rate variability and QT dynamics in patients with Brugada syndrome. Pacing Clin Electrophysiol 30(Suppl 1):S188–S191PubMed Pierre B, Babuty D, Poret P, Giraudeau C, Marie O, Cosnay P, Fauchier L (2007) Abnormal nocturnal heart rate variability and QT dynamics in patients with Brugada syndrome. Pacing Clin Electrophysiol 30(Suppl 1):S188–S191PubMed
42.
Zurück zum Zitat Kostopoulou A, Koutelou M, Theodorakis G, Theodorakos A, Livanis E, Maounis T, Chaidaroglou A, Degiannis D, Voudris V, Kremastinos D, Cokkinos D (2010) Disorders of the autonomic nervous system in patients with Brugada syndrome: a pilot study. J Cardiovasc Electrophysiol 21:773–780PubMed Kostopoulou A, Koutelou M, Theodorakis G, Theodorakos A, Livanis E, Maounis T, Chaidaroglou A, Degiannis D, Voudris V, Kremastinos D, Cokkinos D (2010) Disorders of the autonomic nervous system in patients with Brugada syndrome: a pilot study. J Cardiovasc Electrophysiol 21:773–780PubMed
43.
Zurück zum Zitat Nomura M, Nada T, Endo J, Kondo Y, Yukinaka M, Saito K, Ito S, Mori H, Nakaya Y, Shinomiya H (1998) Brugada syndrome associated with an autonomic disorder. Heart 80:194–196PubMedPubMedCentralCrossRef Nomura M, Nada T, Endo J, Kondo Y, Yukinaka M, Saito K, Ito S, Mori H, Nakaya Y, Shinomiya H (1998) Brugada syndrome associated with an autonomic disorder. Heart 80:194–196PubMedPubMedCentralCrossRef
44.
Zurück zum Zitat Wichter T, Matheja P, Eckardt L, Kies P, Schäfers K, Schulze-Bahr E, Haverkamp W, Borggrefe M, Schober O, Breithardt G, Schäfers M (2002) Cardiac autonomic dysfunction in Brugada syndrome. Circulation 105:702–706PubMedCrossRef Wichter T, Matheja P, Eckardt L, Kies P, Schäfers K, Schulze-Bahr E, Haverkamp W, Borggrefe M, Schober O, Breithardt G, Schäfers M (2002) Cardiac autonomic dysfunction in Brugada syndrome. Circulation 105:702–706PubMedCrossRef
45.
Zurück zum Zitat Kies P, Wichter T, Schäfers M, Paul M, Schäfers KP, Eckardt L, Stegger L, Schulze-Bahr E, Rimoldi O, Breithardt G, Schober O, Camici PG (2004) Abnormal myocardial presynaptic norepinephrine recycling in patients with Brugada syndrome. Circulation 110:3017–3022PubMedCrossRef Kies P, Wichter T, Schäfers M, Paul M, Schäfers KP, Eckardt L, Stegger L, Schulze-Bahr E, Rimoldi O, Breithardt G, Schober O, Camici PG (2004) Abnormal myocardial presynaptic norepinephrine recycling in patients with Brugada syndrome. Circulation 110:3017–3022PubMedCrossRef
46.
Zurück zum Zitat Paul M, Meyborg M, Boknik P, Gergs U, Schmitz W, Breithardt G, Wichter T, Neumann J (2011) Autonomic dysfunction in patients with Brugada syndrome: further biochemical evidence of altered signaling pathways. Pacing Clin Electrophysiol 34:1147–1153PubMedCrossRef Paul M, Meyborg M, Boknik P, Gergs U, Schmitz W, Breithardt G, Wichter T, Neumann J (2011) Autonomic dysfunction in patients with Brugada syndrome: further biochemical evidence of altered signaling pathways. Pacing Clin Electrophysiol 34:1147–1153PubMedCrossRef
47.
Zurück zum Zitat Scornik FS, Desai M, Brugada R, Guerchicoff A, Pollevick GD, Antzelevitch C, Pérez GJ (2006) Functional expression of “cardiac-type” Nav1.5 sodium channel in canine intracardiac ganglia. Heart Rhythm 3:842–850PubMedPubMedCentralCrossRef Scornik FS, Desai M, Brugada R, Guerchicoff A, Pollevick GD, Antzelevitch C, Pérez GJ (2006) Functional expression of “cardiac-type” Nav1.5 sodium channel in canine intracardiac ganglia. Heart Rhythm 3:842–850PubMedPubMedCentralCrossRef
48.
Zurück zum Zitat Pappone C, Brugada J, Vicedomini G, Ciconte G, Manguso F, Saviano M, Vitale R, Cuko A, Giannelli L, Calovic Z, Conti M, Pozzi P, Natalizia A, Crisà S, Borrelli V, Brugada R, Sarquella-Brugada G, Guazzi M, Frigiola A, Menicanti L, Santinelli V (2017) Electrical substrate elimination in 135 consecutive patients with Brugada syndrome. Circ Arrhythm Electrophysiol 10:e5053PubMedCrossRef Pappone C, Brugada J, Vicedomini G, Ciconte G, Manguso F, Saviano M, Vitale R, Cuko A, Giannelli L, Calovic Z, Conti M, Pozzi P, Natalizia A, Crisà S, Borrelli V, Brugada R, Sarquella-Brugada G, Guazzi M, Frigiola A, Menicanti L, Santinelli V (2017) Electrical substrate elimination in 135 consecutive patients with Brugada syndrome. Circ Arrhythm Electrophysiol 10:e5053PubMedCrossRef
49.
Zurück zum Zitat Mizumaki K, Nishida K, Iwamoto J, Nakatani Y, Yamaguchi Y, Sakamoto T, Tsuneda T, Kataoka N, Inoue H (2012) Vagal activity modulates spontaneous augmentation of J‑wave elevation in patients with idiopathic ventricular fibrillation. Heart Rhythm 9:249–255PubMedCrossRef Mizumaki K, Nishida K, Iwamoto J, Nakatani Y, Yamaguchi Y, Sakamoto T, Tsuneda T, Kataoka N, Inoue H (2012) Vagal activity modulates spontaneous augmentation of J‑wave elevation in patients with idiopathic ventricular fibrillation. Heart Rhythm 9:249–255PubMedCrossRef
50.
Zurück zum Zitat Haïssaguerre M, Shoda M, Jaïs P, Nogami A, Shah DC, Kautzner J, Arentz T, Kalushe D, Lamaison D, Griffith M, Cruz F, de Paola A, Gaïta F, Hocini M, Garrigue S, Macle L, Weerasooriya R, Clémenty J (2002) Mapping and ablation of idiopathic ventricular fibrillation. Circulation 106:962–967PubMedCrossRef Haïssaguerre M, Shoda M, Jaïs P, Nogami A, Shah DC, Kautzner J, Arentz T, Kalushe D, Lamaison D, Griffith M, Cruz F, de Paola A, Gaïta F, Hocini M, Garrigue S, Macle L, Weerasooriya R, Clémenty J (2002) Mapping and ablation of idiopathic ventricular fibrillation. Circulation 106:962–967PubMedCrossRef
51.
Zurück zum Zitat Haïssaguerre M, Derval N, Sacher F, Jesel L, Deisenhofer I, de Roy L, Pasquié JL, Nogami A, Babuty D, Yli-Mayry S, De Chillou C, Scanu P, Mabo P, Matsuo S, Probst V, Le Scouarnec S, Defaye P, Schlaepfer J, Rostock T, Lacroix D, Lamaison D, Lavergne T, Aizawa Y, Englund A, Anselme F, O’Neill M, Hocini M, Lim KT, Knecht S, Veenhuyzen GD, Bordachar P, Chauvin M, Jais P, Coureau G, Chene G, Klein GJ, Clémenty J (2008) Sudden cardiac arrest associated with early repolarization. N Engl J Med 358:2016–2023PubMedCrossRef Haïssaguerre M, Derval N, Sacher F, Jesel L, Deisenhofer I, de Roy L, Pasquié JL, Nogami A, Babuty D, Yli-Mayry S, De Chillou C, Scanu P, Mabo P, Matsuo S, Probst V, Le Scouarnec S, Defaye P, Schlaepfer J, Rostock T, Lacroix D, Lamaison D, Lavergne T, Aizawa Y, Englund A, Anselme F, O’Neill M, Hocini M, Lim KT, Knecht S, Veenhuyzen GD, Bordachar P, Chauvin M, Jais P, Coureau G, Chene G, Klein GJ, Clémenty J (2008) Sudden cardiac arrest associated with early repolarization. N Engl J Med 358:2016–2023PubMedCrossRef
52.
Zurück zum Zitat Aizawa Y, Chinushi M, Hasegawa K, Naiki N, Horie M, Kaneko Y, Kurabayashi M, Ito S, Imaizumi T, Aizawa Y, Takatsuki S, Joo K, Sato M, Ebe K, Hosaka Y, Haissaguerre M, Fukuda K (2013) Electrical storm in idiopathic ventricular fibrillation is associated with early repolarization. J Am Coll Cardiol 62:1015–1019PubMedCrossRef Aizawa Y, Chinushi M, Hasegawa K, Naiki N, Horie M, Kaneko Y, Kurabayashi M, Ito S, Imaizumi T, Aizawa Y, Takatsuki S, Joo K, Sato M, Ebe K, Hosaka Y, Haissaguerre M, Fukuda K (2013) Electrical storm in idiopathic ventricular fibrillation is associated with early repolarization. J Am Coll Cardiol 62:1015–1019PubMedCrossRef
53.
Zurück zum Zitat Haïssaguerre M, Sacher F, Nogami A, Komiya N, Bernard A, Probst V, Yli-Mayry S, Defaye P, Aizawa Y, Frank R, Mantovan R, Cappato R, Wolpert C, Leenhardt A, de Roy L, Heidbuchel H, Deisenhofer I, Arentz T, Pasquié JL, Weerasooriya R, Hocini M, Jais P, Derval N, Bordachar P, Clémenty J (2009) Characteristics of recurrent ventricular fibrillation associated with inferolateral early repolarization role of drug therapy. J Am Coll Cardiol 53:612–619PubMedCrossRef Haïssaguerre M, Sacher F, Nogami A, Komiya N, Bernard A, Probst V, Yli-Mayry S, Defaye P, Aizawa Y, Frank R, Mantovan R, Cappato R, Wolpert C, Leenhardt A, de Roy L, Heidbuchel H, Deisenhofer I, Arentz T, Pasquié JL, Weerasooriya R, Hocini M, Jais P, Derval N, Bordachar P, Clémenty J (2009) Characteristics of recurrent ventricular fibrillation associated with inferolateral early repolarization role of drug therapy. J Am Coll Cardiol 53:612–619PubMedCrossRef
54.
Zurück zum Zitat Yan GX, Antzelevitch C (1996) Cellular basis for the electrocardiographic J‑wave. Circulation 93:372–379PubMedCrossRef Yan GX, Antzelevitch C (1996) Cellular basis for the electrocardiographic J‑wave. Circulation 93:372–379PubMedCrossRef
55.
Zurück zum Zitat Baek YS, Park SD, Lee MJ, Kwon SW, Shin SH, Woo SI, Kwan J, Kim DH (2015) Relationship between J Waves and Vagal Activity in Patients Who Do Not Have Structural Heart Disease. Ann Noninvasive Electrocardiol 20:464–473PubMedPubMedCentralCrossRef Baek YS, Park SD, Lee MJ, Kwon SW, Shin SH, Woo SI, Kwan J, Kim DH (2015) Relationship between J Waves and Vagal Activity in Patients Who Do Not Have Structural Heart Disease. Ann Noninvasive Electrocardiol 20:464–473PubMedPubMedCentralCrossRef
56.
Zurück zum Zitat Miyazaki H, Nakagawa M, Shin Y, Wakisaka O, Shinohara T, Ezaki K, Teshima Y, Yufu K, Takahashi N, Hara M (2013) Comparison of autonomic J‑wave modulation in patients with idiopathic ventricular fibrillation and control subjects. Circ J 77:330–337PubMedCrossRef Miyazaki H, Nakagawa M, Shin Y, Wakisaka O, Shinohara T, Ezaki K, Teshima Y, Yufu K, Takahashi N, Hara M (2013) Comparison of autonomic J‑wave modulation in patients with idiopathic ventricular fibrillation and control subjects. Circ J 77:330–337PubMedCrossRef
57.
Zurück zum Zitat Aizawa Y, Sato A, Watanabe H, Chinushi M, Furushima H, Horie M, Kaneko Y, Imaizumi T, Okubo K, Watanabe I, Shinozaki T, Aizawa Y, Fukuda K, Joo K, Haissaguerre M (2012) Dynamicity of the J‑wave in idiopathic ventricular fibrillation with a special reference to pause-dependent augmentation of the J‑wave. J Am Coll Cardiol 59:1948–1953PubMedCrossRef Aizawa Y, Sato A, Watanabe H, Chinushi M, Furushima H, Horie M, Kaneko Y, Imaizumi T, Okubo K, Watanabe I, Shinozaki T, Aizawa Y, Fukuda K, Joo K, Haissaguerre M (2012) Dynamicity of the J‑wave in idiopathic ventricular fibrillation with a special reference to pause-dependent augmentation of the J‑wave. J Am Coll Cardiol 59:1948–1953PubMedCrossRef
58.
Zurück zum Zitat Leenhardt A, Glaser E, Burguera M, Nürnberg M, Maison-Blanche P, Coumel P (1994) Short-coupled variant of torsade de pointes. A new electrocardiographic entity in the spectrum of idiopathic ventricular tachyarrhythmias. Circulation 89:206–215PubMedCrossRef Leenhardt A, Glaser E, Burguera M, Nürnberg M, Maison-Blanche P, Coumel P (1994) Short-coupled variant of torsade de pointes. A new electrocardiographic entity in the spectrum of idiopathic ventricular tachyarrhythmias. Circulation 89:206–215PubMedCrossRef
60.
Zurück zum Zitat Franciosi S, Perry FKG, Roston TM, Armstrong KR, Claydon VE, Sanatani S (2017) The role of the autonomic nervous system in arrhythmias and sudden cardiac death. Auton Neurosci 205:1–1PubMedCrossRef Franciosi S, Perry FKG, Roston TM, Armstrong KR, Claydon VE, Sanatani S (2017) The role of the autonomic nervous system in arrhythmias and sudden cardiac death. Auton Neurosci 205:1–1PubMedCrossRef
61.
62.
Zurück zum Zitat Myers MM, Burtchen N, Retamar MO, Lucchini M, Fifer WP. Neonatal Monitoring: Prediction of Autonomic Regulation at 1 Month from Newborn Assessments. In: Duncan JR, Byard RW, editors. SIDS Sudden Infant and Early Childhood Death: The Past, the Present and the Future. Adelaide (AU): University of Adelaide Press; 2018 May. Chapter 21, pp 431–448 Myers MM, Burtchen N, Retamar MO, Lucchini M, Fifer WP. Neonatal Monitoring: Prediction of Autonomic Regulation at 1 Month from Newborn Assessments. In: Duncan JR, Byard RW, editors. SIDS Sudden Infant and Early Childhood Death: The Past, the Present and the Future. Adelaide (AU): University of Adelaide Press; 2018 May. Chapter 21, pp 431–448
63.
Zurück zum Zitat Yoshinaga M, Kucho Y, Ushinohama H, Ishikawa Y, Ohno S, Ogata H (2018) Autonomic Function and QT Interval During Night-Time Sleep in Infant Long QT Syndrome. Circ J 82:2152–2159PubMedCrossRef Yoshinaga M, Kucho Y, Ushinohama H, Ishikawa Y, Ohno S, Ogata H (2018) Autonomic Function and QT Interval During Night-Time Sleep in Infant Long QT Syndrome. Circ J 82:2152–2159PubMedCrossRef
64.
Zurück zum Zitat Winbo PDJ (2020) Heart Connection in Sympathetically Triggered Inherited Arrhythmia Syndromes Heart Lung Circ. Brain 29:529–537 Winbo PDJ (2020) Heart Connection in Sympathetically Triggered Inherited Arrhythmia Syndromes Heart Lung Circ. Brain 29:529–537
Metadaten
Titel
Autonomic cardiac innervation: impact on the evolution of arrhythmias in inherited cardiac arrhythmia syndromes
verfasst von
Dr. Philippe Maury, MD
Hubert Delasnerie, MD
Maxime Beneyto, MD
Anne Rollin, MD
Publikationsdatum
29.06.2021
Verlag
Springer Medizin
Erschienen in
Herzschrittmachertherapie + Elektrophysiologie / Ausgabe 3/2021
Print ISSN: 0938-7412
Elektronische ISSN: 1435-1544
DOI
https://doi.org/10.1007/s00399-021-00774-3

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