Skip to main content
Erschienen in: Clinical Autonomic Research 2/2018

01.03.2018 | Research Article

Autonomic symptoms following Zika virus infection

Erschienen in: Clinical Autonomic Research | Ausgabe 2/2018

Einloggen, um Zugang zu erhalten

Abstract

Purpose

To determine if autonomic symptoms are associated with previous Zika virus infection.

Methods

Case–control study including 35 patients with Zika virus infection without evidence of neurological disease and 105 controls. Symptoms of autonomic dysfunction were assessed with the composite autonomic symptom scale 31 (COMPASS-31).

Results

Patients with previous Zika virus infection had significantly higher COMPASS-31 score than controls regardless of age and sex (p = 0.007). The main drivers for the higher scores where orthostatic intolerance (p = 0.003), secretomotor (p = 0.04) and bladder symptoms (p < 0.001).

Conclusion

Zika virus infection is associated with autonomic dysfunction. The mechanisms remain to be elucidated.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
2.
Zurück zum Zitat Dick GWA, Kitchen SF, Haddow AJ (1952) Zika virus. I. Isolations and serological specificity. Trans R Soc Trop Med Hyg 46:509–520CrossRefPubMed Dick GWA, Kitchen SF, Haddow AJ (1952) Zika virus. I. Isolations and serological specificity. Trans R Soc Trop Med Hyg 46:509–520CrossRefPubMed
3.
Zurück zum Zitat Ioos S, Mallet H-P, Leparc Goffart I et al (2014) Current Zika virus epidemiology and recent epidemics. Med Mal Infect 44:302–307CrossRefPubMed Ioos S, Mallet H-P, Leparc Goffart I et al (2014) Current Zika virus epidemiology and recent epidemics. Med Mal Infect 44:302–307CrossRefPubMed
4.
Zurück zum Zitat Cao-Lormeau V-M, Blake A, Mons S, Lastère S, Roche C, Vanhomwegen J et al (2016) Guillain-Barré Syndrome outbreak associated with Zika virus infection in French Polynesia: a case–control study. Lancet 387:1531–1539CrossRefPubMedPubMedCentral Cao-Lormeau V-M, Blake A, Mons S, Lastère S, Roche C, Vanhomwegen J et al (2016) Guillain-Barré Syndrome outbreak associated with Zika virus infection in French Polynesia: a case–control study. Lancet 387:1531–1539CrossRefPubMedPubMedCentral
5.
Zurück zum Zitat Zanluca C, Melo VC, Mosimann AL, Santos GI, Santos CN, Luz K (2015) First report of autochthonous transmission of Zika virus in Brazil. Mem Inst Oswaldo Cruz 110:569–572CrossRefPubMedPubMedCentral Zanluca C, Melo VC, Mosimann AL, Santos GI, Santos CN, Luz K (2015) First report of autochthonous transmission of Zika virus in Brazil. Mem Inst Oswaldo Cruz 110:569–572CrossRefPubMedPubMedCentral
7.
Zurück zum Zitat Anaya J-M, Rodríguez Y, Monsalve DM, Vega D, Ojeda E, Gonz Alez-Bravo D et al (2016) A comprehensive analysis and immunobiology of autoimmune neurological syndromes during the Zika virus outbreak in Cúcuta, Colombia. J Autoimmun 77:123–138CrossRef Anaya J-M, Rodríguez Y, Monsalve DM, Vega D, Ojeda E, Gonz Alez-Bravo D et al (2016) A comprehensive analysis and immunobiology of autoimmune neurological syndromes during the Zika virus outbreak in Cúcuta, Colombia. J Autoimmun 77:123–138CrossRef
8.
Zurück zum Zitat Freeman R, Miyawaki E (1993) The treatment of autonomic dysfunction. J Clin Neurophysiol 10:61–82CrossRefPubMed Freeman R, Miyawaki E (1993) The treatment of autonomic dysfunction. J Clin Neurophysiol 10:61–82CrossRefPubMed
9.
10.
Zurück zum Zitat Carod-Artal FJ (2018) Infectious diseases causing autonomic dysfunction. Clin Auton Res 28(1):67–81CrossRefPubMed Carod-Artal FJ (2018) Infectious diseases causing autonomic dysfunction. Clin Auton Res 28(1):67–81CrossRefPubMed
11.
Zurück zum Zitat Morrey JD, Siddharthan V, Wang H (2013) Neurological approaches for investigating West Nile virus disease and its treatment in rodents. Antiviral Res 100:535–545CrossRefPubMedPubMedCentral Morrey JD, Siddharthan V, Wang H (2013) Neurological approaches for investigating West Nile virus disease and its treatment in rodents. Antiviral Res 100:535–545CrossRefPubMedPubMedCentral
12.
Zurück zum Zitat Leis AA, Stokic DS (2012) Neuromuscular manifestations of West Nile virus infection. Front Neurol 3:1–10CrossRef Leis AA, Stokic DS (2012) Neuromuscular manifestations of West Nile virus infection. Front Neurol 3:1–10CrossRef
13.
Zurück zum Zitat Weiss D, Carr D, Kellachan J, Tan C, Phillips M, Bresnitz E et al (2001) Clinical findings of West Nile virus infection in hospitalized patients, New York and New Jersey, 2000. Emerg Infect Dis 7:654–658CrossRefPubMedPubMedCentral Weiss D, Carr D, Kellachan J, Tan C, Phillips M, Bresnitz E et al (2001) Clinical findings of West Nile virus infection in hospitalized patients, New York and New Jersey, 2000. Emerg Infect Dis 7:654–658CrossRefPubMedPubMedCentral
14.
Zurück zum Zitat Sletten DM, Suarez GA, Low PA, Mandrekar J, Singer W (2012) COMPASS 31: a refined and abbreviated composite autonomic symptom score. Mayo Clin Proc 87:1196–1201CrossRefPubMedPubMedCentral Sletten DM, Suarez GA, Low PA, Mandrekar J, Singer W (2012) COMPASS 31: a refined and abbreviated composite autonomic symptom score. Mayo Clin Proc 87:1196–1201CrossRefPubMedPubMedCentral
15.
Zurück zum Zitat Pierangeli G, Turrini A, Giannini G, Del Sorbo F, Calandra-Buonaura G, Guaraldi P et al (2015) Translation and linguistic validation of the composite autonomic symptom score COMPASS 31. Neurol Sci 36:1897–1902CrossRefPubMed Pierangeli G, Turrini A, Giannini G, Del Sorbo F, Calandra-Buonaura G, Guaraldi P et al (2015) Translation and linguistic validation of the composite autonomic symptom score COMPASS 31. Neurol Sci 36:1897–1902CrossRefPubMed
16.
Zurück zum Zitat González P, García X, Guerra A, Arango JC, Delgado H, Uribe CS et al (2014) Experience with Guillain–Barré syndrome in a neurological intensive care unit. Neurologia 31:389–394CrossRefPubMed González P, García X, Guerra A, Arango JC, Delgado H, Uribe CS et al (2014) Experience with Guillain–Barré syndrome in a neurological intensive care unit. Neurologia 31:389–394CrossRefPubMed
17.
Zurück zum Zitat Wang H, Siddharthan V, Hall JO, Morrey JD (2014) Autonomic deficit not the cause of death in West Nile virus neurological disease. Clin Auton Res 24:15–23CrossRefPubMed Wang H, Siddharthan V, Hall JO, Morrey JD (2014) Autonomic deficit not the cause of death in West Nile virus neurological disease. Clin Auton Res 24:15–23CrossRefPubMed
19.
Zurück zum Zitat Versace V, Gutmann B, Sebastianelli L, Martignago S, Saltuari L, Nardone R, Wiedermann CJ (2017) Tick-borne viral encephalomyeloradiculitis complicated by severe autonomic myenteric involvement resulting in irreversible adynamic ileus. Clin Auton Res 27(3):205–207CrossRefPubMed Versace V, Gutmann B, Sebastianelli L, Martignago S, Saltuari L, Nardone R, Wiedermann CJ (2017) Tick-borne viral encephalomyeloradiculitis complicated by severe autonomic myenteric involvement resulting in irreversible adynamic ileus. Clin Auton Res 27(3):205–207CrossRefPubMed
Metadaten
Titel
Autonomic symptoms following Zika virus infection
Publikationsdatum
01.03.2018
Erschienen in
Clinical Autonomic Research / Ausgabe 2/2018
Print ISSN: 0959-9851
Elektronische ISSN: 1619-1560
DOI
https://doi.org/10.1007/s10286-018-0515-1

Weitere Artikel der Ausgabe 2/2018

Clinical Autonomic Research 2/2018 Zur Ausgabe