Skip to main content
Erschienen in: International Ophthalmology 1/2019

19.12.2017 | Original Paper

Baseline demographics, clinical features, and treatment protocols of 240 patients with optic neuropathy: experiences from a neuro-ophthalmological clinic in the Aegean region of Turkey

verfasst von: Omer Karti, Dilek Top Karti, İlay Hilal Kilic, Figen Gokcay, Nese Celebisoy

Erschienen in: International Ophthalmology | Ausgabe 1/2019

Einloggen, um Zugang zu erhalten

Abstract

Purpose

To analyze the demographic patterns, clinical characteristics, and treatment protocols of optic neuropathies.

Materials and methods

The hospital data of patients with optic neuropathy admitted to the Department of Neuro-ophthalmology in a tertiary referral center in Turkey between January 2010 to January 2017 were retrospectively analyzed. Demographic patterns, clinical features, treatment protocols, and the natural disease courses were assessed.

Results

The total number of patients with optic neuropathy seen over this period was 240, which consist of 43 with idiopathic optic neuritis (17.9%), 40 with multiple sclerosis-related optic neuritis (16.7%), 12 with chronic relapsing inflammatory optic neuritis (5.0%), 12 with atypical optic neuritis (5.0%), 11 with neuromyelitis optica spectrum disorders-related optic neuritis (4.6%), 90 with non-arteritic ischemic optic neuropathy (37.5%), 4 with arteritic ischemic optic neuropathy (1.7%), 10 with traumatic optic neuropathy (4.1%), 6 with compressive optic neuropathy (2.5%), and 12 with mitochondrial optic neuropathy [9 with toxic optic neuropathy (3.7%) and 3 with Leber’s hereditary optic neuropathy (1.2%)]. There were 101 males (42%) and 139 females (58%). The mean age was 43.34 ± 15.86 years.

Conclusion

This study reported the demographics, clinical characteristics, and treatment protocols of optic neuropathies in a neuro-ophthalmology specialty clinic at a tertiary referral center in Turkey during the past decade. The data may be useful in assessing the global status of optic neuropathies.
Literatur
1.
Zurück zum Zitat Miller NR, Newman NJ, Biousse V et al (2007) Walsh & Hoyt’s Clinical Neuro-Ophthalmology: the essentials, 2nd edn. Lippincott Williams & Wilkins, Philadelphia Miller NR, Newman NJ, Biousse V et al (2007) Walsh & Hoyt’s Clinical Neuro-Ophthalmology: the essentials, 2nd edn. Lippincott Williams & Wilkins, Philadelphia
3.
Zurück zum Zitat Barkhof F, Filippi M, Miller DH et al (1997) Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis. Brain 120:2059–2069CrossRefPubMed Barkhof F, Filippi M, Miller DH et al (1997) Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis. Brain 120:2059–2069CrossRefPubMed
4.
Zurück zum Zitat Polman C, Reingold S, Banwell B et al (2011) Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol 69:292–302CrossRefPubMedPubMedCentral Polman C, Reingold S, Banwell B et al (2011) Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol 69:292–302CrossRefPubMedPubMedCentral
5.
Zurück zum Zitat Wingerchuk DM, Lennon VA, Pittock SJ et al (2006) Revised diagnostic criteria for neuromyelitis optica. Neurology 66:1485–1489CrossRefPubMed Wingerchuk DM, Lennon VA, Pittock SJ et al (2006) Revised diagnostic criteria for neuromyelitis optica. Neurology 66:1485–1489CrossRefPubMed
6.
Zurück zum Zitat Kidd D, Burtin B, Plant GT et al (2003) Chronic relapsing inflammatory optic neuropathy (CRION). Brain 126:276–284CrossRefPubMed Kidd D, Burtin B, Plant GT et al (2003) Chronic relapsing inflammatory optic neuropathy (CRION). Brain 126:276–284CrossRefPubMed
7.
Zurück zum Zitat Steinsapir KD, Goldberg RA (2011) Traumatic optic neuropathy: an evolving understanding. Am J Ophthalmol 151:928–933CrossRefPubMed Steinsapir KD, Goldberg RA (2011) Traumatic optic neuropathy: an evolving understanding. Am J Ophthalmol 151:928–933CrossRefPubMed
8.
Zurück zum Zitat Newman NJ, Dickersin K, Kaufman D, Kelman S, Scherer R (1996) Characteristics of patients with nonarteritic anterior ischemic optic neuropathy eligible for the ischemic optic neuropathy decompression trial. Arch Ophthalmol 114:1366–1374CrossRef Newman NJ, Dickersin K, Kaufman D, Kelman S, Scherer R (1996) Characteristics of patients with nonarteritic anterior ischemic optic neuropathy eligible for the ischemic optic neuropathy decompression trial. Arch Ophthalmol 114:1366–1374CrossRef
9.
Zurück zum Zitat Swartz NG, Beck RW, Savino PJ et al (1995) Pain in anterior ischemic optic neuropathy. J Neuroophthalmol 15:9–10CrossRefPubMed Swartz NG, Beck RW, Savino PJ et al (1995) Pain in anterior ischemic optic neuropathy. J Neuroophthalmol 15:9–10CrossRefPubMed
10.
Zurück zum Zitat Wakakura M, Minel-Higa R, Oono S et al (1999) Baseline features of idiopathic optic neuritis as determined by a multicenter treatment trial in Japan. Optic Neuritis Treatment Trial Multicenter Cooperative Research Group (ONMRG). Jpn J Ophthalmol 43:127–132CrossRefPubMed Wakakura M, Minel-Higa R, Oono S et al (1999) Baseline features of idiopathic optic neuritis as determined by a multicenter treatment trial in Japan. Optic Neuritis Treatment Trial Multicenter Cooperative Research Group (ONMRG). Jpn J Ophthalmol 43:127–132CrossRefPubMed
11.
Zurück zum Zitat Hickman Simon J, Ko Michael, Frasat C et al (2007) Optic neuritis: an update typical and atypical optic neuritis. Neuro Ophthalmol 32:237–248CrossRef Hickman Simon J, Ko Michael, Frasat C et al (2007) Optic neuritis: an update typical and atypical optic neuritis. Neuro Ophthalmol 32:237–248CrossRef
13.
Zurück zum Zitat Levin LA, Beck RW, Joseph MP et al (1999) The treatment of traumatic optic neuropathy: the international optic nerve trauma study. Ophthalmology 106:1268–1277CrossRefPubMed Levin LA, Beck RW, Joseph MP et al (1999) The treatment of traumatic optic neuropathy: the international optic nerve trauma study. Ophthalmology 106:1268–1277CrossRefPubMed
14.
Zurück zum Zitat Shields AJ, Shields CL, Scartozzi R (2004) Survey of 1264 patients with orbital tumors and simulating lesions: the 2002 Montgomery Lecture, Part 1. Ophthalmology 111:997–1008CrossRefPubMed Shields AJ, Shields CL, Scartozzi R (2004) Survey of 1264 patients with orbital tumors and simulating lesions: the 2002 Montgomery Lecture, Part 1. Ophthalmology 111:997–1008CrossRefPubMed
15.
Zurück zum Zitat Purvin V, Kawasaki A, Borruat F (2006) Optic neuropathy in patients using amiodarone. Arch Ophthalmol 124:696–701CrossRefPubMed Purvin V, Kawasaki A, Borruat F (2006) Optic neuropathy in patients using amiodarone. Arch Ophthalmol 124:696–701CrossRefPubMed
16.
Zurück zum Zitat Kerrison JB (2005) Latent, acute, and chronic Leber’s hereditary optic neuropathy. Ophthalmology 112:1–2CrossRefPubMed Kerrison JB (2005) Latent, acute, and chronic Leber’s hereditary optic neuropathy. Ophthalmology 112:1–2CrossRefPubMed
17.
Zurück zum Zitat The clinical profile of optic neuritis (1991) Experience of the optic neuritis treatment trial. Optic Neuritis Study Group. Arch Ophthalmol 109:1673–1678CrossRef The clinical profile of optic neuritis (1991) Experience of the optic neuritis treatment trial. Optic Neuritis Study Group. Arch Ophthalmol 109:1673–1678CrossRef
18.
Zurück zum Zitat Pokroy R, Modi G, Saffer D (2001) Optic neuritis in urban black African Community. Eye (Lond) 15:469–473CrossRef Pokroy R, Modi G, Saffer D (2001) Optic neuritis in urban black African Community. Eye (Lond) 15:469–473CrossRef
19.
Zurück zum Zitat Phillips PH, Newman NJ, Lynn MJ (1998) Optic neuritis in African Americans. Arch Neurol 55:186–192CrossRefPubMed Phillips PH, Newman NJ, Lynn MJ (1998) Optic neuritis in African Americans. Arch Neurol 55:186–192CrossRefPubMed
20.
Zurück zum Zitat Perkin GD, Rose FC (1979) Optic neuritis and its differential diagnosis. Oxford University Press, Oxford, p 248 Perkin GD, Rose FC (1979) Optic neuritis and its differential diagnosis. Oxford University Press, Oxford, p 248
21.
Zurück zum Zitat Hickman SJ, Toosy AT, Miszkiel KA et al (2004) Visual recovery following acute optic neuritis: a clinical, electrophysiological and magnetic resonance imaging study. J Neurol 251:996–1005CrossRefPubMed Hickman SJ, Toosy AT, Miszkiel KA et al (2004) Visual recovery following acute optic neuritis: a clinical, electrophysiological and magnetic resonance imaging study. J Neurol 251:996–1005CrossRefPubMed
22.
Zurück zum Zitat BrusaA Jones SJ, Plant GT (2001) Long–term remyelination after optic neuritis: a 2-year visual evoked potential and psychophysical serial study. Brain 124:468–479CrossRef BrusaA Jones SJ, Plant GT (2001) Long–term remyelination after optic neuritis: a 2-year visual evoked potential and psychophysical serial study. Brain 124:468–479CrossRef
23.
Zurück zum Zitat Bee Y-S, Lin M-C, Wang C-C et al (2003) Optic neuritis: clinical analysis of 27 cases. Kaohsiung J Med Sci 19:105–112CrossRefPubMed Bee Y-S, Lin M-C, Wang C-C et al (2003) Optic neuritis: clinical analysis of 27 cases. Kaohsiung J Med Sci 19:105–112CrossRefPubMed
24.
Zurück zum Zitat Chuenkongkaew W, Chirapapaisan N (2003) Optic neuritis: characteristics and visual outcome. J Med Assoc Thai 86:238–243PubMed Chuenkongkaew W, Chirapapaisan N (2003) Optic neuritis: characteristics and visual outcome. J Med Assoc Thai 86:238–243PubMed
26.
Zurück zum Zitat Wang JC, Tow S, Aung T et al (2001) The presentation, aetiology, management and outcome of optic neuritis in an Asian population. Clin Exp Ophthalmol 29:312–315CrossRefPubMed Wang JC, Tow S, Aung T et al (2001) The presentation, aetiology, management and outcome of optic neuritis in an Asian population. Clin Exp Ophthalmol 29:312–315CrossRefPubMed
27.
Zurück zum Zitat Singh Sethi H, Menon V, Sharma P et al (2006) Visual outcome after intravenous dexamethasone therapy for idiopathic optic neuritis in an Indian population: a clinical case series. Indian J Ophthalmol 54:177–183CrossRef Singh Sethi H, Menon V, Sharma P et al (2006) Visual outcome after intravenous dexamethasone therapy for idiopathic optic neuritis in an Indian population: a clinical case series. Indian J Ophthalmol 54:177–183CrossRef
28.
Zurück zum Zitat Hayreh SS (2000) Ischaemic optic neuropathy. Indian J Ophthalmol 48:171–194PubMed Hayreh SS (2000) Ischaemic optic neuropathy. Indian J Ophthalmol 48:171–194PubMed
29.
Zurück zum Zitat Hayreh SS, Zimmerman MB (2008) Non-arteritic anterior ischemic optic neuropathy: role of systemic corticosteroid therapy. Graefes Arch Clin Exp Ophthalmol 246:1029–1046CrossRefPubMedPubMedCentral Hayreh SS, Zimmerman MB (2008) Non-arteritic anterior ischemic optic neuropathy: role of systemic corticosteroid therapy. Graefes Arch Clin Exp Ophthalmol 246:1029–1046CrossRefPubMedPubMedCentral
30.
Zurück zum Zitat Tang R, Li H, Regner V et al (1986) Traumatic optic neuropathy: analysis of 37 cases. Invest Ophthalmol Vis Sci 27:102 Tang R, Li H, Regner V et al (1986) Traumatic optic neuropathy: analysis of 37 cases. Invest Ophthalmol Vis Sci 27:102
31.
Zurück zum Zitat Lepore FE (1991) The origin of pain in optic neuritis. determinants of pain in 101 eyes with optic neuritis. Arch Neurol 48:748–749CrossRefPubMed Lepore FE (1991) The origin of pain in optic neuritis. determinants of pain in 101 eyes with optic neuritis. Arch Neurol 48:748–749CrossRefPubMed
32.
Zurück zum Zitat Lim SA, Goh KY, Tow S et al (2008) Optic neuritis in Singapore. Singapore Med J 49:667–671PubMed Lim SA, Goh KY, Tow S et al (2008) Optic neuritis in Singapore. Singapore Med J 49:667–671PubMed
33.
Zurück zum Zitat Woung LC, Lin CH, Tsai CY et al (2007) Optic neuritis among national health insurance enrollees in Taiwan, 2000–2004. Neuroepidemilogy 29:250–254CrossRef Woung LC, Lin CH, Tsai CY et al (2007) Optic neuritis among national health insurance enrollees in Taiwan, 2000–2004. Neuroepidemilogy 29:250–254CrossRef
34.
Zurück zum Zitat Beck RW, Cleary PA, Backlund JC (1994) The course of visual recovery after optic neuritis. Experience of optic neuritis treatment trial. Ophthalmology 101:1771–1778CrossRefPubMed Beck RW, Cleary PA, Backlund JC (1994) The course of visual recovery after optic neuritis. Experience of optic neuritis treatment trial. Ophthalmology 101:1771–1778CrossRefPubMed
35.
Zurück zum Zitat Rizzo JF, Lessell S (1991) Optic neuritis and ischemic optic neuropathy. Overlapping clinical profiles. Arch Ophthalmol 109:1668–1672CrossRefPubMed Rizzo JF, Lessell S (1991) Optic neuritis and ischemic optic neuropathy. Overlapping clinical profiles. Arch Ophthalmol 109:1668–1672CrossRefPubMed
37.
Zurück zum Zitat The Ischemic Optic Neuropathy Decompression Trial Research Group (1995) Optic nerve decompression surgery for nonarteritic anterior ischemic optic neuropathy (NAION) is not effective and may be harmful. JAMA 273:625–632CrossRef The Ischemic Optic Neuropathy Decompression Trial Research Group (1995) Optic nerve decompression surgery for nonarteritic anterior ischemic optic neuropathy (NAION) is not effective and may be harmful. JAMA 273:625–632CrossRef
38.
Zurück zum Zitat Arnold AC, Hepler RS (1994) Natural history of nonarteritic anterior ischemic optic neuropathy. J Neuroophthalmol 14:66–69CrossRefPubMed Arnold AC, Hepler RS (1994) Natural history of nonarteritic anterior ischemic optic neuropathy. J Neuroophthalmol 14:66–69CrossRefPubMed
39.
Zurück zum Zitat Yee RD, Selky AK, Purvin VA (1994) Outcomes of optic nerve sheath decompression for nonarteritic ischemic optic neuropathy. J Neuroophthalmol 14:70–76PubMed Yee RD, Selky AK, Purvin VA (1994) Outcomes of optic nerve sheath decompression for nonarteritic ischemic optic neuropathy. J Neuroophthalmol 14:70–76PubMed
40.
Zurück zum Zitat Sawle GV, James CB, Russell RW (1990) The natural history of non-arteritic anterior ischaemic optic neuropathy. J Neurol Neurosurg Psychiatry 53:830–833CrossRefPubMedPubMedCentral Sawle GV, James CB, Russell RW (1990) The natural history of non-arteritic anterior ischaemic optic neuropathy. J Neurol Neurosurg Psychiatry 53:830–833CrossRefPubMedPubMedCentral
41.
Zurück zum Zitat Hayreh SS, Zimmerman MB (2008) Nonarteritic anterior ischemic optic neuropathy: natural history of visual outcome. Ophthalmology 115:298–305CrossRefPubMed Hayreh SS, Zimmerman MB (2008) Nonarteritic anterior ischemic optic neuropathy: natural history of visual outcome. Ophthalmology 115:298–305CrossRefPubMed
42.
Zurück zum Zitat Hayreh SS, Zimmerman B (2003) Management of giant cell arteritis. Our 27-year clinical study: new light on old controversies. Ophthalmologica 217:239–259CrossRefPubMed Hayreh SS, Zimmerman B (2003) Management of giant cell arteritis. Our 27-year clinical study: new light on old controversies. Ophthalmologica 217:239–259CrossRefPubMed
43.
Zurück zum Zitat Liu GT, Glaser JS, Schatz NJ et al (1994) Visual morbidity in giant cell arteritis: clinical characteristics and prognosis for vision. Ophthalmology 101:1779–1785CrossRefPubMed Liu GT, Glaser JS, Schatz NJ et al (1994) Visual morbidity in giant cell arteritis: clinical characteristics and prognosis for vision. Ophthalmology 101:1779–1785CrossRefPubMed
44.
Zurück zum Zitat Kupersmith MJ, Langer R, Mitnick H et al (1999) Visual performance in giant cell arteritis (temporal arteritis) after 1 year of therapy. Br J Ophthalmol 83:796–801CrossRefPubMedPubMedCentral Kupersmith MJ, Langer R, Mitnick H et al (1999) Visual performance in giant cell arteritis (temporal arteritis) after 1 year of therapy. Br J Ophthalmol 83:796–801CrossRefPubMedPubMedCentral
45.
Zurück zum Zitat Danesh-Meyer H, Savino PJ, Gamble GG (2005) Poor prognosis of visual outcome after visual loss from giant cell arteritis. Ophthalmology 112:1098–1103CrossRefPubMed Danesh-Meyer H, Savino PJ, Gamble GG (2005) Poor prognosis of visual outcome after visual loss from giant cell arteritis. Ophthalmology 112:1098–1103CrossRefPubMed
46.
Zurück zum Zitat Hayreh SS, Zimmerman B, Kardon RH (2002) Visual improvement with corticosteroid therapy in giant cell arteritis: report of a large study and review of the literature. Acta Ophthalmol Scand 80:353–367CrossRef Hayreh SS, Zimmerman B, Kardon RH (2002) Visual improvement with corticosteroid therapy in giant cell arteritis: report of a large study and review of the literature. Acta Ophthalmol Scand 80:353–367CrossRef
47.
Zurück zum Zitat Foroozan R, Deramo VA, Buono LM et al (2003) Recovery of visual function in patients with biopsy-proven giant cell arteritis. Ophthalmology 110:539–542CrossRefPubMed Foroozan R, Deramo VA, Buono LM et al (2003) Recovery of visual function in patients with biopsy-proven giant cell arteritis. Ophthalmology 110:539–542CrossRefPubMed
49.
Zurück zum Zitat Radoi C, Garcia T, Brugniart C (2014) Intravitreal triamcinolone injections in non-arteritic anterior ischemic optic neuropathy. Graefes Arch Clin Exp Ophthalmol 252:339–345CrossRefPubMed Radoi C, Garcia T, Brugniart C (2014) Intravitreal triamcinolone injections in non-arteritic anterior ischemic optic neuropathy. Graefes Arch Clin Exp Ophthalmol 252:339–345CrossRefPubMed
50.
Zurück zum Zitat Yaman A, Selver OB, Saatci AO et al (2008) Intravitreal triamcinolone acetonide injection for acute non-arteritic anterior ischaemic optic neuropathy. Clin Exp Optom 91:561–564CrossRefPubMed Yaman A, Selver OB, Saatci AO et al (2008) Intravitreal triamcinolone acetonide injection for acute non-arteritic anterior ischaemic optic neuropathy. Clin Exp Optom 91:561–564CrossRefPubMed
51.
Zurück zum Zitat Bajin MS, Selver OB, Taskin O et al (2011) Single intravitreal ranibizumab injection in eyes with acute non-arteritic anterior ischaemic optic neuropathy. Clin Exp Optom 94:367–370CrossRefPubMed Bajin MS, Selver OB, Taskin O et al (2011) Single intravitreal ranibizumab injection in eyes with acute non-arteritic anterior ischaemic optic neuropathy. Clin Exp Optom 94:367–370CrossRefPubMed
52.
Zurück zum Zitat Thorne JE, Jabs DA (2005) Ocular manifestations of the rheumatic diseases. In: William T (ed) Duane’s clinical ophthalmology, vol 5. Lippincott Williams & Wilkins, Philadelphia, pp 22–24 Thorne JE, Jabs DA (2005) Ocular manifestations of the rheumatic diseases. In: William T (ed) Duane’s clinical ophthalmology, vol 5. Lippincott Williams & Wilkins, Philadelphia, pp 22–24
53.
Zurück zum Zitat Piccolo L, Woodhall M, Tackley G et al (2016) Isolated new onset atypical optic neuritis in the NMO clinic: serum antibodies, prognoses and diagnoses at follow-up. J Neurol 263:370–379CrossRefPubMed Piccolo L, Woodhall M, Tackley G et al (2016) Isolated new onset atypical optic neuritis in the NMO clinic: serum antibodies, prognoses and diagnoses at follow-up. J Neurol 263:370–379CrossRefPubMed
54.
Zurück zum Zitat Petzold A, Plant GT (2014) Chronic relapsing inflammatory optic neuropathy: a systematic review of 122 cases reported. J Neurol 261:17–26CrossRefPubMed Petzold A, Plant GT (2014) Chronic relapsing inflammatory optic neuropathy: a systematic review of 122 cases reported. J Neurol 261:17–26CrossRefPubMed
Metadaten
Titel
Baseline demographics, clinical features, and treatment protocols of 240 patients with optic neuropathy: experiences from a neuro-ophthalmological clinic in the Aegean region of Turkey
verfasst von
Omer Karti
Dilek Top Karti
İlay Hilal Kilic
Figen Gokcay
Nese Celebisoy
Publikationsdatum
19.12.2017
Verlag
Springer Netherlands
Erschienen in
International Ophthalmology / Ausgabe 1/2019
Print ISSN: 0165-5701
Elektronische ISSN: 1573-2630
DOI
https://doi.org/10.1007/s10792-017-0799-5

Weitere Artikel der Ausgabe 1/2019

International Ophthalmology 1/2019 Zur Ausgabe

Neu im Fachgebiet Augenheilkunde

Ophthalmika in der Schwangerschaft

Die Verwendung von Ophthalmika in der Schwangerschaft und Stillzeit stellt immer eine Off-label-Anwendung dar. Ein Einsatz von Arzneimitteln muss daher besonders sorgfältig auf sein Risiko-Nutzen-Verhältnis bewertet werden. In der vorliegenden …

Operative Therapie und Keimnachweis bei endogener Endophthalmitis

Vitrektomie Originalie

Die endogene Endophthalmitis ist eine hämatogen fortgeleitete, bakterielle oder fungale Infektion, die über choroidale oder retinale Gefäße in den Augapfel eingeschwemmt wird [ 1 – 3 ]. Von dort infiltrieren die Keime in die Netzhaut, den …

Bakterielle endogene Endophthalmitis

Vitrektomie Leitthema

Eine endogene Endophthalmitis stellt einen ophthalmologischen Notfall dar, der umgehender Diagnostik und Therapie bedarf. Es sollte mit geeigneten Methoden, wie beispielsweise dem Freiburger Endophthalmitis-Set, ein Keimnachweis erfolgen. Bei der …

So erreichen Sie eine bestmögliche Wundheilung der Kornea

Die bestmögliche Wundheilung der Kornea, insbesondere ohne die Ausbildung von lichtstreuenden Narben, ist oberstes Gebot, um einer dauerhaften Schädigung der Hornhaut frühzeitig entgegenzuwirken und die Funktion des Auges zu erhalten.   

Update Augenheilkunde

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.