Ausgabe 1/2023
Inhalt (49 Artikel)
Anti-angiogenic effect of exo-LncRNA TUG1 in myocardial infarction and modulation by remote ischemic conditioning
Yini Dang, Wenjie Hua, Xintong Zhang, Hao Sun, Yingjie Zhang, Binbin Yu, Shengrui Wang, Min Zhang, Zihao Kong, Dijia Pan, Ying Chen, Shurui Li, Liang Yuan, Jan D. Reinhardt, Xiao Lu, Yu Zheng
Imatinib attenuates reperfusion injury in a rat model of acute myocardial infarction
Lara S. F. Konijnenberg, Tom T. J. Luiken, Andor Veltien, Laween Uthman, Carolien T. A. Kuster, Laura Rodwell, Guus A. de Waard, Mariska Kea-te Lindert, Anat Akiva, Dick H. J. Thijssen, Robin Nijveldt, Niels van Royen
Reduction in mitochondrial ROS improves oxidative phosphorylation and provides resilience to coronary endothelium in non-reperfused myocardial infarction
Rayane Brinck Teixeira, Melissa Pfeiffer, Peng Zhang, Ehtesham Shafique, Bonnie Rayta, Catherine Karbasiafshar, Nagib Ahsan, Frank W. Sellke, M. Ruhul Abid
Monoamine oxidase A-dependent ROS formation modulates human cardiomyocyte differentiation through AKT and WNT activation
Moises Di Sante, Salvatore Antonucci, Laura Pontarollo, Ilaria Cappellaro, Francesca Segat, Soni Deshwal, Elisa Greotti, Luis F. Grilo, Roberta Menabò, Fabio Di Lisa, Nina Kaludercic
The endothelial-enriched lncRNA LINC00607 mediates angiogenic function
Frederike Boos, James A. Oo, Timothy Warwick, Stefan Günther, Judit Izquierdo Ponce, Melina Lopez, Diba Rafii, Giulia Buchmann, Minh Duc Pham, Zahraa S. Msheik, Tianfu Li, Sandra Seredinski, Shaza Haydar, Sepide Kashefiolasl, Karl H. Plate, Rüdiger Behr, Matthias Mietsch, Jaya Krishnan, Soni S. Pullamsetti, Sofia-Iris Bibli, Rabea Hinkel, Andrew H. Baker, Reinier A. Boon, Marcel H. Schulz, Ilka Wittig, Francis J. Miller Jr., Ralf P. Brandes, Matthias S. Leisegang
Toll-like receptor-3 contributes to the development of aortic valve stenosis
Sven Thomas Niepmann, Nicola Willemsen, Ann Sophie Boucher, Marta Stei, Philip Goody, Andreas Zietzer, Marko Bulic, Hannah Billig, Alexandru Odainic, Christina Katharina Weisheit, Christine Quast, Matti Adam, Susanne V. Schmidt, Farhad Bakhtiary, Felix Jansen, Georg Nickenig, Eike Latz, Sebastian Zimmer
Single-cell RNA sequencing to identify cellular heterogeneity and targets in cardiovascular diseases: from bench to bedside
Xinjie Xu, Xiumeng Hua, Han Mo, Shengshou Hu, Jiangping Song
Ploidy-stratified single cardiomyocyte transcriptomics map Zinc Finger E-Box Binding Homeobox 1 to underly cardiomyocyte proliferation before birth
Sara Thornby Bak, Eva Bang Harvald, Ditte Gry Ellman, Sabrina Bech Mathiesen, Ting Chen, Shu Fang, Kristian Skriver Andersen, Christina Dühring Fenger, Mark Burton, Mads Thomassen, Ditte Caroline Andersen
Indirect epigenetic testing identifies a diagnostic signature of cardiomyocyte DNA methylation in heart failure
Christian U. Oeing, Mark E. Pepin, Kerstin B. Saul, Ayça Seyhan Agircan, Yassen Assenov, Tobias S. Merkel, Farbod Sedaghat-Hamedani, Tanja Weis, Benjamin Meder, Kaomei Guan, Christoph Plass, Dieter Weichenhan, Dominik Siede, Johannes Backs
A cardiologist’s guide to machine learning in cardiovascular disease prognosis prediction
Karl-Patrik Kresoja, Matthias Unterhuber, Rolf Wachter, Holger Thiele, Philipp Lurz
Multi-omic analysis of the cardiac cellulome defines a vascular contribution to cardiac diastolic dysfunction in obese female mice
Malathi S. I. Dona, Ian Hsu, Alex I. Meuth, Scott M. Brown, Chastidy A. Bailey, Christian G. Aragonez, Jacob J. Russell, Crisdion Krstevski, Annayya R. Aroor, Bysani Chandrasekar, Luis A. Martinez-Lemus, Vincent G. DeMarco, Laurel A. Grisanti, Iris Z. Jaffe, Alexander R. Pinto, Shawn B. Bender
Oxygen-sensing pathways below autoregulatory threshold act to sustain myocardial oxygen delivery during reductions in perfusion pressure
Cooper M. Warne, Salman I. Essajee, Selina M. Tucker, C. Alberto Figueroa, Daniel A. Beard, Gregory M. Dick, Johnathan D. Tune
Membrane remodelling triggers maturation of excitation–contraction coupling in 3D-shaped human-induced pluripotent stem cell-derived cardiomyocytes
Fatemeh Kermani, Matias Mosqueira, Kyra Peters, Enrico D. Lemma, Kleopatra Rapti, Dirk Grimm, Martin Bastmeyer, Magdalena Laugsch, Markus Hecker, Nina D. Ullrich
Electrophysiological and calcium-handling development during long-term culture of human-induced pluripotent stem cell-derived cardiomyocytes
Fitzwilliam Seibertz, Henry Sutanto, Rebekka Dülk, Julius Ryan D. Pronto, Robin Springer, Markus Rapedius, Aiste Liutkute, Melanie Ritter, Philipp Jung, Lea Stelzer, Luisa M. Hüsgen, Marie Klopp, Tony Rubio, Funsho E. Fakuade, Fleur E. Mason, Nico Hartmann, Steffen Pabel, Katrin Streckfuss-Bömeke, Lukas Cyganek, Samuel Sossalla, Jordi Heijman, Niels Voigt
Sexual dimorphism in bidirectional SR-mitochondria crosstalk in ventricular cardiomyocytes
Richard T. Clements, Radmila Terentyeva, Shanna Hamilton, Paul M. L. Janssen, Karim Roder, Benjamin Y. Martin, Fruzsina Perger, Timothy Schneider, Zuzana Nichtova, Anindhya S. Das, Roland Veress, Beth S. Lee, Do-Gyoon Kim, Gideon Koren, Matthew S. Stratton, Gyorgy Csordas, Federica Accornero, Andriy E. Belevych, Sandor Gyorke, Dmitry Terentyev
Integration of epigenetic regulatory mechanisms in heart failure
Miron Sopic, Emma L. Robinson, Costanza Emanueli, Prashant Srivastava, Claudio Angione, Carlo Gaetano, Gianluigi Condorelli, Fabio Martelli, Thierry Pedrazzini, Yvan Devaux
Multilineage contribution of CD34+ cells in cardiac remodeling after ischemia/reperfusion injury
Jun Xie, Liujun Jiang, Junzhuo Wang, Yong Yin, Ruilin Wang, Luping Du, Ting Chen, Zhichao Ni, Shuaihua Qiao, Hui Gong, Biao Xu, Qingbo Xu
Matrix metalloproteinases in coronary artery disease and myocardial infarction
Hanna Bräuninger, Saskia Krüger, Lucas Bacmeister, Alexander Nyström, Kilian Eyerich, Dirk Westermann, Diana Lindner
In-ovo echocardiography for application in cardiovascular research
Niklas Hegemann, Willem Bintig, Paul-Lennard Perret, Judith Rees, Alessandra Viperino, Britta Eickholt, Wolfgang M. Kuebler, Michael Höpfner, Bianca Nitzsche, Jana Grune
SMYD1a protects the heart from ischemic injury by regulating OPA1-mediated cristae remodeling and supercomplex formation
Marta W. Szulik, Steven Valdez, Maureen Walsh, Kathryn Davis, Ryan Bia, Emilee Horiuchi, Sean O’Very, Anil K. Laxman, Linda Sandaklie-Nicolova, David R. Eberhardt, Jessica R. Durrant, Hanin Sheikh, Samuel Hickenlooper, Magnus Creed, Cameron Brady, Mickey Miller, Li Wang, June Garcia-Llana, Christopher Tracy, Stavros G. Drakos, Katsuhiko Funai, Dipayan Chaudhuri, Sihem Boudina, Sarah Franklin
Deficiency of mitochondrial calcium uniporter abrogates iron overload-induced cardiac dysfunction by reducing ferroptosis
Nadezhda Fefelova, Suwakon Wongjaikam, Sri Harika Pamarthi, Natthaphat Siri-Angkul, Thomas Comollo, Anshu Kumari, Vivek Garg, Andreas Ivessa, Siriporn C. Chattipakorn, Nipon Chattipakorn, Judith K. Gwathmey, Lai-Hua Xie
The RISK pathway leading to mitochondria and cardioprotection: how everything started
Derek M. Yellon, Siavash Beikoghli Kalkhoran, Sean M. Davidson
No robust reduction of infarct size and no-reflow by metoprolol pretreatment in adult Göttingen minipigs
Petra Kleinbongard, Helmut Raphael Lieder, Andreas Skyschally, Gerd Heusch
Retraction Note to: NR4A1 aggravates the cardiac microvascular ischemia reperfusion injury through suppressing FUNDC1‑mediated mitophagy and promoting Mff‑required mitochondrial fission by CK2α
Hao Zhou, Jin Wang, Pingjun Zhu, Hong Zhu, Sam Toan, Shunying Hu, Jun Ren, Yundai Chen
Translational control of Ybx1 expression regulates cardiac function in response to pressure overload in vivo
Eshita Varma, Jana Burghaus, Thomas Schwarzl, Thileepan Sekaran, Parul Gupta, Agnieszka A. Górska, Christoph Hofmann, Claudia Stroh, Lonny Jürgensen, Verena Kamuf-Schenk, Xue Li, Rebekka Medert, Florian Leuschner, Vivien Kmietczyk, Marc Freichel, Hugo A. Katus, Matthias W. Hentze, Norbert Frey, Mirko Völkers
Three-vessel coronary infusion of cardiosphere-derived cells for the treatment of heart failure with preserved ejection fraction in a pre-clinical pig model
Romain Gallet, Jin-Bo Su, Daphné Corboz, Paul-Matthieu Chiaroni, Alain Bizé, Jianping Dai, Mathieu Panel, Pierre Boucher, Gaëtan Pallot, Juliette Brehat, Lucien Sambin, Guillaume Thery, Nadir Mouri, Aurélien de Pommereau, Pierre Denormandie, Stéphane Germain, Alain Lacampagne, Emmanuel Teiger, Eduardo Marbán, Bijan Ghaleh
Endothelial ILK induces cardioprotection by preventing coronary microvascular dysfunction and endothelial-to-mesenchymal transition
P. Reventun, S. Sánchez-Esteban, A. Cook-Calvete, M. Delgado-Marín, C. Roza, S. Jorquera-Ortega, I. Hernandez, L. Tesoro, L. Botana, J. L. Zamorano, C. Zaragoza, M. Saura
Matrix metalloproteinase-2 proteolyzes mitofusin-2 and impairs mitochondrial function during myocardial ischemia–reperfusion injury
Wesam Bassiouni, Robert Valencia, Zabed Mahmud, John M. Seubert, Richard Schulz
The heterocellular heart: identities, interactions, and implications for cardiology
Achim Lother, Peter Kohl
Rivaroxaban attenuates neutrophil maturation in the bone marrow niche
R. Schneckmann, M. Döring, S. Gerfer, S. Gorressen, S. Heitmeier, C. Helten, A. Polzin, C. Jung, M. Kelm, A. C. Fender, U. Flögel, M. Grandoch
Perspective: mitochondrial STAT3 in cardioprotection
Petra Kleinbongard
Identification of the specific molecular and functional signatures of pre-beta-HDL: relevance to cardiovascular disease
Isabelle Guillas, Marie Lhomme, Cédric Pionneau, Lucrèce Matheron, Maharajah Ponnaiah, Sophie Galier, Sandrine Lebreton, Marie Delbos, Feng Ma, Maryam Darabi, Petra El Khoury, Marianne Abifadel, Philippe Couvert, Philippe Giral, Philippe Lesnik, Maryse Guerin, Wilfried Le Goff, Anatol Kontush
Preventing mitochondrial reverse electron transport as a strategy for cardioprotection
Hiran A. Prag, Michael P. Murphy, Thomas Krieg
Cardiac fibroblast GSK-3α aggravates ischemic cardiac injury by promoting fibrosis, inflammation, and impairing angiogenesis
Prachi Umbarkar, Suma Ejantkar, Sulivette Y. Ruiz Ramirez, Angelica Toro Cora, Qinkun Zhang, Sultan Tousif, Hind Lal
Myeloperoxidase is a critical mediator of anthracycline-induced cardiomyopathy
Felix Sebastian Nettersheim, Johannes David Schlüter, Wiebke Kreuzberg, Dennis Mehrkens, Simon Grimm, Harshal Nemade, Simon Braumann, Alexander Hof, Henning Guthoff, Vera Peters, Friedrich Felix Hoyer, Yulia Kargapolova, Jan-Wilm Lackmann, Stefan Müller, Christian P. Pallasch, Michael Hallek, Agapios Sachinidis, Matti Adam, Holger Winkels, Stephan Baldus, Simon Geißen, Martin Mollenhauer
Ketone body 3-hydroxybutyrate elevates cardiac output through peripheral vasorelaxation and enhanced cardiac contractility
Casper Homilius, Jacob Marthinsen Seefeldt, Julie Sørensen Axelsen, Tina Myhre Pedersen, Trine Monberg Sørensen, Roni Nielsen, Henrik Wiggers, Jakob Hansen, Vladimir V. Matchkov, Hans Erik Bøtker, Ebbe Boedtkjer
The roles of intracellular proteolysis in cardiac ischemia–reperfusion injury
Bridgette Hartley, Wesam Bassiouni, Richard Schulz, Olivier Julien
Giant mitochondria in cardiomyocytes: cellular architecture in health and disease
Amy Li, Gerald J. Shami, Lisa Griffiths, Sean Lal, Helen Irving, Filip Braet
Novel GSDMD inhibitor GI-Y1 protects heart against pyroptosis and ischemia/reperfusion injury by blocking pyroptotic pore formation
Lingfeng Zhong, Jibo Han, Xiaoxi Fan, Zhouqing Huang, Lan Su, Xueli Cai, Shuang Lin, Xudong Chen, Weijian Huang, Shanshan Dai, Bozhi Ye
Recent advances on the role of monoamine oxidases in cardiac pathophysiology
Nina Kaludercic, Ruth Jepchirchir Arusei, Fabio Di Lisa
Mitophagy for cardioprotection
Allen Sam Titus, Eun-Ah Sung, Daniela Zablocki, Junichi Sadoshima
Outcomes of hypothalamic oxytocin neuron-driven cardioprotection after acute myocardial infarction
Kathryn J. Schunke, Jeannette Rodriguez, Jhansi Dyavanapalli, John Schloen, Xin Wang, Joan Escobar, Grant Kowalik, Emily C. Cheung, Caitlin Ribeiro, Rebekah Russo, Bridget R. Alber, Olga Dergacheva, Sheena W. Chen, Alejandro E. Murillo-Berlioz, Kyongjune B. Lee, Gregory Trachiotis, Emilia Entcheva, Christine A. Brantner, David Mendelowitz, Matthew W. Kay
Splenic monocytes mediate inflammatory response and exacerbate myocardial ischemia/reperfusion injury in a mitochondrial cell-free DNA-TLR9-NLRP3-dependent fashion
Dina Xie, Hanliang Guo, Mingbiao Li, Liqun Jia, Hao Zhang, Degang Liang, Naishi Wu, Zequan Yang, Yikui Tian
Succinate dehydrogenase is essential for epigenetic and metabolic homeostasis in hearts
Wenwen Li, Li Quan, Kun Peng, Yanru Wang, Xianhua Wang, Quan Chen, Heping Cheng, Qi Ma
Musashi-2 causes cardiac hypertrophy and heart failure by inducing mitochondrial dysfunction through destabilizing Cluh and Smyd1 mRNA
Sandhya Singh, Aakash Gaur, Rakesh Kumar Sharma, Renu Kumari, Shakti Prakash, Sunaina Kumari, Ayushi Devendrasingh Chaudhary, Pankaj Prasun, Priyanka Pant, Hannah Hunkler, Thomas Thum, Kumaravelu Jagavelu, Pragya Bharati, Kashif Hanif, Pragya Chitkara, Shailesh Kumar, Kalyan Mitra, Shashi Kumar Gupta
Activation of the integrated stress response rewires cardiac metabolism in Barth syndrome
Ilona Kutschka, Edoardo Bertero, Christina Wasmus, Ke Xiao, Lifeng Yang, Xinyu Chen, Yasuhiro Oshima, Marcus Fischer, Manuela Erk, Berkan Arslan, Lin Alhasan, Daria Grosser, Katharina J. Ermer, Alexander Nickel, Michael Kohlhaas, Hanna Eberl, Sabine Rebs, Katrin Streckfuss-Bömeke, Werner Schmitz, Peter Rehling, Thomas Thum, Takahiro Higuchi, Joshua Rabinowitz, Christoph Maack, Jan Dudek
The role of glycolytic metabolic pathways in cardiovascular disease and potential therapeutic approaches
Shuxian Chen, Yuanming Zou, Chunyu Song, Kexin Cao, Kexin Cai, Yanjiao Wu, Zhaobo Zhang, Danxi Geng, Wei Sun, Nanxiang Ouyang, Naijin Zhang, Zhao Li, Guozhe Sun, Yixiao Zhang, Yingxian Sun, Ying Zhang
Targeting mitochondrial shape: at the heart of cardioprotection
Sauri Hernandez-Resendiz, Aishwarya Prakash, Sze Jie Loo, Martina Semenzato, Kroekkiat Chinda, Gustavo E. Crespo-Avilan, Linh Chi Dam, Shengjie Lu, Luca Scorrano, Derek J. Hausenloy