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Erschienen in: Journal of Cancer Research and Clinical Oncology 6/2019

29.04.2019 | Review – Cancer Research

Beyond a chemopreventive reagent, aspirin is a master regulator of the hallmarks of cancer

verfasst von: Xiao Zhang, Yukuan Feng, Xi Liu, Jianhui Ma, Yafei Li, Tianzhen Wang, Xiaobo Li

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 6/2019

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Abstract

Purpose

Aspirin, one of the most commonly used nonsteroidal anti-inflammatory drugs (NAIDS), not only shows cancer chemoprevention effects but also improves cancer therapeutic effects when combined with other therapies. Studies that focus on aspirin regulation of the hallmarks of cancer and the associated molecular mechanisms facilitate a more thorough understanding of aspirin in mediating chemoprevention and may supply additional information for the development of novel cancer therapeutic agents.

Methods

The relevant literatures from PubMed have been reviewed in this article.

Results

Current studies have revealed that aspirin regulates almost all the hallmarks of cancer. Within tumor tissue, aspirin suppresses the bioactivities of cancer cells themselves and deteriorates the tumor microenvironment that supports cancer progression. In addition to tumor tissues, blocking of platelet activation also contributes to the ability of aspirin to inhibit cancer progression. In terms of the molecular mechanism, aspirin targets oncogenes and cancer-related signaling pathways and activates certain tumor suppressors.

Conclusion

Beyond a chemopreventive agent, aspirin is a master regulator of the hallmarks of cancer.
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Metadaten
Titel
Beyond a chemopreventive reagent, aspirin is a master regulator of the hallmarks of cancer
verfasst von
Xiao Zhang
Yukuan Feng
Xi Liu
Jianhui Ma
Yafei Li
Tianzhen Wang
Xiaobo Li
Publikationsdatum
29.04.2019
Verlag
Springer Berlin Heidelberg
Erschienen in
Journal of Cancer Research and Clinical Oncology / Ausgabe 6/2019
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI
https://doi.org/10.1007/s00432-019-02902-6

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