Introduction
Palmaris longus (PL) is a muscle of the anterior compartment of the forearm. It is located within the superficial group of flexor muscles, medial and superficial to pronator teres and flexor carpi radialis, and lateral to flexor carpi ulnaris. It is attached to the medial epicondyle and epicondylar ridge of the humerus via the common flexor tendon. Typically, the fusiform muscle belly runs distally and becomes tendinous in the mid-forearm. Tendinous fibers insert into the flexor retinaculum and palmar aponeurosis of the hand. Due to its insertion points, PL acts as an accessory flexor muscle and as an anchor of the skin and fascia to resist horizontal shearing forces. The neurovascular supply to PL is through the median nerve and branches of the ulnar artery [
43].
Palmaris longus is considered to be the most variable muscle in human anatomy. The most common variation is complete agenesis, which is prevalent in 20.25% of the global population [
49]. When present, PL can be digastric, duplicated, bifurcated, trifurcated or have atypical tendinous insertions [
16]. While variations of PL are common, it is essential that rare presentations of the muscle are reported on, as these variations have important surgical and clinical implication. Firstly, PL is often used for tendon grafting and reconstructive surgeries as the removal of the muscle does not affect the function of the forearm and it is easily resected due to its superficial location [
36]. The presence of a reversed PL (RPL) may prevent the tendon from being harvested for tendon grafting. Secondly, if present, RPL may be a rare cause of symptoms of neuropathy and neural compression, due to its close anatomical relationship to the median and ulnar nerves [
15,
16].
Discussion
One of the earliest reports of RPL was discovered through dissection in 1868 at King’s College London [
48]. The earliest clinical presentation, from our literature review, of bilateral RPL was reported in Germany in 1993 in a 21-year-old male who had suffered from median nerve compression, outside the carpal tunnel, as a result of hypertrophy of the muscle. Resection of the muscle belly relieved the symptoms immediately [
19]. Three cases of bilateral RPL were reported in male donors from Chile [
39], Brazil [
23] and India [
21]. All reports of RPL originated from the medial epicondyle of the humerus; however, the distal insertion points varied. One case reported on a short distal tendon on the left side, similar to our findings, which inserted into the distal aponeurosis [
39]. Conversely, the remaining RPL attached to their distal insertion points via the distal muscular bellies directly [
23]. Another case reported on a trifid insertion, which was laterally continuous with the fascia of the thenar muscles, centrally continuous with the palmar aponeurosis, and medially continuous with the fascia covering abductor digiti minimi [
21]. The reported cases of RPL also showed differences in their relationship with the median nerve in the wrist. The right muscle and tendon were situated lateral to the median nerve, whereas the distal third of the left muscle compressed the median nerve [
39].
There was no obvious correlation between sex and RPL. However, it is interesting to note that reports of bilateral cases of RPL have only been discovered in male donors to date, despite widespread anatomical dissection throughout the world. Perhaps this occurrence of RPL serves as an example of a minor evolutionary dimorphism between the sexes. A hypothesis warrants further investigations. Collating results from literature revealed a higher frequency of RPL in right upper limb. However, when only taking cadaveric studies into consideration, there is no difference in sidedness. This suggests that results for sidedness may not reflect the frequency of RPL in the population, but rather be skewed due to presentation in clinical scenarios. As RPL in right and left hand mirrors the population proportions of left and right handedness, this suggests that clinical presentations of symptoms of RPL result from increased activity of dominant limbs.
Previous studies have assessed the prevalence of bilateral agenesis of PL to sex and also reported no statistical correlation [
26]. Conversely, a meta-analysis performed by Yammine et al. found that there is a statistically higher rate of agenesis on the right side compared to the left, but no significant difference between the combination of side and sex. In addition, the proportion of agenesis varies between different ethnic groups, with the lowest proportion among the East Asian and African population, and the highest observed in the Arab Middle Eastern population [
49].
Only six sets of measurements of RPL muscle have been recorded in the literature from three previous studies [
16,
20,
22]. As we report on a bilateral occurrence, we contribute two further measurements. Both tendon measurements were similar to those reported in the literature. The left tendon was 3 mm shorter than the average tendon measurement, whereas the right tendon did not deviate from the average (Table
2). Conversely, both muscle bellies were considerably shorter than the average measurement. The right muscle belly deviated 46 mm from the mean, while the left deviated 22 mm (Table
2).
Accurate measurements of PL are necessary as the muscle is often used in tendon grafting procedures to treat facial paralysis, ptosis correction and lip augmentation [
36] and reconstructive surgeries [
14]. According to Harvey and colleagues, a tendon must be greater than 150 mm for it to be suitable for tendon grafting [
22]. We report that the average tendon length of RPL is 126 mm implying that this muscular anomaly is not suitable for tissue harvesting. Although it must be noted that a graft longer than 15 cm may not always be required depending on the type of reconstruction taking place [
24]. Therefore, if possible ultrasound should be utilized to measure the tendon length and suitability for grafting pre-operatively. If ultrasound is not available, ineligibility of the muscle for use in tendon grafting may only be discovered intraoperatively [
24,
25]. This may result in negative consequences for both the patient and surgeon as morbidity may increase and the patient may not have given consent for the harvesting of alternative tissue [
11].
When discovered in a clinical scenario, RPL is often present in athletes or in professions that require intense physical exertion, such as lumberjacks, soldiers and manual laborers [
14,
17,
48]. The repeated action of axial loading, power gripping and flexion/extension stresses can cause the muscle belly of the RPL to hypertrophy. The additional volume and pressure in the flexor compartment of the forearm may cause exertional compartment syndrome resulting in median or ulnar nerve paranesthesia and effort-related volar forearm pain [
1,
8,
39]. Clinicians, physiotherapists and radiologists should be aware of this rare muscular anomaly, as it may be overlooked when diagnosing forearm pain and could be mistaken for a tumor or ganglion on MRI or clinical examination [
4,
17].
Anatomical variations in the PL muscle are a consequence of phylogenetic degeneration [
43]. This occurred as a result of a shift from quadrupedal or arboreal locomotion to habitual bipedalism during human evolution. As the function of the forearm evolved from a weight-bearing forelimb to a prehensile limb, capable of precise movement, the flexor muscles have partially atrophied in a caudocranial direction [
2]. In fact, the relative tendon size of PL increases from ancestral genera, such as lemuriformes and new world primates, to more derived genera such as great apes including modern humans [
3]. This shortening of the muscular belly has resulted in an overall weakening of the muscle and, as a result, complete agenesis of the PL does not affect forearm function. The anatomical variations of PL and its rudimentary function have led to the hypothesis that the upper extremity in man is still undergoing a process of evolution [
6,
10].
Variations of the PL muscle are caused by disturbances of the intracellular or extracellular pathways that control embryonic muscle growth, which cannot be compensated for during later development. Anomalies and agenesis of PL in human fetuses are similar to those observed in adults [
35]. Interestingly, variations in PL are distinctly heritable. Thomson et al. hypothesized that partial or complete absence of the muscle is due to a single dominant gene, which acts as an inhibitor of its development, but this inhibition is frequently incomplete due to modifying conditions such as sex and side [
46].
Although a search strategy was implemented, it cannot be assumed that all articles containing information on this variant were included. However, efforts were made to include the most relevant studies containing the most information relevant to this review.
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