Erschienen in:
01.09.2004 | Oral presentation
Biochemical markers of bone and cartilage in osteoarthritis
verfasst von:
P Garnero
Erschienen in:
Arthritis Research & Therapy
|
Sonderheft 3/2004
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Excerpt
Osteoarthritis (OA), the most prevalent joint disease, is characterized by abnormal and degraded cartilage, inflamed and/or thickened synovial tissue, and alterations of bone metabolism (sclerosis, cysts, osteophytes). The extracellular matrix of joint tissues is composed primarily of collagens including type I (bone and synovium), type II (cartilage) and type III (synovium) associated with proteoglycans (e.g. aggrecan in cartilage) and other glycoproteins. Potential biological markers for OA include matrix components (and/or their breakdown products), cytokines, and proteases [
1]. …