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Journal of Bone and Mineral Metabolism

Erschienen in:

24.01.2022 | Original Article

Bone markers and bone mineral density associates with periodontitis in females with poly-cystic ovarian syndrome

verfasst von: Afaf Zia, S. Hakim, A. U. Khan, A. Bey, H. Ateeq, S. Parveen, S. Khalid, FNK. Yusufi

Erschienen in: Journal of Bone and Mineral Metabolism | Ausgabe 3/2022

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Abstract

Introduction

Studies suggest an association between poly-cystic ovarian syndrome (PCOS) and chronic periodontitis (CP), both being inflammatory conditions. However, insufficient evidence assesses the impact of this inflammation on bone metabolism and bone turnover markers (BTMs). The present study aimed to determine the association between BTMs, bone mineral density (BMD), and clinical periodontal parameters in PCOS women with CP.

Materials and methods

Three groups, each with 40 newly diagnosed (1) PCOS+CP, (2) PCOS alone, (3) CP alone, and fourth group (n = 20) systemically and periodontally healthy females aged 18–30 years were included in the study. Full mouth clinical periodontal parameters, C-terminal telopeptides of type I collagen (CTX), bone alkaline phosphatase (ALP), BMD and 25-hydroxyvitamin D (VD) were recorded for all.

Results

Low BMD (0.89 ± 0.11 g/cm²), increased CTX levels (2.76 ± 4.64 ng/ml), decreased bone ALP levels (11.09 ± 6.86 ng/ml), higher VD levels (289.02 ± 168.28 nmol/l) and poor clinical periodontal status were observed in PCOS + CP females. BMD-spine showed weak positive correlation with CTX, bone ALP, VD (r = 0.02, r = 0.07, r = 0.15, respectively) in PCOS + CP group. ANCOVA depicted covariates had no confounding effect. Multiple regression model explained 21.0% for BMD-spine and 12.7% for BMD-femur of total variability signifying association with all measured parameters among all groups.

Conclusion

Enhanced inflammatory thrust by periodontitis increases CTX levels and decreases bone ALP and BMD levels in women with PCOS. Screening PCOS women for periodontal disease and vice versa may have a direct bearing on overall bone health.

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Titel: Bone markers and bone mineral density associates with periodontitis in females with poly-cystic ovarian syndrome
verfasst von: Afaf Zia
S. Hakim
A. U. Khan
A. Bey
H. Ateeq
S. Parveen
S. Khalid
FNK. Yusufi
Publikationsdatum: 24.01.2022
Verlag: Springer Nature Singapore
Erschienen in: Journal of Bone and Mineral Metabolism / Ausgabe 3/2022
Print ISSN: 0914-8779
Elektronische ISSN: 1435-5604
DOI: https://doi.org/10.1007/s00774-021-01302-6

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Bone markers and bone mineral density associates with periodontitis in females with poly-cystic ovarian syndrome

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