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Im April diskutierten die Herz-Kreislauf-Spezialisten aus der ganzen Welt auf dem  Kongress des American College of Cardiology (ACC) u.a. neue Therapieansätze bei akutem Myokardinfarkt, koronarer Herzerkrankung, kardiogenem Schock oder Aortenklappenstenose. In unserem Kongress-Dossier haben wir für Sie Berichte über die „Late-Breaking Trials“ und andere wichtige Studien zusammengestellt. 
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Translational Stroke Research
Erschienen in: Translational Stroke Research 3/2014

01.06.2014 | Review Article

Brain Arteriovenous Malformation Modeling, Pathogenesis, and Novel Therapeutic Targets

verfasst von: Wanqiu Chen, Eun-Jung Choi, Cameron M. McDougall, Hua Su

Erschienen in: Translational Stroke Research | Ausgabe 3/2014

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Abstract

Patients harboring brain arteriovenous malformation (bAVM) are at life-threatening risk of rupture and intracranial hemorrhage (ICH). The pathogenesis of bAVM has not been completely understood. Current treatment options are invasive, and ≈ 20 % of patients are not offered interventional therapy because of excessive treatment risk. There are no specific medical therapies to treat bAVMs. The lack of validated animal models has been an obstacle for testing hypotheses of bAVM pathogenesis and testing new therapies. In this review, we summarize bAVM model development and bAVM pathogenesis and potential therapeutic targets that have been identified during model development.
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Metadaten
Titel
Brain Arteriovenous Malformation Modeling, Pathogenesis, and Novel Therapeutic Targets
verfasst von
Wanqiu Chen
Eun-Jung Choi
Cameron M. McDougall
Hua Su
Publikationsdatum
01.06.2014
Verlag
Springer US
Erschienen in
Translational Stroke Research / Ausgabe 3/2014
Print ISSN: 1868-4483
Elektronische ISSN: 1868-601X
DOI
https://doi.org/10.1007/s12975-014-0343-0

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