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Breast Cancer Research and Treatment

Ausgabe 1/2010

Inhalt (37 Artikel)

Review

Bevacizumab in metastatic breast cancer: a meta-analysis of randomized controlled trials

A. Valachis, N. P. Polyzos, N. Α. Patsopoulos, V. Georgoulias, D. Mavroudis, D. Mauri

Review

Effect of BRCA1/2 mutation on short-term and long-term breast cancer survival: a systematic review and meta-analysis

Eun-Ha Lee, Sue K. Park, Boyoung Park, Sung-Won Kim, Min Hyuk Lee, Sei Hyun Ahn, Byung Ho Son, Keun-Young Yoo, Daehee Kang

Review

Multicentric and multifocal versus unifocal breast cancer: is the tumor-node-metastasis classification justified?

Tobias M. Weissenbacher, Madeleine Zschage, Wolfgang Janni, Udo Jeschke, Thomas Dimpfl, Doris Mayr, Brigitte Rack, Christian Schindlbeck, Klaus Friese, Darius Dian

Preclinical study

HER2 signaling pathway activation and response of breast cancer cells to HER2-targeting agents is dependent strongly on the 3D microenvironment

Britta Weigelt, Alvin T. Lo, Catherine C. Park, Joe W. Gray, Mina J. Bissell

Preclinical study

PIK3CA expression in invasive breast cancer: a biomarker of poor prognosis

Mohammed A. Aleskandarany, Emad A. Rakha, Mohamed A. H. Ahmed, Desmond G. Powe, Emma C. Paish, R. Douglas Macmillan, Ian O. Ellis, Andrew R. Green

Preclinical study

The RNA-binding protein HuR regulates GATA3 mRNA stability in human breast cancer cell lines

Lauren A. Licata, Christine L. Hostetter, James Crismale, Anjali Sheth, Judith Clancy Keen

Preclinical study

Evidence for a transcriptional signature of breast cancer

Yumei Feng, Xiaoqing Li, Baocun Sun, Yuli Wang, Lina Zhang, Xiuhua Pan, Xiaohui Chen, Xiaoyan Wang, Jinfeng Wang, Xishan Hao

Preclinical study

In primary breast cancer the mitotic activity yields similar prognostic information as the histological grade: a study with long-term follow-up

P. Bult, P. Manders, H. M. P. M. Straatman, V. C. G. Tjan-Heijnen, L. V. A. M. Beex, J. Hendriks, J. W. Leer, A. L. M. Verbeek, R. Holland

Preclinical study

A dose- and time-controllable syngeneic animal model of breast cancer microcalcification

Fangbing Liu, Preeti Misra, Elaine P. Lunsford, Joanne T. Vannah, Yuxia Liu, Robert E. Lenkinski, John V. Frangioni

Preclinical study

The complete family of epidermal growth factor receptors and their ligands are co-ordinately expressed in breast cancer

Emmet McIntyre, Edith Blackburn, Philip J. Brown, Colin G. Johnson, William J. Gullick

Preclinical study

Transactivation of ErbB-2 induced by tumor necrosis factor α promotes NF-κB activation and breast cancer cell proliferation

Martín A. Rivas, Mercedes Tkach, Wendy Beguelin, Cecilia J. Proietti, Cinthia Rosemblit, Eduardo H. Charreau, Patricia V. Elizalde, Roxana Schillaci

Preclinical study

Four human breast cancer cell lines with biallelic inactivating α-catenin gene mutations

Antoinette Hollestelle, Fons Elstrodt, Mieke Timmermans, Anieta M. Sieuwerts, Jan G. M. Klijn, John A. Foekens, Michael A. den Bakker, Mieke Schutte

Preclinical study

Adoptively transferred ex vivo expanded γδ-T cells mediate in vivo antitumor activity in preclinical mouse models of breast cancer

Benjamin H. Beck, Hyung-Gyoon Kim, Hyunki Kim, Sharon Samuel, Zhiyong Liu, Robin Shrestha, Hilary Haines, Kurt Zinn, Richard D. Lopez

Preclinical study

Coadministration of nanosystems of short silencing RNAs targeting oestrogen receptor α and anti-oestrogen synergistically induces tumour growth inhibition in human breast cancer xenografts

Céline Bouclier, Véronique Marsaud, Olivia Bawa, Valérie Nicolas, Laurence Moine, Paule Opolon, Jack-Michel Renoir

Preclinical study

Induction of the small heat shock protein αB-crystallin by genotoxic stress is mediated by p53 and p73

Joseph R. Evans, Joshua D. Bosman, Lauren Brown-Endres, Fruma Yehiely, Vincent L. Cryns

Clinical trial

Maintenance treatment with Pegylated liposomal doxorubicin versus observation following induction chemotherapy for metastatic breast cancer: GEICAM 2001-01 study

Emilio Alba, Manuel Ruiz-Borrego, Mireia Margelí, Álvaro Rodríguez-Lescure, Pedro Sánchez-Rovira, Amparo Ruiz, Jose Ramón Mel-Lorenzo, Manuel Ramos-Vázquez, Nuria Ribelles, Elisa Calvo, Antonio Casado, Antonia Márquez, David Vicente, José Angel García-Sáenz, Miguel Martín

Invited Commentary

Holding back the sea: the role for maintenance chemotherapy in metastatic breast cancer

C. G. Murphy, M. Khasraw, A. D. Seidman

Clinical trial

Bevacizumab and osteonecrosis of the jaw: incidence and association with bisphosphonate therapy in three large prospective trials in advanced breast cancer

Valentina Guarneri, David Miles, Nicholas Robert, Véronique Diéras, John Glaspy, Ian Smith, Christoph Thomssen, Laura Biganzoli, Tanya Taran, PierFranco Conte

Invited Commentary

Osteonecrosis of the jaw and bevacizumab therapy

Catherine Van Poznak

Epidemiology

SULT1A1 R213H polymorphism and breast cancer risk: a meta-analysis based on 8,454 cases and 11,800 controls

Zhanwei Wang, Yuanyuan Fu, Chunbo Tang, Su Lu, Wen-ming Chu

Epidemiology

Dietary acrylamide intake and estrogen and progesterone receptor-defined postmenopausal breast cancer risk

Grete S. Pedersen, Janneke G. F. Hogervorst, Leo J. Schouten, Erik J. M. Konings, R. Alexandra Goldbohm, Piet A. van den Brandt

Epidemiology

Modeling the relationship between circulating tumour cells number and prognosis of metastatic breast cancer

Edoardo Botteri, Maria Teresa Sandri, Vincenzo Bagnardi, Elisabetta Munzone, Laura Zorzino, Nicole Rotmensz, Chiara Casadio, Maria Cristina Cassatella, Angela Esposito, Giuseppe Curigliano, Michela Salvatici, Elena Verri, Laura Adamoli, Aron Goldhirsch, Franco Nolè

Epidemiology

Dietary lignan intakes in relation to survival among women with breast cancer: the Western New York Exposures and Breast Cancer (WEB) Study

Susan E. McCann, Lilian U. Thompson, Jing Nie, Joan Dorn, Maurizio Trevisan, Peter G. Shields, Christine B. Ambrosone, Stephen B. Edge, Hsin-Fang Li, Christina Kasprzak, Jo L. Freudenheim

Epidemiology

The functional promoter polymorphism (−842G>C) in the PIN1 gene is associated with decreased risk of breast cancer in non-Hispanic white women 55 years and younger

Chan H. Han, Jiachun Lu, Qingyi Wei, Melissa L. Bondy, Abenaa M. Brewster, Tse-Kuan Yu, Thomas A. Buchholz, Banu K. Arun, Li-E Wang

Epidemiology

Current evidence on the relationship between polymorphisms in the COX-2 gene and breast cancer risk: a meta-analysis

Ke-Da Yu, Ao-Xiang Chen, Chen Yang, Li-Xin Qiu, Lei Fan, Wen-Huan Xu, Zhi-Ming Shao

Epidemiology

Lack of association between CYP17 MspA1 polymorphism and breast cancer risk: a meta-analysis of 22,090 cases and 28,498 controls

Chen Mao, Xi-Wen Wang, Ben-Fu He, Li-Xin Qiu, Ru-Yan Liao, Rong-Cheng Luo, Qing Chen

Epidemiology

Transforming growth factor-β1 polymorphisms and breast cancer risk: a meta-analysis based on 27 case–control studies

Xiaowei Qi, Fan Zhang, Xinhua Yang, Linjun Fan, Yi Zhang, Li Chen, Yan Zhou, Xianchun Chen, Ling Zhong, Jun Jiang

Brief Report

Pooled analysis indicates that the GSTT1 deletion, GSTM1 deletion, and GSTP1 Ile105Val polymorphisms do not modify breast cancer risk in BRCA1 and BRCA2 mutation carriers

Amanda B. Spurdle, Paul Fahey, Xiaoqing Chen, Lesley McGuffog, Douglas Easton, Susan Peock, Margaret Cook, Jacques Simard, Tim R. Rebbeck, Antonis C. Antoniou, Georgia Chenevix-Trench

Brief Report

High-throughput resequencing in the diagnosis of BRCA1/2 mutations using oligonucleotide resequencing microarrays

Christopher Schroeder, Fanny Stutzmann, Bernhard H. F. Weber, Olaf Riess, Michael Bonin

Letter to the Editor

PALB2 mutations in male breast cancer: a population-based study in Central Italy

Valentina Silvestri, Piera Rizzolo, Ines Zanna, Mario Falchetti, Giovanna Masala, Simonetta Bianchi, Laura Papi, Giuseppe Giannini, Domenico Palli, Laura Ottini

Letter to the Editor

PALB2 mutations 1592delT and 229delT are not present in Korean breast cancer patients negative for BRCA1 and BRCA2 mutations

Jin Ho Kim, Doo Ho Choi, Dae Yeon Cho, Sei Hyun Ahn, Byung Ho Son, Bruce G. Haffty

Adjuvante Immuntherapie verlängert Leben bei RCC

25.04.2024 Nierenkarzinom Nachrichten

Nun gibt es auch Resultate zum Gesamtüberleben: Eine adjuvante Pembrolizumab-Therapie konnte in einer Phase-3-Studie das Leben von Menschen mit Nierenzellkarzinom deutlich verlängern. Die Sterberate war im Vergleich zu Placebo um 38% geringer.

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

25.04.2024 NSCLC Nachrichten

Das Risiko für Rezidiv oder Tod von Patienten und Patientinnen mit reseziertem ALK-positivem NSCLC ist unter einer adjuvanten Therapie mit dem Tyrosinkinase-Inhibitor Alectinib signifikant geringer als unter platinbasierter Chemotherapie.

Bei Senioren mit Prostatakarzinom auf Anämie achten!

24.04.2024 DGIM 2024 Nachrichten

Patienten, die zur Behandlung ihres Prostatakarzinoms eine Androgendeprivationstherapie erhalten, entwickeln nicht selten eine Anämie. Wer ältere Patienten internistisch mitbetreut, sollte auf diese Nebenwirkung achten.

ICI-Therapie in der Schwangerschaft wird gut toleriert

Müssen sich Schwangere einer Krebstherapie unterziehen, rufen Immuncheckpointinhibitoren offenbar nicht mehr unerwünschte Wirkungen hervor als andere Mittel gegen Krebs.

Update Onkologie

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