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Erschienen in:

01.12.2011

Bronchoscopically Obtained Volatile Biomarkers in Lung Cancer

verfasst von: Kaid Darwiche, Joerg Ingo Baumbach, Urte Sommerwerck, Helmut Teschler, Lutz Freitag

Erschienen in: Lung | Ausgabe 6/2011

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Abstract

Background

The exhaled breath of lung cancer patients contains volatile organic compounds (VOCs) that differ from those in healthy individuals. These VOCs can be detected with methods such as ion mobility spectrometry (IMS); their origin remains unknown.

Methods

In 19 patients with lung cancer, exhaled breath was aspirated via the working channel of a flexible bronchoscope from both the tumor-bearing and the opposite lung and analyzed with IMS.

Results

IMS measurement through the working channel of a bronchoscope was feasible and safe. In comparison to the opposite lung, we found two peaks that were significantly higher and three peaks that were significantly lower on the IMS of the tumor-bearing site. VOCs differ in concentration depending on the histologic subtype.

Conclusion

Our results indicate that VOCs in lung cancer patients are produced locally in or around the tumor, and it is most likely that these VOCs represent underlying metabolic processes of the tumor.

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Titel: Bronchoscopically Obtained Volatile Biomarkers in Lung Cancer
verfasst von: Kaid Darwiche
Joerg Ingo Baumbach
Urte Sommerwerck
Helmut Teschler
Lutz Freitag
Publikationsdatum: 01.12.2011
Verlag: Springer-Verlag
Erschienen in: Lung / Ausgabe 6/2011
Print ISSN: 0341-2040
Elektronische ISSN: 1432-1750
DOI: https://doi.org/10.1007/s00408-011-9324-1

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Abstract

Background

Methods

Results

Conclusion

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