nach oben

Erschienen in:

01.02.2010 | Nuclear Medicine

Can calcification predict ¹³¹I accumulation on metastatic lymph nodes in papillary thyroid carcinoma patients receiving ¹³¹I therapy? Comparison of CT, ¹³¹I WBS and ¹⁸F-FDG PET/CT

verfasst von: Koichiro Kaneko, Koichiro Abe, Shingo Baba, Yoshitaka Tanabe, Hidetake Yabuuchi, Masamitsu Hatakenaka, Masayuki Sasaki, Hiroshi Honda

Erschienen in: European Radiology | Ausgabe 2/2010

Einloggen, um Zugang zu erhalten

Abstract

Objective

The aim of this study was to clarify the predictive significance of nodal calcification in terms of the therapeutic option of ¹³¹I therapy in papillary thyroid carcinoma (PTC) patients.

Methods

We reviewed 19 computed tomography (CT) examinations of PTC patients on receiving ¹³¹I therapy for the presence of nodal calcification, and compared the ¹³¹I whole-body scintigraphy and ¹⁸F-2-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET)/CT findings. The metastatic lymph nodes (mLNs) were divided into three groups: A, those with calcification; B, those without calcification but belonging to patients who had calcified mLNs; C, those without calcification and belonging to patients who had no calcified mLNs. The incidences of ¹³¹I accumulation and maximum standardised uptake values (SUV max) in the three groups were compared.

Results

A total of 70 mLNs were evaluated. Twelve mLNs belonged to group A, 13 to group B and 45 to group C. The incidences of ¹³¹I accumulation were significantly higher in groups A (100%) and B (100%) than in group C (11.1%) (p < 0.0001 for both). The SUVmax was significantly lower in groups A (4.1 ± 1.9) and B (3.9 ± 1.4) than in group C (7.1 ± 4.4) (p = 0.01, p = 0.002, respectively).

Conclusions

Our results indicated that calcification in mLNs related to the ability of ¹³¹I accumulation and less dedifferentiation.

Lam AK, Lo CY, Lam KS (2005) Papillary carcinoma of thyroid: a 30-yr clinicopathological review of the histological variants. Endocr Pathol 16:323–330CrossRefPubMed

Wang N, Xu Y, Ge C et al (2006) Association of sonographically detected calcification with thyroid carcinoma. Head Neck 28:1077–1083CrossRefPubMed

Hoang JK, Lee WK, Lee M et al (2007) US Features of thyroid malignancy: pearls and pitfalls. Radiographics 27:847–860CrossRefPubMed

Fish SA, Langer JE, Mandel SJ (2008) Sonographic imaging of thyroid nodules and cervical lymph nodes. Endocrinol Metab Clin N Am 37:401–417CrossRef

Shetty SK, Maher MM, Hahn PF et al (2006) Significance of incidental thyroid lesions detected on CT: correlation among CT, sonography, and pathology. AJR Am J Roentgenol 187:1349–1356CrossRefPubMed

Chan JK (1990) Papillary carcinoma of thyroid: classical and variants. Histol Histopathol 5:241–257PubMed

Machens A, Hinze R, Thomusch O et al (2002) Pattern of nodal metastasis for primary and reoperative thyroid cancer. World J Surg 26:22–28CrossRefPubMed

Mirallié E, Sagan C, Hamy A et al (1999) Predictive factors for node involvement in papillary thyroid carcinoma. Univariate and multivariate analyses. Eur J Cancer 35:420–423CrossRefPubMed

Wada N, Duh QY, Sugino K et al (2003) Lymph node metastasis from 259 papillary thyroid microcarcinomas: frequency, pattern of occurrence and recurrence, and optimal strategy for neck dissection. Ann Surg 237:399–407CrossRefPubMed

10.

Mittendorf EA, Wang X, Perrier ND et al (2007) Follow up of patients with papillary thyroid cancer: in search of the optimal algorithm. J Am Coll Surg 205:239–247CrossRefPubMed

11.

Ahuja AT, Chow L, Chick W et al (1995) Metastatic cervical nodes in papillary carcinoma of the thyroid: ultrasound and histological correlation. Clin Radiol 50:229–231CrossRefPubMed

12.

Rosário PW, de Faria S, Bicalho L et al (2005) Ultrasonographic differentiation between metastatic and benign lymph nodes in patients with papillary thyroid carcinoma. J Ultrasound Med 24:1385–1389PubMed

13.

Langer JE, Mandel SJ (2008) Sonographic imaging of cervical lymph nodes in patients with thyroid cancer. Neuroimaging Clin N Am 18:479–489CrossRefPubMed

14.

Som PM, Brandwein M, Lidov M et al (1994) The varied presentations of papillary thyroid carcinoma cervical nodal disease: CT and MR findings. Am J Neuroradiol 15:1123–1128PubMed

15.

Pacini F, Cetani F, Miccoli P et al (1994) Outcome of 309 patients with metastatic differentiated thyroid carcinoma treated with radioiodine. World J Surg 18:600–604CrossRefPubMed

16.

Woodrum DT, Gauger PG (2005) Role of 131I in the treatment of well differentiated thyroid cancer. J Surg Oncol 89:114–121CrossRefPubMed

17.

Feine U, Lietzenmayer R, Hanke JP et al (1996) Fluorine-18-FDG and iodine-131-iodide uptake in thyroid cancer. J Nucl Med 37:1468–1472PubMed

18.

Wang W, Macapinlac H, Larson SM et al (1999) [18F]-2-fluoro-2-deoxy-D-glucose positron emission tomography localizes residual thyroid cancer in patients with negative diagnostic (131)I whole body scans and elevated serum thyroglobulin levels. J Clin Endocrinol Metab 84:2291–2302CrossRefPubMed

19.

Wang W, Larson SM, Tuttle RM et al (2001) Resistance of [18F]-fluorodeoxyglucose-avid metastatic thyroid cancer lesions to treatment with high-dose radioactive iodine. Thyroid 11:1169–1175CrossRefPubMed

20.

van den Brekel MW, Stel HV, Castelijns JA et al (1990) Cervical lymph node metastasis: assessment of radiologic criteria. Radiology 177:379–384PubMed

21.

Khoo ML, Asa SL, Witterick IJ et al (2002) Thyroid calcification and its association with thyroid carcinoma. Head Neck 24:651–655CrossRefPubMed

22.

Merino MJ, Middleton LP (2001) Pathology of thyroid. In: Pilch BZ (ed) Head and neck surgical pathology. Lippincott and Williams & Wilkins, Philadelphia, pp 358–363

23.

Ellison E, Lapuerta P, Martin SE (1998) Psammoma bodies in fine-needle aspirates of the thyroid: predictive value for papillary carcinoma. Cancer 84:169–175CrossRefPubMed

24.

Eisenkraft BL, Som PM (1999) The spectrum of benign and malignant etiologies of cervical node calcification. AJR Am J Roentgenol 172:1433–1437PubMed

25.

Shammas A, Degirmenci B, Mountz JM et al (2007) 18F-FDG PET/CT in patients with suspected recurrent or metastatic well-differentiated thyroid cancer. J Nucl Med 48:221–226PubMed

26.

Moog F, Linke R, Manthey N et al (2000) Influence of thyroid-stimulating hormone levels on uptake of FDG in recurrent and metastatic differentiated thyroid carcinoma. J Nucl Med 41:1989–1995PubMed

27.

Chin BB, Patel P, Cohade C et al (2004) Recombinant human thyrotropin stimulation of fluoro-D-glucose positron emission tomography uptake in well-differentiated thyroid carcinoma. J Clin Endocrinol Metab 89:91–95CrossRefPubMed

28.

Ma C, Kuang A, Xie J, Ma T (2005) Possible explanations for patients with discordant findings of serum thyroglobulin and 131I whole-body scanning. J Nucl Med 46:1473–1480PubMed

29.

Wang W, Larson SM, Fazzari M et al (2000) Prognostic value of [18F] fluorodeoxyglucose positron emission tomographic scanning in patients with thyroid cancer. J Clin Endocrinol Metab 85:1107–1113CrossRefPubMed

30.

Schoder H, Yeung HW (2004) Positron emission imaging of head and neck cancer, including thyroid carcinoma. Semin Nucl Med 34:180–197CrossRefPubMed

Titel: Can calcification predict 131I accumulation on metastatic lymph nodes in papillary thyroid carcinoma patients receiving 131I therapy? Comparison of CT, 131I WBS and 18F-FDG PET/CT
verfasst von: Koichiro Kaneko
Koichiro Abe
Shingo Baba
Yoshitaka Tanabe
Hidetake Yabuuchi
Masamitsu Hatakenaka
Masayuki Sasaki
Hiroshi Honda
Publikationsdatum: 01.02.2010
Verlag: Springer-Verlag
Erschienen in: European Radiology / Ausgabe 2/2010
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-009-1557-5

Update Radiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Can calcification predict ¹³¹I accumulation on metastatic lymph nodes in papillary thyroid carcinoma patients receiving ¹³¹I therapy? Comparison of CT, ¹³¹I WBS and ¹⁸F-FDG PET/CT