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Pediatric Nephrology

Erschienen in:

10.11.2018 | Review

Can childhood obesity influence later chronic kidney disease?

verfasst von: Lyda Jadresic, Richard J. Silverwood, Sanjay Kinra, Dorothea Nitsch

Erschienen in: Pediatric Nephrology | Ausgabe 12/2019

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Abstract

Childhood overweight and obesity affects more and more children. Whilst associations of childhood overweight with later outcomes such as hypertension, diabetes and cardiovascular disease have been well documented, less is known about the association of childhood overweight and obesity with kidney disease. We review the existing evidence for the association of childhood obesity with markers of childhood and adult kidney disease. Whilst there is some evidence for an association, studies have not been able to distinguish between childhood being a sensitive time to develop later kidney problems, or whether observed associations of childhood obesity with poor outcomes are driven by greater lifelong exposure to obesity.

de Onis M, Blossner M, Borghi E (2010) Global prevalence and trends of overweight and obesity among preschool children. Am J Clin Nutr 92:1257–1264PubMedCrossRef

Wang Y, Lobstein T (2006) Worldwide trends in childhood overweight and obesity. Int J Pediatr Obes 1:11–25PubMedCrossRef

Ng M, Fleming T, Robinson M, Thomson B, Graetz N, Margono C, Mullany EC, Biryukov S, Abbafati C, Abera SF, Abraham JP, Abu-Rmeileh NME, Achoki T, AlBuhairan FS, Alemu ZA, Alfonso R, Ali MK, Ali R, Guzman NA, Ammar W, Anwari P, Banerjee A, Barquera S, Basu S, Bennett DA, Bhutta Z, Blore J, Cabral N, Nonato IC, Chang J-C, Chowdhury R, Courville KJ, Criqui MH, Cundiff DK, Dabhadkar KC, Dandona L, Davis A, Dayama A, Dharmaratne SD, Ding EL, Durrani AM, Esteghamati A, Farzadfar F, Fay DFJ, Feigin VL, Flaxman A, Forouzanfar MH, Goto A, Green MA, Gupta R, Hafezi-Nejad N, Hankey GJ, Harewood HC, Havmoeller R, Hay S, Hernandez L, Husseini A, Idrisov BT, Ikeda N, Islami F, Jahangir E, Jassal SK, Jee SH, Jeffreys M, Jonas JB, Kabagambe EK, Khalifa SEAH, Kengne AP, Khader YS, Khang Y-H, Kim D, Kimokoti RW, Kinge JM, Kokubo Y, Kosen S, Kwan G, Lai T, Leinsalu M, Li Y, Liang X, Liu S, Logroscino G, Lotufo PA, Lu Y, Ma J, Mainoo NK, Mensah GA, Merriman TR, Mokdad AH, Moschandreas J, Naghavi M, Naheed A, Nand D, Narayan KMV, Nelson EL, Neuhouser ML, Nisar MI, Ohkubo T, Oti SO, Pedroza A, Prabhakaran D, Roy N, Sampson U, Seo H, Sepanlou SG, Shibuya K, Shiri R, Shiue I, Singh GM, Singh JA, Skirbekk V, Stapelberg NJC, Sturua L, Sykes BL, Tobias M, Tran BX, Trasande L, Toyoshima H, van de Vijver S, Vasankari TJ, Veerman JL, Velasquez-Melendez G, Vlassov VV, Vollset SE, Vos T, Wang C, Wang X, Weiderpass E, Werdecker A, Wright JL, Yang YC, Yatsuya H, Yoon J, Yoon S-J, Zhao Y, Zhou M, Zhu S, Lopez AD, Murray CJL, Gakidou E (2014) Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013;2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 384:766–781PubMedPubMedCentralCrossRef

World Health Organization (2018) Facts and figures on childhood obesity. http://www.who.int/end-childhood-obesity/facts/en/. Accessed 4th February 2018

Prospective Studies Collaboration (2009) Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies. Lancet 373:1083–1096PubMedCentralCrossRef

Lewington S, Whitlock G, Clarke R, Sherliker P, Emberson J, Halsey J, Qizilbash N, Peto R, Collins R (2007) Blood cholesterol and vascular mortality by age, sex, and blood pressure: a meta-analysis of individual data from 61 prospective studies with 55,000 vascular deaths. Lancet 370:1829–1839PubMedCrossRef

Singh AS, Mulder C, Twisk JW, van Mechelen W, Chinapaw MJ (2008) Tracking of childhood overweight into adulthood: a systematic review of the literature. Obes Rev 9:474–488PubMedCrossRef

Park MH, Falconer C, Viner RM, Kinra S (2012) The impact of childhood obesity on morbidity and mortality in adulthood: a systematic review. Obes Rev 13:985–1000PubMedCrossRef

Reilly JJ, Kelly J (2011) Long-term impact of overweight and obesity in childhood and adolescence on morbidity and premature mortality in adulthood: systematic review. Int J Obes 35:891–898CrossRef

10.

Wang Y, Chen X, Song Y, Caballero B, Cheskin LJ (2008) Association between obesity and kidney disease: a systematic review and meta-analysis. Kidney Int 73:19–33PubMedCrossRef

11.

Garofalo C, Borrelli S, Minutolo R, Chiodini P, De Nicola L, Conte G (2017) A systematic review and meta-analysis suggests obesity predicts onset of chronic kidney disease in the general population. Kidney Int 91:1224–1235PubMedCrossRef

12.

Neff KJ, Frankel AH, Tam FW, Sadlier DM, Godson C, le Roux CW (2013) The effect of bariatric surgery on renal function and disease: a focus on outcomes and inflammation. Nephrol Dial Transplant 28(Suppl 4):iv73–iv82PubMedCrossRef

13.

Li K, Zou J, Ye Z, Di J, Han X, Zhang H, Liu W, Ren Q, Zhang P (2016) Effects of bariatric surgery on renal function in obese patients: a systematic review and meta analysis. PLoS One 11:e0163907PubMedPubMedCentralCrossRef

14.

Lee AM, Charlton JR, Carmody JB, Gurka MJ, Deboer MD (2017) Metabolic risk factors in nondiabetic adolescents with glomerular hyperfiltration. Nephrol Dial Transplant 32:1517–1524PubMed

15.

Tajbakhsh R, Heshmat R, Safiri S, Vafaeenia M, Motlagh ME, Mansourian M, Beshtar S, Safari O, Asayesh H, Ansari H, Qorbani M, Kelishadi R (2017) Association of glomerular filtration rate with cardiometabolic risk factors in Iranian adolescents CASPIAN III study. Iran J Kidney Dis 11:345–351PubMed

16.

Marmarinos A, Garoufi A, Panagoulia A, Dimou S, Drakatos A, Paraskakis I, Gourgiotis D (2016) Cystatin-C levels in healthy children and adolescents: influence of age, gender, body mass index and blood pressure. Clin Biochem 49:150–153PubMedCrossRef

17.

Correia-Costa L, Afonso AC, Schaefer F, Guimaraes JT, Bustorff M, Guerra A, Barros H, Azevedo A (2015) Decreased renal function in overweight and obese prepubertal children. Pediatr Res 78:436–444PubMedCrossRef

18.

Di Bonito P, Sanguigno E, Forziato C, Di Fraia T, Moio N, Cavuto L, Sibilio G, Iardino MR, Di Carluccio C, Capaldo B (2014) Glomerular filtration rate and cardiometabolic risk in an outpatient pediatric population with high prevalence of obesity. Obesity 22:585–589PubMedCrossRef

19.

Ma YT, Xie X, Yang YN, Li XM, Zheng YY (2014) Relationship between serum creatinine and obesity in children in Xinjiang, China. Genet Mol Res 13:2409–2416PubMedCrossRef

20.

Soylemezoglu O, Duzova A, Yalcinkaya F, Arinsoy T, Suleymanlar G (2012) Chronic renal disease in children aged 5-18 years: a population-based survey in Turkey, the CREDIT-C study. Nephrol Dial Transplant 27(Suppl 3):46–51CrossRef

21.

Maitland K, Kiguli S, Opoka RO, Engoru C, Olupot-Olupot P, Akech SO, Nyeko R, Mtove G, Reyburn H, Lang T, Brent B, Evans JA, Tibenderana JK, Crawley J, Russell EC, Levin M, Babiker AG, Gibb DM, Group FT (2011) Mortality after fluid bolus in African children with severe infection. N Engl J Med 364:2483–2495PubMedCrossRef

22.

Koulouridis E, Georgalidis K, Kostimpa I, Koulouridis I, Krokida A, Houliara D (2010) Metabolic syndrome risk factors and estimated glomerular filtration rate among children and adolescents. Pediatr Nephrol 25:491–498PubMedCrossRef

23.

Cindik N, Baskin E, Agras PI, Kinik ST, Turan M, Saatci U (2005) Effect of obesity on inflammatory markers and renal functions. Acta Paediatrica 94:1732–1737PubMedCrossRef

24.

Hammer LD, Kraemer HC, Wilson DM, Ritter PL, Dornbusch SM (1991) Standardized percentile curves of body-mass index for children and adolescents. Am J Dis Child 145:259–263PubMed

25.

Pacifico L, Bonci E, Andreoli GM, Di Martino M, Gallozzi A, De Luca E, Chiesa C (2016) The impact of nonalcoholic fatty liver disease on renal function in children with overweight/obesity. Int J Mol Sci. https://doi.org/10.3390/ijms17081218 PubMedCentralCrossRef

26.

Bartz SK, Caldas MC, Tomsa A, Krishnamurthy R, Bacha F (2015) Urine albumin-to-creatinine ratio: a marker of early endothelial dysfunction in youth. J Clin Endocrinol Metab 100:3393–3399PubMedCrossRef

27.

Franchini S, Savino A, Marcovecchio ML, Tumini S, Chiarelli F, Mohn A (2015) The effect of obesity and type 1 diabetes on renal function in children and adolescents. Pediatr Diabetes 16:427–433PubMedCrossRef

28.

Falakaflaki B, Mazloomzadeh S, Moradzade A (2012) Comparison of renal function between normal-weight and overweight children. Indian J Nephrol 22:193–195PubMedPubMedCentralCrossRef

29.

Savino A, Pelliccia P, Giannini C, de Giorgis T, Cataldo I, Chiarelli F, Mohn A (2011) Implications for kidney disease in obese children and adolescents. Pediatr Nephrol 26:749–758PubMedCrossRef

30.

Xiao N, Jenkins TM, Nehus E, Inge TH, Michalsky MP, Harmon CM, Helmrath MA, Brandt ML, Courcoulas A, Moxey-Mims M, Mitsnefes MM (2014) Kidney function in severely obese adolescents undergoing bariatric surgery. Obesity 22:2319–2325PubMedCrossRef

31.

Larkins N, Teixeira-Pinto A, Craig J (2017) The population-based prevalence of albuminuria in children. Pediatr Nephrol 32:2303–2309PubMedCrossRef

32.

Cho H, Kim JH (2017) Prevalence of microalbuminuria and its associated cardiometabolic risk factors in Korean youth: data from the Korea National Health and Nutrition Examination Survey. PLoS One 12:e0178716PubMedPubMedCentralCrossRef

33.

Machluf Y, Fink D, Farkash R, Rotkopf R, Pirogovsky A, Tal O, Shohat T, Weisz G, Ringler E, Dagan D, Chaiter Y (2016) Adolescent BMI at Northern Israel: from trends, to associated variables and comorbidities, and to medical signatures. Medicine. https://doi.org/10.1097/MD.0000000000003022 PubMedPubMedCentralCrossRef

34.

Gracchi V, Van Den Belt SM, Küpers LK, Corpeleijn E, De Zeeuw D, Heerspink HJL (2016) Prevalence and distribution of (micro)albuminuria in toddlers. Nephrol Dial Transplant 31:1686–1692PubMedCrossRef

35.

Gurecka R, Koborova I, Sebek J, Sebekova K (2015) Presence of cardiometabolic risk factors is not associated with microalbuminuria in 14-to-20-years old Slovak adolescents: a cross-sectional, population study. PLoS One 10:e0129311PubMedPubMedCentralCrossRef

36.

Rutkowski B, Czarniak P, Krol E, Szczeoniak P, Zdrojewski T (2013) Overweight, obesity, hypertension and albuminuria in polish adolescents-results of the sopkard 15 study. Nephrol Dial Transplant 28:iv204–iv211PubMedCrossRef

37.

Okpere AN, Anochie IC, Eke FU (2012) Prevalence of microalbuminuria among secondary school children. Afr Health Sci 12:140–147PubMedPubMedCentralCrossRef

38.

Hirschler V, Molinari C, Maccallini G, Aranda C (2010) Is albuminuria associated with obesity in school children? Pediatr Diabetes 11:322–330PubMedCrossRef

39.

Haysom L, Williams RE, Hodson EM, Lopez-Vargas P, Roy LP, Lyle DM, Craig JC (2009) Cardiovascular risk factors in Australian indigenous and non-indigenous children: a population-based study. J Paediatr Child Health 45:20–27PubMedCrossRef

40.

Haysom L, Williams R, Hodson E, Lopez-Vargas P, Roy LP, Lyle D, Craig JC (2009) Risk of CKD in Australian indigenous and nonindigenous children: a population-based cohort study. Am J Kidney Dis 53:229–237PubMedCrossRef

41.

Haysom L, Williams R, Hodson EM, Lopez-Vargas PA, Roy LP, Lyle DM, Craig JC (2009) Natural history of chronic kidney disease in Australian indigenous and non-indigenous children: a 4-year population-based follow-up study. Med J Aust 190:303–306PubMedCrossRef

42.

Nguyen S, McCulloch C, Brakeman P, Portale A, Hsu CY (2008) Being overweight modifies the association between cardiovascular risk factors and microalbuminuria in adolescents. Pediatrics 121:37–45PubMedCrossRef

43.

Jafar TH, Chaturvedi N, Hatcher J, Khan I, Rabbani A, Khan AQ, Portman R, Schmid CH, Levey AS (2005) Proteinuria in South Asian children: prevalence and determinants. Pediatr Nephrol 20:1458–1465PubMedCrossRef

44.

Csernus K, Lanyi E, Erhardt E, Molnar D (2005) Effect of childhood obesity and obesity-related cardiovascular risk factors on glomerular and tubular protein excretion. Eur J Pediatr 164:44–49PubMedCrossRef

45.

Radhakishun NNE, Van Vliet M, Von Rosenstiel IA, Beijnen JH, Diamant M (2013) Limited value of routine microalbuminuria assessment in multi-ethnic obese children. Pediatr Nephrol 28:1145–1149PubMedCrossRef

46.

Lurbe E, Torro MI, Alvarez J, Aguilar F, Fernandez-Formoso JA, Redon J (2013) Prevalence and factors related to urinary albumin excretion in obese youths. J Hypertens 31:2230–2236PubMedCrossRef

47.

Sanad M, Gharib A (2011) Evaluation of microalbuminuria in obese children and its relation to metabolic syndrome. Pediatr Nephrol 26:2193–2199PubMedCrossRef

48.

Burgert TS, Dziura J, Yeckel C, Taksali SE, Weiss R, Tamborlane W, Caprio S (2006) Microalbuminuria in pediatric obesity: prevalence and relation to other cardiovascular risk factors. Int J Obes 30:273–280CrossRef

49.

Levey AS, Becker C, Inker LA (2015) Glomerular filtration rate and albuminuria for detection and staging of acute and chronic kidney disease in adults: a systematic review. JAMA 313:837–846PubMedPubMedCentralCrossRef

50.

Roos JF, Doust J, Tett SE, Kirkpatrick CM (2007) Diagnostic accuracy of cystatin C compared to serum creatinine for the estimation of renal dysfunction in adults and children—a meta-analysis. Clin Biochem 40:383–391PubMedCrossRef

51.

Miliku K, Bakker H, Dorresteijn EM, Cransberg K, Franco OH, Felix JF, Jaddoe VW (2017) Childhood estimates of glomerular filtration rate based on creatinine and cystatin C: importance of body composition. Am J Nephrol 45:320–326PubMedCrossRef

52.

Plumb LA, Pitcher D, Tse Y, Shield JP, Inward C, Sinha MD (2014) Longitudinal changes in body mass index following renal transplantation in UK children. Nephrol Dial Transplant 29:196–203PubMedCrossRef

53.

Boschetti SB, Nogueira PC, Pereira AM, Fisberg M, Pestana JO (2013) Prevalence, risk factors, and consequences of overweight in children and adolescents who underwent renal transplantation—short- and medium-term analysis. Pediatr Transplant 17:41–47PubMedCrossRef

54.

Mitsnefes MM, Khoury P, McEnery PT (2002) Body mass index and allograft function in pediatric renal transplantation. Pediatr Nephrol 17:535–539PubMedCrossRef

55.

Hanevold CD, Ho PL, Talley L, Mitsnefes MM (2005) Obesity and renal transplant outcome: a report of the North American Pediatric Renal Transplant Cooperative Study. Pediatrics 115:352–356PubMedCrossRef

56.

Ladhani M, Lade S, Alexander SI, Baur LA, Clayton PA, McDonald S, Craig JC, Wong G (2017) Obesity in pediatric kidney transplant recipients and the risks of acute rejection, graft loss and death. Pediatr Nephrol 32:1443–1450PubMedCrossRef

57.

Fowler SM, Kon V, Ma L, Richards WO, Fogo AB, Hunley TE (2009) Obesity-related focal and segmental glomerulosclerosis: normalization of proteinuria in an adolescent after bariatric surgery. Pediatr Nephrol 24:851–855PubMedCrossRef

58.

Nehus EJ, Khoury JC, Inge TH, Xiao N, Jenkins TM, Moxey-Mims MM, Mitsnefes MM (2017) Kidney outcomes three years after bariatric surgery in severely obese adolescents. Kidney Int 91:451–458PubMedCrossRef

59.

Patel HP, Saland JM, Ng DK, Jiang S, Warady BA, Furth SL, Flynn JT (2017) Waist circumference and body mass index in children with chronic kidney disease and metabolic, cardiovascular, and renal outcomes. J Pediatr 191:133–139PubMedPubMedCentralCrossRef

60.

Muntner P, Arshad A, Morse SA, Patel DA, Manapatra PD, Reisin E, Aguilar EA, Chen W, Srinivasan S, Berenson GS (2009) End-stage renal disease in young black males in a black-white population: longitudinal analysis of the Bogalusa Heart Study. BMC Nephrol 10:40PubMedPubMedCentralCrossRef

61.

Vivante A, Golan E, Tzur D, Leiba A, Tirosh A, Skorecki K, Calderon-Margalit R (2012) Body mass index in 1.2 million adolescents and risk for end-stage renal disease. Arch Intern Med 172:1644–1650PubMedPubMedCentralCrossRef

62.

Sundin PO, Udumyan R, Sjostrom P, Montgomery S (2014) Predictors in adolescence of ESRD in middle-aged men. Am J Kidney Dis 64:723–729PubMedCrossRef

63.

Ejerblad E, Fored CM, Lindblad P, Fryzek J, McLaughlin JK, Nyren O (2006) Obesity and risk for chronic renal failure. J Am Soc Nephrol 17:1695–1702PubMedCrossRef

64.

Silverwood RJ, Pierce M, Thomas C, Hardy R, Ferro C, Sattar N, Whincup P, Savage C, Kuh D, Nitsch D, National Survey of Health and Development Scientific and Data Collection Teams (2013) Association between younger age when first overweight and increased risk for CKD. J Am Soc Nephrol 24:813–821PubMedPubMedCentralCrossRef

65.

Silverwood RJ, Pierce M, Hardy R, Thomas C, Ferro C, Savage C, Sattar N, Kuh D, Nitsch D (2013) Early-life overweight trajectory and CKD in the 1946 British birth cohort study. Am J Kidney Dis 62:276–284PubMedPubMedCentralCrossRef

66.

Stevens PE, Levin A (2013) Evaluation and management of chronic kidney disease: synopsis of the kidney disease: improving global outcomes 2012 clinical practice guideline. Ann Intern Med 158:825–830CrossRefPubMed

67.

Yim HE, Yoo KH (2015) Early life obesity and chronic kidney disease in later life. Pediatr Nephrol 30:1255–1263PubMedCrossRef

68.

Wahba IM, Mak RH (2007) Obesity and obesity-initiated metabolic syndrome: mechanistic links to chronic kidney disease. Clin J Am Soc Nephrol 2:550–562PubMedCrossRef

69.

Helal I, Fick-Brosnahan GM, Reed-Gitomer B, Schrier RW (2012) Glomerular hyperfiltration: definitions, mechanisms and clinical implications. Nat Rev Nephrol 8:293–300PubMedCrossRef

70.

Henegar JR, Bigler SA, Henegar LK, Tyagi SC, Hall JE (2001) Functional and structural changes in the kidney in the early stages of obesity. J Am Soc Nephrol 12:1211–1217PubMedCrossRef

71.

Wolf G, Chen S, Han DC, Ziyadeh FN (2002) Leptin and renal disease. Am J Kidney Dis 39:1–11PubMedCrossRef

72.

Tomaszewski M, Charchar FJ, Maric C, McClure J, Crawford L, Grzeszczak W, Sattar N, Zukowska-Szczechowska E, Dominiczak AF (2007) Glomerular hyperfiltration: a new marker of metabolic risk. Kidney Int 71:816–821PubMedCrossRef

73.

Marlais M, Coward RJ (2015) Paediatrics, insulin resistance and the kidney. Pediatr Nephrol 30:1217–1224PubMedCrossRef

74.

Gunta SS, Mak RH (2013) Is obesity a risk factor for chronic kidney disease in children? Pediatr Nephrol 28:1949–1956PubMedCrossRef

75.

Savino A, Pelliccia P, Chiarelli F, Mohn A (2010) Obesity-related renal injury in childhood. Horm Res Paediatr 73:303–311PubMedCrossRef

76.

Silverwood RJ, Pierce M, Hardy R, Sattar N, Whincup P, Ferro C, Savage C, Kuh D, Nitsch D (2013) Low birth weight, later renal function, and the roles of adulthood blood pressure, diabetes, and obesity in a British birth cohort. Kidney Int 84:1262–1270PubMedPubMedCentralCrossRef

77.

Kuh D, Ben-Shlomo Y, Lynch J, Hallqvist J, Power C (2003) Life course epidemiology. J Epidemiol Community Health 57:778–783PubMedPubMedCentralCrossRef

78.

Abdullah A, Wolfe R, Stoelwinder JU, de Courten M, Stevenson C, Walls HL, Peeters A (2011) The number of years lived with obesity and the risk of all-cause and cause-specific mortality. Int J Epidemiol 40:985–996PubMedCrossRef

79.

de Koning L, Hu FB (2011) Commentary: obesity-years—a new metric to measure health effects of obesity. Int J Epidemiol 40:996–997PubMedCrossRef

80.

WHO (2010) Global status report on noncommunicable disease. World Health Organization, Geneva www.who.int/nmh/publications/ncd_report2010/en/

81.

Bailey PK, Tomson CR, Kinra S, Ebrahim S, Radhakrishna KV, Kuper H, Nitsch D, Ben-Shlomo Y (2013) The effect of rural-to-urban migration on renal function in an Indian population: cross-sectional data from the Hyderabad arm of the Indian migration study. BMC Nephrol 14:240PubMedPubMedCentralCrossRef

Titel: Can childhood obesity influence later chronic kidney disease?
verfasst von: Lyda Jadresic
Richard J. Silverwood
Sanjay Kinra
Dorothea Nitsch
Publikationsdatum: 10.11.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: Pediatric Nephrology / Ausgabe 12/2019
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-018-4108-y

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Can childhood obesity influence later chronic kidney disease?

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