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19.07.2016 | Urogenital

Can pre- and postoperative magnetic resonance imaging predict recurrence-free survival after whole-gland high-intensity focused ablation for prostate cancer?

verfasst von: Rémy Rosset, Flavie Bratan, Sébastien Crouzet, Hélène Tonoli-Catez, Florence Mège-Lechevallier, Albert Gelet, Olivier Rouvière

Erschienen in: European Radiology | Ausgabe 4/2017

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Abstract

Objectives

Our aim was to assess whether magnetic resonance imaging (MRI) features predict recurrence-free survival (RFS) after prostate cancer high-intensity focused ultrasound (HIFU) ablation.

Methods

We retrospectively selected 81 patients who underwent (i) whole-gland HIFU ablation between 2007 and 2011 as first-line therapy or salvage treatment after radiotherapy or brachytherapy, and (ii) pre- and postoperative MRI. On preoperative imaging, two senior (R1, R2) and one junior (R3) readers assessed the number of sectors invaded by the lesion with the highest Likert score (dominant lesion) using a 27-sector diagram. On postoperative imaging, readers assessed destruction of the dominant lesion using a three-level score. Multivariate analysis included the number of sectors invaded by the dominant lesion, its Likert and destruction scores, the pre-HIFU prostate-specific antigen (PSA) level, Gleason score, and the clinical setting (primary/salvage).

Results

The most significant predictor was the number of prostate sectors invaded by the dominant lesion for R2 and R3 (p≤0.001) and the destruction score of the dominant lesion for R1 (p = 0.011). The pre-HIFU PSA level was an independent predictor for R2 (p = 0.014), but with only marginal significance for R1 (p = 0.059) and R3 (p = 0.053).

Conclusion

The dominant lesion’s size and destruction assessed by MRI provide independent prognostic information compared with usual predictors.

Key Points

• The size of the MR-dominant lesion significantly influences post-HIFU recurrence-free survival.

• The destruction score of the MR-dominant lesion predicts post-HIFU recurrence-free survival.

• Patients with a completely devascularized MR-dominant lesion show better recurrence-free survival

• Pre- and post-HIFU MRI provide prognostic information independent of usual predictors.

Chapelon JY, Rouviere O, Crouzet S, Gelet A (2016) Prostate Focused Ultrasound Therapy. Adv Exp Med Biol 880:21–41CrossRefPubMed

Crouzet S, Chapelon JY, Rouviere O et al (2014) Whole-gland ablation of localized prostate cancer with high-intensity focused ultrasound: oncologic outcomes and morbidity in 1002 patients. Eur Urol 65(5):907–914CrossRefPubMed

Crouzet S, Murat FJ, Pommier P et al (2012) Locally recurrent prostate cancer after initial radiation therapy: early salvage high-intensity focused ultrasound improves oncologic outcomes. Radiother Oncol 105(2):198–202CrossRefPubMed

Ahmed HU, Cathcart P, McCartan N et al (2012) Focal salvage therapy for localized prostate cancer recurrence after external beam radiotherapy: a pilot study. Cancer 118(17):4148–4155CrossRefPubMed

Ahmed HU, Freeman A, Kirkham A et al (2011) Focal therapy for localized prostate cancer: a phase I/II trial. J Urol 185(4):1246–1254CrossRefPubMed

Ganzer R, Fritsche HM, Brandtner A et al (2013) Fourteen-year oncological and functional outcomes of high-intensity focused ultrasound in localized prostate cancer. BJU Int 112(3):322–329CrossRefPubMed

Bratan F, Niaf E, Melodelima C et al (2013) Influence of imaging and histological factors on prostate cancer detection and localisation on multiparametric MRI: a prospective study. Eur Radiol 23(7):2019–2029CrossRefPubMed

Turkbey B, Pinto PA, Mani H et al (2010) Prostate cancer: value of multiparametric MR imaging at 3 T for detection--histopathologic correlation. Radiology 255(1):89–99CrossRefPubMedPubMedCentral

Rouviere O, Vitry T, Lyonnet D (2010) Imaging of prostate cancer local recurrences: why and how? Eur Radiol 20(5):1254–1266CrossRefPubMed

10.

Donati OF, Jung SI, Vargas HA et al (2013) Multiparametric prostate MR imaging with T2-weighted, diffusion-weighted, and dynamic contrast-enhanced sequences: are all pulse sequences necessary to detect locally recurrent prostate cancer after radiation therapy? Radiology 268(2):440–450CrossRefPubMed

11.

Abd-Alazeez M, Ramachandran N, Dikaios N et al (2015) Multiparametric MRI for detection of radiorecurrent prostate cancer: added value of apparent diffusion coefficient maps and dynamic contrast-enhanced images. Prostate Cancer Prostatic Dis 18(2):128–136CrossRefPubMed

12.

Alonzo F, Melodelima C, Bratan F et al (2016) Detection of locally radio-recurrent prostate cancer at multiparametric MRI: Can dynamic contrast-enhanced imaging be omitted? Diagn Interv Imaging 97(4):433–441CrossRefPubMed

13.

Mozer P, Roupret M, Le Cossec C et al (2015) First round of targeted biopsies using magnetic resonance imaging/ultrasonography fusion compared with conventional transrectal ultrasonography-guided biopsies for the diagnosis of localised prostate cancer. BJU Int 115(1):50–57CrossRefPubMed

14.

Costa DN, Lotan Y, Rofsky NM et al (2016) Assessment of Prospectively Assigned Likert Scores for Targeted Magnetic Resonance Imaging-Transrectal Ultrasound Fusion Biopsies in Patients with Suspected Prostate Cancer. J Urol 195(1):80–87CrossRefPubMed

15.

Rouviere O, Lyonnet D, Raudrant A et al (2001) MRI appearance of prostate following transrectal HIFU ablation of localized cancer. Eur Urol 40(3):265–274CrossRefPubMed

16.

Kirkham AP, Emberton M, Hoh IM, Illing RO, Freeman AA, Allen C (2008) MR imaging of prostate after treatment with high-intensity focused ultrasound. Radiology 246(3):833–844CrossRefPubMed

17.

Fry FJ (1993) Intense focused ultrasound in medicine. Some practical guiding physical principles from sound source to focal site in tissue. Eur Urol 23(Suppl 1):2–7PubMed

18.

Boni RA, Sulser T, Jochum W, Romanowski B, Debatin JF, Krestin GP (1997) Laser ablation-induced changes in the prostate: findings at endorectal MR imaging with histologic correlation. Radiology 202(1):232–236CrossRefPubMed

19.

Beerlage HP, van Leenders GJ, Oosterhof GO et al (1999) High-intensity focused ultrasound (HIFU) followed after one to two weeks by radical retropubic prostatectomy: results of a prospective study. Prostate 39(1):41–46CrossRefPubMed

20.

Fite BZ, Wong A, Liu Y et al (2015) Magnetic resonance imaging assessment of effective ablated volume following high intensity focused ultrasound. PLoS ONE 10(3), e0120037CrossRefPubMedPubMedCentral

21.

Rouviere O, Girouin N, Glas L et al (2010) Prostate cancer transrectal HIFU ablation: detection of local recurrences using T2-weighted and dynamic contrast-enhanced MRI. Eur Radiol 20(1):48–55CrossRefPubMed

22.

Oto A, Kayhan A, Jiang Y et al (2010) Prostate cancer: differentiation of central gland cancer from benign prostatic hyperplasia by using diffusion-weighted and dynamic contrast-enhanced MR imaging. Radiology 257(3):715–723CrossRefPubMed

23.

Hoeks CM, Hambrock T, Yakar D et al (2013) Transition Zone Prostate Cancer: Detection and Localization with 3-T Multiparametric MR Imaging. Radiology 266(1):207–217CrossRefPubMed

24.

Chesnais AL, Niaf E, Bratan F et al (2013) Differentiation of transitional zone prostate cancer from benign hyperplasia nodules: evaluation of discriminant criteria at multiparametric MRI. Clin Radiol 68(6):e323–e330CrossRefPubMed

25.

Barentsz JO, Richenberg J, Clements R et al (2012) ESUR prostate MR guidelines 2012. Eur Radiol 22(4):746–757CrossRefPubMedPubMedCentral

26.

Vache T, Bratan F, Mege-Lechevallier F, Roche S, Rabilloud M, Rouviere O (2014) Characterization of prostate lesions as benign or malignant at multiparametric MR imaging: comparison of three scoring systems in patients treated with radical prostatectomy. Radiology 272(2):446–455CrossRefPubMed

27.

Uchida T, Shoji S, Nakano M et al (2009) Transrectal high-intensity focused ultrasound for the treatment of localized prostate cancer: eight-year experience. Int J Urol 16(11):881–886CrossRefPubMed

28.

Rouviere O, Sbihi L, Gelet A, Chapelon JY (2013) Salvage high-intensity focused ultrasound ablation for prostate cancer local recurrence after external-beam radiation therapy: prognostic value of prostate MRI. Clin Radiol 68(7):661–667CrossRefPubMed

29.

Cho S, Kang SH (2014) Current status of cryotherapy for prostate and kidney cancer. Korean J Urol 55(12):780–788CrossRefPubMedPubMedCentral

30.

Livraghi T, Goldberg SN, Lazzaroni S et al (2000) Hepatocellular carcinoma: radio-frequency ablation of medium and large lesions. Radiology 214(3):761–768CrossRefPubMed

31.

Gervais DA, McGovern FJ, Arellano RS, McDougal WS, Mueller PR (2005) Radiofrequency ablation of renal cell carcinoma: part 1, Indications, results, and role in patient management over a 6-year period and ablation of 100 tumors. AJR Am J Roentgenol 185(1):64–71CrossRefPubMed

32.

Salomon L, Colombel M, Patard JJ et al (1999) Value of ultrasound-guided systematic sextant biopsies in prostate tumor mapping. Eur Urol 35(4):289–293CrossRefPubMed

33.

Murat FJ, Poissonnier L, Rabilloud M et al (2009) Mid-term results demonstrate salvage high-intensity focused ultrasound (HIFU) as an effective and acceptably morbid salvage treatment option for locally radiorecurrent prostate cancer. Eur Urol 55(3):640–647CrossRefPubMed

34.

Anzai Y, Lufkin RB, Hirschowitz S, Farahani K, Castro DJ (1992) MR imaging-histopathologic correlation of thermal injuries induced with interstitial Nd:YAG laser irradiation in the chronic model. J Magn Reson Imaging 2(6):671–678CrossRefPubMed

35.

Barentsz JO, Weinreb JC, Verma S et al (2016) Synopsis of the PI-RADS v2 Guidelines for Multiparametric Prostate Magnetic Resonance Imaging and Recommendations for Use. Eur Urol 69(1):41–49CrossRefPubMed

36.

Rouviere O, Papillard M, Girouin N et al (2012) Is it possible to model the risk of malignancy of focal abnormalities found at prostate multiparametric MRI? Eur Radiol 22(5):1149–1157CrossRefPubMed

37.

Ahmed HU, Dickinson L, Charman S et al (2015) Focal Ablation Targeted to the Index Lesion in Multifocal Localised Prostate Cancer: a Prospective Development Study. Eur Urol 68(6):927–936CrossRefPubMed

38.

Haffner MC, Mosbruger T, Esopi DM et al (2013) Tracking the clonal origin of lethal prostate cancer. J Clin Invest 123(11):4918–4922CrossRefPubMedPubMedCentral

39.

Zelefsky MJ, Reuter VE, Fuks Z, Scardino P, Shippy A (2008) Influence of local tumor control on distant metastases and cancer related mortality after external beam radiotherapy for prostate cancer. J Urol 179(4):1368–1373, discussion 1373 CrossRefPubMedPubMedCentral

Titel: Can pre- and postoperative magnetic resonance imaging predict recurrence-free survival after whole-gland high-intensity focused ablation for prostate cancer?
verfasst von: Rémy Rosset
Flavie Bratan
Sébastien Crouzet
Hélène Tonoli-Catez
Florence Mège-Lechevallier
Albert Gelet
Olivier Rouvière
Publikationsdatum: 19.07.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 4/2017
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-016-4491-3

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Springer Medizin

Can pre- and postoperative magnetic resonance imaging predict recurrence-free survival after whole-gland high-intensity focused ablation for prostate cancer?

Abstract

Objectives

Methods

Results

Conclusion

Key Points

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Fünf Dinge, die im Kindernotfall besser zu unterlassen sind

„Nur wer sich gut aufgehoben fühlt, kann auch für Patientensicherheit sorgen“

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Abstract

Objectives

Methods

Results

Conclusion

Key Points

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