Can two different TCRs that react with the same peptide-MHC complex influence the differentiation of naive CD4 T cells?

Excerpt

Several studies have demonstrated that antigenic peptides can modulate the magnitude of T cell activation by influencing the rate of phosphorylation by protein kinases in the T cells and by controlling the direction of the functional immune response. For example, high doses of moth cytochrome c peptide induced a Th1 commitment in vivo, while low doses of the peptide drove Th2 differentiation. Likewise, agonist peptides forming high affinity interactions with the MHC molecule favored Th1 differentiation of naive CD4⁺ T cells, whereas altered peptide ligands with affinities either for the presenting MHC or for the TCR favored Th2 differentiation. Moreover, the MHC haplotype itself might influence T cell differentiation as MHC molecules that bound to a peptide with high avidity promoted Th1 differentiation, in contrast to MHC molecules expressing a lower avidity for the given peptide, which favored Th2 differentiation. To investigate whether a single amino acid alteration in the TCR's peptide contacting residues affects the differentiation of naive CD4⁺T cells in response to priming with antigenic peptide. …