Ausgabe Sonderheft 1/2014
Metabolism, Diet and Disease 2014: Cancer and metabolism
Inhalt (98 Artikel)
Metabolic analysis of the loss of Rb1 in vivo
Brandon N Nicolay, Paul S Danielian, Wilhelm Haas, Gregory Stephanopoulos, Jacqueline A Lees, Nicholas J Dyson
Fructose-2,6-bisphosphate links glucose to survival and growth
Abdullah Yalcin, Yoannis Imbert-Fernandez, Amy Clem, Julie O’Neal, Sucheta Telang, Brian Clem, Jason Chesney
Nutrition and metabolic factors in cancer causation and prevention
Elio Riboli
A hypothetical means of treating or preventing cancer
Steven L McKnight
Acetyl-coA synthetase 2 promotes acetate utilization and maintains cell growth under metabolic stress
Zachary Schug, Barrie Peck, Dylan Jones, Qifeng Zhang, Israt Alam, Tim Witney, Elizabeth Smethurst, Shaun Grosskurth, Adrian Harris, Susan Critchlow, Eric Aboagye, Michael Wakelam, Almut Schulze, Eyal Gottlieb
Antagonistic effects of MYC and hypoxia in channeling glucose and glutamine into de novo nucleotide biosynthesis
Teresa Fan, Anne Le, Zachary Stine, Ye Yang, Karen Zeller, Weiqiang Zhou, Hongkai Ji, Richard Higashi, Chi Dang, Andrew Lane
Role of autophagy in K-RAS- and B-RAF-driven lung cancers
Eileen White
The mitochondrial pyruvate carrier as a mediator of the Warburg Effect and its impact on cancer growth and metabolism
John Schell, Kristofor Olson, Jared Rutter
Regulation of metabolism by a neuroendocrine FGF signaling pathway
David J Mangelsdorf, Steven A Kliewer
Loss of SIRT3 leads to a compensatory shift in cellular metabolism promoting cancer cell growth
Eoin McDonnell, Olga R Ilkayeva, Robert D Stevens, Michael J Muehlbauer, James R Bain, Tomas C Becker, Matthew D Hirschey
A Drosophila model linking diet-induced metabolic disease and cancer
Susumu Hirabayashi, Thomas Baranski, Ross Cagan
The high colon cancer risk in African Americans can be reduced by dietary modification
Stephen O’Keefe
AMPK regulated metabolic programing: oncogenic or growth suppressive? Evolving lessons from genetic and pharmacologic studies
Xiaona Liu, Rishi Raj Chhipa, Lionel ML Chow, Matthew Wortman, Christopher McPherson, Ady Kendler, Biplab Dasgupta
Metformin targets the GTPase Rac1 to inhibit prostate cancer cell migration
Béatrice Dirat, Isabelle Ader, Muriel Golzio, Amel Mettouchi, Kathiane Laurent, Frédéric Larbret, Bernard Malavaud, Mireille Cormont, Emmanuel Lemichez, Jean François Tanti, Frédéric Bost
Biguanide therapy for diabetes and cancer & a novel methyltransferase that regulates energy expenditure and adiposity and is elevated in many cancers
Barbara B Kahn, Daniel Kraus, Qin Yang
Energy balance at the organism and cellular level: effects of biguanides
Michael Pollak
Can inhibiting insulin/IGF signaling with dietary carbohydrate restriction play a role in treatment/prevention of cancers?
Eugene J Fine, C Segal-Isaacson, Silvia Herzkopf, Joseph Sparano, Maria Romano, Richard Feinman, Nora Tomuta, Amanda Bontempo, Abdissa Negassa
A metabolic map of hematopoietic stem cells
Michalis Agathocleous, Zeping Hu, Sean Morrison
Doxorubicin leads to impaired insulin signaling in skeletal muscle
Edson Alves de Lima Junior, Camila Oliveira de Souza, Alexandre Abílio de Souza Teixeira, Helena Angélica Batatinha, Fábio de Santos Lira, José César Rosa Neto
Dual mode of action of metformin on mitochondrial metabolism
Sylvia Andrzejewski, Simon-Pierre Gravel, Julie St-Pierre, Michael N Pollak
Adipose tissue homeostasis is deeply disrupted by doxorubicin treatment
Helena Batatinha, Camila Souza, Edson Lima, Maria Isabel Alonso-Vale, Maysa Cruz, Roberta Da Cunha, Fabio Lira, Jose Rosa
mTORC1 stimulates nucleotide synthesis through both transcriptional and post-translational mechanisms
Issam Ben-Sahra, Stephane Ricoult, Jessica Howell, John Asara, Brendan Manning
Profiling metabolic changes in breast cancer with targeted proteomics
Stephan Bernhardt, Devina Mitra, Zita Soons, Rainer König, Martina Vetter, Christoph Thomssen, Eva Kantelhardt, Stefan Wiemann, Ulrike Korf
1H Nuclear magnetic resonance based targeted profiling of metabolic responses induced by DNA damaging agents and PARP inhibition in MCF-7 cells
Vijesh Bhute, Daniel Beard, Stephen Kron, Sean Palecek
Dichloroacetate is an effective treatment for sarcoma models in vitro and in vivo
Melissa Rooke, Lucy A Coupland, Thy Truong, Anneke C Blackburn
Chemoprevention with the metabolism modifying drugs dichloroacetate and metformin in the Li-Fraumeni Syndrome model, Trp53 +/- mice
Anneke C Blackburn, Melissa Rooke, Yiming Li, Jane E Dahlstrom, Philip G Board
Biochemical and biophysical characterization of pyruvate kinase M2 activation by L-serine
Barbara Chaneton, Finn Holding, Adam Hold, Jiska Van Der Reest, Gabriele Marciano, Marc O’Reilly, Eyal Gottlieb
Metabolic diversity in human non-small cell lung cancer
Pei-Hsuan Chen, Ling Cai, Hyun Seok Kim, Rebecca Britt, Guanghua Xiao, Michael A White, John D Minna, Ralph J DeBerardinis
Discovery of a PFKFB3 inhibitor for phase I trial testing that synergizes with the B-Raf inhibitor vemurafenib
Sucheta Telang, Julie O’Neal, Gilles Tapolsky, Brian Clem, Alan Kerr, Yoannis Imbert-Ferndandez, Jason Chesney
The in vivo function of TIGAR, a p53 target gene that regulates glucose metabolism
Eric Cheung, Pearl Lee, Celia Berkers, Karen Blyth, Owen Sansom, Karen Vousden
Inhibiting glucose-regulated protein 78 modulates lipid metabolism through controlling stearoyl-CoA desaturase 1
Katherine Cook, Pamela Clarke, Anni Warri, Robert Clarke
Altered cancer cell metabolism and cachexia: Calculating the energetic cost of cancer
Douglas Friesen, Vickie Baracos, Jack Tuszynski
Effects of the ghrelin receptor agonist anamorelin on lean body mass in cancer patients with cachexia; results from a Phase II randomized, double blind, multicenter study
Jose M Garcia, Ying Yan, Elizabeth Manning-Duus, John Friend
Investigation of the role of Ras and other signaling kinases on the regulation of pyruvate dehydrogenase complex activity
Antonio Garcia-Trinidad, Nicky Whalley, Susan Critchlow
Extracts from medicinal plants inhibit cancer cell proliferation, induce apoptosis in ovary, lung and neuronal cancer cell lines
Wafa Ghali, David Vaudry, Thierry Jouenne, Mohamed Nejib Marzouki
Metformin suppresses pediatric acute myeloid leukemia cell viability and clonogenicity
Anilkumar Gopalakrishnapillai, E Anders Kolb, Sonali Barwe
Chemosensitization of leukemia cells through inhibition of NAMPT
Theresa Gorski, Stefanie Petzold-Quinque, Susanne Schuster, Melanie Penke, Sandy Richter, Wieland Kiess, Antje Garten
Influence of polyphenol-rich apple pomace extract on oxidative damage to DNA in type 2 diabetes mellitus individuals
Annemarie Grindel, Elisabeth Müllner, Helmut Brath, Walther Jäger, Trine Henriksen, Henrik Enghusen Poulsen, Doris Marko, Karl-Heinz Wagner
Radiation-induction of MMPs limited the NK-mediated anticancer immunity in lung cancer cells
Woong Heo, Young Shin Lee, Cheol Hun Son, Kwang Mo Yang, You Soo Park, Jae Ho Bae
Inhibition of glutamine uptake regulates mTORC1, glutamine metabolism and cell growth in prostate cancer
Qian Wang, Rae-Anne Hardie, Seher Balaban, Mark Schreuder, Andrew Hoy, Michelle van Geldermalsen, Ladan Fazli, Rajini Nagarajah, Charles Bailey, John Rasko, Jeff Holst
Mechanisms and consequences of hepatic regulation of mTORC1 by metformin
Jessica J Howell, Kristina Hellberg, Reuben J Shaw, Brendan D Manning
Simultaneous inhibition of the estrogen receptor and 6-phosphofructo-2-kinase (PFKFB3) for the treatment of ER+ breast cancer
Yoannis Imbert-Fernandez, Sucheta Telang, Jason Chesney
Reductive carboxylation mediated oxidative stress defense supports anchorage independent cell growth
Lei Jiang, Matthew Mitsche, Ralph Deberardinis, Karine Smans
CRTC1 transcriptional coactivator is required for hepatitis B virus gene expression and replication
Hei-Man Vincent Tang, Wei-Wei Gao, Chi-Ping Chan, Kin-Hang Kok, Dong-Yan Jin
A metabolic signature of colon cancer initiating cells
Christelle Johnson, Kai-Yuan Chen, Xiaojing Liu, Pengcheng Bu, Jason Locasale, Xiling Shen
Quantifying the demand for central carbon metabolism precursors for biosynthesis in proliferating cells
Mark Keibler, Thomas Wasylenko, Joanne Kelleher, Gregory Stephanopoulos
The biochemical mechanism of hypoxia-induced mobilization of glycogen in cultured cancer cell
Mung Kwan Long, Wong Nai Sum
Quantification of NADPH balance during adipogenesis
Ling Liu, Supriya Shah, Jing Fan, Kathryn Wellen, Joshua Rabinowitz
LC-MS and GC-MS based metabolomics platform for cancer research
Wenyun Lu, Sisi Zhang, Xin Teng, Eugene Melamud, Mitchell A Lazar, Eileen White, Joshua D Rabinowitz
Roles of endocrine FGF signaling in metabolic health and cancer
Yongde Luo, James Abbruzzese, Wallace McKeehan
Pancreatic cancers depend on a non-canonical glutamine metabolism pathway
Costas Lyssiotis, Jaekyoung Son, Joesph Mancias, Haoqiang Ying, Alec Kimmelman, Lewis Cantley
Associations between diet, gut microbiota and markers of CRC risk
Tyler Culpepper, Maria Ukhanova, Xiaoyu Wang, Yijun Sun, Volker Mai
Metabolic transformations in breast cancer subtypes
Devina Mitra, Stephan Bernhardt, Zita Soons, Gernot Poschet, Ruediger Hell, Rainer Koenig, Ulrike Korf, Stefan Wiemann
Extracellular lactate cooperates with limited glucose and glutamine to sustain breast cancer cell survival by providing ATP, NADPH, amino acids, and glutathione
Jennifer Molina, Pietro Morlacchi, Leslie Silva, Jennifer Dennison, Gordon Mills
Palmitoleate attenuates diet induced insulin resistance and hepatic inflammation independently of PPAR-α
Camila O Souza, Alexandre A de S Teixeira, Edson A de Lima, Helena A Batatinha, Sandro M Hirabara, William T Festuccia, José Cesar Rosa Neto
Comprehensive quantitation of metabolite concentrations, gross reaction fluxes, and reaction free energies across cells from four organisms
Junyoung Park, Sara Rubin, Yi-Fan Xu, Daniel Amador-Noguez, Jing Fan, Joshua Rabinowitz
Investigating the role of inorganic phosphate in tumor metabolism and metastasis
Cesar Perez Ramirez, Dorothea Fiedler
Metabolic mechanisms regulating distinct steps of the melanoma metastatic cascade
Elena Piskounova, Michalis Agathocleous, Zeping Hu, Sean Morrison
Pyruvate dehydrogenase activity is required for optimal growth under lipid deficient conditions
Kartik Rajagopalan, Ralph DeBerardinis
Mitochondrial complex I modulation targets metabolic plasticity in breast cancer cells
V Krishnan Ramanujan, Qijin Xu, Eva Biener-Ramanujan
Metabolic biomarkers for the differential diagnosis of pancreatic ductal adenocarcinoma vs. chronic pancreatitis
Julia Mayerle, Holger Kalthoff, Regina C Reszka, Beate Kamlage, Erik Peter, Bodo Schniewind, Sandra González-Maldonado, Volker Liebenberg, Christian Pilarsky, Philipp Schatz, Jonas A Schreiber, Ulrich F Weiss, Robert Grützmann
Troglitazone suppresses tumor cell growth and glutamine metabolism through a PPAR-independent mechanism
Miriam Reynolds, Brian Clem
Oncogenic signaling upstream of mTORC1 drives lipogenesis and proliferation through SREBP
Stéphane Ricoult, Jessica Yecies, Brendan Manning
Mitochondria, metabolism and cancer: a growing role in cancer cell differentiation and cancer cell dormancy
Roberto Scatena, Patrizia Bottoni, Bruno Giardina
Resveratrol differentially regulates NAMPT and SIRT1 in hepatocarcinoma cells and primary human hepatocytes
Susanne Schuster, Melanie Penke, Theresa Gorski, Anja Barnikol-Oettler, Rolf Gebhardt, Wieland Kiess, Antje Garten
Glutamine metabolism and the unfolded protein response in MYC-driven breast cancer
Ayesha Shajahan-Haq, Katherine Cook, Jessica Schwartz-Roberts, Ahreej Eltayeb, Diane Demas, Anni Warri, Leena Hilakivi-Clarke, Robert Clarke
Identifying metabolomic features that predict metastasis of melanoma from a primary site
Xiaolei Shi, Zeping Hu, Elena Piskounova, Michalis Agathocleous, Sean Morrison, Ralph DeBerardinis
Characterization of the different S6Ks isoforms interacting partners
Isadora Pavan, Flávia Ferreira, Lidia de Freitas, Mariana Tavares, Camila do Amaral, Fernando Simabuco
A role for central carbon metabolism in mammalian embryonic development?
Marteinn Snaebjornsson, Nicole Prior, Vinay Bulusu, Bernd Simon, Teresa Carlomagno, Alexander Aulehla
Catechin-rich green tea extract increases the expression of genes of the cholesterol synthetic pathways in livers of normal diet- and high-fat diet-fed rats
Toshikazu Suzuki, Mayumi Nagata, Ayumi Takagi
Long-term hospitalized elderly people have lowered L-carnitine and coenzyme Q10 in blood than healthy elderly people
Michiyo Takahashi, Toshikazu Suzuki, Hikaru Matsumoto, Hitoshi Nukada, Naotaka Hashizume
Short treatment of metformin attenuated insulin resistance and hepatic steatosis in obese mice by mechanisms independents of PPAR-alpha
Alexandre Teixeira, Camila Souza, Edson Lima, Helena Batatinha, José Rosa Neto
The kinase domain of PFKFB4 is required to stimulate the glucose metabolism and growth of H460 xenografts
J Clark, Y Imbert-Fernandez, J Chesney, S Telang
Human phosphoglycerate dehydrogenase produces the oncometabolite D-2-hydroxyglutarate and promotes histone methylation
Jing Fan, Xin Teng, Ling Liu, Ryan Looper, Joshua Rabinowitz
Disruption of the endocannabinoid system is prominent in lung adenocarcinoma and associated with poor patient survival
Kelsie Thu, Roland Hubaux, Stephen Lam, Wan Lam
Pioglitazone and thyroid cancer risk in patients with type 2 diabetes
Chin-Hsiao Tseng
Mesenchymal phenotype predisposes lung cancer cells to impaired proliferation and redox stress in response to glutaminase inhibition
Danielle Ulanet, Abhishek Jha, Kiley Couto, Sung Choe, Amanda Wang, Hin-Koon Woo, Mya Steadman, Byron DeLaBarre, Stefan Gross, Edward Driggers, Marion Dorsch, Jonathan Hurov
The NADP+-dependent IDH1 mutation and its relevance for glioblastoma patient survival
Cornelis JF Van Noorden
Cell proliferation and tissue remodeling are major determinants of cancer metabolism and the response to drugs targeting metabolism
Elke Markert, Philip Tedeschi, Sonia Dolphi, Kim Hirshfield, Joseph Bertino, Zoltan Oltvai, Alexei Vazquez
The power of natural phenolic compounds: caffeic acid is able to enhance the retinoid-induced differentiation of tumor cells
Renata Veselska, Petr Chlapek, Miroslava Krzyzankova, Silvia Chovanova, Jakub Neradil, Karel Zitterbart, Jaroslav Sterba
Lung tumors and non-malignant airways from patients with chronic lung inflammatory disease bear distinct genetic and epigenetic disruptions corresponding to metabolic processes involved in senescence and methylation
Emily Vucic, Kelsie Thu, Victor Martinez, Chiara Pastrello, John Yee, Igor Jurisica, Stephen Lam, Wan Lam
Glycine decarboxylase is a target for transcriptional repressor Snail
Guohua Chen, Stephanie Lucas, Jian Wang
Metformin down-regulates epithelial-mesenchymal transition (EMT) in fibroblasts from burned patients
Michael Wetzel, David Herndon, Celeste Finnerty
The interaction of botanicals and AMPK signaling in the inhibition of castrate-resistant prostate cancer
Jay Whelan, Yi Zhao
Phosphoinositide 3-Kinase regulates glycolysis through mobilization of Aldolase A from the actin cytoskeleton
Hai Hu, Ashish Juvekar, Costas Lyssiotis, John G Albeck, Dean R Tolan, John M Asara, Gerburg M Wulf, Lewis C Cantley
Metabolic reprogramming by KSHV in cellular transformation
Ying Zhu, Suzane Ramos da Silva, Shou-Jiang Gao
Preventing feedback activation of glycolytic ATP production enhances metformin cytotoxicity in breast cancer cells when oxidative phosphorylation is inhibited
Yongxian Zhuang, Daniel K Chan, W Keith Miskimins
Metformin inhibits urothelial tumorigenesis in the UPII-mutant Ha-ras transgenic mouse model
Zhongbo Liu, Noriko Yokoyama, Michael Pollak, Xiaolin Zi