Ausgabe 1/2020
Inhalt (29 Artikel)
Tissue of origin dictates GOT1 dependence and confers synthetic lethality to radiotherapy
Barbara S. Nelson, Lin Lin, Daniel M. Kremer, Cristovão M. Sousa, Cecilia Cotta-Ramusino, Amy Myers, Johanna Ramos, Tina Gao, Ilya Kovalenko, Kari Wilder-Romans, Joseph Dresser, Mary Davis, Ho-Joon Lee, Zeribe C. Nwosu, Scott Campit, Oksana Mashadova, Brandon N. Nicolay, Zachary P. Tolstyka, Christopher J. Halbrook, Sriram Chandrasekaran, John M. Asara, Howard C. Crawford, Lewis C. Cantley, Alec C. Kimmelman, Daniel R. Wahl, Costas A. Lyssiotis
Metabolic regulation of calcium pumps in pancreatic cancer: role of phosphofructokinase-fructose-bisphosphatase-3 (PFKFB3)
D. A. Richardson, P. Sritangos, A. D. James, A. Sultan, J. I. E. Bruce
Metabolic models predict bacterial passengers in colorectal cancer
Daniel R. Garza, Rahwa Taddese, Jakob Wirbel, Georg Zeller, Annemarie Boleij, Martijn A. Huynen, Bas E. Dutilh
Glutaminase-1 (GLS1) inhibition limits metastatic progression in osteosarcoma
L. Ren, V. Ruiz-Rodado, T. Dowdy, S. Huang, S. H. Issaq, J. Beck, H. Wang, C. Tran Hoang, A. Lita, M. Larion, A. K. LeBlanc
Common biochemical properties of metabolic genes recurrently dysregulated in tumors
Krishnadev Oruganty, Scott Edward Campit, Sainath Mamde, Costas A. Lyssiotis, Sriram Chandrasekaran
PHGDH supports liver ceramide synthesis and sustains lipid homeostasis
Yun Pyo Kang, Aimee Falzone, Min Liu, Paloma González-Sánchez, Bo-Hyun Choi, Jonathan L. Coloff, James J. Saller, Florian A. Karreth, Gina M. DeNicola
Fumarate hydratase-deficient renal cell carcinoma cells respond to asparagine by activation of the unfolded protein response and stimulation of the hexosamine biosynthetic pathway
Rony Panarsky, Daniel R. Crooks, Andrew N. Lane, Youfeng Yang, Teresa A. Cassel, Teresa W.-M. Fan, W. Marston Linehan, Jeffrey A. Moscow
Fine-tuning the metabolic rewiring and adaptation of translational machinery during an epithelial-mesenchymal transition in breast cancer cells
Tamara Fernández-Calero, Marcos Davyt, Karen Perelmuter, Cora Chalar, Giovana Bampi, Helena Persson, Juan Pablo Tosar, Völundur Hafstað, Hugo Naya, Carlos Rovira, Mariela Bollati-Fogolín, Ricardo Ehrlich, Gilles Flouriot, Zoya Ignatova, Mónica Marín
Glutamine uptake and utilization of human mesenchymal glioblastoma in orthotopic mouse model
Kristell Oizel, Chendong Yang, Ophelie Renoult, Fabien Gautier, Quyen N. Do, Noemie Joalland, Xiaofei Gao, Bookyung Ko, François Vallette, Woo-Ping Ge, François Paris, Ralph J. DeBerardinis, Claire Pecqueur
Metformin sensitizes therapeutic agents and improves outcome in pre-clinical and clinical diffuse large B-cell lymphoma
Anil R. Singh, Juan J. Gu, Qunling Zhang, Pallawi Torka, Suchitra Sundaram, Cory Mavis, Francisco J. Hernandez-Ilizaliturri
Therapy-induced lipid uptake and remodeling underpin ferroptosis hypersensitivity in prostate cancer
Kaylyn D. Tousignant, Anja Rockstroh, Berwyck L. J. Poad, Ali Talebi, Reuben S. E. Young, Atefeh Taherian Fard, Rajesh Gupta, Tuo Zang, Chenwei Wang, Melanie L. Lehman, Johan V. Swinnen, Stephen J. Blanksby, Colleen C. Nelson, Martin C. Sadowski
Modulating pyrimidine ribonucleotide levels for the treatment of cancer
Tanzina Mollick, Sonia Laín
Disruption of hypoxia-inducible fatty acid binding protein 7 induces beige fat-like differentiation and thermogenesis in breast cancer cells
Masahiro Kawashima, Karim Bensaad, Christos E. Zois, Alessandro Barberis, Esther Bridges, Simon Wigfield, Christoffer Lagerholm, Ruslan I. Dmitriev, Mariko Tokiwa, Masakazu Toi, Dmitri B. Papkovsky, Francesca M. Buffa, Adrian L. Harris
Tumor-associated collagen signatures: pushing tumor boundaries
Elizabeth A. Brett, Matthias A. Sauter, Hans-Günther Machens, Dominik Duscher
Metabolite AutoPlotter - an application to process and visualise metabolite data in the web browser
Matthias Pietzke, Alexei Vazquez
Fructose contributes to the Warburg effect for cancer growth
Takahiko Nakagawa, Miguel A. Lanaspa, Inigo San Millan, Mehdi Fini, Christopher J. Rivard, Laura G. Sanchez-Lozada, Ana Andres-Hernando, Dean R. Tolan, Richard J. Johnson
Treatment of ErbB2 breast cancer by mitochondrial targeting
Sophia Eldad, Rachel Hertz, Gilad Vainer, Ann Saada, Jacob Bar-Tana
Correction to: Disruption of hypoxia-inducible fatty acid binding protein 7 induces beige fat-like differentiation and thermogenesis in breast cancer cells
Masahiro Kawashima, Karim Bensaad, Christos E. Zois, Alessandro Barberis, Esther Bridges, Simon Wigfield, Christoffer Lagerholm, Ruslan I. Dmitriev, Mariko Tokiwa, Masakazu Toi, Dmitri B. Papkovsky, Francesca M. Buffa, Adrian L. Harris
Metabolic plasticity imparts erlotinib-resistance in pancreatic cancer by upregulating glucose-6-phosphate dehydrogenase
Neha Sharma, Alok Bhushan, Jun He, Gagan Kaushal, Vikas Bhardwaj
The conversion of formate into purines stimulates mTORC1 leading to CAD-dependent activation of pyrimidine synthesis
Jacqueline Tait-Mulder, Kelly Hodge, David Sumpton, Sara Zanivan, Alexei Vazquez
Body mass index-associated molecular characteristics involved in tumor immune and metabolic pathways
Chao Hu, Xiong Chen, Chengyun Yao, Yu Liu, Haojun Xu, Guoren Zhou, Hongping Xia, Jinglin Xia
Disruption of redox homeostasis for combinatorial drug efficacy in K-Ras tumors as revealed by metabolic connectivity profiling
Daniela Gaglio, Marcella Bonanomi, Silvia Valtorta, Rohit Bharat, Marilena Ripamonti, Federica Conte, Giulia Fiscon, Nicole Righi, Elisabetta Napodano, Federico Papa, Isabella Raccagni, Seth J. Parker, Ingrid Cifola, Tania Camboni, Paola Paci, Anna Maria Colangelo, Marco Vanoni, Christian M. Metallo, Rosa Maria Moresco, Lilia Alberghina
Metabolic plasticity of IDH1-mutant glioma cell lines is responsible for low sensitivity to glutaminase inhibition
Victor Ruiz-Rodado, Adrian Lita, Tyrone Dowdy, Orieta Celiku, Alejandra Cavazos Saldana, Herui Wang, Chun Zhang Yang, Raj Chari, Aiguo Li, Wei Zhang, Hua Song, Meili Zhang, Susie Ahn, Dionne Davis, Xiang Chen, Zhengping Zhuang, Christel Herold-Mende, Kylie J. Walters, Mark R. Gilbert, Mioara Larion
Treatment of glioblastoma multiforme with “classic” 4:1 ketogenic diet total meal replacement
Pavel Klein, Ivana Tyrlikova, Giulio Zuccoli, Adam Tyrlik, Joseph C. Maroon
The effect of statin treatment on intratumoral cholesterol levels and LDL receptor expression: a window-of-opportunity breast cancer trial
Maria Feldt, Julien Menard, Ann H. Rosendahl, Barbara Lettiero, Pär-Ola Bendahl, Mattias Belting, Signe Borgquist
Deficiency of malate-aspartate shuttle component SLC25A12 induces pulmonary metastasis
H. Furkan Alkan, Paul W. Vesely, Hubert Hackl, Johannes Foßelteder, Daniel R. Schmidt, Matthew G. Vander Heiden, Martin Pichler, Gerald Hoefler, Juliane G. Bogner-Strauss
Protein synthesis inhibitors stimulate MondoA transcriptional activity by driving an accumulation of glucose 6-phosphate
Blake R. Wilde, Mohan R. Kaadige, Katrin P. Guillen, Andrew Butterfield, Bryan E. Welm, Donald E. Ayer
Estrogen-related receptor alpha directly binds to p53 and cooperatively controls colon cancer growth through the regulation of mitochondrial biogenesis and function
Humberto De Vitto, Joohyun Ryu, Ali Calderon-Aparicio, Josh Monts, Raja Dey, Abhijit Chakraborty, Mee-Hyun Lee, Ann M. Bode, Zigang Dong
In vivo assessment of glutamine anaplerosis into the TCA cycle in human pre-malignant and malignant clonal plasma cells
Wilson I. Gonsalves, Jin Sung Jang, Erik Jessen, Taro Hitosugi, Laura A. Evans, Dragan Jevremovic, Xuan-Mai Pettersson, Alexander Graham Bush, Jaimee Gransee, Emilie I. Anderson, Shaji K. Kumar, K. Sreekumaran Nair