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Sport Sciences for Health

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06.03.2022 | Original Article

Cardioprotective effects of exercise and curcumin supplementation against myocardial ischemia–reperfusion injury

verfasst von: Zahra Sayevand, Farzad Nazem, Afshin Nazari, Mohsen Sheykhlouvand, Scott C. Forbes

Erschienen in: Sport Sciences for Health | Ausgabe 3/2022

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Abstract

Purpose

Myocardial injury induced by ischemia–reperfusion is the main pathological contributing factor of cardiovascular disease (CVD) including heart failure. Individually, both moderate-intensity aerobic exercise and curcumin supplementation have anti-amyloidogenic effects, however, the concurrent effects are unclear. We, therefore, investigated the effects of 10 weeks of moderate-intensity aerobic exercise with and without curcumin supplementation in rats.

Methods

Male Wistar rats (6–8 weeks old) were randomly assigned to one of five groups (N = 10): (a) sedentary control; (b) sedentary ischemia–reperfusion; (c) exercise (15–45 min at 12–24 m/min) with ischemia–reperfusion; (d) curcumin (50 mg/kg/day) + ischemia–reperfusion; and (e) both exercise and curcumin + ischemia–reperfusion. Infarct size, gene expression of amyloid precursor protein, enzymes involved in the cleavage of amyloid precursor protein (β-secretase-1, presenilin-1 and -2) and neprilysin, a marker of degradation of β-amyloid peptide in the left ventricle of rats were investigated.

Results

A reduction in mRNA expression of amyloid precursor protein, β-secretase-1, presenilin-1 and -2 and infarct size, and an increase in gene expression of neprilysin in the myocardium occurred in both the exercise- and the curcumin-treated rats with no further benefit with concurrent treatments.

Conclusion

Exercise and curcumin individually provided cardioprotective effects against ischemia–reperfusion-induced injury which appears to be associated with an attenuation in mRNA expression of β-amyloid peptide precursor in addition to processing enzymes and an increase in mRNA expression of neprilysin. There were no further benefits with concurrent treatments (exercise with curcumin) compared to either treatment alone.

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Titel: Cardioprotective effects of exercise and curcumin supplementation against myocardial ischemia–reperfusion injury
verfasst von: Zahra Sayevand
Farzad Nazem
Afshin Nazari
Mohsen Sheykhlouvand
Scott C. Forbes
Publikationsdatum: 06.03.2022
Verlag: Springer Milan
Erschienen in: Sport Sciences for Health / Ausgabe 3/2022
Print ISSN: 1824-7490
Elektronische ISSN: 1825-1234
DOI: https://doi.org/10.1007/s11332-021-00886-w

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Cardioprotective effects of exercise and curcumin supplementation against myocardial ischemia–reperfusion injury

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