Skip to main content
Erschienen in: Heart Failure Reviews 6/2022

08.02.2022

Cardiorenal syndrome: long road between kidney and heart

verfasst von: Carolina Victoria Cruz Junho, Mayra Trentin-Sonoda, Karine Panico, Raquel Silva Neres dos Santos, Mariana Vieira Abrahão, Imara Caridad Stable Vernier, Cristina Ribas Fürstenau, Marcela Sorelli Carneiro-Ramos

Erschienen in: Heart Failure Reviews | Ausgabe 6/2022

Einloggen, um Zugang zu erhalten

Abstract

Almost 200 years ago, the first evidence described by Robert Bright (1836) showed the strong interaction between the kidneys and heart and, since then, the scientific community has dedicated itself to better understanding the mechanisms involved in the kidney–heart relationship, known in recent decades as cardiorenal syndrome (CRS). This syndrome includes a wide clinical variety that affects the kidneys and heart, in an acute or chronic manner. Moreover, it is well established in the literature that the immune system, the sympathetic nervous system, the renin–angiotensin–aldosterone, and the oxidative stress actively play a strong role in the cellular and molecular processes present in CRS. More recently, uremic molecules and epigenetic factors have been also shown to be key mediators in the development of syndrome. The present review intends to present the state of the art regarding CRS and to show the paths known, until now, in the long road between the kidneys and heart.
Literatur
1.
Zurück zum Zitat Bright R (1836) Cases and observations illustrative of renal disease, accompanied with the secretion of albuminous urine. Medico-chirurgical Rev 25:23–35 Bright R (1836) Cases and observations illustrative of renal disease, accompanied with the secretion of albuminous urine. Medico-chirurgical Rev 25:23–35
10.
Zurück zum Zitat Navarro-García JA, Fernández-Velasco M, Delgado C et al (2018) PTH, vitamin D, and the FGF-23–klotho axis and heart: Going beyond the confines of nephrology. Eur J Clin Invest 48 Navarro-García JA, Fernández-Velasco M, Delgado C et al (2018) PTH, vitamin D, and the FGF-23–klotho axis and heart: Going beyond the confines of nephrology. Eur J Clin Invest 48
14.
Zurück zum Zitat Ronco C, Di Lullo L (2014) Cardiorenal syndrome Heart Fail Clin 10:251–280CrossRef Ronco C, Di Lullo L (2014) Cardiorenal syndrome Heart Fail Clin 10:251–280CrossRef
21.
Zurück zum Zitat Ueda S, Ayano Y, Yano S et al (1981) Changes in vascular reactivity in rats with experimental renal insufficiency. Arch Int Pharmacodyn Ther 253:257–265PubMed Ueda S, Ayano Y, Yano S et al (1981) Changes in vascular reactivity in rats with experimental renal insufficiency. Arch Int Pharmacodyn Ther 253:257–265PubMed
35.
Zurück zum Zitat Panico K, Abrahão MV, Trentin-Sonoda M et al (2019) Cardiac inflammation after ischemia-reperfusion of the kidney: Role of the sympathetic nervous system and the renin-angiotensin system. Cell Physiol Biochem 53:587–605. https://doi.org/10.33594/000000159 Panico K, Abrahão MV, Trentin-Sonoda M et al (2019) Cardiac inflammation after ischemia-reperfusion of the kidney: Role of the sympathetic nervous system and the renin-angiotensin system. Cell Physiol Biochem 53:587–605. https://​doi.​org/​10.​33594/​000000159
42.
Zurück zum Zitat Carter JR, Goldstein DS (2014) Sympathoneural and adrenomedullary responses to mental stress. Comprehensive physiology. John Wiley & Sons Inc, Hoboken, NJ, USA, pp 119–146CrossRef Carter JR, Goldstein DS (2014) Sympathoneural and adrenomedullary responses to mental stress. Comprehensive physiology. John Wiley & Sons Inc, Hoboken, NJ, USA, pp 119–146CrossRef
43.
Zurück zum Zitat Burnstock G (2013) Cotransmission in the autonomic nervous system. Handbook Clin Neurol 23–35 Burnstock G (2013) Cotransmission in the autonomic nervous system. Handbook Clin Neurol 23–35
51.
Zurück zum Zitat Elenkov IJ, Wilder RL, Chrousos GP, Vizi ES (2000) The sympathetic nerve–an integrative interface between two supersystems: the brain and the immune system. Pharmacol Rev 52:595–638PubMed Elenkov IJ, Wilder RL, Chrousos GP, Vizi ES (2000) The sympathetic nerve–an integrative interface between two supersystems: the brain and the immune system. Pharmacol Rev 52:595–638PubMed
53.
Zurück zum Zitat Stupin A, Drenjancevic I, Rasic L et al (2017) A cross-talk between the renin-angiotensin and adrenergic systems in cardiovascular health and disease. Eur Med J 1:90–107 Stupin A, Drenjancevic I, Rasic L et al (2017) A cross-talk between the renin-angiotensin and adrenergic systems in cardiovascular health and disease. Eur Med J 1:90–107
68.
Zurück zum Zitat Ronco C, Di Lullo L (2018) Cardiorenal acute kidney injury: epidemiology, presentation, causes, pathophysiology, and treatment. core concepts in acute kidney injury. Springer, US, New York, NY, pp 257–269CrossRef Ronco C, Di Lullo L (2018) Cardiorenal acute kidney injury: epidemiology, presentation, causes, pathophysiology, and treatment. core concepts in acute kidney injury. Springer, US, New York, NY, pp 257–269CrossRef
72.
Zurück zum Zitat Machado Rocha Ribeiro S, Humberto de Queiroz J, do Carmo Gouveia Peluzio M et al (2005) The formation and the effects of the reactive oxygen species in biological media. Biosci J 21:133–149 Machado Rocha Ribeiro S, Humberto de Queiroz J, do Carmo Gouveia Peluzio M et al (2005) The formation and the effects of the reactive oxygen species in biological media. Biosci J 21:133–149
73.
Zurück zum Zitat Pruchniak MP, Araźna M, Demkc U (2016) Biochemistry of oxidative stress. Advances in experimental medicine and biology. Springer, New York LLC, pp 9–19 Pruchniak MP, Araźna M, Demkc U (2016) Biochemistry of oxidative stress. Advances in experimental medicine and biology. Springer, New York LLC, pp 9–19
74.
Zurück zum Zitat Siti HN, Kamisah Y, Kamsiah J (2015) The role of oxidative stress, antioxidants and vascular inflammation in cardiovascular disease (a review). Vascul Pharmacol 71:40–56CrossRef Siti HN, Kamisah Y, Kamsiah J (2015) The role of oxidative stress, antioxidants and vascular inflammation in cardiovascular disease (a review). Vascul Pharmacol 71:40–56CrossRef
75.
Zurück zum Zitat Duann P, Lin PH (2017) Mitochondria damage and kidney disease. Advances in experimental medicine and biology. Springer, New York LLC, pp 529–551 Duann P, Lin PH (2017) Mitochondria damage and kidney disease. Advances in experimental medicine and biology. Springer, New York LLC, pp 529–551
76.
Zurück zum Zitat Ratliff BB, Abdulmahdi W, Pawar R, Wolin MS (2016) Oxidant mechanisms in renal injury and disease. Antioxidants Redox Signal 25:119–146CrossRef Ratliff BB, Abdulmahdi W, Pawar R, Wolin MS (2016) Oxidant mechanisms in renal injury and disease. Antioxidants Redox Signal 25:119–146CrossRef
77.
Zurück zum Zitat Thomas SR, Witting PK, Drummond GR (2008) Redox control of endothelial function and dysfunction: molecular mechanisms and therapeutic opportunities. Antioxidants Redox Signal 10:1713–1765CrossRef Thomas SR, Witting PK, Drummond GR (2008) Redox control of endothelial function and dysfunction: molecular mechanisms and therapeutic opportunities. Antioxidants Redox Signal 10:1713–1765CrossRef
79.
Zurück zum Zitat Jha JC, Banal C, Chow BSM et al (2016) Diabetes and kidney disease: role of oxidative stress. Antioxidants Redox Signal 25:657–684CrossRef Jha JC, Banal C, Chow BSM et al (2016) Diabetes and kidney disease: role of oxidative stress. Antioxidants Redox Signal 25:657–684CrossRef
85.
Zurück zum Zitat Hamilton CA, Miller WH, Al-Benna S et al (2004) Strategies to reduce oxidative stress in cardiovascular disease. Clin Sci 106:219–234CrossRef Hamilton CA, Miller WH, Al-Benna S et al (2004) Strategies to reduce oxidative stress in cardiovascular disease. Clin Sci 106:219–234CrossRef
86.
Zurück zum Zitat Tsutsui H, Kinugawa S, Matsushima S (2009) Mitochondrial oxidative stress and dysfunction in myocardial remodelling. Cardiovasc Res 81:449–456CrossRef Tsutsui H, Kinugawa S, Matsushima S (2009) Mitochondrial oxidative stress and dysfunction in myocardial remodelling. Cardiovasc Res 81:449–456CrossRef
88.
90.
Zurück zum Zitat Giam B, Kaye DM, Rajapakse NW (2016) Role of renal oxidative stress in the pathogenesis of the cardiorenal syndrome. Hear Lung Circ 25:874–880CrossRef Giam B, Kaye DM, Rajapakse NW (2016) Role of renal oxidative stress in the pathogenesis of the cardiorenal syndrome. Hear Lung Circ 25:874–880CrossRef
104.
Zurück zum Zitat Edmonston D, Wolf M (2020) FGF23 at the crossroads of phosphate, iron economy and erythropoiesis. Nat Rev Nephrol 16:7–19CrossRef Edmonston D, Wolf M (2020) FGF23 at the crossroads of phosphate, iron economy and erythropoiesis. Nat Rev Nephrol 16:7–19CrossRef
112.
Zurück zum Zitat McCullough PA, Ronco C (2021) Textbook of cardiorenal medicine. Springer International Publishing, ChamCrossRef McCullough PA, Ronco C (2021) Textbook of cardiorenal medicine. Springer International Publishing, ChamCrossRef
151.
Zurück zum Zitat Sevinc M, Hasbal NB, Yilmaz V et al (2020) Comparison of circulating levels of uremic toxins in hemodialysis patients treated with medium cut-off membranes and high-flux membranes: Theranova in Sisli Hamidiye Etfal (THE SHE) Randomized Control Study. Blood Purif 49:733–742. https://doi.org/10.1159/000508061CrossRefPubMed Sevinc M, Hasbal NB, Yilmaz V et al (2020) Comparison of circulating levels of uremic toxins in hemodialysis patients treated with medium cut-off membranes and high-flux membranes: Theranova in Sisli Hamidiye Etfal (THE SHE) Randomized Control Study. Blood Purif 49:733–742. https://​doi.​org/​10.​1159/​000508061CrossRefPubMed
Metadaten
Titel
Cardiorenal syndrome: long road between kidney and heart
verfasst von
Carolina Victoria Cruz Junho
Mayra Trentin-Sonoda
Karine Panico
Raquel Silva Neres dos Santos
Mariana Vieira Abrahão
Imara Caridad Stable Vernier
Cristina Ribas Fürstenau
Marcela Sorelli Carneiro-Ramos
Publikationsdatum
08.02.2022
Verlag
Springer US
Erschienen in
Heart Failure Reviews / Ausgabe 6/2022
Print ISSN: 1382-4147
Elektronische ISSN: 1573-7322
DOI
https://doi.org/10.1007/s10741-022-10218-w

Weitere Artikel der Ausgabe 6/2022

Heart Failure Reviews 6/2022 Zur Ausgabe

Vorsicht, erhöhte Blutungsgefahr nach PCI!

10.05.2024 Koronare Herzerkrankung Nachrichten

Nach PCI besteht ein erhöhtes Blutungsrisiko, wenn die Behandelten eine verminderte linksventrikuläre Ejektionsfraktion aufweisen. Das Risiko ist umso höher, je stärker die Pumpfunktion eingeschränkt ist.

Triglyzeridsenker schützt nicht nur Hochrisikopatienten

10.05.2024 Hypercholesterinämie Nachrichten

Patienten mit Arteriosklerose-bedingten kardiovaskulären Erkrankungen, die trotz Statineinnahme zu hohe Triglyzeridspiegel haben, profitieren von einer Behandlung mit Icosapent-Ethyl, und zwar unabhängig vom individuellen Risikoprofil.

Gibt es eine Wende bei den bioresorbierbaren Gefäßstützen?

In den USA ist erstmals eine bioresorbierbare Gefäßstütze – auch Scaffold genannt – zur Rekanalisation infrapoplitealer Arterien bei schwerer PAVK zugelassen worden. Das markiert einen Wendepunkt in der Geschichte dieser speziellen Gefäßstützen.

Darf man die Behandlung eines Neonazis ablehnen?

08.05.2024 Gesellschaft Nachrichten

In einer Leseranfrage in der Zeitschrift Journal of the American Academy of Dermatology möchte ein anonymer Dermatologe bzw. eine anonyme Dermatologin wissen, ob er oder sie einen Patienten behandeln muss, der eine rassistische Tätowierung trägt.

Update Kardiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.