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01.12.2012 | Case report | Ausgabe 1/2012 Open Access

World Journal of Surgical Oncology 1/2012

Castleman disease mimicked pancreatic carcinoma: report of two cases

World Journal of Surgical Oncology > Ausgabe 1/2012
Hua Guo, Yan Shen, Wei-Lin Wang, Min Zhang, Hong Li, Ying-Sheng Wu, Sheng Yan, Xiao Xu, Jian Wu, Shu-Sen Zheng
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1477-7819-10-154) contains supplementary material, which is available to authorized users.

Competing interest

The authors declare that they have no competing interests.

Authors’ contributions

Guo H had the idea of case report and wrote the main manuscript. Wang WL, Shen Y, and Zhang M performed the operations. Wu YS, Yan S, Xu X, and Wu J collected the patients’ data and follow-up radiological images. Li H participated in the manuscript preparation. Zheng SS revised the manuscript for important intellectual content, and gave the final approval for the version to be submitted for publication. All authors read and approve the final manuscript.


Castleman disease (CD) is an uncommon benign lymphoproliferative disorder, which usually presents as solitary or multiple masses in the mediastinum. Peripancreatic CD was rarely reported. Herein, we report two cases of unicentric peripancreatic CD from our center. A 43-year-old man and a 58-year-old woman were detected to have a pancreatic mass in the routine medical examinations. Both of them were asymptomatic. The computed tomography and ultrasonographic examination revealed a mild enhancing solitary mass at the pancreatic head/neck. No definite preoperative diagnosis was established and Whipple operations were originally planned. The intraoperative frozen section diagnosis of both patients revealed lymphoproliferation. Then the local excisions of mass were performed. Histological examination revealed features of CD of hyaline-vascular type. No recurrence was found during the follow-up period. CD should be included in the differential diagnosis of pancreatic tumors. Local excision is a suitable surgical choice.
Authors’ original file for figure 1
Authors’ original file for figure 2
Authors’ original file for figure 3
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