Erschienen in:
16.09.2022 | Editorial
Caution!! Reappearance of remimazolam effect after a flumazenil bolus: a larger bolus of flumazenil and a lower total remimazolam clearance are higher risks
verfasst von:
Kenichi Masui
Erschienen in:
Journal of Anesthesia
|
Ausgabe 1/2023
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Excerpt
Remimazolam is a novel benzodiazepine anesthetic [
1]. A previous study has suggested that large individual variability exists in appropriate remimazolam concentration for anesthesia maintenance [
2]. As there are limited clinical experiences and limited studies, it may be difficult to determine the dosage of remimazolam during anesthesia maintenance. To avoid intraoperative awareness, remimazolam may be overdosed. The too high concentration may cause delayed recovery from remimazolam anesthesia. In such cases, one may consider the use of flumazenil, which is an antagonist of benzodiazepine, for immediate emergence from remimazolam anesthesia. …