Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Typ-2-Diabetes und Adipositas Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende
Erweiterte Suche
Anmelden
nach oben
The Cerebellum
Erschienen in: The Cerebellum 3/2011

01.09.2011

Cerebellar Theta-Burst Stimulation Selectively Enhances Lexical Associative Priming

verfasst von: Giorgos P. Argyropoulos

Erschienen in: The Cerebellum | Ausgabe 3/2011

Einloggen, um Zugang zu erhalten

Abstract

Recent research in cerebellar cognitive and linguistic functions makes plausible the idea that the cerebellum is involved in processing temporally contiguous linguistic input. In order to assess this hypothesis, a simple lexical decision task was constructed to study whether the effect of transcranial magnetic stimulation on two different cerebellar sites would have a selective impact on associative as opposed to semantic priming. This is the first experiment applying transcranial magnetic stimulation of the cerebellum to a linguistic task. The results show a selective drop in lexical decision accuracy after stimulation of a medial cerebellar site in the first session of participation. Most importantly, they also demonstrate a selective increase of associative priming sizes after stimulation of the same site that cannot be attributed to changes in sensorimotor performance or in accuracy rates. The finding is discussed within the context of domain-general associative cerebellar computations.
Fußnoten
1
As the reviewer correctly notes, a limitation in the design was that only unilateral (right) cerebellar stimulation was used, while laterality of limb responses (right-/left-hand index finger) was confounded with lexical decisions (“word”/“nonword” responses). The number of participants did not suffice to introduce further between-subjects variables to address these issues, and a more elaborate study with more experimental conditions would be required. As noted above, though, trials corresponding to “nonword” responses were all filler trials, and the primary focus of the study was on the speed and accuracy in different types of word–word trials. Furthermore, any motor-related disruptions induced by (right) cerebellar stimulation were expected to selectively affect performance in “word” responses, performed by the ipsilateral (right) index finger (see “Discussion” section).
 
Literatur
1.
Pickering MJ, Garrod S. Do people use language production to make predictions during comprehension? Trends Cogn Sci. 2007;11(3):105–10.PubMedCrossRef
2.
Paulin MG. A Kalman filter theory of the cerebellum. In: Arbib MA, Amari SI, editors. Dynamic interactions in neural networks: models and data. New York: Springer; 1989. p. 239–59.
3.
Wolpert DM, Miall RC, Kawato M. Internal models in the cerebellum. Trends Cogn Sci. 1998;2(9):338–47.PubMedCrossRef
4.
Courchesne E, Allen G. Prediction and preparation, fundamental functions of the cerebellum. Learn Memory. 1997;4(1):1–35.CrossRef
5.
Bellebaum C, Daum I. Mechanisms of cerebellar involvement in associative learning. Cortex. 2011;47(1):128–36.PubMedCrossRef
6.
Timmann D, Drepper J, Frings M, Maschke M, Richter S, Gerwig M, et al. The human cerebellum contributes to motor, emotional and cognitive associative learning. A review. Cortex. 2010;46:845–57.PubMedCrossRef
7.
Schmahmann JD. The role of the cerebellum in affect and psychosis. J Neurolinguist. 2000;13:189–214.CrossRef
8.
Argyropoulos GP. Neocerebellar emulation in language processing. In: Alter K, Horne M, Lindgren M, Roll M, von Koss Torkildsen J, editors. Brain talk: discourse with and in the brain. Papers from the first Birgit Rausing Language. Program Conference in Linguistics. Lund: Lund University, Media Tryck; 2009. pp. 193–206.
9.
Hutchison KA. Is semantic priming due to association strength or feature overlap? A microanalytic review. Psychon B Rev. 2003;10(4):785–813.CrossRef
10.
Thompson-Schill SL, Kurtz KJ, Gabrieli JDE. Effects of semantic and associative relatedness on automatic priming. J Mem Lang. 1998;38:440–58.CrossRef
11.
Rogers SL, Friedman RB. The underlying mechanisms of semantic memory in Alzheimer’s disease and semantic dementia. Neuropsychologia. 2008;46:12–21.PubMedCrossRef
12.
Thompson RF, Bao S, Chen L, Cipriano BD, Grethe JS, Kim JJ, et al. Associative learning. Int Rev Neurobiol. 1997;41:152–89.CrossRef
13.
Christian KM, Thompson RF. Long-term storage of an associative memory trace in the cerebellum. Behav Neurosci. 2005;119:526–37.PubMedCrossRef
14.
McCormick DA, Thompson RF. Cerebellum: essential involvement in the classically conditioned eyelid response. Science. 1984;223:296–9.PubMedCrossRef
15.
Daum I, Ackermann H, Schugens MM, Reimold C, Dichgans J, Birbaumer N. The cerebellum and cognitive functions in humans. Behav Neurosci. 1993;107(3):411–19.PubMedCrossRef
16.
Timmann D, Kolb FP, Baier C, Rijntjes M, Mueller SP, Diener HC, et al. Cerebellar activation during classical conditioning of the human flexion reflex: a PET study. Neuroreport. 1996;7:2056–60.PubMedCrossRef
17.
Woodruff-Pak DS, Papka M, Ivry RB. Cerebellar involvement in eyeblink classical conditioning in humans. Neuropsychology. 1996;10:443–58.CrossRef
18.
Canavan AG, Sprengelmeyer R, Diener HC, Hömberg V. Conditional associative learning is impaired in cerebellar disease in humans. Behav Neurosci. 1994;108:475–85.PubMedCrossRef
19.
Tucker J, Harding AE, Jahanshahi M, Nixon PD, Rushworth M, Quinn NP, et al. Associative learning in patients with cerebellar ataxia. Behav Neurosci. 1996;110:1229–34.PubMedCrossRef
20.
Woodruff-Pak DS, Vogel III RW, Ewers M, Coffey J, Boyko OB, Lemieux SK. MRI-assessed volume of cerebellum correlates with associative learning. Neurobiol Learn Mem. 2001;76:342–57.PubMedCrossRef
21.
Drepper J, Timmann D, Kolb FP, Diener HC. Non- motor associative learning in patients with isolated degenerative cerebellar disease. Brain. 1999;122:87–97.PubMedCrossRef
22.
Timmann D, Drepper J, Maschke M, Kolb FP, Böring D, Thilmann AF, et al. Motor deficits cannot explain impaired cognitive associative learning in cerebellar patients. Neuropsychologia. 2002;40:788–800.PubMedCrossRef
23.
Timmann D, Drepper J, Calabrese S, Bürgerhoff K, Maschke M, Kolb FP, et al. Use of sequence information in associative learning in control subjects and cerebellar patients. Cerebellum. 2004;3:75–82.PubMedCrossRef
24.
Fiez JA, Petersen SE, Cheney MK, Raichle ME. Impaired non-motor learning and error detection associated with cerebellar damage. A single case study. Brain. 1992;115:155–78.PubMedCrossRef
25.
Gebhart AL, Petersen SE, Thach WT. Role of the posterolateral cerebellum in language. Ann NY Acad Sci. 2002;978:318–33.PubMedCrossRef
26.
Leggio MG, Silveri MC, Petrosini L, Molinari M. Phonological grouping is specifically affected in cerebellar patients: a verbal fluency study. J Neurol Neurosurg Psychiatry. 2000;69:102–6.PubMedCrossRef
27.
Ferrucci R, Marceglia S, Vergari M, Cogiamanian F, Mrakic-Sposta S, Mameli F, et al. Cerebellar transcranial direct current stimulation impairs the practice-dependent proficiency increase in working memory. J Cognitive Neurosci. 2008;20(9):1687–97.CrossRef
28.
Jarvis BG. DirectRT (Version 2008.1.0.11) [Computer software]. New York: Empirisoft Corporation 2008.
29.
Perea M, Rosa E. The effects of associative and semantic priming in the lexical decision task. Psychol Res. 2002;66:180–94.PubMedCrossRef
30.
Forster KI, Davis C. The density constraint on form-priming in the naming task: Interference from a masked prime. J Mem Lang. 1991;30:1–25.CrossRef
31.
Leech G. 100 million words of English: the British National Corpus. Lang Res. 1992;28(1):1–13.
32.
Ober B. RT and non-RT methodology for semantic priming research with Alzheimer’s Disease patients: a critical review. J Clin Exp Neuropsyc. 2002;24(7):883–911.CrossRef
33.
Ferrand L, New B. Semantic and associative priming in the mental lexicon. In: Hauppauge BP, editor. Mental lexicon: some words to talk about words. New York: Nova Science; 2003. p. 25–43.
34.
Kiss GR, Armstrong C, Milroy R, Piper J. An associative thesaurus of English and its computer analysis. In: Aitken AJ, Bailey RW, Hamilton-Smith N, editors. The computer and literary studies. Edinburgh: Edinburgh University Press; 1973. p. 153–65.
35.
McEvoy CL, Nelson DL. Category name and instance norms for 106 categories of various sizes. Am J Psychol. 1982;95(4):581–634.CrossRef
36.
Van Overschelde JP, Rawson KA, Dunlosky J. Category norms: an updated and expanded version of the Battig and Montague (1969) norms. J Mem Lang. 2004;50:289–335.CrossRef
37.
Pedersen T, Patwardhan S, Michelizzi J. Wordnet::similarity—measuring the relatedness of concepts. AAAI-04 2004: 1024–5.
38.
Miall RC, Christensen LO. The effect of rTMS over the cerebellum in normal human volunteers on peg-board movement performance. Neurosci Lett. 2004;371:185–9.PubMedCrossRef
39.
Oliveri M, Koch G, Torriero S, Caltagirone C. Increased facilitation of the primary motor cortex following 1 Hz repetitive transcranial magnetic stimulation of the contralateral cerebellum in normal humans. Neurosci Lett. 2005;376:188–93.PubMedCrossRef
40.
Koch G, Mori F, Marconi B, Codecà C, Pecchioli C, Salerno S, et al. Changes in intracortical circuits of the human motor cortex following theta burst stimulation of the lateral cerebellum. Clin Neurophysiol. 2008;119:2559–69.PubMedCrossRef
41.
Hashimoto M, Ohtsuka K. Transcranial magnetic stimulation over the posterior cerebellum during visual saccades in man. Brain. 1995;118:1185–93.PubMedCrossRef
42.
Ugawa Y, Uesaka Y, Terao Y, Hanajima R, Kanazawa I. Magnetic stimulation over the cerebellum in humans. Ann Neurol. 1995;37(6):703–13.PubMedCrossRef
43.
Ohtsuka K, Enoki T. Transcranial magnetic stimulation over the posterior cerebellum during smooth pursuit eye movements in man. Brain. 1998;121:429–35.PubMedCrossRef
44.
Larsell O, Jansen J. The comparative anatomy and histology of the cerebellum, vol 3 III: the human cerebellum, cerebellar connections and cerebellar cortex. Minneapolis: University of Minnesota Press; 1972.
45.
Schmahmann JD, Doyon J, McDonald D, Holmes C, Lavoie K, Hurwitz AS, et al. Three-dimensional MRI atlas of the human cerebellum in proportional stereotaxic space. Neuroimage. 1999;10:233–60.PubMedCrossRef
46.
Huang Y, Edwards MJ, Rounis E, Bhatia KP, Rothwell JC. Theta burst stimulation of the human motor cortex. Neuron. 2005;45:201–6.PubMedCrossRef
47.
1Demirtas-Tatlidede A, Freitas C, Cromer JR, Safar L, Ongur D, Stone WS, et al. Safety and proof of principle study of cerebellar vermal theta burst stimulation in refractory schizophrenia. Schizophr Res. 2010;124(1–3):91–100.PubMedCrossRef
48.
Koch G, Brusa L, Carrillo F, Lo Gerfo E, Torriero S, Oliveri M, et al. Cerebellar magnetic stimulation decreases levodopa-induced dyskinesias in Parkinson disease. Neurology. 2009;73:113–9.PubMedCrossRef
49.
Stewart LM, Walsh V, Rothwell JC. Motor and phosphene thresholds: a transcranial magnetic stimulation correlation study. Neuropsychologia. 2001;39(4):415–9.PubMedCrossRef
50.
51.
Del Olmo MF, Cheeran B, Koch G, Rothwell JC. Role of the cerebellum in externally paced rhythmic finger movements. J Neurophysiol. 2007;98:145–52.PubMedCrossRef
52.
Torriero S, Oliveri M, Koch G, Lo Gerfo E, Salerno S, Petrosini L, et al. Cortical networks of procedural learning: evidence from cerebellar damage. Neuropsychologia. 2007;45(6):1208–14.PubMedCrossRef
53.
Perea M, Gotor A. Associative and semantic priming effects occur at very short stimulus-onset asynchronies in lexical decision and naming. Cognition. 1997;62:223–40.PubMedCrossRef
54.
Moretti R, Bava A, Torre P, Antonello RM, Cazzato G. Reading errors in patients with cerebellar vermis lesions. J Neurol. 2002;249(4):1432–59.CrossRef
55.
Ilg UJ, Thier P. The neural basis of smooth pursuit eye movements in the rhesus monkey brain. Brain Cogn. 2008;68(3):229–40.PubMedCrossRef
56.
Nagel M, Zangemeister WH. The effect of transcranial magnetic stimulation over the cerebellum on the synkinesis of coordinated eye and head movements. J Neurol Sci. 2003;213:35–45.PubMedCrossRef
57.
Leggio MG, Chiricozzi FR, Clausi S, Tedesco AM, Molinari M. The neuropsychological profile of cerebellar damage: the sequencing hypothesis. Cortex. 2011;47(1):137–44.PubMedCrossRef
58.
Okugawa G, Sedvall GC, Agartz I. Smaller cerebellar vermis but not hemisphere volumes in patients with chronic schizophrenia. Am J Psychiat. 2003;160:1614–7.PubMedCrossRef
59.
Okugawa G, Nobuhara K, Takase K, Kinoshita T. Cerebellar posterior superior vermis and cognitive cluster scores in drug-naïve patients with first-episode schizophrenia. Neuropsychobiology. 2007;56:216–9.PubMedCrossRef
60.
Picard H, Amado I, Mouchet-Mages S, Olié J-P, Krebs M-O. The role of the cerebellum in schizophrenia: an update of clinical, cognitive, and functional evidences. Schizophrenia Bull. 2008;34(1):155–72.CrossRef
61.
Nestor P, Valdman O, Niznikiewicz M, Spencer K, McCarley R, Shenton M. Word priming in schizophrenia: associational and semantic influences. Schizophr Res. 2006;82(2):139–42.PubMedCrossRef
62.
Schmahmann JD. Dysmetria of thought: clinical consequences of cerebellar dysfunction on cognition and affect. Trends Cogn Sci. 1998;2(9):362–71.PubMedCrossRef
63.
64.
Théoret H, Haque J, Pascual-Leone A. Increased variability of paced finger tapping accuracy following repetitive magnetic stimulation of the cerebellum in humans. Neurosci Lett. 2001;306:29–32.PubMedCrossRef
Metadaten
Titel
Cerebellar Theta-Burst Stimulation Selectively Enhances Lexical Associative Priming
verfasst von
Giorgos P. Argyropoulos
Publikationsdatum
01.09.2011
Verlag
Springer-Verlag
Erschienen in
The Cerebellum / Ausgabe 3/2011
Print ISSN: 1473-4222
Elektronische ISSN: 1473-4230
DOI
https://doi.org/10.1007/s12311-011-0269-y

Weitere Artikel der Ausgabe 3/2011

The Cerebellum 3/2011 Zur Ausgabe

OriginalPaper

Ethanol and Vestibular Stimulation Reveal Simple and Complex Aspects of Cerebellar Heterogeneity

Review

Unusual CT Hyperattenuating Dermoid Cyst of Cerebellum: A New Case Report and Literature Review

OriginalPaper

Cerebellar Zones: A Personal History

OriginalPaper

Neurofilament Heavy Chain Expression Reveals a Unique Parasagittal Stripe Topography in the Mouse Cerebellum

OriginalPaper

Learning Stimulus Intervals—Adaptive Timing of Conditioned Purkinje Cell Responses

Cerebellar Classics VIII

The Saga of Zones in the Cerebellar Cortex as Reflected in the Corticonuclear System: A Different Approach, a Specific Hypothesis, and the Proof Begins (Voogd, 1969)

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Kostenlos registrieren

Neu im Fachgebiet Neurologie

Demenzkranke durch Antipsychotika vielfach gefährdet

Demenz Nachrichten

Der Einsatz von Antipsychotika gegen psychische und Verhaltenssymptome in Zusammenhang mit Demenzerkrankungen erfordert eine sorgfältige Nutzen-Risiken-Abwägung. Neuen Erkenntnissen zufolge sind auf der Risikoseite weitere schwerwiegende Ereignisse zu berücksichtigen.

Nicht Creutzfeldt Jakob, sondern Abführtee-Vergiftung

29.05.2024 Hyponatriämie Nachrichten

Eine ältere Frau trinkt regelmäßig Sennesblättertee gegen ihre Verstopfung. Der scheint plötzlich gut zu wirken. Auf Durchfall und Erbrechen folgt allerdings eine Hyponatriämie. Nach deren Korrektur kommt es plötzlich zu progredienten Kognitions- und Verhaltensstörungen.

Schutz der Synapsen bei Alzheimer

29.05.2024 Morbus Alzheimer Nachrichten

Mit einem Neurotrophin-Rezeptor-Modulator lässt sich möglicherweise eine bestehende Alzheimerdemenz etwas abschwächen: Erste Phase-2-Daten deuten auf einen verbesserten Synapsenschutz.

Sozialer Aufstieg verringert Demenzgefahr

24.05.2024 Demenz Nachrichten

Ein hohes soziales Niveau ist mit die beste Versicherung gegen eine Demenz. Noch geringer ist das Demenzrisiko für Menschen, die sozial aufsteigen: Sie gewinnen fast zwei demenzfreie Lebensjahre. Umgekehrt steigt die Demenzgefahr beim sozialen Abstieg.

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen
Bildnachweise