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Current Heart Failure Reports
Erschienen in: Current Heart Failure Reports 3/2014

01.09.2014 | Comorbidities of Heart Failure (CE Angermann, Section Editor)

Cerebral Impairment in Heart Failure

verfasst von: Jennifer A. Ogren, Gregg C. Fonarow, Mary A. Woo

Erschienen in: Current Heart Failure Reports | Ausgabe 3/2014

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Abstract

Patients with heart failure (HF) exhibit a wide range of symptoms, including dyspnea, sleep-disordered breathing, autonomic abnormalities, cognitive dysfunction, and neuropsychological disturbances. These symptoms, which affect quality of life and morbidity and mortality in the condition, are largely related to structural and functional changes in the brain. There are increasing reports of brain abnormalities in HF, but often the linkages between brain injury and common HF clinical symptomatology are not clearly described. In this review, we will discuss the current evidence of brain injury and the associated clinical symptoms in HF, focusing on those brain regions that are commonly damaged in the condition. We will also provide a brief exploration of some potential mechanisms for brain injury in HF.
Literatur
1.
Go AS, Mozaffarian D, Roger VL, et al. Heart disease and stroke statistics—2014 update: a report from the American Heart Association. Circulation. 2014;129(3):e28–292.PubMedCrossRef
2.
3.
National Heart, Lung, and Blood Institute. Mortality and morbidity: 2000 chart book on cardiovascular, lung, and blood diseases. Bethesda: National Institutes of Health; 2000.
4.
Opie LH. The neuroendocrinology of congestive heart failure. Cardiovasc J South Afr Off J South Afr Card Soc South Afr Soc Card Pract. 2002;13(4):171–8.
5.
Almeida JR, Alves TC, Wajngarten M, et al. Late-life depression, heart failure and frontal white matter hyperintensity: a structural magnetic resonance imaging study. Braz J Med Biol Res. 2005;38(3):431–6.PubMedCrossRef
6.
7.
Jiang W, Kuchibhatla M, Clary GL, et al. Relationship between depressive symptoms and long-term mortality in patients with heart failure. Am Heart J. 2007;154(1):102–8.PubMedCrossRef
8.
Pressler SJ, Kim J, Riley P, et al. Memory dysfunction, psychomotor slowing, and decreased executive function predict mortality in patients with heart failure and low ejection fraction. J Card Fail. 2010;16(9):750–60.PubMedCentralPubMedCrossRef
9.•
Alosco ML, Brickman AM, Spitznagel MB, et al. Independent and interactive effects of blood pressure and cardiac function on brain volume and white matter hyperintensities in heart failure. J Am Soc Hypertens. 2013;7(5):336–43. This study shows that elevated blood pressure and reduced cardiac index are associated with a decrease in gray matter volume in heart failure patients.PubMedCrossRef
10.
Alosco ML, Brickman AM, Spitznagel MB, et al. Cerebral perfusion is associated with white matter hyperintensities in older adults with heart failure. Congest Heart Fail. 2013;19(4):E29–34.PubMedCentralPubMedCrossRef
11.
Peiffer C, Poline JB, Thivard L, et al. Neural substrates for the perception of acutely induced dyspnea. Am J Respir Crit Care Med. 2001;163(4):951–7.PubMedCrossRef
12.
Parsons LM, Egan G, Liotti M, et al. Neuroimaging evidence implicating cerebellum in the experience of hypercapnia and hunger for air. Proc Natl Acad Sci U S A. 2001;98(4):2041–6.PubMedCentralPubMedCrossRef
13.•
Ogren JA, Macey PM, Kumar R, et al. Impaired cerebellar and limbic responses to the valsalva maneuver in heart failure. Cerebellum. 2012;11(4):931–8. This study shows the time course of abnormal brain responses in heart failure patients during autonomic challenge.PubMedCrossRef
14.
von Leupoldt A, Sommer T, Kegat S, et al. Dyspnea and pain share emotion-related brain network. Neuroimage. 2009;48(1):200–6.CrossRef
15.
Woo MA, Kumar R, Macey PM, et al. Brain injury in autonomic, emotional, and cognitive regulatory areas in patients with heart failure. J Card Fail. 2009;15(3):214–23.PubMedCentralPubMedCrossRef
16.•
Almeida OP, Garrido GJ, Beer C, et al. Cognitive and brain changes associated with ischaemic heart disease and heart failure. Eur Heart J. 2012;33(14):1769–76. This cross-sectional study is one of the few to demonstrate memory impairment and gray matter loss in brain cognitive areas within the same group of heart failure patients.PubMedCrossRef
17.
18.
Cheng DT, Knight DC, Smith CN, et al. Functional MRI of human amygdala activity during Pavlovian fear conditioning: stimulus processing versus response expression. Behav Neurosci. 2003;117(1):3–10.PubMedCrossRef
19.
von Leupoldt A, Sommer T, Kegat S, et al. The unpleasantness of perceived dyspnea is processed in the anterior insula and amygdala. Am J Respir Crit Care Med. 2008;177(9):1026–32.CrossRef
20.
Banzett RB, Mulnier HE, Murphy K, et al. Breathlessness in humans activates insular cortex. Neuroreport. 2000;11(10):2117–20.PubMedCrossRef
21.
Henderson LA, Gandevia SC, Macefield VG. Somatotopic organization of the processing of muscle and cutaneous pain in the left and right insula cortex: a single-trial fMRI study. Pain. 2007;128(1–2):20–30.PubMedCrossRef
22.
Henderson LA, Rubin TK, Macefield VG. Within-limb somatotopic representation of acute muscle pain in the human contralateral dorsal posterior insula. Hum Brain Mapp. 2011;32(10):1592–601.PubMedCrossRef
23.
Lieber C, Mohsenin V. Cheyne-Stokes respiration in congestive heart failure. Yale J Biol Med. 1992;65(1):39–50.PubMedCentralPubMed
24.
Javaheri S, Shukla R, Zeigler H, et al. Central sleep apnea, right ventricular dysfunction, and low diastolic blood pressure are predictors of mortality in systolic heart failure. J Am Coll Cardiol. 2007;49(20):2028–34.PubMedCrossRef
25.
Bradley TD, Floras JS. Sleep apnea and heart failure: part II: central sleep apnea. Circulation. 2003;107(13):1822–6.PubMedCrossRef
26.
Woo MA, Macey PM, Fonarow GC, et al. Regional brain gray matter loss in heart failure. J Appl Physiol. 2003;95(2):677–84.PubMed
27.
Ben-Tal A, Shamailov SS, Paton JF. Evaluating the physiological significance of respiratory sinus arrhythmia: looking beyond ventilation-perfusion efficiency. J Physiol. 2012;590(Pt 8):1989–2008.PubMedCentralPubMedCrossRef
28.
Woo MA, Macey PM, Keens PT, et al. Aberrant central nervous system responses to the Valsalva maneuver in heart failure. Congest Heart Fail. 2007;13(1):29–35.PubMedCrossRef
29.
Xu F, Frazier DT. Role of the cerebellar deep nuclei in respiratory modulation. Cerebellum. 2002;1(1):35–40.PubMedCrossRef
30.
Oppenheimer SM, Kedem G, Martin WM. Left-insular cortex lesions perturb cardiac autonomic tone in humans. Clin Auton Res. 1996;6(3):131–40.PubMedCrossRef
31.
Nagai M, Hoshide S, Kario K. The insular cortex and cardiovascular system: a new insight into the brain-heart axis. J Am Soc Hypertens. 2010;4(4):174–82.PubMedCrossRef
32.
Benarroch EE. The central autonomic network: functional organization, dysfunction, and perspective. Mayo Clin Proc. 1993;68(10):988–1001.PubMedCrossRef
33.
Cechetto DF, Ciriello J, Calaresu FR. Afferent connections to cardiovascular sites in the amygdala: a horseradish peroxidase study in the cat. J Auton Nerv Syst. 1983;8(2):97–110.PubMedCrossRef
34.
Allen GV, Cechetto DF. Functional and anatomical organization of cardiovascular pressor and depressor sites in the lateral hypothalamic area. II. Ascending projections. J Comp Neurol. 1993;330(3):421–38.PubMedCrossRef
35.
Laowattana S, Zeger SL, Lima JA, et al. Left insular stroke is associated with adverse cardiac outcome. Neurology. 2006;66(4):477–83. discussion 63.PubMedCrossRef
36.
Cechetto DF, Hachinski V. Cardiovascular consequence of experimental stroke. Bailliere Clin Neurol. 1997;6(2):297–308.
37.
Oppenheimer SM, Gelb A, Girvin JP, et al. Cardiovascular effects of human insular cortex stimulation. Neurology. 1992;42(9):1727–32.PubMedCrossRef
38.
Bannister R, Sever P, Gross M. Cardiovascular reflexes and biochemical responses in progressive autonomic failure. Brain. 1977;100(2):327–44.PubMedCrossRef
39.
Harper RM, Gozal D, Bandler R, et al. Regional brain activation in humans during respiratory and blood pressure challenges. Clin Exp Pharmacol Physiol. 1998;25(6):483–6.PubMedCrossRef
40.
Parisi AF, Harrington JJ, Askenazi J, et al. Echocardiographic evaluation of the Valsalva Maneuver in healthy subjects and patients with and without heart failure. Circulation. 1976;54(6):921–7.PubMedCrossRef
41.
Woo MA, Macey PM, Keens PT, et al. Functional abnormalities in brain areas that mediate autonomic nervous system control in advanced heart failure. J Card Fail. 2005;11(6):437–46.PubMedCrossRef
42.
Vogels RL, Oosterman JM, van Harten B, et al. Neuroimaging and correlates of cognitive function among patients with heart failure. Dement Geriatr Cogn Disord. 2007;24(6):418–23.PubMedCrossRef
43.•
Almeida OP, Garrido GJ, Etherton-Beer C, et al. Brain and mood changes over 2 years in healthy controls and adults with heart failure and ischaemic heart disease. Eur J Heart Fail. 2013;15(8):850–8. In this longitudinal study, heart failure patients showed an increase in severity of symptoms of anxiety and depression over a two-year period, and also showed subtle gray matter loss in areas such as the thalamus and cingulate, which are known to play a significant role in depression.PubMedCrossRef
44.
Sairafian K, Ogren JA, Macey PM, et al. Depression correlates with right amygdala damage in heart failure patients. ESC Heart Failure Congress. 2013; Lisbon, Portugal, May 17-20.
45.•
Pan A, Kumar R, Macey PM, et al. Visual assessment of brain magnetic resonance imaging detects injury to cognitive regulatory sites in patients with heart failure. J Card Fail. 2013;19(2):94–100. Like many other studies, this shows brain injury in heart failure in areas regulating cognition and mood. However, unlike previous studies, this establishes that the structural injury is extensive enough so as to be detectable through visual, as opposed to quantitative, assessment of MRI.PubMedCrossRef
46.
Lutherer LO, Lutherer BC, Dormer KJ, et al. Bilateral lesions of the fastigial nucleus prevent the recovery of blood pressure following hypotension induced by hemorrhage or administration of endotoxin. Brain Res. 1983;269(2):251–7.PubMedCrossRef
47.
Moruzzi G. Paleocerebellar inhibition of vasomotor and respiratory carotid sinus reflexes. J Neurophysiol. 1940;3(1):20–32.
48.
Shamsham F, Mitchell J. Essentials of the diagnosis of heart failure. Am Fam Physician. 2000;61(5):1319–28.PubMed
49.
Rutledge T, Reis VA, Linke SE, et al. Depression in heart failure a meta-analytic review of prevalence, intervention effects, and associations with clinical outcomes. J Am Coll Cardiol. 2006;48(8):1527–37.PubMedCrossRef
50.
Hwang B, Moser DK, Dracup K. knowledge is insufficient for self-care among heart failure patients with psychological distress. Health Psychol 2014;33(7):588–98.
51.
Hastings RS, Parsey RV, Oquendo MA, et al. Volumetric analysis of the prefrontal cortex, amygdala, and hippocampus in major depression. Neuropsychopharmacol Off Publ Am Coll Neuropsychopharmacol. 2004;29(5):952–9.CrossRef
52.
Malykhin NV, Carter R, Hegadoren KM, et al. Fronto-limbic volumetric changes in major depressive disorder. J Affect Disord. 2012;136(3):1104–13.PubMedCrossRef
53.
Pannekoek JN, van der Werff SJ, van den Bulk BG, et al. Reduced anterior cingulate gray matter volume in treatment-naive clinically depressed adolescents. NeuroImage Clin. 2014;4:336–42.PubMedCentralPubMedCrossRef
54.
Lorenzetti V, Allen NB, Fornito A, et al. Structural brain abnormalities in major depressive disorder: a selective review of recent MRI studies. J Affect Disord. 2009;117(1–2):1–17.PubMedCrossRef
55.
Bernstein HG, Klix M, Dobrowolny H, et al. A postmortem assessment of mammillary body volume, neuronal number and densities, and fornix volume in subjects with mood disorders. Eur Arch Psychiatry Clin Neurosci. 2012;262(8):637–46.PubMedCrossRef
56.
Young KA, Holcomb LA, Yazdani U, et al. Elevated neuron number in the limbic thalamus in major depression. Am J Psychiatry. 2004;161(7):1270–7.PubMedCrossRef
57.
Serber SL, Kumar R, Woo MA, et al. Cognitive test performance and brain pathology. Nurs Res. 2008;57(2):75–83.PubMedCrossRef
58.
Alves TC, Rays J, Fraguas Jr R, et al. Association between major depressive symptoms in heart failure and impaired regional cerebral blood flow in the medial temporal region: a study using 99 m Tc-HMPAO single photon emission computerized tomography (SPECT). Psychol Med. 2006;36(5):597–608.PubMedCrossRef
59.
Menteer J, Macey PM, Woo MA, et al. Central nervous system changes in pediatric heart failure: a volumetric study. Pediatr Cardiol. 2010;31(7):969–76.PubMedCentralPubMedCrossRef
60.
61.
Almeida OP, Flicker L. The mind of a failing heart: a systematic review of the association between congestive heart failure and cognitive functioning. Intern Med J. 2001;31(5):290–5.PubMedCrossRef
62.
Cacciatore F, Abete P, Ferrara N, et al. Congestive heart failure and cognitive impairment in an older population. Osservatorio Geriatrico Campano Study Group. J Am Geriatr Soc. 1998;46(11):1343–8.PubMed
63.
Callegari S, Majani G, Giardini A, et al. Relationship between cognitive impairment and clinical status in chronic heart failure patients. Monaldi Arch Chest Dis. 2002;58(1):19–25.PubMed
64.
Cohen MB, Mather PJ. A review of the association between congestive heart failure and cognitive impairment. Am J Geriatr Cardiol. 2007;16(3):171–4.PubMedCrossRef
65.
Bennett SJ, Sauve MJ. Cognitive deficits in patients with heart failure: a review of the literature. J Cardiovasc Nurs. 2003;18(3):219–42.PubMedCrossRef
66.
Petrucci RJ, Truesdell KC, Carter A, et al. Cognitive dysfunction in advanced heart failure and prospective cardiac assist device patients. Ann Thorac Surg. 2006;81(5):1738–44.PubMedCrossRef
67.
Riegel B, Bennett JA, Davis A, et al. Cognitive impairment in heart failure: issues of measurement and etiology. Am J Crit Care. 2002;11(6):520–8.PubMed
68.
Zuccala G, Cattel C, Manes-Gravina E, et al. Left ventricular dysfunction: a clue to cognitive impairment in older patients with heart failure. J Neurol Neurosurg Psychiatry. 1997;63(4):509–12.PubMedCentralPubMedCrossRef
69.
Bennett SJ, Sauve MJ, Shaw RM. A conceptual model of cognitive deficits in chronic heart failure. J Nurs Scholarsh. 2005;37(3):222–8.PubMedCrossRef
70.
Rozzini R, Sabatini T, Trabucchi M. Cognitive impairment and mortality in elderly patients with heart failure. Am J Med. 2004;116(2):137–8. author reply 8.PubMedCrossRef
71.
Trojano L, Antonelli Incalzi R, Acanfora D, et al. Cognitive impairment: a key feature of congestive heart failure in the elderly. J Neurol. 2003;250(12):1456–63.PubMedCrossRef
72.
Narkiewicz K, Somers VK. Sympathetic nerve activity in obstructive sleep apnoea. Acta Physiol Scand. 2003;177(3):385–90.PubMedCrossRef
73.
Burch GE. The role of the central nervous system in chronic congestive heart failure. Am Heart J. 1978;95(2):255–61.PubMedCrossRef
74.
Ogren JA, Abouzeid CM, Macey PM, et al. Regional hippocampal damage in heart failure. In Preparation.
75.
Ogren JA, Macey PM, Kumar R, et al. Hippocampal volume reductions correlate with impaired memory performance in heart failure. 42nd Annual Meeting of the Society for Neuroscience, New Orleans, LA. Soc Neurosci Abstracts. 2012; 194.23/XX9.
76.
Kumar R, Nguyen HD, Ogren JA, et al. Global and regional putamen volume loss in patients with heart failure. Eur J Heart Fail. 2011;13(6):651–5.PubMedCentralPubMedCrossRef
77.
Hanninen SA, Darling PB, Sole MJ, et al. The prevalence of thiamin deficiency in hospitalized patients with congestive heart failure. J Am Coll Cardiol. 2006;47(2):354–61.PubMedCrossRef
78.
Langlais PJ, Savage LM. Thiamine deficiency in rats produces cognitive and memory deficits on spatial tasks that correlate with tissue loss in diencephalon, cortex and white matter. Behav Brain Res. 1995;68(1):75–89.PubMedCrossRef
79.
Briones TL, Therrien B. Behavioral effects of transient cerebral ischemia. Biol Res Nurs. 2000;1(4):276–86.PubMedCrossRef
80.
Jefferson AL, Himali JJ, Au R, et al. Relation of left ventricular ejection fraction to cognitive aging (from the Framingham Heart Study). Am J Cardiol. 2011;108(9):1346–51.PubMedCentralPubMedCrossRef
81.
Paulson OB, Strandgaard S, Edvinsson L. Cerebral autoregulation. Cerebrovasc Brain Metab Rev. 1990;2(2):161–92.PubMed
82.
Georgiadis D, Sievert M, Cencetti S, et al. Cerebrovascular reactivity is impaired in patients with cardiac failure. Eur Heart J. 2000;21(5):407–13.PubMedCrossRef
83.
Kumar R, Woo MA, Wang DJ, et al. Regional reduction in cerebral blood flow in patients with heart failure. International Society for Magnetic Resonance in Medicine Annual Meeting (#2028), Melbourne, Australia, May 5-11, 2012. 2012.
84.
Endres M. Statins and stroke. J Cereb Blood Flow Metab Off J Int Soc Cereb Blood Flow Metab. 2005;25(9):1093–110.CrossRef
85.
Nybo L, Moller K, Volianitis S, et al. Effects of hyperthermia on cerebral blood flow and metabolism during prolonged exercise in humans. J Appl Physiol. 2002;93(1):58–64.PubMed
86.
Erickson KI, Voss MW, Prakash RS, et al. Exercise training increases size of hippocampus and improves memory. Proc Natl Acad Sci U S A. 2011;108(7):3017–22.PubMedCentralPubMedCrossRef
87.
Pressler SJ, Therrien B, Riley PL, et al. Nurse-Enhanced Memory Intervention in Heart Failure: the MEMOIR study. J Card Fail. 2011;17(10):832–43.PubMedCentralPubMedCrossRef
Metadaten
Titel
Cerebral Impairment in Heart Failure
verfasst von
Jennifer A. Ogren
Gregg C. Fonarow
Mary A. Woo
Publikationsdatum
01.09.2014
Verlag
Springer US
Erschienen in
Current Heart Failure Reports / Ausgabe 3/2014
Print ISSN: 1546-9530
Elektronische ISSN: 1546-9549
DOI
https://doi.org/10.1007/s11897-014-0211-y

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