nach oben

Acta Neurologica Belgica

Erschienen in:

07.06.2022 | Original article

Cerebral microbleeds is associated with dementia in Parkinson’s disease

verfasst von: Huijuan Wan, Huimin Chen, Meimei Zhang, Tao Feng, Yilong Wang

Erschienen in: Acta Neurologica Belgica | Ausgabe 2/2023

Einloggen, um Zugang zu erhalten

Abstract

Introduction

Emerging evidence suggests that cerebral small vessel disease (CSVD) may worsen cognitive functions in Parkinson’s disease (PD). However, the effect of microbleeds on cognitive function in patients with PD remains unknown. This study explored the association between the presence, number and location of microbleeds with dementia in PD patients.

Methods

This cross-sectional study included 431 patients with PD from Beijing Tiantan Hospital from May 2016 to August 2019. Cognition assessments (MMSE, MoCA) were performed for these patients. MRI imaging sequences were obtained and reviewed independently by two well-trained readers who were blind to all clinical data. Spearman’s correlation analysis and logistic regression model analysis were further used for the assessments.

Results

An association between cerebral microbleeds with cognitive ability and dementia in PD patients was revealed. A significance was observed between the total number of microbleeds and two widely used scores of cognitive assessments (Spearman R = − 0.120 to MMSE with a p = 0.016, and − 0.117 to MoCA with a p = 0.020). In detail, infratentorial microbleeds were associated with the level of cognition in PD patients (Spearman R = − 0.099 to MMSE with a p = 0.049, and − 0.116 to MoCA with a p = 0.021). Furthermore, logistic regression analysis results also confirmed such correlations between the number of microbleeds and cognitive ability after adjusting for age, cholesterol level, Hamilton Anxiety Scale, Hamilton Depression Scale, and white matter hyperintensity Fazekas score (OR 3.28, p = 0.035, 95% CI 1.090–9.892).

Conclusions

The occurrence of microbleeds, especially in the infratentorial locations, may worsen the cognitive function of PD patients and result in dementia. Management of cerebral vascular disease could be beneficial to patients with PD.

Marras C, Lang A (2013) Parkinson’s disease subtypes: lost in translation? J Neurol Neurosurg Psychiatry 84:409–415. https://doi.org/10.1136/jnnp-2012-303455CrossRefPubMed

Dickson DW, Braak H, Duda JE, Duyckaerts C, Gasser T, Halliday GM, Hardy J, Leverenz JB, Del Tredici K, Wszolek ZK, Litvan I (2009) Neuropathological assessment of Parkinson’s disease: refining the diagnostic criteria. Lancet Neurol 8:1150–1157. https://doi.org/10.1016/S1474-4422(09)70238-8CrossRefPubMed

Mortal S (2021) Microtubule dynamics in cytoskeleton, neurodegenerative and psychiatric disease. STEMedicine 2:e81. https://doi.org/10.37175/stemedicine.v2i6.81CrossRef

Aarsland D, Creese B, Politis M, Chaudhuri KR, Ffytche DH, Weintraub D, Ballard C (2017) Cognitive decline in Parkinson disease. Nat Rev Neurol 13:217–231. https://doi.org/10.1038/nrneurol.2017.27CrossRefPubMedPubMedCentral

Emre M (2003) Dementia associated with Parkinson’s disease. Lancet Neurol 2:229–237. https://doi.org/10.1016/s1474-4422(03)00351-xCrossRefPubMed

Li H, Yu Z, Zhang W (2020) Misfolded protein aggregation and altered cellular pathways in neurodegenerative diseases. STEMedicine 1:e63. https://doi.org/10.37175/stemedicine.v1i4.63CrossRef

Fisher M, French S, Ji P, Kim RC (2010) Cerebral microbleeds in the elderly: a pathological analysis. Stroke 41:2782–2785. https://doi.org/10.1161/STROKEAHA.110.593657CrossRefPubMedPubMedCentral

Akoudad S, Wolters FJ, Viswanathan A, de Bruijn RF, van der Lugt A, Hofman A, Koudstaal PJ, Ikram MA, Vernooij MW (2016) Association of cerebral microbleeds with cognitive decline and dementia. JAMA Neurol 73:934–943. https://doi.org/10.1001/jamaneurol.2016.1017CrossRefPubMedPubMedCentral

Yang J, Lyu Y, Ma Y, Chen Y (2018) Relationship between cerebral microbleeds location and cognitive impairment in patients with ischemic cerebrovascular disease. NeuroReport 29:1209–1213. https://doi.org/10.1097/WNR.0000000000001098CrossRefPubMed

10.

Ham JH, Yi H, Sunwoo MK, Hong JY, Sohn YH, Lee PH (2014) Cerebral microbleeds in patients with Parkinson’s disease. J Neurol 261:1628–1635. https://doi.org/10.1007/s00415-014-7403-yCrossRefPubMed

11.

Yamashiro K, Tanaka R, Hoshino Y, Hatano T, Nishioka K, Hattori N (2015) The prevalence and risk factors of cerebral microbleeds in patients with Parkinson’s disease. Parkinsonism Relat Disord 21:1076–1081. https://doi.org/10.1016/j.parkreldis.2015.06.019CrossRefPubMed

12.

Kim JH, Park J, Kim YH, Ma HI, Kim YJ (2015) Characterization of cerebral microbleeds in idiopathic Parkinson’s disease. Eur J Neurol 22:377–383. https://doi.org/10.1111/ene.12584CrossRefPubMed

13.

Vernooij MW, van der Lugt A, Ikram MA, Wielopolski PA, Niessen WJ, Hofman A, Krestin GP, Breteler MM (2008) Prevalence and risk factors of cerebral microbleeds: the Rotterdam Scan Study. Neurology 70:1208–1214. https://doi.org/10.1212/01.wnl.0000307750.41970.d9CrossRefPubMed

14.

Postuma RB, Berg D, Stern M, Poewe W, Olanow CW, Oertel W, Obeso J, Marek K, Litvan I, Lang AE, Halliday G, Goetz CG, Gasser T, Dubois B, Chan P, Bloem BR, Adler CH, Deuschl G (2015) MDS clinical diagnostic criteria for Parkinson’s disease. Mov Disord 30:1591–1601. https://doi.org/10.1002/mds.26424CrossRefPubMed

15.

Li H, Jia J, Yang Z (2016) Mini-mental state examination in elderly Chinese: a population-based normative study. J Alzheimers Dis 53:487–496. https://doi.org/10.3233/JAD-160119CrossRefPubMed

16.

Tomlinson CL, Stowe R, Patel S, Rick C, Gray R, Clarke CE (2010) Systematic review of levodopa dose equivalency reporting in Parkinson’s disease. Mov Disord 25:2649–2653. https://doi.org/10.1002/mds.23429CrossRefPubMed

17.

Wardlaw JM, Smith EE, Biessels GJ, Cordonnier C, Fazekas F, Frayne R, Lindley RI, O’Brien JT, Barkhof F, Benavente OR, Black SE, Brayne C, Breteler M, Chabriat H, Decarli C, de Leeuw FE, Doubal F, Duering M, Fox NC, Greenberg S, Hachinski V, Kilimann I, Mok V, Oostenbrugge R, Pantoni L, Speck O, Stephan BC, Teipel S, Viswanathan A, Werring D, Chen C, Smith C, van Buchem M, Norrving B, Gorelick PB, Dichgans M, nEuroimaging STfRVco (2013) Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration. Lancet Neurol 12:822–838. https://doi.org/10.1016/S1474-4422(13)70124-8CrossRefPubMedPubMedCentral

18.

Greenberg SM, Vernooij MW, Cordonnier C, Viswanathan A, Al-Shahi Salman R, Warach S, Launer LJ, Van Buchem MA, Breteler MM, Microbleed Study G (2009) Cerebral microbleeds: a guide to detection and interpretation. Lancet Neurol 8:165–174. https://doi.org/10.1016/S1474-4422(09)70013-4CrossRefPubMedPubMedCentral

19.

Gregoire SM, Chaudhary UJ, Brown MM, Yousry TA, Kallis C, Jager HR, Werring DJ (2009) The Microbleed Anatomical Rating Scale (MARS): reliability of a tool to map brain microbleeds. Neurology 73:1759–1766. https://doi.org/10.1212/WNL.0b013e3181c34a7dCrossRefPubMed

20.

Fazekas F, Kleinert R, Offenbacher H, Schmidt R, Kleinert G, Payer F, Radner H, Lechner H (1993) Pathologic correlates of incidental MRI white matter signal hyperintensities. Neurology 43:1683–1689. https://doi.org/10.1212/wnl.43.9.1683CrossRefPubMed

21.

Sumbria RK, Grigoryan MM, Vasilevko V, Paganini-Hill A, Kilday K, Kim R, Cribbs DH, Fisher MJ (2018) Aging exacerbates development of cerebral microbleeds in a mouse model. J Neuroinflammation 15:69. https://doi.org/10.1186/s12974-018-1092-xCrossRefPubMedPubMedCentral

22.

Griffin AD, Turtzo LC, Parikh GY, Tolpygo A, Lodato Z, Moses AD, Nair G, Perl DP, Edwards NA, Dardzinski BJ, Armstrong RC, Ray-Chaudhury A, Mitra PP, Latour LL (2019) Traumatic microbleeds suggest vascular injury and predict disability in traumatic brain injury. Brain 142:3550–3564. https://doi.org/10.1093/brain/awz290CrossRefPubMedPubMedCentral

23.

Yamashiro K, Tanaka R, Shimo Y, Oyama G, Ogawa T, Umemura A, Hattori N (2018) Cerebral microbleeds and blood pressure abnormalities in Parkinson’s disease. eNeurologicalSci 10:5–11CrossRefPubMed

24.

Gyanwali B, Shaik MA, Tan CS, Vrooman H, Venketasubramanian N, Chen C, Hilal S (2019) Mixed-location cerebral microbleeds as a biomarker of neurodegeneration in a memory clinic population. Aging (Albany NY) 11:10581–10596. https://doi.org/10.18632/aging.102478CrossRefPubMed

25.

Ingala S, Mazzai L, Sudre CH, Salvado G, Brugulat-Serrat A, Wottschel V, Falcon C, Operto G, Tijms B, Gispert JD, Molinuevo JL, Barkhof F, Study A (2020) The relation between APOE genotype and cerebral microbleeds in cognitively unimpaired middle- and old-aged individuals. Neurobiol Aging 95:104–114. https://doi.org/10.1016/j.neurobiolaging.2020.06.015CrossRefPubMed

26.

Liu J, Zhao W, Ware EB, Turner ST, Mosley TH, Smith JA (2018) DNA methylation in the APOE genomic region is associated with cognitive function in African Americans. BMC Med Genom 11:43. https://doi.org/10.1186/s12920-018-0363-9CrossRef

Titel: Cerebral microbleeds is associated with dementia in Parkinson’s disease
verfasst von: Huijuan Wan
Huimin Chen
Meimei Zhang
Tao Feng
Yilong Wang
Publikationsdatum: 07.06.2022
Verlag: Springer International Publishing
Erschienen in: Acta Neurologica Belgica / Ausgabe 2/2023
Print ISSN: 0300-9009
Elektronische ISSN: 2240-2993
DOI: https://doi.org/10.1007/s13760-022-01918-z

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Neurologie

Hirnblutung unter DOAK und VKA ähnlich bedrohlich

17.05.2024 Direkte orale Antikoagulanzien Nachrichten

Kommt es zu einer nichttraumatischen Hirnblutung, spielt es keine große Rolle, ob die Betroffenen zuvor direkt wirksame orale Antikoagulanzien oder Marcumar bekommen haben: Die Prognose ist ähnlich schlecht.

Thrombektomie auch bei großen Infarkten von Vorteil

16.05.2024 Ischämischer Schlaganfall Nachrichten

Auch ein sehr ausgedehnter ischämischer Schlaganfall scheint an sich kein Grund zu sein, von einer mechanischen Thrombektomie abzusehen. Dafür spricht die LASTE-Studie, an der Patienten und Patientinnen mit einem ASPECTS von maximal 5 beteiligt waren.

Schwindelursache: Massagepistole lässt Otholiten tanzen

14.05.2024 Benigner Lagerungsschwindel Nachrichten

Wenn jüngere Menschen über ständig rezidivierenden Lagerungsschwindel klagen, könnte eine Massagepistole der Auslöser sein. In JAMA Otolaryngology warnt ein Team vor der Anwendung hochpotenter Geräte im Bereich des Nackens.

Schützt Olivenöl vor dem Tod durch Demenz?

10.05.2024 Morbus Alzheimer Nachrichten

Konsumieren Menschen täglich 7 Gramm Olivenöl, ist ihr Risiko, an einer Demenz zu sterben, um mehr als ein Viertel reduziert – und dies weitgehend unabhängig von ihrer sonstigen Ernährung. Dafür sprechen Auswertungen zweier großer US-Studien.

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Abstract

Introduction

Methods

Results

Conclusions

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 2/2023

Compound heterozygous variants of MTHFR presenting as treatable leukodystrophy with reversible visuospatial deficits

Early-onset dementia in a middle-aged female: a case reflecting the compromise between pragmatic treatment of mimickers and extensive diagnostics

In situ high fidelity simulation of the pre procedure start timeframe in cerebral thrombectomy

A cytotoxic lesion of the corpus callosum (CLOCC) in a patient with headache and neurological deficits with cerebrospinal fluid lymphocytosis (HaNDL): a hint for pathophysiology?

FUS positive juvenile ALS-diagnostic and therapeutic insights from a 16-year-old female patient