Erschienen in:
01.06.2011
Challenges in the Treatment of Gastroesophageal Cancer: Reply
verfasst von:
Claire L. Donohoe, John V. Reynolds
Erschienen in:
World Journal of Surgery
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Ausgabe 6/2011
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Excerpt
We welcome the comments of Professor Liakakos [
1] in respect of our series of 520 patients with adenocarcinoma of the esophagogastric junction (AEG) [
2]. The series indicates that neither AEG type nor the operative approach was associated with oncologic outcome by multivariate analysis, and it strongly supports the need to achieve an R0 resection irrespective of operative approach. The more favorable pathologic features and improved outcomes of the predominantly Barrett’s-associated AEG type 1, compared with AEG type 2 and AEG type 3, suggests either an earlier diagnosis or altered biology. This observation sets hypotheses for further prospective study with optimal staging in combination with molecular studies. …