nach oben

European Archives of Oto-Rhino-Laryngology

Erschienen in:

01.05.2006 | Otology

Changes in distortion of two-tone cochlear microphonic and otoacoustic emission signals during an acute endolymphatic hydrops in the guinea pig

verfasst von: W. L. Valk, H. P. Wit, F. W. J. Albers

Erschienen in: European Archives of Oto-Rhino-Laryngology | Ausgabe 5/2006

Einloggen, um Zugang zu erhalten

Abstract

An acute endolymphatic hydrops was induced by the injection of 1.1 μl of artificial endolymph into the scala media of guinea pig cochleas. This volume corresponds with an acute endolymphatic hydrops of 23%. During and after the injection, cochlear function was assessed by measuring the 2f₁-f₂and f₂-f₁ distortion products in cochlear microphonics (CMDP) and the 2f₁-f₂ distortion product otoacoustic emission (DPOAE). A reversible pressure increase of 23 Pa and a relatively stable endocochlear potential (EP) were accompanied by a mean decrease in 2f₁-f₂ DPOAE of only 3.4 dB. Similarly, the 2f₁-f₂ CMDP amplitude change was minimal during and after the injection. The only substantial change was measured in the f₂-f₁ CMDP amplitude. The measured range of distortion amplitudes during an acute endolymphatic hydrops can be related to small changes in the cochlear transducer operating point.

Bian L, Chertoff ME, Miller E (2002) Deriving a cochlear transducer function from low-frequency modulation of distortion product otoacoustic emissions. J Acoust Soc Am 112:198–210CrossRefPubMed

Braun M (1996) Impediment of basilar membrane motion reduces overload protection but not threshold sensitivity: evidence from clinical and experimental hydrops. Hear Res 97:1–10CrossRefPubMed

Brownell WE (1990) Outer hair cell electromotility and otoacoustic emissions. Ear Hear 11:82–92PubMed

Conlon BJ, Gibson WP (2000) Electrocochleography in the diagnosis of Meniere’s disease. Acta Otolaryngol 120:480–483CrossRefPubMed

Ferraro JA, Tibbils RP (1999) SP/AP area ratio in the diagnosis of Meniere’s disease. Am J Audiol 8:21–28PubMed

Fetterman BL (2001) Distortion-product otoacoustic emissions and cochlear microphonics: relationships in patients with and without endolymphatic hydrops. Laryngoscope 111:946–954CrossRefPubMed

Fukazawa T, Ohmura M, Yagi N (1987) The effect of injection of high K+ solution into scala media. Acta Otolaryngol 103:170–175PubMed

Hallpike CS, Cairns H (1938) Observations on the pathology of Meniere’s syndrome. J Laryngol Otol 53:625–655

Jin XM, Guo YQ, Huangfu MS (1990) Electrocochleography in an experimental animal model of acute endolymphatic hydrops. Acta Otolaryngol 110:334–341PubMed

10.

Kimura RS, Schuknecht H (1965) Membranous hydrops in the inner ear of the guinea pig after the obliteration of the endolymphatic sac. Pract Otorhinolaryngol 27:343–354

11.

Kitahara M, Takeda T, Yazawa Y, Matsubara H, Kitano H (1982) Experimental study on Meniere’s disease. Otolaryngol Head Neck Surg 90:470–481PubMed

12.

Paparella MM, Djalilian HR (2002) Etiology, pathophysiology of symptoms, and pathogenesis of Meniere’s disease. Otolaryngol Clin North Am 35:529–545CrossRefPubMed

13.

Salt AN, DeMott J (1997) Longitudinal endolymph flow associated with acute volume increase in the guinea pig cochlea. Hear Res 107:29–40CrossRefPubMed

14.

Shinomori Y, Spack DS, Jones DD, Kimura RS (2001) Volumetric and dimensional analysis of the guinea pig inner ear. Ann Otol Rhinol Laryngol 110:91–98PubMed

15.

Sirjani DB, Salt AN, Gill RM, Hale SA (2004) The influence of transducer operating point on distortion generation in the cochlea. J Acoust Soc Am 115:1219–1229CrossRefPubMed

16.

Valk WL, Wit HP, Albers FWJ (2004) Effect of acute inner ear pressure changes on low-level distortion product otoacoustic emissions in the guinea pig. Acta Otolaryngol 124:929–936CrossRefPubMed

17.

Valk WL, Wit HP, Albers FWJ (2004) Evaluation of cochlear function in an acute endolymphatic hydrops model in the guinea pig by measuring low-level DPOAEs. Hear Res 192:47–56CrossRefPubMed

18.

Zhang M, Abbas PJ (1997) Effects of middle ear pressure on otoacoustic emission measures. J Acoust Soc Am 102:1032–1037CrossRefPubMed

Titel: Changes in distortion of two-tone cochlear microphonic and otoacoustic emission signals during an acute endolymphatic hydrops in the guinea pig
verfasst von: W. L. Valk
H. P. Wit
F. W. J. Albers
Publikationsdatum: 01.05.2006
Verlag: Springer-Verlag
Erschienen in: European Archives of Oto-Rhino-Laryngology / Ausgabe 5/2006
Print ISSN: 0937-4477
Elektronische ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-005-1035-x

Update HNO

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.

Newsletter bestellen

Springer Medizin

Changes in distortion of two-tone cochlear microphonic and otoacoustic emission signals during an acute endolymphatic hydrops in the guinea pig

Abstract

Neu im Fachgebiet HNO

Bei schweren Reaktionen auf Insektenstiche empfiehlt sich eine spezifische Immuntherapie

HNO-Op. auch mit über 90?

Intrakapsuläre Tonsillektomie gewinnt an Boden

Bilateraler Hörsturz hat eine schlechte Prognose

Update HNO

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 5/2006

Incidental metastases of well-differentiated thyroid carcinoma in lymph nodes of patients with squamous cell head and neck cancer: eight cases with a review of the literature

S.E. Kountakis, B.A. Senior, W. Draf (ed): The frontal sinus

A new shoulder orthosis for paralysis of the trapezius muscle after radical neck dissection: a preliminary report

Microvascular transplantation and replantation of the dog submandibular gland

Treatment of recurrent respiratory papillomatosis with microsurgery in combination with intralesional cidofovir—a prospective study

In vivo measurement of the elastic properties of the human vocal fold

Neu im Fachgebiet HNO

Bei schweren Reaktionen auf Insektenstiche empfiehlt sich eine spezifische Immuntherapie

HNO-Op. auch mit über 90?

Intrakapsuläre Tonsillektomie gewinnt an Boden

Bilateraler Hörsturz hat eine schlechte Prognose

Update HNO