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CardioVascular and Interventional Radiology

Erschienen in:

01.12.2012 | Case Report

Chemoembolic Hepatopulmonary Shunt Reduction to Allow Safe Yttrium-90 Radioembolization Lobectomy of Hepatocellular Carcinoma

verfasst von: Ron C. Gaba, Kyle A. VanMiddlesworth

Erschienen in: CardioVascular and Interventional Radiology | Ausgabe 6/2012

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Abstract

Yttrium-90 (⁹⁰Y) radioembolization represents an emerging transcatheter treatment option for the management of hepatocellular carcinoma (HCC). Elevation of the hepatopulmonary shunt fraction risks nontarget radiation to the lungs and may limit the use of ⁹⁰Y therapy in patients with locally advanced disease with vascular invasion, who often demonstrate increased shunting. We present two cases in which patients with HCC and portal vein invasion resulting in elevated hepatopulmonary shunt fractions underwent chemoembolic shunt closure to allow safe ⁹⁰Y radioembolization. Both patients demonstrated excellent tumor response and patient survival. On this basis, we propose a role for chemoembolic reduction of the lung shunt fraction before ⁹⁰Y radioembolization in patients with extensive tumor-related hepatopulmonary shunting.

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Titel: Chemoembolic Hepatopulmonary Shunt Reduction to Allow Safe Yttrium-90 Radioembolization Lobectomy of Hepatocellular Carcinoma
verfasst von: Ron C. Gaba
Kyle A. VanMiddlesworth
Publikationsdatum: 01.12.2012
Verlag: Springer-Verlag
Erschienen in: CardioVascular and Interventional Radiology / Ausgabe 6/2012
Print ISSN: 0174-1551
Elektronische ISSN: 1432-086X
DOI: https://doi.org/10.1007/s00270-012-0371-7

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Chemoembolic Hepatopulmonary Shunt Reduction to Allow Safe Yttrium-90 Radioembolization Lobectomy of Hepatocellular Carcinoma

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