Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Typ-2-Diabetes und Adipositas Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Häufige urologisch-sexualmedizinische Themen in der Praxis sind das Thema des MMW-Webinars am 5. Juni von 17.30 bis 19 Uhr. Konkret geht es um die Frage, wann bei Harnwegsinfektionen auf Antibiotika verzichtet werden kann, und um ein Update zur Therapie von Libido- und Potenzstörungen des Mannes. Der dritte Vortrag behandelt sexuell übertragbare Krankheiten. Stellen Sie Ihre Fragen an die Experten und sammeln Sie 2 CME-Punkte. Jetzt gleich anmelden!
Erweiterte Suche
Anmelden
nach oben
Inflammation
Erschienen in: Inflammation 6/2015

01.12.2015

Chitotriosidase Expression during Monocyte-Derived Dendritic Cells Differentiation and Maturation

verfasst von: Michelino Di Rosa, Daniele Tibullo, Daniela Cambria, Gisella Distefano, Salvatore Saccone, Francesco Di Raimondo, Lucia Malaguarnera

Erschienen in: Inflammation | Ausgabe 6/2015

Einloggen, um Zugang zu erhalten

Abstract

The chitotriosidase (CHIT-1) is a glycosyl hydrolase (GH), which has been found highly expressed in activated macrophages and in different monocyte-derived cell lines such as Kupffer cells and osteoclasts, as well is differently produced in diverse stages of macrophage polarization (M1 and M2). Recent finding suggests that CHIT-1 plays a crucial role in innate and acquired immunity. Dendritic cells (DCs) are a complex group of cells that play a critical role in immune response. The aim of this study was to investigate the presence of CHIT-1 during the differentiation and maturation of DCs. Magnetically-isolated peripheral blood monocytes were differentiated toward immature DCs (iDC) and mature DCs (mDCs). Our results showed, for the first time, that CHIT-1 is expressed during the process of differentiation and maturation of DCs in a time-dependent manner. We found that CHIT1 is evenly distributed in cytoplasm of both the iDCs and mDCs. Additionally, a significantly increased expression of CHIT1 mRNA and protein was observed in mature DCs. These results suggest that CHIT-1 play an important role in the DCs immunoresponse.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
1.
Cantarel, B.L., P.M. Coutinho, C. Rancurel, T. Bernard, V. Lombard, and B. Henrissat. 2009. The Carbohydrate-Active EnZymes database [CAZy]: an expert resource for Glycogenomics. Nucleic Acids Research 37: D233–D238.PubMedCentralCrossRefPubMed
2.
Sumarac, Z., N. Suvajdzic, S. Ignjatovic, N. Majkic-Singh, D. Janic, M. Petakov, et al. 2011. Biomarkers in Serbian patients with Gaucher disease. Clinical Biochemistry 44: 950–954.CrossRefPubMed
3.
Di Rosa, M., A.M. Zambito, A.R. Marsullo, G. Li Volti, and L. Malaguarnera. 2009. Prolactin induces chitotriosidase expression in human macrophages through PTK, PI3-K, and MAPK pathways. Journal of Cellular Biochemistry 107: 881–889.CrossRefPubMed
4.
Malaguarnera, L. 2006. Chitotriosidase: the yin and yang. Cellular and Molecular Life Sciences 63: 3018–3029.CrossRefPubMed
5.
Aerts, J.M., C.E. Hollak, M. van Breemen, M. Maas, J.E. Groener, and R.G. Boot. 2005. Identification and use of biomarkers in Gaucher disease and other lysosomal storage diseases. Acta Paediatrica 94: 43–46.CrossRefPubMed
6.
Guffon, N. 2006. Gaucher disease and chitotriosidase. La Revue de Médecine Interne / Fondee par la Societe Nationale Francaise de Medecine Interne 27(Suppl 1): S26–S29.CrossRefPubMed
7.
Boot, R.G., E.F. Blommaart, E. Swart, K. Ghauharali-van der Vlugt, N. Bijl, C. Moe, et al. 2001. Identification of a novel acidic mammalian chitinase distinct from chitotriosidase. The Journal of Biological Chemistry 276: 6770–6778.CrossRefPubMed
8.
van Eijk, M., C.P. van Roomen, G.H. Renkema, A.P. Bussink, L. Andrews, E.F. Blommaart, et al. 2005. Characterization of human phagocyte-derived chitotriosidase, a component of innate immunity. International Immunology 17: 1505–1512.CrossRefPubMed
9.
Boot, R.G., G.H. Renkema, A. Strijland, A.J. van Zonneveld, and J.M. Aerts. 1995. Cloning of a cDNA encoding chitotriosidase, a human chitinase produced by macrophages. The Journal of Biological Chemistry 270: 26252–26256.CrossRefPubMed
10.
Malaguarnera, L., J. Simpore, D.A. Prodi, A. Angius, A. Sassu, I. Persico, et al. 2003. A 24-bp duplication in exon 10 of human chitotriosidase gene from the sub-Saharan to the Mediterranean area: Role of parasitic diseases and environmental conditions. Genes and Immunity 4: 570–574.CrossRefPubMed
11.
Labadaridis, I., E. Dimitriou, M. Theodorakis, G. Kafalidis, A. Velegraki, and H. Michelakakis. 2005. Chitotriosidase in neonates with fungal and bacterial infections. Archives of Disease in Childhood. Fetal and Neonatal Edition 90: F531–F532.PubMedCentralCrossRefPubMed
12.
Elias, J.A., R.J. Homer, Q. Hamid, and C.G. Lee. 2005. Chitinases and chitinase-like proteins in T[H]2 inflammation and asthma. Journal of Allergy and Clinical Immunology 116(3): 497–500.CrossRefPubMed
13.
Bargagli, E., M. Margollicci, N. Nikiforakis, A. Luddi, A. Perrone, S. Grosso, et al. 2007. Chitotriosidase activity in the serum of patients with sarcoidosis and pulmonary tuberculosis. Respiration: Intern Review Thoracic Diseases 74: 548–552.CrossRef
14.
Malaguarnera, L., M. Di Rosa, A.M. Zambito, N. dell’Ombra, R. Di Marco, and M. Malaguarnera. 2006. Potential role of chitotriosidase gene in nonalcoholic fatty liver disease evolution. American Journal of Gastroenterology 101: 2060–2069.CrossRefPubMed
15.
Ross, R. 1999. Atherosclerosis is an inflammatory disease. American Heart Journal 138: S419–S420.CrossRefPubMed
16.
Moreno, P.R., E. Falk, I.F. Palacios, J.B. Newell, V. Fuster, and J.T. Fallon. 1994. Macrophage infiltration in acute coronary syndromes. Implications for plaque rupture. Circulation 90: 775–778.CrossRefPubMed
17.
Di Rosa, M., G. Malaguarnera, C. De Gregorio, F. Drago, and L. Malaguarnera. 2013. Evaluation of CHI3L-1 and CHIT-1 expression in differentiated and polarized macrophages. Inflammation 36: 482–492.CrossRefPubMed
18.
Steinman, R.M. 1991. The dendritic cell system and its role in immunogenicity. Annual Review of Immunology 9: 271–296.CrossRefPubMed
19.
Di Rosa, M., M. Musumeci, A. Scuto, S. Musumeci, and L. Malaguarnera. 2005. Effect of interferon-gamma, interleukin-10, lipopolysaccharide and tumor necrosis factor-alpha on chitotriosidase synthesis in human macrophages. Clinical Chemistry and Laboratory Medicine 43: 499–502.PubMed
20.
Di Rosa, M., G. Malaguarnera, C. De Gregorio, M. Palumbo, G. Nunnari, L. Malaguarnera. 2012. Immuno-modulatory effects of vitamin D3 in human monocyte and macrophages. Cell Immunology 280: 36–43.
21.
Di Rosa, M., D. Tibullo, M. Vecchio, G. Nunnari, S. Saccone, F. Di Raimondo, et al. 2014. Determination of chitinases family during osteoclastogenesis. Bone 61: 55–63.CrossRefPubMed
22.
Bradford, M.M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry 72: 248–254.CrossRefPubMed
23.
Malaguarnera, L., M. Musumeci, F. Licata, M. Di Rosa, A. Messina, and S. Musumeci. 2004. Prolactin induces chitotriosidase gene expression in human monocyte-derived macrophages. Immunology Letters 94(1–2): 57–63.CrossRefPubMed
24.
Jin, P., T.H. Han, J. Ren, S. Saunders, E. Wang, F.M. Marincola, et al. 2010. Molecular signatures of maturing dendritic cells: Implications for testing the quality of dendritic cell therapies. Journal of Translational Medicine 8: 4.PubMedCentralCrossRefPubMed
25.
Guilliams, M., F. Ginhoux, C. Jakubzick, S.H. Naik, N. Onai, B.U. Schraml, et al. 2014. Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny. Nature Reviews Immunology 14: 571–578.CrossRefPubMed
26.
Leon, B., and C. Ardavin. 2008. Monocyte-derived dendritic cells in innate and adaptive immunity. Immunology and Cell Biology 86: 320–324.CrossRefPubMed
27.
Banchereau, J., and A.K. Palucka. 2005. Dendritic cells as therapeutic vaccines against cancer. Nature Reviews Immunology 5: 296–306.CrossRefPubMed
28.
Luo, X., L. Liu, N. Tang, K.Q. Lu, T.S. McCormick, K. Kang, et al. 2005. Inhibition of monocyte-derived dendritic cell differentiation and interleukin-12 production by complement iC3b via a mitogen-activated protein kinase signalling pathway. Experimental Dermatology 14: 303–310.CrossRefPubMed
29.
Schmeisser, A., C. Graffy, W.G. Daniel, and R.H. Strasser. 2003. Phenotypic overlap between monocytes and vascular endothelial cells. Advances in Experimental Medicine and Biology 522: 59–74.CrossRefPubMed
30.
Di Rosa, M., G. Malaguarnera, C. De Gregorio, F. D’Amico, M.C. Mazzarino, and L. Malaguarnera. 2013. Modulation of chitotriosidase during macrophage differentiation. Cell Biochemistry and Biophysics 66: 239–247.CrossRefPubMed
31.
Iyer, A., M. van Eijk, E. Silva, M. Hatta, W. Faber, J.M. Aerts, and P.K. Das. 2009. Increased chitotriosidase activity in serum of leprosy patients: association with bacillary leprosy. Clinical Immunology 131: 501–509.CrossRefPubMed
Metadaten
Titel
Chitotriosidase Expression during Monocyte-Derived Dendritic Cells Differentiation and Maturation
verfasst von
Michelino Di Rosa
Daniele Tibullo
Daniela Cambria
Gisella Distefano
Salvatore Saccone
Francesco Di Raimondo
Lucia Malaguarnera
Publikationsdatum
01.12.2015
Verlag
Springer US
Erschienen in
Inflammation / Ausgabe 6/2015
Print ISSN: 0360-3997
Elektronische ISSN: 1573-2576
DOI
https://doi.org/10.1007/s10753-015-0190-5

Weitere Artikel der Ausgabe 6/2015

Inflammation 6/2015 Zur Ausgabe

OriginalPaper

Riparin B, a Synthetic Compound Analogue of Riparin, Inhibits the Systemic Inflammatory Response and Oxidative Stress in Mice

OriginalPaper

Ameliorative Effect of Vicenin-2 and Scolymoside on TGFBIp-Induced Septic Responses

OriginalPaper

Disturbed Th17/Treg Balance in Patients with Non-small Cell Lung Cancer

OriginalPaper

Thymoquinone Inhibits IL-1β-Induced Inflammation in Human Osteoarthritis Chondrocytes by Suppressing NF-κB and MAPKs Signaling Pathway

OriginalPaper

Cytokine Responses to Specific Immunotherapy in House Dust Mite-Induced Allergic Rhinitis Patients

OriginalPaper

Observing Anti-inflammatory and Anti-nociceptive Activities of Glycyrrhizin Through Regulating COX-2 and Pro-inflammatory Cytokines Expressions in Mice

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

Positiver FIT: Die Ursache liegt nicht immer im Dickdarm

27.05.2024 Blut im Stuhl Nachrichten

Immunchemischer Stuhltest positiv, Koloskopie negativ – in solchen Fällen kann die Blutungsquelle auch weiter proximal sitzen. Ein Forschungsteam hat nachgesehen, wie häufig und in welchen Lokalisationen das der Fall ist.

GLP-1-Agonisten können Fortschreiten diabetischer Retinopathie begünstigen

24.05.2024 Diabetische Retinopathie Nachrichten

Möglicherweise hängt es von der Art der Diabetesmedikamente ab, wie hoch das Risiko der Betroffenen ist, dass sich sehkraftgefährdende Komplikationen verschlimmern.

Mehr Lebenszeit mit Abemaciclib bei fortgeschrittenem Brustkrebs?

24.05.2024 Mammakarzinom Nachrichten

In der MONARCHE-3-Studie lebten Frauen mit fortgeschrittenem Hormonrezeptor-positivem, HER2-negativem Brustkrebs länger, wenn sie zusätzlich zu einem nicht steroidalen Aromatasehemmer mit Abemaciclib behandelt wurden; allerdings verfehlte der numerische Zugewinn die statistische Signifikanz.

ADT zur Radiatio nach Prostatektomie: Wenn, dann wohl länger

24.05.2024 Prostatakarzinom Nachrichten

Welchen Nutzen es trägt, wenn die Strahlentherapie nach radikaler Prostatektomie um eine Androgendeprivation ergänzt wird, hat die RADICALS-HD-Studie untersucht. Nun liegen die Ergebnisse vor. Sie sprechen für länger dauernden Hormonentzug.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen
Bildnachweise