Erschienen in:
Open Access
01.12.2012 | Poster presentation
Cigarette smoke downregulates HDAC2 in rheumatoid arthritis synovial fibroblasts
verfasst von:
Anna Engler, Astrid Jüngel, Christoph Kolling, Beat A Michel, Renate Gay, Steffen Gay, Caroline Ospelt
Erschienen in:
Arthritis Research & Therapy
|
Sonderheft 1/2012
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Excerpt
Cigarette smoking has been shown as major environmental risk factor for rheumatoid arthritis (RA). Epidemiological studies indicate an association of cigarette smoking with development of RA [
1,
2], although molecular mechanisms remain unknown. The aim of this study is to analyze the influence of cigarette smoke on the gene expression regulated by histone deacetylases (HDACs) in RA synovial fibroblasts (RASF). …