Background
The regulation mechanisms of circRNAs
Translation of circRNAs
Exosome delivery of circRNAs in cancer
Expression profiles and identification of circRNAs in cancer
The circRNA regulation network in cancer
Clinically relevant implications of circRNAs in cancer
Cancer type | CircRNA | Samples | Cases | Expression | Association | Reference |
---|---|---|---|---|---|---|
Bladder cancer | CircPTK2 | Tissue/blood | 40 pairs | Up | Poor differentiation, higher lymph node metastasis and T stage | [83] |
Circ-ITCH | Tissue | 72 pairs | Down | Higher TNM stage and histological grade | [96] | |
Esophageal cancer | Has_circ_0067934 | Tissue | 51 pairs | Up | Poor differentiation and higher TNM stage | [84] |
CiRS-7 | Tissue | 86 pairs | Up | Higher clinical stage and pathological grade | [97] | |
Colorectal cancer | Hsa_circ_0007534 | Tissue | 33 pairs | Up | Higher clinical stage and lymph node metastasis | [68] |
Hsa_circ_001988 | Tissue | 31 pairs | Down | Associated with differentiation and perineural invasion | [67] | |
Hsa_circ_0000069 | Tissue | 30 pairs | Up | Associated with patient age and TNM stage | [98] | |
CiRS-7 | Tissue | 40 pairs | Up | Higher T-stage and metastasis/poor prognosis | [70] | |
Circular BANP | Tissue | 35 pairs | Up | Unknown | [41] | |
CircRNA0003906 | Tissue | 122 pairs | Down | Poor differentiation, higher lymphatic metastasis/diagnosis value | [99] | |
Hsa_circ_0001649 | Tissue/blood | Total 146 | Down (tissue)/up (blood) | Associated with differentiation | [100] | |
Circ_0014717 | Tissue | 46 pairs | Down | Associated with TNM stage and distal metastasis/poor prognosis | [69] | |
Hsa_circ_0000567 | Tissue | 102 pairs | Down | Lower clinical stage and lymph node metastasis/diagnosis value | [101] | |
CircHIPK3 | Tissue | Total 218 | Up | Associated with TNM stage and metastasis/poor prognosis | [102] | |
Hepatocellular carcinoma | CiRS-7 | Tissue | 108 pairs | Up (39.8%)/down (60.2%) | Associated with MVI | [103] |
Hsa_circ_0005075 | Tissue | 66 pairs | Up | Larger size tumors/diagnostic potential | [75] | |
Hsa_circ_0001649 | Tissue | 89 pairs | Down | Larger tumor size and tumor embolus formation/poor prognosis | [104] | |
Hsa_circ_0003570 | Tissue | 107 pairs | Down | Associated with tumor diameter, differentiation and vascular formation | [73] | |
CircMTO1 | Tissue | 261 pairs | Down | Poor prognosis | [74] | |
CircZKSCAN1 | Tissue | 102 pairs | Down | Potential diagnostic value | [76] | |
Hsa_circ_0000673 | Tissue | 51 pairs | Up | Poor overall survival | [105] | |
CircC3P1 | Tissue | 47 pairs | Down | Higher TNM stage, tumor size and vascular invasion | [106] | |
Gastric cancer | Hsa_circ_002059 | Tissue/plasma | Total 147 | Down | Associated with distal metastasis, TNM stage, gender and age | [11] |
Hsa_circ_0000190 | Tissue/plasma | 104 pairs | Down | Associated with tumor diameter, metastasis and TNM stage (tissue)/CEA (plasma) | [81] | |
Circ-104916 | Tissue | 70 pairs | Down | Higher tumor stage and lymphatic metastasis | [80] | |
CircRNA_100269 | Tissue | 112 pairs | Down | Associated with histological subtypes and nodes invasion | [107] | |
Hsa_circ_0000745 | Tissue/plasma | 20 pairs | Down | Associated with tumor differentiation (tissue)/node metastasis (plasma) | [108] | |
Hsa circ 0074362 | Tissue | 127 pairs | Down | Associated with CA19–9 and lymphatic metastasis | [109] | |
CircPVT1 | Tissue | 187 pairs | Up | Associated with overall survival | [110] | |
Hsa_circ_0006633 | Tissue/plasma | Total 338 | Down(tissue)/up(plasma) | Associated with distal metastasis and CEA (tissue) | [78] | |
Hsa_circ_0001895 | Tissue | Total 257 | Down | Associated with differentiation, Borrmann type and CEA | [111] | |
Hsa_circ_0014717 | Tissue/gastric juice | Total 122 | Down | Associated with tumor stage, metastasis, CEA and CA19–9 (tissue) | [79] | |
Hsa_circ_0003159 | Tissue | 108 pairs | Down | Higher gender, distal metastasis and node metastasis | [112] | |
Hsa_circ_0000181 | Tissue/plasma | Total 115 | Down | Associated with tumor diameter, metastasis and CA19–9 (tissue)/differentiation and CEA | [82] | |
Hsa_circ_0000520 | Tissue | 56 pairs | Down | Higher TNM stage | [113] | |
CircMYO9B | Tissue | 21 pairs | Up | Lower survival rate | [114] | |
Breast cancer | CircGFRA1 | Tissue | Total 222 | Up | Higher tumor size, TNM stage, lymphatic metastasis and histological grade | [115] |
Cir-ITCH | Tissue | Total 78 | Up | Associated with age | [58] | |
CircRNA_100876 | Tissue | 101 pairs | Up | Associated with lymphatic metastasis and advanced stage | [116] | |
Osteosarcoma | CircPVT1 | Tissue/serum/lung metastasis | Total 80 | Up | Poor prognosis/diagnosis value | [95] |
Lung cancer | CircFADS2 | Tissue | 43 pairs | Up | Poor differentiation, advanced TNM stage and lymphatic metastasis | [117] |
CircRNA_102231 | Tissue | 57 pairs | Up | Associated with TNM stage and lymph node metastasis | [118] |