The impact of COPD on patient’s quality of life is well established, but gender differences have received little attention.
Methods
To describe factors associated with the health-related quality of life by gender: A cross-sectional observational study (NCT01007734) was conducted in COPD patients followed by pulmonologists. The first patient included had to be a woman. Data concerning the patient, COPD and their management were collected by the physician. The patient had to fill in several questionnaires: Saint-George Hospital respiratory Questionnaire (SGRQ-C), and motivation to quit smoking.
Results
Four hundred and thirty patients were included: mean age 63.9 ± 11.3 years; 57.4% were women. Women were significantly younger than men (61.9 vs. 66.6) and their tobacco use was lower (37.1 vs. 40.4 PY). Cardiovascular comorbidities were more frequent in men while osteoporosis, anxiety and depression were frequent in women. The frequency of cough, sputum and the severity of dyspnea did not differ significantly between genders. Lung function impairment was less severe in women than in men (mean FEV1 52% predicted normal vs. 47. 8%). Anxiety score was higher (score 9.8 vs. 7.1) and quality of life (SGRQ-C) more impaired in women (scores 50.6 vs. 45.4; p < 0.02) than in men. Moreover, in multivariate analysis, chronic sputum was associated with higher SGRQ-C scores in women but not in men.
Conclusions
This study underlines that despite less airflow limitation, quality of life is more impacted by chronic sputum in women than in men.
The online version of this article (doi:10.1186/1472-6874-14-31) contains supplementary material, which is available to authorized users.
Competing interest
Chantal Raherison received speaker fees and congress invitations from the following companies: Novartis, Astra Zeneca, MundiPharma, Chiesi, Nycomed, Pierre Fabre. Isabelle Tillie-Leblond received speaker fees and congress invitations from the following companies: Novartis, Astra Zeneca, MundiPharma, Chiesi, Nycomed, GlaxoSmithKline. Camille Taillé received speaker fees and congress invitations from the following companies: Novartis, Astra Zeneca, GlaxoSmithKline, MSD, Chiesi, Teva. Anne Prudhomme received speaker fees and congress invitations from the following companies: Novartis, AstraZeneca, MundiPharma, GlaxoSmithKline. Elisabeth Biron received speaker fees and congress invitations from the following companies: AstraZeneca. Cecilia Nocent received speaker fess and congress invitations from the following companies: Astra Zeneca, Novartis, Merck Sharp & Dohme-Chibret, GlaxoSmithKline, ALK. Bénigne Mathieu and Juliette Ostinelli are full time employees of AstraZeneca France, Medical Department.
Authors’ contributions
All authors were involved in the study design, discussed the results. CR wrote the paper. All authors commented on the revised manuscript. All authors read and approved the final manuscript.
Abkürzungen
COPD
Chronic obstructive pulmonary disease
SGRQ-C
Saint-George Hospital respiratory Questionnaire
HADS
Hospital anxiety and depression scale
QMAT
Motivation to quit smoking
WHO
World Health Organization
BOD index
Body mass, Obstruction, dyspnea index.
Background
According to WHO, chronic obstructive pulmonary disease (COPD) is now the fourth leading cause of death and will become the third in 2020. Some studies have shown that prevalence of COPD is increasing faster among women than men with different geographic distributions. In industrialized countries, COPD is usually associated with the increase in active smoking in women [1, 2], probably with an underestimation of the impact of working exposure [3]. In the developing countries, the impact of COPD seems to be more associated with exposure to biomass in women [4].
Although COPD is the consequence of an interaction between genetic predisposition and environmental exposure, the influence of gender on the clinical expression of COPD has received limited attention. In general practice, COPD in women who smoke is often underdiagnosed [5, 6]. Previous studies suggested that for the same severity of the disease, women with COPD seem to report more dyspnea and worse quality of life than men.
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Quality of life is now a major component of the management of the disease, and valid criteria are needed to assess the efficacy of medication. Health status measurement is becoming an important issue for the day-to-day management of COPD patients in both primary and secondary health care [7]. Studies report that a shorter survival is related to worse health status/HRQoL (Health-related Quality of Life). Since health status is considered a major goal in managing the disease, physicians should focus on improving it. In addition, previous studies suggested that determinants of quality of life related to respiratory status differ by gender [8].
The first objective of our study (NCT01007734) was to describe the main factors determining the quality of life related to respiratory status according to gender in patients with moderate-to-severe COPD. The second objective was to determine the characteristics of COPD by gender after adjusting on age and active smoking.
Methods
This was a multicenter, descriptive, cross-sectional study conducted in France from September 2009 to November 2010.
Physicians were recruited by telephone at random among a database of French pulmonologists. Each pulmonologist recruited at least three consecutive patients once the first woman was included. Inclusion criteria were outpatients more than 40 years old, with a spirometric diagnosis of COPD according to GOLD guidelines with post-bronchodilator FEV1/FVC under 0.70 and FEV1 under 80% predicted. Patients might have been followed for COPD for at least three months. They provided written informed consent and had to be able to complete the Saint George Hospital Respiratory Questionnaire (SGRQ).
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Exclusion criteria were as follows: recent exacerbation within 6 weeks, current or history of asthma, patients with long-term requirement of oxygen, non-invasive ventilation or tracheotomy, or participating in another trial. The physician filled in a medical questionnaire with demographics, comorbidities, COPD description, and COPD treatment concerning the patient. Chronic cough was defined as cough during 3 months and during two consecutive years, which the admitted definition of chronic bronchitis, the same definition was made for chronic sputum.
The BOD index was made with Body mass (<21 kg/m2), Obstruction (FEV1) and level of Dyspnea (MRC) without 6 minutes walking test (not available). Patients completed the following self-administered questionnaires, the (SGRQ-C), the Hospital Anxiety and Depression Scale (HADS) and the Motivation to quit smoking (Q-MAT, active smokers only).
The SGRQ is scaled from 0 (optimal health) to 100 (worst health) [9]. A total score and three sub-scores (symptoms, activities, impacts) are calculated.
The French translated version of SGRQ had been studied by Bourbeau et al. [10] and showed higher test-retest reliability (0.80).
The HADS is scaled [11] from 0 (no anxiety, no depression) to 21 (severe anxiety, or depression) for each subscale, French version used since 1985 [12].
The Q-MAT [13] is scaled from 0 (lack of motivation) to 20 (excellent motivation).
Statistical analysis
Descriptive statistics (qualitative and quantitative data) were performed at baseline. We compared for clinical components and quality of life, men and women, then and after including significant factors, a multivariate model was used to determine factors related to quality of life, specifically for men and women, by stratifying by gender. Correlations were determined using Spearman correlation. Then, we correlated SGRQ total score with different variables using a multiple linear regression analysis using backward Wald criteria (p < 0.20), with those variables that significantly correlated with total SGRQ score. The criterion for statistical significance was 0.05. The software program used was SAS version 8.2.
The protocol was approved in France by the Comité Consultatif sur le Traitement de l’Information en matière de Recherche dans le domaine de la Santé (CCTIRS) and the Commission National Computer and Freedoms (CNIL). All patients were informed about the objectives of the study, and agreed to participate and fill in the questionnaires. The study was conducted according to the recommendations of the declaration of Helsinki for investigation with human subjects.
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Results
One hundred and forty-six physicians included 446 patients, among them 430 had data available for analysis. Mean age of physicians was 51.9 years (SD 7.9) and 77.3% of them were men. 60% of them were private practitioners and 40% were employed by hospitals.
Among the patients, 57.4% of them were female and 42.6% male. Descriptive analysis (Table 1) showed that women with COPD were younger, had lower BMI, and were more un-employed and lived alone more than men. Men were more frequently smokers or ex smokers than women (97.8% versus 84. 6% p < 0.001) but frequency of active smoking was higher in women, with a significant difference in the amount of smoking. Cardiovascular comorbidities, dyslipidemia, alcoholism and sleep apnea syndrome were more frequent in men. By contrast, osteoporosis, past anxiety and depression were more frequent in women.
Table 1
Descriptive characteristics and co-morbities by gender
Men (n = 183) 42.6%
Women (n = 247) 57.4%
p
n (M/W)
Mean age (years)
66.6 ± 10.8
61.9 ± 11.3
<0.001
175/242
% of subjects BMI <21 (Kg/m2)
14.9
29.5
0.002
102/147
Living alone at home (%)
17.6
36.1
<0.001
181/244
Unemployed
11.8
25.2
<0.001
170/238
Non-smoker/current smokers (%)
2.2/30.2
15.4/44.1
<0.001
182/247
Tobacco use (pack- years)
40.5 ±19
37 ±16
0.041
170/203
Comorbidities (%)
Arterial hypertension
41.4
32.9
NS
181/246
Ischemic heart disease
24.4
5.7
<0.001
180/245
Arteriopathy
12.2
3.7
0.001
181/245
Heart failure
8.4
2.9
0.011
178/245
Diabetes
11.5
6.5
NS
182/246
Dyslipidemia
26
16.7
< 0.02
181/246
Alcoholism
8.8
3.3
0.013
181/246
Sleep apnea syndrome
13.3
4.1
0.001
180/245
Osteoporosis
2.8
19.6
<0.001
178/240
Anxiety disorder
16.8
29.4
0.003
179/245
Depression disorder
4.6
19
<0.001
175/242
There was no difference between men and women regarding the frequency of cough and sputum and the severity of dyspnea (Table 2). Women seemed to have more exacerbations than men but the difference was not statistically significant. Regarding the severity of COPD according to the GOLD classification, there was a higher proportion of stage 2 and less stage 4 in women compared to men. Women used more short-acting ß2-agonists, with no difference for other inhaled treatment for COPD. There was a higher proportion of women with anxiety as measured by the HAD questionnaire compared to men.
Table 2
Clinical description of COPD by gender
Men (n = 183)
Women (n = 247)
p
n (M/W)
COPD symptoms (%)
42.6%
57.4%
Chronic cough
75.6
78.5
Chronic sputum
62
64.2
NS
182/245
Dyspnea MRC stage 0- 1–2 (%)
73.7
72.7
NS
179/242
Dyspnea MRC stage 3–4 (%)
26.3
27.3
COPD exacerbation (< 12 months) (%)
58.2
65.7
NS
182/245
FEV1(% predicted)
46.2 ±14.4
52.1 ± 15.9
< 0.001
162/224
FEV1/FVC post BD
57.9 ± 13.6
58.9 ± 13.1
NS
170/231
GOLD stage 2
42.9%
54.6%
3
39.5%
37.4%
0.026
119/163
4
17.6%
8.0%
Short- acting ß2 -agonists
40
53.1
0.010
170/226
BOD index
2.9 ±1.6
2.6 ±1.6
NS
183/247
HAD anxiety sub-score (0–21)
7.1 ± 4.3
9.8 ± 4.3
< 0.001
131/177
HAD depression sub-score (0–21)
6.1 ± 4.4
6.6 ± 4.6
NS
128/177
Q- MAT score (0–20)
9.3 ±6
8.7 ±5.9
NS
46/93
In active smokers, there was no difference in terms of motivation to quit smoking between men and women (Table 2). Women with COPD had significantly worse quality of life total scores (4 points of difference for clinical relevance) compared with men, and a trend was observed for each domain: symptoms, activities and impacts (Figure 1).
Figure 1
Quality of life: SGRQ total score and subscores.
×
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In the multivariate model to determine factors associated with quality of life, we only included variables with less than 25% of data lacking, which decreased the size of the sample.
Regarding factors associated with poor quality of life (Table 3), the following factors were related in the global population: severity of COPD (FEV1), severity of dyspnea, chronic sputum, high number of treatments, previous lower respiratory infections, and higher level of anxiety and depression (HAD). Factors related to poor quality of life were different in women compared with men. Chronic sputum was significantly associated with poor quality of life in women, whereas the number of treatments was associated with it in men.
Table 3
Factors determining quality of life (SGRQ-C total score): multivariate analysis
Men
Women
Total
N = 75
N = 100
N = 175
COPD stage (GOLD)
4.37 [0.31; 8.43]
3.07 [−0.89; 7.02]
3.16 [0.37; 5.94]
p = 0.035
p = 0.127
p = 0.027
HAD depression
1.84 [1.12; 2.56]
1.89 [1.36; 2.41]
1.62 [1.09; 2.15]
Sub-score
p < 0.001
p < 0.001
p < 0.001
MRC dyspnea score
17.07 [9.71; 24.44]
10.73 [4.80; 16.65]
12.37 [7.56; 17.19]
p < 0.001
p = 0.001
p < 0.001
Chronic sputum
NS
8.33 [3.20; 13.45] p = 0.002
6.23 [2.22; 10.23] p = 0.003
Number of treatments
3.13 [1.26; 5.00] p = 0.001
NS
1.89 [0.50; 3.28] p = 0.008
β (95% IC); analysis done using factors with less than 25% of data lacking.
NS: non significant.
Discussion
This study was conducted to assess clinical differences by gender in COPD patients and to determine factors related to quality of life in an outpatient setting in France.
Our study describes the clinical profile of COPD in women and adds evidence for gender-related differences adjusted on COPD severity. Women with COPD were younger, had lower BMI, more unemployed and lived more alone than men. Despite the lower severity of the disease as assessed by GOLD staging, women with COPD had a worse quality of life compared to men, and were more impacted by chronic cough.
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In the large Muvice Study [14], lower BMI was found in women compared to men, suggesting that COPD may affect nutritional status differently in women. Previously, a high proportion of non-smokers and a lower proportion of active smokers were found in women [14]. However, this was not the case in our study, with a higher proportion of active smokers in women compared to men. This may be due to a change in smoking trends in France, although a selection bias cannot be ruled out.
Skuliem et al. reported a greater proportion of women living alone compared to men [15]. Social support could be included in the management of these patients, in order to improve education about treatment and adherence to it. In turn, this could also help to reduce the anxiety-depression that patients experience [16].
Cardiovascular comorbidities, dyslipidemia, alcoholism and sleep apnea syndrome were more frequent in men. By contrast, osteoporosis, past anxiety and depression were more frequent in women. In the large EPIDEPOC study [17], ischemic heart disease was more frequent in men whereas hypertension, diabetes, anxiety and depression were more frequent in women. Our finding could also reveal an underestimation of cardiovascular disease in women in general practice. A high proportion of anxiety-depression could influence the under-diagnosis of COPD in women, as asthenia could mask dyspnea in women and could be a negative factor of smoking cessation. The impact of osteoporosis could also be important, because of the frequent prescription of oral corticosteroids to treat exacerbation of COPD, which in turn could increase the risk of osteoporosis and complications [18].
There was no difference between men and women regarding the frequency of cough, sputum and dyspnea. However, with regard to the severity of the disease as assessed by FEV1, COPD was less severe in women. In other studies focusing on gender difference in patients with COPD, this was previously observed [8, 14, 17] and it was also the case in the Uplift study [19].
Finally, despite the lower severity of the disease as assessed by GOLD staging, women with COPD had a worse quality of life as measured by the SGRQ questionnaire compared with men, as reported previously [8, 20]. In addition, chronic sputum was significantly associated with poor quality of life in women, whereas it was the number of treatments which was associated with it in men. In a recent meta-analysis by Tsiligianni et al. [7], health status was evaluated by various questionnaires whose pertinence was influenced by several factors. Dyspnea, anxiety and depression were more correlated with worse quality of life than spirometric measurements, suggesting that quality of life should be measured in addition to spirometry in the management of patients with COPD [7].
Our findings suggest that management of COPD should take psychological distress and socioeconomic status into account, particularly in women like those in our population, who were more unemployed than men and lived alone more. It is widely admitted in clinical practice that women feel uneasy about expectorating or eliminating sputum, or simply are unable to do so, but there is no published evidence. Among our COPD patients followed by specialists, there was the same proportion of patients with sputum in women and in men, while this is a key symptom of a lower quality of life mainly in women. Management with physiotherapy could improve quality of life in such women.
Our study had some limitations. This could be due to the design of the study, because the first patient included had to be a woman so as to be sure that as many women as men were included. Secondly, in the final model to determine factors associated with quality of life, we only included variables with less than 25% of data lacking, which decreased the size of the sample. A causal inference cannot be drawn because of the cross sectional design of the study. Our sample was made by patients with COPD referred to pulmonologists, so we cannot generalize our results to the population of COPD patients followed in general practice.
Conclusions
These findings show that although women experience less airflow limitation, their quality of life in COPD seems more impaired than that of men. Although FEV1 values were higher in women compared to men, COPD had a greater impact on them. It is too restrictive to assess COPD severity only by testing lung function. Assessment of COPD severity could take into account gender, co-morbidities and quality of life in order to obtain a composite severity score. Factors associated with quality of life differ according to gender, with a specific impact of chronic sputum in women. Management of women with COPD should incorporate these specific characteristics, the impact of the disease and gender-specific comorbidities in order to improve their quality of life.
Acknowledgments
We would like to acknowledge the investigators and patients for participation in the study, Nicolas Lemaire, statistician (Axonal, France) for analyzing the data and Ray Cooke for editorial assistance.
We are also indebted to Professor Paul W. Jones for granting us permission to use the SGRQ.
Financial support
AstraZeneca France.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
Competing interest
Chantal Raherison received speaker fees and congress invitations from the following companies: Novartis, Astra Zeneca, MundiPharma, Chiesi, Nycomed, Pierre Fabre. Isabelle Tillie-Leblond received speaker fees and congress invitations from the following companies: Novartis, Astra Zeneca, MundiPharma, Chiesi, Nycomed, GlaxoSmithKline. Camille Taillé received speaker fees and congress invitations from the following companies: Novartis, Astra Zeneca, GlaxoSmithKline, MSD, Chiesi, Teva. Anne Prudhomme received speaker fees and congress invitations from the following companies: Novartis, AstraZeneca, MundiPharma, GlaxoSmithKline. Elisabeth Biron received speaker fees and congress invitations from the following companies: AstraZeneca. Cecilia Nocent received speaker fess and congress invitations from the following companies: Astra Zeneca, Novartis, Merck Sharp & Dohme-Chibret, GlaxoSmithKline, ALK. Bénigne Mathieu and Juliette Ostinelli are full time employees of AstraZeneca France, Medical Department.
Authors’ contributions
All authors were involved in the study design, discussed the results. CR wrote the paper. All authors commented on the revised manuscript. All authors read and approved the final manuscript.
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