Background
Methods
Eligibility
Search strategy and selection of studies
Article extraction
Quality assessment
Statistical analysis
Results
Study selection
Quality assessment
Study characteristics
No | Author | Country (continent) | Age (year), sex | Presenting symptoms or signs | Murmur | Comorbidities and medical history | Diagnosis imaging | ECG changes | Histopathology |
---|---|---|---|---|---|---|---|---|---|
1 | Tansel et al. (2011) [20] | Turkey (Asia) | 57, F | Progressive dyspnea, palpitation, and chest pain | A grade 3/6 systolic ejection murmur was heard at the left sternal border | None | TTE | Normal | Myxoma |
2 | Kumagai K et al. (2008) [15] | Japan (Asia) | 2, F | Common cold | A grade 3/6 systolic ejection murmur was heard at the left sternal border | None | TTE, CT, and MRI | NA | Myxoma |
3 | Catton et al. (1963) [22] | USA (America) | 0.17, M | Cough, poor intake, vomiting, palpitation, and tachypnea. Congestive heart failure | Grade 3/6 systolic murmur was best heard at the third intercostal space in the left sternal border | Murmur at birth | Angiography | RVH, RBBB, RAE, and wide QRS-T angle | Myxoma |
4 | Tanabe et al. (2022) [18] | Japan (Asia) | 82, F | Asymptomatic in first presentation. Then, congestive heart failure | None | Right femoral neck fracture, hypertension, previous surgery for uterine fibroid | TTE, CT, MRI | Normal | Myxoma |
5 | Yakirevich et al. (1982) [14] | Israel (Asia) | 0.42, M | Intermittent fever, hyperkinesia, anorexia, hepatosplenomegaly, and vomiting | A grade 3/6 systolic murmur was audible over the lower left sternal border and a grade 1/6 diastolic murmur was audible at Erb’s point | Prematurity, low birth weight, and respiratory distress syndrome in first week of life | NA | RVH, RBBB, and RAE | Myxoma |
6 | Yang et al. (2010) [16] | USA (America) | 58, M | Weakness, fevers, chills, and weight loss | Murmur was positive | Heavy alcohol use | TTE | NA | Infected myxoma |
7 | Sargar et al. (2014) [17] | India (Asia) | 66, M | Syncope | None | History of syncope and temporary pacemaker | TTE, CT, MRI | Complete heart block | Myxoma |
8 | Mai et al. (2012) [21] | China (Asia) | 57, F | Paroxysmal frothy cough, chest tightness, intermittent chills, night sweats, weight loss, and fatigue | None | History of paroxysmal cough with a little frothy white sputum | CT | Normal | Myxoma |
9 | Roux et al. (2017) [19] | Switzerland (Europe) | 16, M | Asymptomatic | None | Family history of hypertrophic obstructive cardiomyopathy | TTE | Normal | Myxoma |
Clinical characteristic
No | Author | Location and extension | Size or diameter (mm) | Complication | Valvular status | Management | Follow-up duration | Recurrence | Deceased or alive |
---|---|---|---|---|---|---|---|---|---|
1 | Tansel et al. (2011) [20] | Pulmonary valve commissure extending to PA | 35 × 26 | Moderate pulmonary stenosis and regurgitation | Mass adherent to pulmonary commissure | Myxoma excision and pulmonary arteriotomy | 6 months | No | Alive |
2 | Kumagai K et al. (2008) [15] | Pulmonary annulus and RVOT | 24 × 15 | Cardiomegaly | NA | Myxoma excision, partial resection of the pulmonary valve, and anterior wall of RVOT Reconstruction of RVOT and PA (transannular patch) | 24 months | No | Alive |
3 | Catton et al. (1963) [22] | Pulmonary valve and RV infundibulum | 8 × 10 × 4 | Right ventricular hypertrophy, severe pulmonary stenosis, cyanosis, and Eisenmenger syndrome | Abnormal structures in all cusps | Myxoma excision and widening RVOT | 7 days | NA | Died |
4 | Tanabe et al. (2022) [18] | All cusps extended to RV posterior wall and PA | 36 × 30 | Mild tricuspid regurgitation. Significant PA stenosis | All cusps lumped by the tumor | Myxoma excision and pulmonary valve replacement (bioprosthetic valve) | 1 year | Yes | Died |
5 | Yakirevich et al. (1982) [14] | Pulmonary valves and RV infundibulum | 10 × 8 | Severe pulmonary valve stenosis | Abnormal structures in all cusps | Myxoma excision and Bougie dilatation of the valve ring | 6 months | NA | Alive |
6 | Yang et al. (2010) [16] | Pulmonary valve and annulus. Extending to RV infundibulum | 32 × 40 | Right ventricular outflow tract obstruction and endocarditis | NA | Myxoma excision and pulmonary valve replacement (epic tissue valve) | NA | NA | Alive |
7 | Sargar et al. (2014) [17] | Posterior pulmonary leaflet and RVOT | 30 × 30 × 20 | Hemorrhagic pericardial effusion due to pacing lead in RV | Abnormal structure in posterior pulmonary valve leaflet | Myxoma and valve excision. Permanent pacemaker implantation | NA | NA | Alive |
8 | Mai et al. (2012) [21] | Pulmonary valve root and PA | NA | Cyanosis | Abnormal structure in pulmonary valve root | Myxoma excision and reconstruction of RVOT and PA (transannular pericardial patch) | NA | NA | Alive |
9 | Roux et al. (2012) [19] | Pulmonary valve and RV infundibulum | 8 × 10 | NA | NA | Myxoma excision | NA | NA | Alive |