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International Journal of Hematology
Erschienen in: International Journal of Hematology 2/2023

02.05.2023 | Original Article

Clinical management of second-generation tyrosine kinase inhibitor therapy in patients with newly diagnosed chronic myeloid leukemia in the chronic phase, focusing on age and dose effects

verfasst von: Michihide Tokuhira, Yuta Kimura, Takayuki Tabayashi, Naoki Watanabe, Shun Tsuchiya, Tomoiku Takaku, Noriyoshi Iriyama, Eriko Sato, Tomonori Nakazato, Toru Mitsumori, Maho Ishikawa, Hiroyuki Fujita, Masahiro Kizaki, Miki Ando, Yoshihiro Hatta, Eisaku Iwanaga, Tatsuya Kawaguchi

Erschienen in: International Journal of Hematology | Ausgabe 2/2023

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Abstract

ABL1-tyrosine kinase inhibitors (TKIs) are an established treatment choice for patients with chronic myeloid leukemia in the chronic phase (CML-CP). However, effects of TKI dose modification have not been well investigated. In this study, we retrospectively analyzed 178 patients with newly diagnosed CML-CP who were treated with dasatinib or nilotinib, focusing on age and dose effects. Efficacy as measured by cumulative major molecular response (MMR) and molecular response 4.5 rates did not differ significantly between the younger group and elderly group. Elderly patients who started nilotinib at a reduced dose had similar or better efficacy outcomes (including cumulative MMR and continuation ratios) than other groups, and elderly patients who started dasatinib at a reduced dose had the lowest MMR ratio and longest MMR duration. Effects of dose modification based on age and TKI selection can be attributed to flexible management of TKI therapy in real-world practice, but further studies are required to validate the findings of this study.
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Metadaten
Titel
Clinical management of second-generation tyrosine kinase inhibitor therapy in patients with newly diagnosed chronic myeloid leukemia in the chronic phase, focusing on age and dose effects
verfasst von
Michihide Tokuhira
Yuta Kimura
Takayuki Tabayashi
Naoki Watanabe
Shun Tsuchiya
Tomoiku Takaku
Noriyoshi Iriyama
Eriko Sato
Tomonori Nakazato
Toru Mitsumori
Maho Ishikawa
Hiroyuki Fujita
Masahiro Kizaki
Miki Ando
Yoshihiro Hatta
Eisaku Iwanaga
Tatsuya Kawaguchi
Publikationsdatum
02.05.2023
Verlag
Springer Nature Singapore
Erschienen in
International Journal of Hematology / Ausgabe 2/2023
Print ISSN: 0925-5710
Elektronische ISSN: 1865-3774
DOI
https://doi.org/10.1007/s12185-023-03606-x

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