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International Ophthalmology

Erschienen in:

19.07.2018 | Original Paper

Clinicopathological features of considerable reduction in androgen receptor expression in sebaceous gland carcinoma of the eyelid

verfasst von: Tatsuya Yunoki, Akio Miyakoshi, Mitsuya Otsuka, Atsushi Hayashi

Erschienen in: International Ophthalmology | Ausgabe 8/2019

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Abstract

Purpose

This study aimed to evaluate the relationships between androgen receptor (AR) expression and clinicopathologic features of sebaceous gland carcinoma (SGC) of the eyelid.

Methods

AR expression was evaluated via immunohistochemistry analysis of surgically derived samples from 11 patients with SGC of the eyelid.

Results

The expression of AR was evident in 9 of 11 patients (82%). We divided patients into high AR (7 patients) and low AR (4 patients: 2 patients with low expression and 2 patients with no expression) groups. The low AR group showed significantly greater progression than the high AR group with regard to T category and exhibited a lower grade of differentiation.

Conclusion

In patients with SGC of the eyelid, a marked decrease in AR expression may be associated with a poor prognosis. AR may be a prognostic factor and a potential therapeutic target in cases of SGC of the eyelid.

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Titel: Clinicopathological features of considerable reduction in androgen receptor expression in sebaceous gland carcinoma of the eyelid
verfasst von: Tatsuya Yunoki
Akio Miyakoshi
Mitsuya Otsuka
Atsushi Hayashi
Publikationsdatum: 19.07.2018
Verlag: Springer Netherlands
Erschienen in: International Ophthalmology / Ausgabe 8/2019
Print ISSN: 0165-5701
Elektronische ISSN: 1573-2630
DOI: https://doi.org/10.1007/s10792-018-0990-3

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Springer Medizin

Clinicopathological features of considerable reduction in androgen receptor expression in sebaceous gland carcinoma of the eyelid

Abstract

Purpose

Methods

Results

Conclusion

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Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

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