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01.10.2012 | Original Contribution

Coenzyme Q₁₀ supplementation ameliorates inflammatory signaling and oxidative stress associated with strenuous exercise

verfasst von: Javier Díaz-Castro, Rafael Guisado, Naroa Kajarabille, Carmen García, Isabel M. Guisado, Carlos de Teresa, Julio J. Ochoa

Erschienen in: European Journal of Nutrition | Ausgabe 7/2012

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Abstract

Background

Exhausting exercise induces muscle damage associated with high production of free radicals and pro-inflammatory mediators.

Aim

The objective of this study was to determine for the first time and simultaneously whether oral coenzyme Q₁₀ (CoQ₁₀) supplementation can prevent over-expression of inflammatory mediators and oxidative stress associated with strenuous exercise.

Methods

The participants were classified in two groups: CoQ₁₀ group (CG) and placebo group (PG). The physical test consisted in a constant run (50 km) that combined several degrees of high effort (mountain run and ultra-endurance), in permanent climbing.

Results

Exercise was associated with an increase in TNF-α, IL-6, 8-hydroxy-2′-deoxyguanosine (8-OHdG), and isoprostane levels, revealing the degree of inflammation and oxidative stress induced. Oral supplementation of CoQ₁₀ during exercise was efficient reducing oxidative stress (decreased membrane hydroperoxides, 8-OHdG and isoprostanes generation, increased catalase, and total antioxidant status), which would lead to the maintenance of the cell integrity. Data obtained also indicate that CoQ₁₀ prevents over-expression of TNF-α after exercise, together with an increase in sTNF-RII that limits the pro-inflammatory actions of TNF. Moreover, CoQ₁₀ supplementation reduced creatinine production.

Conclusions

CoQ₁₀ supplementation before strenuous exercise decreases the oxidative stress and modulates the inflammatory signaling, reducing the subsequent muscle damage.

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Titel: Coenzyme Q10 supplementation ameliorates inflammatory signaling and oxidative stress associated with strenuous exercise
verfasst von: Javier Díaz-Castro
Rafael Guisado
Naroa Kajarabille
Carmen García
Isabel M. Guisado
Carlos de Teresa
Julio J. Ochoa
Publikationsdatum: 01.10.2012
Verlag: Springer-Verlag
Erschienen in: European Journal of Nutrition / Ausgabe 7/2012
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-011-0257-5

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Abstract

Background

Aim

Methods

Results

Conclusions

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